| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lawrence K Fung, Ryan E Flores, Meng Gu, Kevin L Sun, David James, Rachel K Schuck, Booil Jo, Jun Hyung Park, Byung Chul Lee, Jae Ho Jung, Sang Eun Kim, Manish Saggar, Matthew D Sacchet, Geoff Warnock, Mohammad Mehdi Khalighi, Daniel Spielman, Frederick T Chin, Antonio Y Harda. Thalamic and prefrontal GABA concentrations but not GABA Molecular psychiatry. vol 26. issue 5. 2021-06-11. PMID:32376999. |
thalamic and prefrontal gaba concentrations but not gaba the gamma aminobutyric acid (gaba) neurotransmission system has been implicated in autism spectrum disorder (asd). |
2021-06-11 |
2023-08-13 |
Not clear |
| Jie Wang, Sarah Poliquin, Felicia Mermer, Jaclyn Eissman, Eric Delpire, Juexin Wang, Wangzhen Shen, Kefu Cai, Bing-Mei Li, Zong-Yan Li, Dong Xu, Gerald Nwosu, Carson Flamm, Wei-Ping Liao, Yi-Wu Shi, Jing-Qiong Kan. Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism. Molecular brain. vol 13. issue 1. 2021-06-03. PMID:32398021. |
mutations in slc6a1, encoding γ-aminobutyric acid (gaba) transporter 1 (gat-1), have been recently associated with a spectrum of epilepsy syndromes, intellectual disability and autism in clinic. |
2021-06-03 |
2023-08-13 |
Not clear |
| Jie Wang, Sarah Poliquin, Felicia Mermer, Jaclyn Eissman, Eric Delpire, Juexin Wang, Wangzhen Shen, Kefu Cai, Bing-Mei Li, Zong-Yan Li, Dong Xu, Gerald Nwosu, Carson Flamm, Wei-Ping Liao, Yi-Wu Shi, Jing-Qiong Kan. Endoplasmic reticulum retention and degradation of a mutation in SLC6A1 associated with epilepsy and autism. Molecular brain. vol 13. issue 1. 2021-06-03. PMID:32398021. |
here we report a novel slc6a1 missense mutation in a patient with epilepsy and autism spectrum disorder and characterized the molecular defects of the mutant gat-1, from transporter protein trafficking to gaba uptake function in heterologous cells and neurons. |
2021-06-03 |
2023-08-13 |
Not clear |
| Tiffany Hong, Carmen Falcone, Brett Dufour, Sarwat Amina, Rosalia Perez Castro, Jade Regalado, Weston Pearson, Stephen C Noctor, Verónica Martínez-Cerdeñ. GABA Neuroscience. vol 437. 2021-05-14. PMID:32335215. |
gaba some forms of autism spectrum disorder, a neurodevelopmental syndrome characterized by impaired communication and social skills as well as repetitive behaviors, are purportedly associated with dysregulation of the excitation/inhibition balance in the cerebral cortex. |
2021-05-14 |
2023-08-13 |
human |
| Tiffany Hong, Carmen Falcone, Brett Dufour, Sarwat Amina, Rosalia Perez Castro, Jade Regalado, Weston Pearson, Stephen C Noctor, Verónica Martínez-Cerdeñ. GABA Neuroscience. vol 437. 2021-05-14. PMID:32335215. |
through human postmortem tissue analysis, we previously found a significant decrease in the number of a gamma-aminobutyric acid (gaba)ergic interneuron subtype, the chandelier (ch) cell, in the prefrontal cortex of subjects with autism. |
2021-05-14 |
2023-08-13 |
human |
| Tiffany Hong, Carmen Falcone, Brett Dufour, Sarwat Amina, Rosalia Perez Castro, Jade Regalado, Weston Pearson, Stephen C Noctor, Verónica Martínez-Cerdeñ. GABA Neuroscience. vol 437. 2021-05-14. PMID:32335215. |
thus, we herein investigated this crucial link between ch and pyr cells in the anatomy of autism neuropathology by examining gaba receptor protein expression in the pyr cell ais in subjects with autism. |
2021-05-14 |
2023-08-13 |
human |
| Tracie A Paine, Sara Chang, Rachel Poyl. Contribution of GABA Behavioural brain research. vol 378. 2021-04-28. PMID:31560920. |
