| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Iveta Jahodova, Martina Baliova, Frantisek Jursk. PDZ interaction of the GABA transporter GAT1 with the syntenin-1 in Neuro-2a cells. Neurochemistry international. 2023-03-26. PMID:36966820. |
the gaba transporter gat1 regulates brain inhibitory neurotransmission and it is considered a potential therapeutic target for the treatment of wide spectrum of neurological diseases including epilepsy, stroke and autism. |
2023-03-26 |
2023-08-14 |
Not clear |
| Hiroshi Hanamoto, Yohsuke Hirose, Midori Toyama, Chizuko Yokoe, Aiko Oyamaguchi, Hitoshi Niw. Effect of midazolam in autism spectrum disorder: A retrospective observational analysis. Acta anaesthesiologica Scandinavica. 2023-02-08. PMID:36754992. |
while midazolam is commonly used as premedication for uncooperative patients, its effects are difficult to predict in patients with autism spectrum disorder for whom abnormalities in gamma-aminobutyric acid have been reported. |
2023-02-08 |
2023-08-14 |
Not clear |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
excitatory/inhibitory imbalance in autism: the role of glutamate and gaba gene-sets in symptoms and cortical brain structure. |
2023-01-21 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
using competitive gene-set analyses, we investigated whether aggregated genetic variation in glutamate and gaba gene-sets could be associated with behavioral measures of autism symptoms and brain structural variation. |
2023-01-21 |
2023-08-14 |
human |
| Viola Hollestein, Geert Poelmans, Natalie J Forde, Christian F Beckmann, Christine Ecker, Caroline Mann, Tim Schäfer, Carolin Moessnang, Sarah Baumeister, Tobias Banaschewski, Thomas Bourgeron, Eva Loth, Flavio Dell'Acqua, Declan G M Murphy, Nicolaas A Puts, Julian Tillmann, Tony Charman, Emily J H Jones, Luke Mason, Sara Ambrosino, Rosemary Holt, Sven Bölte, Jan K Buitelaar, Jilly Naaije. Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure. Translational psychiatry. vol 13. issue 1. 2023-01-21. PMID:36681677. |
our results suggest complex relationships between e/i related genetics and autism symptom profiles as well as brain structure alterations, where there may be differential roles for glutamate and gaba. |
2023-01-21 |
2023-08-14 |
human |
| Elizabeth W Pang, Chris Hammill, Margot J Taylor, Jamie Near, Russell Schachar, Jennifer Crosbie, Paul D Arnold, Evdokia Anagnostou, Jason P Lerc. Cerebellar gamma-aminobutyric acid: Investigation of group effects in neurodevelopmental disorders. Autism research : official journal of the International Society for Autism Research. 2023-01-10. PMID:36626308. |
neurodevelopmental disorders (ndds) including autism spectrum disorder (asd), attention-deficit hyperactivity disorder (adhd) and obsessive-compulsive disorder (ocd) are thought to arise in part from the disruption in the excitatory/inhibitory balance of gamma-aminobutyric acid (gaba) and glutamate in the brain. |
2023-01-10 |
2023-08-14 |
Not clear |
| Sara Haratizadeh, Mehdi Ranjbar, Fatemeh Darvishzadeh-Mahani, Mohsen Basiri, Masoumeh Nozar. The effects of postnatal erythropoietin and nano-erythropoietin on behavioral alterations by mediating K-Cl co-transporter 2 in the valproic acid-induced rat model of autism. Developmental psychobiology. vol 65. issue 1. 2022-12-26. PMID:36567653. |
in this study, based on the excitatory/inhibitory imbalance theory of autism, the time window of gaba switch, the role of k-cl co-transporter 2 (kcc2) in adjustment gaba switch, and brain permeability to erythropoietin (epo), the effects of postnatal -epo and- nano- erythropoietin (nepo) have been evaluated in the valproic acid (vpa) rat model of autism. |
2022-12-26 |
2023-08-14 |
rat |
| Xi Gu, Junhao Wang, Xiaodan Jian. miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons. ACS chemical neuroscience. 2022-09-08. PMID:36074953. |
dysfunction of γ-aminobutyric acid (gaba)ergic interneurons may cause a variety of neurological and psychiatric disorders such as epilepsy, autism, alzheimer's disease, and depression. |
2022-09-08 |
2023-08-14 |
human |
| Ming-Chia Chu, Han-Fang Wu, Chi-Wei Lee, Yueh-Jung Chung, Hsiang Chi, Po See Chen, Hui-Ching Li. Generational synaptic functions of GABA Journal of biomedical science. vol 29. issue 1. 2022-07-12. PMID:35821032. |
generational synaptic functions of gaba disruption of normal brain development is implicated in numerous psychiatric disorders with neurodevelopmental origins, including autism spectrum disorder (asd). |
2022-07-12 |
2023-08-14 |
Not clear |
| Qingyang Li, Lingli Zhang, Haidi Shan, Juehua Yu, Yuan Dai, Hua He, Wei-Guang Li, Christelle Langley, Barbara J Sahakian, Yin Yao, Qiang Luo, Fei L. The immuno-behavioural covariation associated with the treatment response to bumetanide in young children with autism spectrum disorder. Translational psychiatry. vol 12. issue 1. 2022-06-06. PMID:35660740. |
