| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L E O'Dell, L H Parson. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15226384. |
this study used dual probe microdialysis to investigate whether activation of serotonin(1b) (5-ht(1b)) receptors in the ventral tegmental area (vta) alters the ability of peripherally administered cocaine to elevate dopamine (da) levels in the ipsilateral nucleus accumbens (nacc) of drug-naive wistar rats. |
2005-01-25 |
2023-08-12 |
rat |
| L E O'Dell, L H Parson. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15226384. |
intra-vta administration of the 5-ht(1a/7) receptor agonist 8-hydroxy-2-dipropylaminotetralin (8-oh-dpat; 100 microm) did not alter cocaine-induced alterations in nacc da or vta gaba, suggesting that the effects of cp 93,129 were not mediated through 5-ht(1a) receptors. |
2005-01-25 |
2023-08-12 |
rat |
| L E O'Dell, L H Parson. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15226384. |
moreover, the effects of intra-vta cp 93,129 (100 microm) on both cocaine-induced increases in nacc da levels and cocaine-induced decreases in vta gaba levels were reversed by coadministration of the selective 5-ht(1b) receptor antagonist 3-[3-(dimethylamine)propyl]-4-hydroxy-n-[4-(4-pyridinyl] phenyl] benzamide dihydrochloride (gr 55562; 300 microm). |
2005-01-25 |
2023-08-12 |
rat |
| L E O'Dell, L H Parson. Serotonin1B receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels. The Journal of pharmacology and experimental therapeutics. vol 311. issue 2. 2005-01-25. PMID:15226384. |
these findings indicate that activation of vta 5-ht(1b) receptors potentiates cocaine-induced increases in nacc da levels by enhancing the ability of cocaine to decrease vta gaba efflux. |
2005-01-25 |
2023-08-12 |
rat |
| G Garcia, P Tagliaferro, A Ferri, A M Evangelista de Duffard, R Duffard, A Brusc. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. vol 25. issue 6. 2005-01-14. PMID:15474613. |
dorsal raphe serotonin (5-ht) projections to sn and vta were also studied by 5-ht transporter (5-htt) immunostaining and results were quantified by image analysis. |
2005-01-14 |
2023-08-12 |
rat |
| G Garcia, P Tagliaferro, A Ferri, A M Evangelista de Duffard, R Duffard, A Brusc. Study of tyrosine hydroxylase immunoreactive neurons in neonate rats lactationally exposed to 2,4-dichlorophenoxyacetic Acid. Neurotoxicology. vol 25. issue 6. 2005-01-14. PMID:15474613. |
after 100mg/kg of 2,4-d exposure, a 25% diminution in the sn and a 33% diminution in the vta neurons' th immunostaining along with a significantly 5-ht fiber density diminution were observed. |
2005-01-14 |
2023-08-12 |
rat |
| S Singer, S Rossi, S Verzosa, A Hashim, R Lonow, T Cooper, H Sershen, A Lajth. Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453274. |
nicotine-induced changes in the levels of three neurotransmitters, dopamine (da), serotonin (5-ht), norepinepherine (ne), their metabolites, homovanillic acid (hva), dihydroxyphenylacetic acid (dopac), 5-hydroxyindoleacetic acid (5-hiaa), and their precursor, l-dopa, were evaluated in the ventral and dorsal hippocampus (vh and dh), prefrontal and medial temporal cortex (pfc and mtc), and the ventral tegmental area (vta) using in vivo microdialysis in awake, freely moving, male sprague-dawley rats. |
2004-12-07 |
2023-08-12 |
rat |
| S Singer, S Rossi, S Verzosa, A Hashim, R Lonow, T Cooper, H Sershen, A Lajth. Nicotine-induced changes in neurotransmitter levels in brain areas associated with cognitive function. Neurochemical research. vol 29. issue 9. 2004-12-07. PMID:15453274. |
5-ht was increased in the dh, mtc, and vta in the presence of fluoxetine; its metabolite, 5-hiaa, was increased in the presence and absence of fluoxetine. |
2004-12-07 |
2023-08-12 |
rat |
| Albert Adell, Francesc Artiga. The somatodendritic release of dopamine in the ventral tegmental area and its regulation by afferent transmitter systems. Neuroscience and biobehavioral reviews. vol 28. issue 4. 2004-10-26. PMID:15289006. |
apart from intrinsic dopaminergic mechanisms, other transmitter systems such as serotonin, noradrenaline, acetylcholine, gaba and glutamate play a role in the control of the activity of dopaminergic neurons of the vta, although the final action depends on the particular receptor involved as well as the neuronal type where it is localized. |
2004-10-26 |
2023-08-12 |
Not clear |
| S T Bland, C Twining, M J Schmid, A Der-Avakian, L R Watkins, S F Maie. Stress potentiation of morphine-induced dopamine efflux in the nucleus accumbens shell is dependent upon stressor uncontrollability and is mediated by the dorsal raphe nucleus. Neuroscience. vol 126. issue 3. 2004-09-14. PMID:15183519. |
no effect of is was found on morphine-induced 5-ht or da efflux in the ventral tegmental area. |
2004-09-14 |
2023-08-12 |
rat |
| Edmund Przegaliński, Iwona Papla, Joanna Siwanowicz, Małgorzata Fili. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 3. 2004-06-21. PMID:15056481. |