contribution of gaba gaba dysfunction is associated with a number of psychiatric conditions including schizophrenia, autism and depression. |
2021-04-28 |
2023-08-13 |
Not clear |
| Samantha T Reyes, Sanaz Mohajeri, Karolina Krasinska, Scarlett G Guo, Meng Gu, Laura Pisani, Jarrett Rosenberg, Daniel M Spielman, Frederick T Chi. GABA Measurement in a Neonatal Fragile X Syndrome Mouse Model Using Frontiers in molecular neuroscience. vol 13. 2021-03-23. PMID:33390902. |
gaba measurement in a neonatal fragile x syndrome mouse model using fragile x syndrome (fxs) is the leading monogenetic cause of autism spectrum disorder and inherited cause of intellectual disability that affects approximately one in 7,000 males and one in 11,000 females. |
2021-03-23 |
2023-08-13 |
mouse |
| Ángel Alberto Puig-Lagunes, Luisa Rocha, Consuelo Morgado-Valle, Luis BeltrÁn-Parrazal, MarÍa-Leonor LÓpez-Mera. Brain and plasma amino acid concentration in infant rats prenatally exposed to valproic acid. Anais da Academia Brasileira de Ciencias. vol 93. issue 2. 2021-03-19. PMID:33729379. |
here, we aimed to determine the concentration of gaba, glutamate, glutamine, aspartate, taurine, and glycine in brain tissue and plasma of rats prenatally exposed to valproic acid (vpa), a well-characterized experimental model of autism. |
2021-03-19 |
2023-08-13 |
rat |
| Annio Posar, Paola Viscont. Syndromic Autism Spectrum Disorder: Let Us Not Forget about Succinic Semialdehyde Dehydrogenase Deficiency. A Case Report with Literature Review. Journal of pediatric neurosciences. vol 15. issue 3. 2021-02-06. PMID:33531951. |
we describe a girl with syndromic autism spectrum disorder (asd), who at the end of the medical workup proved affected by a succinic semialdehyde dehydrogenase (ssadh) deficiency, a rare autosomal-recessive disorder of degradation of the γ-aminobutyric acid (gaba), that is, the most important central nervous system inhibitory neurotransmitter. |
2021-02-06 |
2023-08-13 |
Not clear |
| Jon DelaCuesta-Barrutia, Olga Peñagarikano, Amaia M Erdozai. G Protein-Coupled Receptor Heteromers as Putative Pharmacotherapeutic Targets in Autism. Frontiers in cellular neuroscience. vol 14. 2020-11-17. PMID:33192330. |
the majority of developing strategies mainly aim at restoring the brain excitatory/inhibitory imbalance described in autism, by targeting glutamate or gaba receptors. |
2020-11-17 |
2023-08-13 |
Not clear |
| Yumi Umesawa, Kanae Matsushima, Takeshi Atsumi, Toshihiro Kato, Reiko Fukatsu, Makoto Wada, Masakazu Id. Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder. Journal of autism and developmental disorders. vol 50. issue 8. 2020-11-02. PMID:31997060. |
altered gaba concentration in brain motor area is associated with the severity of motor disabilities in individuals with autism spectrum disorder. |
2020-11-02 |
2023-08-13 |
human |
| Christopher Heise, Jonathan M Preuss, Jan C Schroeder, Chiara R Battaglia, Jonas Kolibius, Rebecca Schmid, Michael R Kreutz, Martien J H Kas, J Peter H Burbach, Tobias M Boecker. Heterogeneity of Cell Surface Glutamate and GABA Receptor Expression in Shank and CNTN4 Autism Mouse Models. Frontiers in molecular neuroscience. vol 11. 2020-10-01. PMID:29970989. |
heterogeneity of cell surface glutamate and gaba receptor expression in shank and cntn4 autism mouse models. |
2020-10-01 |
2023-08-13 |
mouse |
| Qianling Hou, Yan Wang, Yingbo Li, Di Chen, Feng Yang, Shali Wan. A Developmental Study of Abnormal Behaviors and Altered GABAergic Signaling in the VPA-Treated Rat Model of Autism. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30186123. |
