| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Olga Zolochevska, Giulio Taglialatel. Selected microRNAs Increase Synaptic Resilience to the Damaging Binding of the Alzheimer's Disease Amyloid Beta Oligomers. Molecular neurobiology. vol 57. issue 5. 2021-02-03. PMID:31997075. |
non-demented individuals with alzheimer's neuropathology (ndan) are capable of withstanding aβ and tau toxicity, thus remaining cognitively intact despite presence of ad neuropathology. |
2021-02-03 |
2023-08-13 |
mouse |
| Zhonglei Bao, Huixue Zhang, Hong Jiao, Xiaojie Chu, Jin Fu, Lihua Wan. Dihydrotanshinone I Increase Amyloid-β Clearance and Decrease Tau Phosphorylation via Enhancing Autophagy. Pharmacology. vol 105. issue 5-6. 2021-02-03. PMID:32200384. |
the plaques formed by amyloid-β (aβ) accumulation and neurofibrillary tangles formed by hyper-phosphorylated tau protein are the 2 major pathologies of alzheimer's disease (ad). |
2021-02-03 |
2023-08-13 |
Not clear |
| Yao Qi, Lin Guo, Yibing Jiang, Yijie Shi, Haijuan Sui, Liang Zha. Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles. Drug delivery. vol 27. issue 1. 2021-02-03. PMID:32397764. |
it is reported that quercetin (que) can prevent tau pathology and induce neuroprotection by improving cognitive and functional symptoms in the treatment of alzheimer's disease (ad). |
2021-02-03 |
2023-08-13 |
mouse |
| Jianlan Gu, Wen Xu, Nana Jin, Longfei Li, Yan Zhou, Dandan Chu, Cheng-Xin Gong, Khalid Iqbal, Fei Li. Truncation of Tau selectively facilitates its pathological activities. The Journal of biological chemistry. vol 295. issue 40. 2021-02-03. PMID:32737201. |
neurofibrillary tangles of abnormally hyperphosphorylated tau are a hallmark of alzheimer's disease (ad) and related tauopathies. |
2021-02-03 |
2023-08-13 |
Not clear |
| Marson Putra, Sreekanth Puttachary, Guanghao Liu, Gloria Lee, Thimmasettappa Thippeswam. Fyn-tau Ablation Modifies PTZ-Induced Seizures and Post-seizure Hallmarks of Early Epileptogenesis. Frontiers in cellular neuroscience. vol 14. 2021-02-02. PMID:33363455. |
both fyn and tau have been associated with neuronal hyperexcitability and neurotoxicity in many tauopathies, including alzheimer's disease (ad). |
2021-02-02 |
2023-08-13 |
Not clear |
| Rashmi Das, Abhishek Ankur Balmik, Subashchandrabose Chinnathamb. Effect of Melatonin on Tau aggregation and Tau-mediated cell surface morphology. International journal of biological macromolecules. vol 152. 2021-02-01. PMID:32044365. |
aggregation of microtubule-associated protein tau and its deposition in the form of neurofibrillary tangles (nfts) is one of the pathological hallmarks of alzheimer's disease (ad). |
2021-02-01 |
2023-08-13 |
Not clear |
| Ian W Weidling, Russell H Swerdlo. Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis. Experimental neurology. vol 330. 2021-02-01. PMID:32339611. |
alzheimer's disease (ad) is a progressive brain disorder characterized by memory loss and the accumulation of two insoluble protein aggregates, tau neurofibrillary tangles and beta-amyloid plaques. |
2021-02-01 |
2023-08-13 |
Not clear |
| Daniel Albrecht, A Lisette Isenberg, Joy Stradford, Teresa Monreal, Abhay Sagare, Maricarmen Pachicano, Melanie Sweeney, Arthur Toga, Berislav Zlokovic, Helena Chui, Elizabeth Joe, Lon Schneider, Peter Conti, Kay Jann, Judy P. Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 44. 2021-02-01. PMID:33046556. |
tau pathology and vascular dysfunction are important contributors to alzheimer's disease (ad), but vascular-tau associations and their effects on cognition are poorly understood. |
2021-02-01 |
2023-08-13 |
human |
| Solomiia Boyko, Krystyna Surewicz, Witold K Surewic. Regulatory mechanisms of tau protein fibrillation under the conditions of liquid-liquid phase separation. Proceedings of the National Academy of Sciences of the United States of America. vol 117. issue 50. 2021-02-01. PMID:33262278. |
one of the hallmarks of alzheimer's disease and several other neurodegenerative disorders is the aggregation of tau protein into fibrillar structures. |
2021-02-01 |
2023-08-13 |
Not clear |
| Yoko Shigemoto, Daichi Sone, Kyoji Okita, Norihide Maikusa, Tensho Yamao, Yukio Kimura, Fumio Suzuki, Hiroyuki Fujii, Koichi Kato, Noriko Sato, Hiroshi Matsud. Gray matter structural networks related to eNeurologicalSci. vol 22. 2021-01-30. PMID:33511292. |
gray matter structural networks related to this study aimed to examine the alterations in gray matter networks related to tau retention in alzheimer's disease (ad) patients and cognitively normal (cn) older individuals. |
2021-01-30 |
2023-08-13 |
Not clear |
