| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sarah Poliquin, Inna Hughes, Wangzhen Shen, Felicia Mermer, Juexin Wang, Taralynn Mack, Dong Xu, Jing-Qiong Kan. Genetic mosaicism, intrafamilial phenotypic heterogeneity, and molecular defects of a novel missense SLC6A1 mutation associated with epilepsy and ADHD. Experimental neurology. vol 342. 2021-10-11. PMID:33961861. |
mutations in slc6a1, encoding γ-aminobutyric acid (gaba) transporter 1 (gat-1), have been recently associated with a spectrum of neurodevelopmental disorders ranging from variable epilepsy syndromes, intellectual disability (id), autism and others. |
2021-10-11 |
2023-08-13 |
Not clear |
| b' P Ballester, A L Richdale, E K Baker, A M Peir\\xc3\\xb. Sleep in autism: A biomolecular approach to aetiology and treatment. Sleep medicine reviews. vol 54. 2021-10-04. PMID:32759030.' |
this review approaches sleep in autism from several perspectives: sleep-wake mechanisms and problems, and brain areas and molecules controlling sleep (e.g., gaba and melatonin) and wake maintenance (e.g., serotonin, acetylcholine and glutamate). |
2021-10-04 |
2023-08-13 |
Not clear |
| Dorit Möhrle, Wenxuan Wang, Shawn N Whitehead, Susanne Schmi. GABA Frontiers in integrative neuroscience. vol 15. 2021-09-08. PMID:34489651. |
gaba altered sensory information processing, and auditory processing, in particular, is a common impairment in individuals with autism spectrum disorder (asd). |
2021-09-08 |
2023-08-13 |
Not clear |
| b' Volkan Solmaz, Aslan Tekatas, M\\xc3\\xbcmin Alper Erdo\\xc4\\x9fan, Oytun Erba\\xc5\\x9. Exenatide, a GLP-1 analog, has healing effects on LPS-induced autism model: Inflammation, oxidative stress, gliosis, cerebral GABA, and serotonin interactions. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 80. issue 7. 2021-08-26. PMID:32745285.' |
exenatide, a glp-1 analog, has healing effects on lps-induced autism model: inflammation, oxidative stress, gliosis, cerebral gaba, and serotonin interactions. |
2021-08-26 |
2023-08-13 |
rat |
| Jan J Sprengers, Dorinde M van Andel, Hilgo Bruinin. Dr. Sprengers et al. Reply. Journal of the American Academy of Child and Adolescent Psychiatry. vol 60. issue 8. 2021-08-06. PMID:33450401. |
before we elaborate on the postulated discrepancies between our trial and previous bumetanide in autism spectrum disorder (asd) trials, we would like to acknowledge the crucial pioneering work on the γ-aminobutyric acid (gaba) developmental sequence by dr. ben-ari and colleagues. |
2021-08-06 |
2023-08-13 |
Not clear |
| Marilena M DeMayo, Ashley D Harris, Yun Ju C Song, Izabella Pokorski, Rinku Thapa, Shrujna Patel, Zahava Ambarchi, Emma E Thomas, Ian B Hickie, Adam J Guastell. Age-related parietal GABA alterations in children with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. vol 14. issue 5. 2021-07-28. PMID:33634588. |
age-related parietal gaba alterations in children with autism spectrum disorder. |
2021-07-28 |
2023-08-13 |
Not clear |
| Marilena M DeMayo, Ashley D Harris, Yun Ju C Song, Izabella Pokorski, Rinku Thapa, Shrujna Patel, Zahava Ambarchi, Emma E Thomas, Ian B Hickie, Adam J Guastell. Age-related parietal GABA alterations in children with autism spectrum disorder. Autism research : official journal of the International Society for Autism Research. vol 14. issue 5. 2021-07-28. PMID:33634588. |
reductions in gaba are proposed to result in an overly excitatory cortex that may cause, or contribute to, symptoms of autism spectrum disorder (asd). |
2021-07-28 |
2023-08-13 |
Not clear |
| Timothy P L Roberts, Luke Bloy, Matt Ku, Lisa Blaskey, Carissa R Jackel, James Christopher Edgar, Jeffrey I Berma. A Multimodal Study of the Contributions of Conduction Velocity to the Auditory Evoked Neuromagnetic Response: Anomalies in Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 10. 2021-07-01. PMID:32924333. |
this multimodal imaging study used magnetoencephalography, diffusion magnetic resonance imaging (mri), and gamma-aminobutyric acid (gaba) magnetic resonance spectroscopy (mrs) to identify and contrast the multiple physiological mechanisms associated with auditory processing efficiency in typically developing (td) children and children with autism spectrum disorder (asd). |
2021-07-01 |
2023-08-13 |
human |
| Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei L. Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066666. |
