| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Santiago Rodriguez Ospina, Danielle M Blazier, Marangelie Criado-Marrero, Lauren A Gould, Niat T Gebru, David Beaulieu-Abdelahad, Xinming Wang, Elizabeth Remily-Wood, Dale Chaput, Stanley Stevens, Vladimir N Uversky, Paula C Bickford, Chad A Dickey, Laura J Blai. Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain. International journal of molecular sciences. vol 23. issue 2. 2022-01-21. PMID:35055033. |
the microtubule-associated protein tau pathologically accumulates and aggregates in alzheimer's disease (ad) and other tauopathies, leading to cognitive dysfunction and neuronal loss. |
2022-01-21 |
2023-08-13 |
mouse |
| Roghayeh Jalili, Salimeh Chenaghlou, Alireza Khataee, Balal Khalilzadeh, Mohammad-Reza Rashid. An Electrochemiluminescence Biosensor for the Detection of Alzheimer's Tau Protein Based on Gold Nanostar Decorated Carbon Nitride Nanosheets. Molecules (Basel, Switzerland). vol 27. issue 2. 2022-01-21. PMID:35056745. |
an electrochemiluminescence biosensor for the detection of alzheimer's tau protein based on gold nanostar decorated carbon nitride nanosheets. |
2022-01-21 |
2023-08-13 |
human |
| Roghayeh Jalili, Salimeh Chenaghlou, Alireza Khataee, Balal Khalilzadeh, Mohammad-Reza Rashid. An Electrochemiluminescence Biosensor for the Detection of Alzheimer's Tau Protein Based on Gold Nanostar Decorated Carbon Nitride Nanosheets. Molecules (Basel, Switzerland). vol 27. issue 2. 2022-01-21. PMID:35056745. |
human tau protein is the most reliable biomarker for the prediction of alzheimer's disease (ad). |
2022-01-21 |
2023-08-13 |
human |
| Gloria S Benson, Chris Bauer, Lucrezia Hausner, Samuel Couturier, Piotr Lewczuk, Oliver Peters, Michael Hüll, Holger Jahn, Frank Jessen, Johannes Pantel, Stefan J Teipel, Michael Wagner, Johannes Schuchhardt, Jens Wiltfang, Johannes Kornhuber, Lutz Frölic. Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network. Journal of neural transmission (Vienna, Austria : 1996). 2022-01-21. PMID:35061102. |
don't forget about tau: the effects of apoe4 genotype on alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the dementia competence network. |
2022-01-21 |
2023-08-13 |
human |
| Gloria S Benson, Chris Bauer, Lucrezia Hausner, Samuel Couturier, Piotr Lewczuk, Oliver Peters, Michael Hüll, Holger Jahn, Frank Jessen, Johannes Pantel, Stefan J Teipel, Michael Wagner, Johannes Schuchhardt, Jens Wiltfang, Johannes Kornhuber, Lutz Frölic. Don't forget about tau: the effects of ApoE4 genotype on Alzheimer's disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment-data from the Dementia Competence Network. Journal of neural transmission (Vienna, Austria : 1996). 2022-01-21. PMID:35061102. |
apoe4, the strongest genetic risk factor for alzheimer's disease (ad), has been shown to be associated with both beta-amyloid (aβ) and tau pathology, with the strongest evidence for effects on aβ, while the association between apoe4 and tau pathology remains inconsistent. |
2022-01-21 |
2023-08-13 |
human |
| Fumiko Konishi, Tadasu Furusho, Yoshiyuki Soeda, Jun Yamauchi, Shoko Kobayashi, Masatoshi Ito, Takuma Araki, Sarasa Kogure, Akihiko Takashima, Susumu Takekosh. Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3 × Tg-AD mice. Scientific reports. vol 12. issue 1. 2022-01-20. PMID:35046433. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by the accumulation of extracellular amyloid-beta peptides (aβ) resulting in senile plaques and intracellular hyperphosphorylated tau protein resulting in neurofibrillary tangles (nfts). |
2022-01-20 |
2023-08-13 |
mouse |
| Ruiqing Ni, Roger M Nitsc. Recent Developments in Positron Emission Tomography Tracers for Proteinopathies Imaging in Dementia. Frontiers in aging neuroscience. vol 13. 2022-01-20. PMID:35046791. |
the clinical utility of amyloid-β pet and the clinical validity of tau pet as diagnostic biomarker for alzheimer's disease continuum have been demonstrated. |
2022-01-20 |
2023-08-13 |
Not clear |
| Ashlyn G Johnson, James A Webster, Chadwick M Hale. Glial profiling of human tauopathy brain demonstrates enrichment of astrocytic transcripts in tau-related frontotemporal degeneration. Neurobiology of aging. vol 112. 2022-01-20. PMID:35051675. |
to understand how glia may be altered in frontotemporal degeneration with tau pathology (ftd-tau), we used a nanostring glial profiling panel to measure 770 transcripts related to glial biology in human control (n = 8), alzheimer's disease (ad) (n = 8), and ftd-tau (n = 8) dorsolateral prefrontal cortex. |
2022-01-20 |
2023-08-13 |
human |
| Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang, Xiaoyue Ta. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-β Deposition in an Alzheimer's Disease Model. Acta biomaterialia. 2022-01-19. PMID:35045359. |
asparagine endopeptidase-targeted ultrasound-responsive nanobubbles alleviate tau cleavage and amyloid-β deposition in an alzheimer's disease model. |
2022-01-19 |
2023-08-13 |
mouse |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant alzheimer's disease. |
2022-01-19 |
2023-08-13 |
human |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
abnormally phosphorylated tau, an indicator of alzheimer's disease, accumulates in the first decades of life in the locus coeruleus (lc), the brain's main noradrenaline supply. |
2022-01-19 |
2023-08-13 |
human |
| Martin J Dahl, Mara Mather, Markus Werkle-Bergner, Briana L Kennedy, Samuel Guzman, Kyle Hurth, Carol A Miller, Yuchuan Qiao, Yonggang Shi, Helena C Chui, John M Ringma. Locus coeruleus integrity is related to tau burden and memory loss in autosomal-dominant Alzheimer's disease. Neurobiology of aging. vol 112. 2022-01-19. PMID:35045380. |
our findings link lc degeneration to tau burden and memory in alzheimer's, and highlight a role of the noradrenergic system in this neurodegenerative disease. |
2022-01-19 |
2023-08-13 |
human |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
biomarkers with plasma amyloid β and tau protein assayed by immunomagnetic reduction in patients with amnestic mild cognitive impairment and alzheimer's disease. |
2022-01-18 |
2023-08-13 |
Not clear |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
this review addresses recent developments in the analyses of plasma amyloid beta (aβ) and total tau (t-tau) protein levels as biomarkers for discriminating amnestic mild cognitive impairment (amci) from alzheimer disease (ad), using immunomagnetic reduction (imr). |
2022-01-18 |
2023-08-13 |
Not clear |
| Pei-Jung Lee, Chia-Lin Tsai, Chih-Sung Liang, Giia-Sheun Peng, Jiunn-Tay Lee, Chia-Kuang Tsai, Yu-Kai Lin, Fu-Chi Yang Yan. Biomarkers with Plasma Amyloid β and Tau Protein Assayed by Immunomagnetic Reduction in Patients with Amnestic Mild Cognitive Impairment and Alzheimer's Disease. Acta neurologica Taiwanica. vol 31(2). 2022-01-18. PMID:35040113. |
keywords: amyloid beta, plasma tau, alzheimer disease, biomarker, mild cognitive impairment. |
2022-01-18 |
2023-08-13 |
Not clear |
| Xiaohu iMa, Linlin Liu, Jing Men. Expression of concern: MicroRNA-125b promotes neurons cell apoptosis and tau phosphorylation in Alzheimer's disease. Neuroscience letters. vol 769. 2022-01-17. PMID:35034691. |
expression of concern: microrna-125b promotes neurons cell apoptosis and tau phosphorylation in alzheimer's disease. |
2022-01-17 |
2023-08-13 |
Not clear |
| Silvia Pelucchi, Fabrizio Gardoni, Monica Di Luca, Elena Marcell. Synaptic dysfunction in early phases of Alzheimer's Disease. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034752. |
moreover, the two main hallmarks of alzheimer's disease, i.e., amyloid-β and tau, act in concert to cause synaptic deficits. |
2022-01-17 |
2023-08-13 |
Not clear |
| Li-Na Zhang, Meng-Jie Li, Ying-Hui Shang, Yun-Ru Liu, Huang Han-Chang, Feng-Xue La. Zeaxanthin Attenuates the Vicious Circle Between Endoplasmic Reticulum Stress and Tau Phosphorylation: Involvement of GSK-3β Activation. Journal of Alzheimer's disease : JAD. 2022-01-17. PMID:35034906. |
alzheimer's disease (ad) characterized by neurofibrillary tangles caused by hyperphosphorylated tau is the most common cause of dementia. |
2022-01-17 |
2023-08-13 |
Not clear |
| Hongxia Yu, Jianhong Shi, Yiyou Lin, Yehui Zhang, Qihang Luo, Suo Huang, Sichen Wang, Jiale Wei, Junhao Huang, Changyu Li, Liting J. Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3 × Tg-AD Mice. Neurochemical research. 2022-01-17. PMID:35037164. |
alzheimer's disease (ad) is a neurodegenerative disease characterized by excessive deposition of β amyloid (aβ), hyperphosphorylation of tau protein, and neuronal cell death. |
2022-01-17 |
2023-08-13 |
mouse |
| Claire J Ciampa, Jourdan H Parent, Theresa M Harrison, Rebekah M Fain, Matthew J Betts, Anne Maass, Joseph R Winer, Suzanne L Baker, Mustafa Janabi, Daniella J Furman, Mark D'Esposito, William J Jagust, Anne S Berr. Associations among locus coeruleus catecholamines, tau pathology, and memory in aging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-01-16. PMID:35034099. |
the locus coeruleus (lc) is the brain's major source of the neuromodulator norepinephrine, and is also profoundly vulnerable to the development of alzheimer's disease (ad)-related tau pathology. |
2022-01-16 |
2023-08-13 |
Not clear |