| Engy Medhat, Laila Rashed, Marwa Abdelgwad, Basma Emad Aboulhoda, Mohamed Mansour Khalifa, Shimaa Saad El-Di. Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer's disease: emphasis on oxidative stress and inflammation. Metabolic brain disease. vol 35. issue 1. 2021-01-29. PMID:31691146. |
in alzheimer group, there was a significant increase in the proinflammatory cytokine il-6, the lipid peroxidation marker mda, amyloid β and tau proteins |
2021-01-29 |
2023-08-13 |
rat |
| Yan Yan, Huihuang Yang, Yuxun Xie, Yuanlin Ding, Danli Kong, Haibing Y. Research Progress on Alzheimer's Disease and Resveratrol. Neurochemical research. vol 45. issue 5. 2021-01-29. PMID:32162143. |
alzheimer's disease (ad), a common irreversible neurodegenerative disease characterized by amyloid-β plaques, neurofibrillary tangles, and changes in tau phosphorylation, is accompanied by memory loss and symptoms of cognitive dysfunction. |
2021-01-29 |
2023-08-13 |
Not clear |
| Rotem Iris Orad, Tamara Shine. Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities. Journal of neurology. 2021-01-29. PMID:33511432. |
however, it is also frequently accompanied by aggregation of amyloid-beta and tau, the pathological hallmarks of alzheimer's disease. |
2021-01-29 |
2023-08-13 |
Not clear |
| Antigoni Katsikoudi, Elena Ficulle, Annalisa Cavallini, Gary Sharman, Amelie Guyot, Michele Zagnoni, Brian J Eastwood, Michael Hutton, Suchira Bos. Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures. The Journal of biological chemistry. vol 295. issue 37. 2021-01-27. PMID:32699110. |
quantitative propagation of assembled human tau from alzheimer's disease brain in microfluidic neuronal cultures. |
2021-01-27 |
2023-08-13 |
human |
| Antigoni Katsikoudi, Elena Ficulle, Annalisa Cavallini, Gary Sharman, Amelie Guyot, Michele Zagnoni, Brian J Eastwood, Michael Hutton, Suchira Bos. Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures. The Journal of biological chemistry. vol 295. issue 37. 2021-01-27. PMID:32699110. |
tau aggregation and hyperphosphorylation is a key neuropathological hallmark of alzheimer's disease (ad), and the temporospatial spread of tau observed during clinical manifestation suggests that tau pathology may spread along the axonal network and propagate between synaptically connected neurons. |
2021-01-27 |
2023-08-13 |
human |
| Carolina Alquezar, Shruti Arya, Aimee W Ka. Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation. Frontiers in neurology. vol 11. 2021-01-26. PMID:33488497. |
prevailing views regard tau as a protein that undergoes abnormal phosphorylation prior to its accumulation into the toxic aggregates implicated in alzheimer's disease (ad) and other tauopathies. |
2021-01-26 |
2023-08-13 |
Not clear |
| Marco Calabrò, Carmela Rinaldi, Giuseppe Santoro, Concetta Crisafull. The biological pathways of Alzheimer disease: a review. AIMS neuroscience. vol 8. issue 1. 2021-01-26. PMID:33490374. |
research in this area has revealed a lot about the biological and environmental underpinnings of alzheimer, especially its correlation with β-amyloid and tau related mechanics; however, the precise molecular events and biological pathways behind the disease are yet to be discovered. |
2021-01-26 |
2023-08-13 |
human |
| Sarah L DeVos, Bianca T Corjuc, Derek H Oakley, Chloe K Nobuhara, Riley N Bannon, Alison Chase, Caitlin Commins, Jose A Gonzalez, Patrick M Dooley, Matthew P Frosch, Bradley T Hyma. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Frontiers in neuroscience. vol 12. 2021-01-25. PMID:29740275. |
synaptic tau seeding precedes tau pathology in human alzheimer's disease brain. |
2021-01-25 |
2023-08-13 |
human |
| Sarah L DeVos, Bianca T Corjuc, Derek H Oakley, Chloe K Nobuhara, Riley N Bannon, Alison Chase, Caitlin Commins, Jose A Gonzalez, Patrick M Dooley, Matthew P Frosch, Bradley T Hyma. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Frontiers in neuroscience. vol 12. 2021-01-25. PMID:29740275. |
alzheimer's disease (ad) is defined by the presence of intraneuronal neurofibrillary tangles (nfts) composed of hyperphosphorylated tau aggregates as well as extracellular amyloid-beta plaques. |
2021-01-25 |
2023-08-13 |
human |
| Ahmad Abu Turab Naqvi, Gulam Mustafa Hasan, Md Imtaiyaz Hassa. Targeting Tau Hyperphosphorylation Current topics in medicinal chemistry. vol 20. issue 12. 2021-01-25. PMID:31903881. |
hyperphosphorylation of tau protein leads to aggregation of tau into paired helical filaments like structures which are major constituents of neurofibrillary tangles, a hallmark of alzheimer's disease. |
2021-01-25 |
2023-08-13 |
Not clear |