bumetanide, a drug being studied in autism spectrum disorder (asd) may act to restore gamma-aminobutyric acid (gaba) function, which may be modulated by the immune system. |
2022-06-06 |
2023-08-14 |
Not clear |
| Sharmistha Saha, Mahasweta Chatterjee, Nilanjana Dutta, Swagata Sinha, Kanchan Mukhopadhya. GABA Receptor SNPs and Elevated Plasma GABA Levels Affect the Severity of the Indian ASD Probands. Journal of molecular neuroscience : MN. 2022-05-13. PMID:35562522. |
altered signaling of the chief inhibitory neurotransmitter, gamma-aminobutyric acid (gaba), has been speculated in the etiology of autism spectrum disorder (asd). |
2022-05-13 |
2023-08-13 |
Not clear |
| Qiyun Huang, Andreia C Pereira, Hester Velthuis, Nichol M L Wong, Claire L Ellis, Francesca M Ponteduro, Mihail Dimitrov, Lukasz Kowalewski, David J Lythgoe, Diana Rotaru, Richard A E Edden, Alison Leonard, Glynis Ivin, Jumana Ahmad, Charlotte M Pretzsch, Eileen Daly, Declan G M Murphy, Gráinne M McAlona. GABA Science translational medicine. vol 14. issue 626. 2022-04-26. PMID:34985973. |
gaba sensory atypicalities in autism spectrum disorder (asd) are thought to arise at least partly from differences in γ-aminobutyric acid (gaba) receptor function. |
2022-04-26 |
2023-08-16 |
Not clear |
| Sum Yi Ma, Kin Ming Kwa. Size Anomaly and Alteration of GABAergic Enzymes Expressions in Cerebellum of a Valproic acid Mouse Model of Autism. Behavioural brain research. 2022-04-18. PMID:35436531. |
this study aimed to investigate the cerebellar structure and determine the expression of rate-limiting gabaergic enzymes in gaba signalling of the autism cerebellum. |
2022-04-18 |
2023-08-13 |
mouse |
| David James, Vicky T Lam, Booil Jo, Lawrence K Fun. Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults. Autism research : official journal of the International Society for Autism Research. 2022-03-09. PMID:35261207. |
the neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid a (gaba |
2022-03-09 |
2023-08-13 |
Not clear |
| Hiroko Kotajima-Murakami, Hideo Hagihara, Atsushi Sato, Yoko Hagino, Miho Tanaka, Yoshihisa Katoh, Yasumasa Nishito, Yukio Takamatsu, Shigeo Uchino, Tsuyoshi Miyakawa, Kazutaka Iked. Exposure to GABA Frontiers in psychiatry. vol 13. 2022-02-21. PMID:35185658. |
exposure to gaba autism spectrum disorder (asd) is a neurodevelopmental disorder that is characterized by impairments in social interaction and restricted/repetitive behaviors. |
2022-02-21 |
2023-08-13 |
Not clear |
| Veronika Meliskova, Tomas Havranek, Zuzana Bacova, Jan Bako. The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models. Journal of integrative neuroscience. vol 20. issue 4. 2022-01-08. PMID:34997728. |
pathological changes in synapse formation, plasticity, and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gamma-aminobutyric acid (gaba)ergic synapses, suggesting their involvement in the etiology of neurodevelopmental disorders, including autism. |
2022-01-08 |
2023-08-13 |
mouse |
| Afaf El-Ansary, Naima Zayed, Laila Al-Ayadhi, Hanan Qasem, Mona Anwar, Nagwa A Meguid, Ramesa Shafi Bhat, Monica Daniela Doşa, Salvatore Chirumbolo, Geir Bjørklun. GABA synaptopathy promotes the elevation of caspases 3 and 9 as pro-apoptotic markers in Egyptian patients with autism spectrum disorder. Acta neurologica Belgica. vol 121. issue 2. 2021-11-01. PMID:31673995. |
gaba synaptopathy promotes the elevation of caspases 3 and 9 as pro-apoptotic markers in egyptian patients with autism spectrum disorder. |
2021-11-01 |
2023-08-13 |
human |
| Afaf El-Ansary, Naima Zayed, Laila Al-Ayadhi, Hanan Qasem, Mona Anwar, Nagwa A Meguid, Ramesa Shafi Bhat, Monica Daniela Doşa, Salvatore Chirumbolo, Geir Bjørklun. GABA synaptopathy promotes the elevation of caspases 3 and 9 as pro-apoptotic markers in Egyptian patients with autism spectrum disorder. Acta neurologica Belgica. vol 121. issue 2. 2021-11-01. PMID:31673995. |
roc and predictiveness curves showed that caspases 3, caspases 9, and gaba might be utilized as predictive markers in autism diagnosis. |
2021-11-01 |
2023-08-13 |
human |
| C Kağan Gürkan, Randi J Hagerma. TARGETED TREATMENTS IN AUTISM AND FRAGILE X SYNDROME. Research in autism spectrum disorders. vol 6. issue 4. 2021-10-21. PMID:23162607. |
examples of this are two drug classes developed to treat fxs, arbaclofen, a gaba(b) agonist, and mglur5 antagonists, and both may be helpful in autism without fxs. |
2021-10-21 |
2023-08-12 |
Not clear |
| Sharmistha Saha, Mahasweta Chatterjee, Swagata Sinha, Kanchan Mukhopadhya. A pioneering study indicate role of GABRQ rs3810651 in ASD severity of Indo-Caucasoid female probands. Scientific reports. vol 11. issue 1. 2021-10-20. PMID:33772085. |
alteration in gamma aminobutyric acid (gaba), the principal inhibitory neurotransmitter, is speculated to be a potential risk factor for autism spectrum disorder (asd) due to an altered expression in the brain. |
2021-10-20 |
2023-08-13 |
human |