the present study was aimed at finding out whether 5-ht(1b) receptors located in the ventral tegmental area (vta) played a role in the locomotor hyperactivity induced by a single dose of cocaine and in the sensitization evoked by repeated exposure to the psychostimulant in rats. |
2004-06-21 |
2023-08-12 |
rat |
| Edmund Przegaliński, Iwona Papla, Joanna Siwanowicz, Małgorzata Fili. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 3. 2004-06-21. PMID:15056481. |
male wistar rats, implanted bilaterally with cannulae in the vta, were microinjected with gr 55562 (an antagonist of 5-ht(1b) receptors) or cp 93129 (an agonist of 5-ht(1b) receptors). |
2004-06-21 |
2023-08-12 |
rat |
| Edmund Przegaliński, Iwona Papla, Joanna Siwanowicz, Małgorzata Fili. Effects of 5-HT1B receptor ligands microinjected into the ventral tegmental area on the locomotor and sensitizating effects of cocaine in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 14. issue 3. 2004-06-21. PMID:15056481. |
our findings suggest that 5-ht(1b) receptors located in the vta play a permissive role in the development of cocaine sensitization, but are not involved in the locomotor hyperactivity induced by a single dose of cocaine or in the expression of the sensitization to the psychostimulant. |
2004-06-21 |
2023-08-12 |
rat |
| J E Olijslagers, T R Werkman, A C McCreary, R Siarey, C G Kruse, W J Wadma. 5-HT2 receptors differentially modulate dopamine-mediated auto-inhibition in A9 and A10 midbrain areas of the rat. Neuropharmacology. vol 46. issue 4. 2004-05-28. PMID:14975674. |
5-ht (20 microm) enhanced dopamine (da) d2-like receptor mediated reduction of the firing rate of da neurons in the substantia nigra pars compacta (a9) and ventral tegmental area (a10) in a rat midbrain slice preparation. |
2004-05-28 |
2023-08-12 |
rat |
| Kari J Buck, Matthew T Reilly, Laura M Rogers, Ken Szeliga, Kathleen Grant, Mark S Brodi. Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Alcoholism, clinical and experimental research. vol 28. issue 2. 2004-05-17. PMID:15112928. |
the presentations were (1) the multiple pdz domain protein may mediate genetic differences in ethanol withdrawal severity via interaction with 5-ht2 receptors, by matthew t. reilly and kari j. buck; (2) the ionic mechanism of serotonin potentiation of ethanol excitation of ventral tegmental area neurons, by mark s. brodie; and (3) 5-ht(2c) receptor agonists in the discriminative stimulus effects of ethanol, by laura m. rogers, ken szeliga, and kathleen grant. |
2004-05-17 |
2023-08-12 |
Not clear |
| Yoshio Minabe, Yukihiko Shirayama, Kenji Hashimoto, Carol Routledge, Jim J Hagan, Charles R Ashb. Effect of the acute and chronic administration of the selective 5-HT6 receptor antagonist SB-271046 on the activity of midbrain dopamine neurons in rats: an in vivo electrophysiological study. Synapse (New York, N.Y.). vol 52. issue 1. 2004-05-07. PMID:14755629. |
administration of the selective 5-ht(6) receptor antagonist sb-271046, on the number, as well as the firing pattern of spontaneously active dopamine (da) neurons in the rat substantia nigra pars compacta (snc) and ventral tegmental area (vta) in anesthetized male sprague-dawley rats. |
2004-05-07 |
2023-08-12 |
rat |
| Paul J Fletcher, Araba F Chintoh, Judy Sinyard, Guy A Higgin. Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14666118. |
ro60-0175 also alters the activity of midbrain dopamine (da) neurons of the ventral tegmental area (vta), a region where 5-ht(2c) receptors are expressed. |
2004-04-27 |
2023-08-12 |
rat |
| Paul J Fletcher, Araba F Chintoh, Judy Sinyard, Guy A Higgin. Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14666118. |
these results demonstrate that stimulation of 5-ht(2c) receptors in the vta is sufficient to attenuate the stimulant and reinforcing effects of cocaine. |
2004-04-27 |
2023-08-12 |
rat |
| Paul J Fletcher, Araba F Chintoh, Judy Sinyard, Guy A Higgin. Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14666118. |
these effects complement electrophysiological and neurochemical findings, and indicate that 5-ht(2c) receptors localized within the vta modulate the activity of mesolimbic da neurons. |
2004-04-27 |
2023-08-12 |
rat |
| Zhaoping Liu, E Bradshaw Bunney, Sarah B Appel, Mark S Brodi. Serotonin reduces the hyperpolarization-activated current (Ih) in ventral tegmental area dopamine neurons: involvement of 5-HT2 receptors and protein kinase C. Journal of neurophysiology. vol 90. issue 5. 2004-01-22. PMID:12890794. |
serotonin reduces the hyperpolarization-activated current (ih) in ventral tegmental area dopamine neurons: involvement of 5-ht2 receptors and protein kinase c. dopaminergic neurons of the ventral tegmental area (vta) have been implicated in the rewarding properties of drugs of abuse and in the etiology of schizophrenia; serotonin modulation of these neurons may play a role in these phenomena. |
2004-01-22 |
2023-08-12 |
rat |