although studies have investigated the role of gamma-aminobutyric acid (gaba)ergic signaling in rodent neural development and behaviors relevant to autism, behavioral ontogeny, as underlain by the changes in gabaergic system, is poorly characterized in different brain regions. |
2020-10-01 |
2023-08-13 |
human |
| Qianling Hou, Yan Wang, Yingbo Li, Di Chen, Feng Yang, Shali Wan. A Developmental Study of Abnormal Behaviors and Altered GABAergic Signaling in the VPA-Treated Rat Model of Autism. Frontiers in behavioral neuroscience. vol 12. 2020-10-01. PMID:30186123. |
our findings indicate an impaired gabaergic system could be a major etiological factor occurring in the cerebral cortex, hc and cerebellum of human cases of autism, which suggests enhancement of gaba signaling would be a promising therapeutic target for its treatment. |
2020-10-01 |
2023-08-13 |
human |
| Toshio Inui, Shinichiro Kumagaya, Masako Myowa-Yamakosh. Neurodevelopmental Hypothesis about the Etiology of Autism Spectrum Disorders. Frontiers in human neuroscience. vol 11. 2020-09-30. PMID:28744208. |
in the model, we assumed the following joint causes as the etiology of autism: (1) hypoplasia of the pons in the brainstem, occurring immediately following neural tube closure; and (2) deficiency in the gaba (γ-aminobutyric acid) developmental switch during the perinatal period. |
2020-09-30 |
2023-08-13 |
Not clear |
| Elzbieta Zieminska, Beata Toczylowska, Dominik Diamandakis, Wojciech Hilgier, Robert Kuba Filipkowski, Rafal Polowy, Jaroslaw Orzel, Michal Gorka, Jerzy Wieslaw Lazarewic. Glutamate, Glutamine and GABA Levels in Rat Brain Measured Using MRS, HPLC and NMR Methods in Study of Two Models of Autism. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30505268. |
glutamate, glutamine and gaba levels in rat brain measured using mrs, hplc and nmr methods in study of two models of autism. |
2020-09-30 |
2023-08-13 |
rat |
| Rosa Marotta, Maria C Risoleo, Giovanni Messina, Lucia Parisi, Marco Carotenuto, Luigi Vetri, Michele Roccell. The Neurochemistry of Autism. Brain sciences. vol 10. issue 3. 2020-09-28. PMID:32182969. |
in this review, we aim to delineate the state-of-the-art main research findings about the neurochemical alterations in autism etiology, and focuses on gamma aminobutyric acid (gaba) and glutamate, serotonin, dopamine, n-acetyl aspartate, oxytocin and arginine-vasopressin, melatonin, vitamin d, orexin, endogenous opioids, and acetylcholine. |
2020-09-28 |
2023-08-13 |
Not clear |
| Melek Hajri, Arwa Ben Amor, Zeineb Abbes, Soumeyya Dhouib, Sami Ouanes, Ali Mrabet, Riadh Daghfous, Asma Boude. Bumetanide in the management of autism. Tunisian experience in Razi Hospital. La Tunisie medicale. vol 97. issue 8-9. 2020-08-26. PMID:32173844. |
some studies suggest changes in brain gaba mediated inhibition in autism, and a higher intracellular chlorine levels in autistic children. |
2020-08-26 |
2023-08-13 |
Not clear |
| Ping Su, Terence K Y Lai, Frankie H F Lee, Andrew R Abela, Paul J Fletcher, Fang Li. Disruption of SynGAP-dopamine D1 receptor complexes alters actin and microtubule dynamics and impairs GABAergic interneuron migration. Science signaling. vol 12. issue 593. 2020-08-14. PMID:31387938. |
disruption of γ-aminobutyric acid (gaba)-ergic interneuron migration is implicated in various neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. |
2020-08-14 |
2023-08-13 |
mouse |