bumetanide has been reported to alter synaptic excitation-inhibition (e-i) balance by potentiating the action of γ-aminobutyric acid (gaba), thereby attenuating the severity of autism spectrum disorder (asd) in animal models. |
2021-06-18 |
2023-08-13 |
Not clear |
| Lingli Zhang, Chu-Chung Huang, Yuan Dai, Qiang Luo, Yiting Ji, Kai Wang, Shining Deng, Juehua Yu, Mingyu Xu, Xiujuan Du, Yun Tang, Chun Shen, Jianfeng Feng, Barbara J Sahakian, Ching-Po Lin, Fei L. Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32066666. |
primary [children autism rating scale (cars)], secondary [clinical global impressions (cgi)], and exploratory [inhibitory (γ-aminobutyric acid, gaba) and excitatory (glutamate, glx) neurotransmitter concentrations measured in the insular cortex (ic) and visual cortex (vc) by magnetic resonance spectroscopy (mrs)] outcome measures were evaluated at baseline and at the 3-month follow-up. |
2021-06-18 |
2023-08-13 |
Not clear |
| Davide Pozzi, Marco Rasile, Irene Corradini, Michela Matteol. Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on? Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:33060559. |
accordingly, developmental disorders such as schizophrenia, autism spectrum disorder, down syndrome, epilepsy, and tuberous sclerosis complex (tsc) have been associated with alterations in the expression of genes codifying for either of the two cotransporters involved in the excitatory-to-inhibitory gaba switch, kcc2 and nkcc1. |
2021-06-18 |
2023-08-13 |
Not clear |
| Kui Wang, Na Li, Min Xu, Meng Huang, Fei Huan. Glyoxalase 1 Inhibitor Alleviates Autism-like Phenotype in a Prenatal Valproic Acid-Induced Mouse Model. ACS chemical neuroscience. vol 11. issue 22. 2021-06-18. PMID:33166134. |
this study aims to evaluate the roles of glyoxalase 1 (glo1)-methylglyoxal (mg)-γ-aminobutyric acid (gaba) signaling in asd using a valproic acid (vpa)-induced animal model of autism. |
2021-06-18 |
2023-08-13 |
mouse |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
concentrations of cortical gaba and glutamate in young adults with autism spectrum disorder. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
the balance of excitation and inhibition in neural circuits is hypothesized to be increased in autism spectrum disorder, possibly mediated by altered signaling of the inhibitory neurotransmitter γ-aminobutyric acid (gaba), yet empirical evidence in humans is inconsistent. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
we used edited magnetic resonance spectroscopy (mrs) to quantify signals associated with both gaba and the excitatory neurotransmitter glutamate in multiple regions of the sensory and sensorimotor cortex, including primary visual, auditory, and motor areas in adult individuals with autism and in neurotypical controls. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
despite the strong a priori hypothesis of reduced gaba in autism spectrum disorder, we found no group differences in neurometabolite concentrations in any of the examined regions and no correlations of mrs measure with psychophysical visual sensitivity or autism symptomatology. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
we conclude that levels of gaba and glx (glutamate, glutamine, and glutathione) in the sensory and sensorimotor cortex, as measured with mrs at 3t, are comparable in adults with autism and neurotypical individuals. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
© 2020 international society for autism research, wiley periodicals, inc. lay summary: γ-aminobutyric acid (gaba) and glutamate are the main inhibitory and excitatory neurotransmitters in the human brain, respectively, and their balanced interaction is necessary for neural function. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
previous research suggests that the gaba and glutamate systems might be altered in autism. |
2021-06-16 |
2023-08-13 |
human |
| Tamar Kolodny, Michael-Paul Schallmo, Jennifer Gerdts, Richard A E Edden, Raphael A Bernier, Scott O Murra. Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder. Autism research : official journal of the International Society for Autism Research. vol 13. issue 7. 2021-06-16. PMID:32297709. |
in contradiction to the common hypothesis of reduced gaba in autism, we demonstrate that concentrations of both gaba and glutamate, in all the brain regions examined, are comparable in individuals with autism and in neurotypical adults. |
2021-06-16 |
2023-08-13 |
human |