| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zachary A Rodd, Victoria E Gryszowka, Jamie E Toalston, Scott M Oster, Dong Ji, Richard L Bell, William J McBrid. The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17325230. |
the study also examined whether there were differences between wistar rats and a line of rats selectively bred for high alcohol consumption with regard to the self-infusion of a 5-ht(3) receptor agonist within the vta. |
2007-07-30 |
2023-08-12 |
rat |
| Zachary A Rodd, Victoria E Gryszowka, Jamie E Toalston, Scott M Oster, Dong Ji, Richard L Bell, William J McBrid. The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17325230. |
adult female alcohol-preferring (p) and wistar rats were allowed to self-infuse the 5-ht(3) receptor agonist 1-(m-chlorophenyl)-biguanide (cpbg) into the posterior or anterior vta. |
2007-07-30 |
2023-08-12 |
rat |
| Zachary A Rodd, Victoria E Gryszowka, Jamie E Toalston, Scott M Oster, Dong Ji, Richard L Bell, William J McBrid. The reinforcing actions of a serotonin-3 receptor agonist within the ventral tegmental area: evidence for subregional and genetic differences and involvement of dopamine neurons. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17325230. |
the results of this study suggest that activation of 5-ht(3) receptors within the posterior vta produces reinforcing effects and that these reinforcing effects are mediated through activation of da neurons. |
2007-07-30 |
2023-08-12 |
rat |
| José M Oliva, Jorge Manzanare. Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 6. 2007-07-27. PMID:17063152. |
voluntary ethanol consumption altered mu-opioid receptor function in the cingulate cortex, caudate-putamen (cpu), nucleus accumbens core (acb c) and shell (acb s), the expression of tyrosine hydroxylase (th) in the ventral tegmental area and substantia nigra, proenkephalin (penk) in the piriform cortex, olfactory tubercle, cpu, acb c and acb s, ventromedial nucleus (vmn) and paraventricular nucleus (pvn) of the hypothalamus, corticotropin releasing factor (crf) in pvn, cannabinoid cb(1) receptor (cb1-r) in the cpu, hippocampus and vmn, and serotonin transporter (5-htt) in the dorsal and median raphe nuclei. |
2007-07-27 |
2023-08-12 |
rat |
| M J Bubar, K A Cunningha. Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience. vol 146. issue 1. 2007-07-18. PMID:17367945. |
distribution of serotonin 5-ht2c receptors in the ventral tegmental area. |
2007-07-18 |
2023-08-12 |
rat |
| M J Bubar, K A Cunningha. Distribution of serotonin 5-HT2C receptors in the ventral tegmental area. Neuroscience. vol 146. issue 1. 2007-07-18. PMID:17367945. |
serotonin 2c receptors (5-ht2cr) appear to exert tonic inhibitory influence over dopamine (da) neurotransmission in the ventral tegmental area (vta), the origin of the mesolimbic da system, thought to be important in psychiatric disorders including addiction and schizophrenia. |
2007-07-18 |
2023-08-12 |
rat |
| Jennifer L Amato, Michael G Bankson, Bryan K Yamamot. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16885935. |
da release in the nacc(sh) and 5-ht in the ventral tegmental area (vta) were measured after a challenge injection of mdma (5 mg/kg, i.p.). |
2007-05-01 |
2023-08-12 |
rat |
| Jennifer L Amato, Michael G Bankson, Bryan K Yamamot. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16885935. |
the combination of pretreatment with mdma+stress decreased basal concentrations of 5-ht in the vta and da in the nacc(sh) and enhanced mdma-stimulated da release in the nacc(sh). |
2007-05-01 |
2023-08-12 |
rat |
| Jennifer L Amato, Michael G Bankson, Bryan K Yamamot. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16885935. |
pretreatment with mdma or stress alone blunted mdma-induced 5-ht release in the vta. |
2007-05-01 |
2023-08-12 |
rat |
| Jennifer L Amato, Michael G Bankson, Bryan K Yamamot. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16885935. |
the augmentation of mdma-induced da release in rats pretreated with mdma+chronic stress was attenuated by perfusion of the 5-ht(1b) antagonist, gr127935 into the vta before the mdma challenge injection. |
2007-05-01 |
2023-08-12 |
rat |
| Jennifer L Amato, Michael G Bankson, Bryan K Yamamot. Prior exposure to chronic stress and MDMA potentiates mesoaccumbens dopamine release mediated by the 5-HT(1B) receptor. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 4. 2007-05-01. PMID:16885935. |
these results suggest that prior exposure to both mdma and stress can produce a long-term augmentation in mesolimbic da transmission and enhanced drug abuse vulnerability that is mediated, in part, by the 5-ht(1b) receptor in the vta. |
2007-05-01 |
2023-08-12 |
rat |
| Yoshimoto Sekine, Katsuaki Suzuki, P Veeraraghavan Ramachandran, Thomas P Blackburn, Charles R Ashb. Acute and repeated administration of fluoxetine, citalopram, and paroxetine significantly alters the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study. Synapse (New York, N.Y.). vol 61. issue 2. 2007-03-02. PMID:17117425. |
we examined the effect of the administration of the selective serotonin reuptake inhibitors (ssris) fluoxetine, citalopram, and paroxetine on the activity of spontaneously active dopamine (da) neurons in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) in anesthetized adult male sprague-dawley rats. |
2007-03-02 |
2023-08-12 |
rat |
| Carrie E John, Sara R Jone. Exocytotic release of dopamine in ventral tegmental area slices from C57BL/6 and dopamine transporter knockout mice. Neurochemistry international. vol 49. issue 8. 2007-01-26. PMID:16901588. |
in addition, dopamine release and uptake kinetics in ventral tegmental area slices from dopamine transporter knockout mice were unaltered by the norepinephrine transporter inhibitor, desipramine (10 microm), or the serotonin transporter inhibitor, fluoxetine (10 microm). |
2007-01-26 |
2023-08-12 |
mouse |
| Sylvia Navailles, Delphine Moison, Dimitri Ryczko, Umberto Spampinat. Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:17018023. |
here, using in vivo microdialysis in halothane-anesthetized rats, we investigated the relative contribution of ventral tegmental area (vta) and nucleus accumbens shell (nac) 5-ht(2c)rs in the phasic/tonic control of accumbal da release, to specifically identify the nature (inhibition/excitation) of the control, and the role of the 5-ht(2c)r ca. |
2007-01-09 |
2023-08-12 |
rat |
| Sylvia Navailles, Delphine Moison, Dimitri Ryczko, Umberto Spampinat. Region-dependent regulation of mesoaccumbens dopamine neurons in vivo by the constitutive activity of central serotonin2C receptors. Journal of neurochemistry. vol 99. issue 4. 2007-01-09. PMID:17018023. |
these findings demonstrate that both vta and nac 5-ht(2c)rs participate in the inhibitory control exerted by 5-ht(2c)rs on accumbal da release, and that the nac shell may represent a primary action site for the ca of 5-ht(2c)rs. |
2007-01-09 |
2023-08-12 |
rat |
| Llorenç Díaz-Mataix, Francesc Artigas, Pau Celad. Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 4. 2006-08-04. PMID:16290106. |
5-ht(1a) receptor agonists increase the activity of dopamine (da) neurons in the ventral tegmental area (vta) and da release in medial prefrontal cortex (mpfc). |
2006-08-04 |
2023-08-12 |
rat |
| Llorenç Díaz-Mataix, Francesc Artigas, Pau Celad. Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 4. 2006-08-04. PMID:16290106. |
the mpfc is enriched in 5-ht(1a) receptors and projects to the vta, where mesocortical dopaminergic neurons originate. |
2006-08-04 |
2023-08-12 |
rat |
| Llorenç Díaz-Mataix, Francesc Artigas, Pau Celad. Activation of pyramidal cells in rat medial prefrontal cortex projecting to ventral tegmental area by a 5-HT1A receptor agonist. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 16. issue 4. 2006-08-04. PMID:16290106. |
we examined whether 5-ht(1a) receptor activation can modulate the activity of mpfc pyramidal neurons projecting to vta. |
2006-08-04 |
2023-08-12 |
rat |
| Thomas P Blackburn, Katsuaki Suzuki, Charles R Ashb. The acute and chronic administration of the 5-HT(2B/2C) receptor antagonist SB-200646A significantly alters the activity of spontaneously active midbrain dopamine neurons in the rat: An in vivo extracellular single cell study. Synapse (New York, N.Y.). vol 59. issue 8. 2006-06-16. PMID:16565966. |
this study examined the effect of the acute and chronic administration of the 5-ht(2b/2c) receptor antagonist n-(1-methyl-5-indolyl)-n'-(3-pyridyl) urea hydrochloride (sb-200646a) on the activity of spontaneously active da cells in the substantia nigra pars compacta (snc) and ventral tegmental area (vta) in anesthetized, male sprague-dawley rats. |
2006-06-16 |
2023-08-12 |
rat |
| Ennio Esposit. Serotonin-dopamine interaction as a focus of novel antidepressant drugs. Current drug targets. vol 7. issue 2. 2006-03-10. PMID:16475959. |
among the multiple classes of 5-ht receptors described in the central nervous system, much attention has been devoted to the role of 5-ht2 receptor family in the control of central dopaminergic activity, because of the moderate to dense localization of both transcript and protein for 5-ht2a and 5-ht2c receptors in the substantia nigra (sn) and ventral tegmental area (vta), as well as their terminal regions. |
2006-03-10 |
2023-08-12 |
human |