| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Josephine C Ferreon, Antrix Jain, Kyoung-Jae Choi, Phoebe S Tsoi, Kevin R MacKenzie, Sung Yun Jung, Allan Chris Ferreo. Acetylation Disfavors Tau Phase Separation. International journal of molecular sciences. vol 19. issue 5. 2018-09-21. PMID:29734651. |
neuropathological aggregates of the intrinsically disordered microtubule-associated protein tau are hallmarks of alzheimer’s disease, with decades of research devoted to studying the protein’s aggregation properties both in vitro and in vivo. |
2018-09-21 |
2023-08-13 |
Not clear |
| Omkar Bihani, Tripti Rai, Debashis Pand. Interaction of proteins with lemon-juice/glutathione-derived carbon nanodot: Interplay of induced-aggregation and co-solubilization. International journal of biological macromolecules. vol 112. 2018-09-20. PMID:29427683. |
the accumulation of protein aggregates (tau) causes alzheimer's disease (ad), parkinson's disease (pd), and a range of neurodegenerative diseases. |
2018-09-20 |
2023-08-13 |
Not clear |
| Yunior Cabrales Fontela, Harindranath Kadavath, Jacek Biernat, Dietmar Riedel, Eckhard Mandelkow, Markus Zweckstette. Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau. Nature communications. vol 8. issue 1. 2018-09-18. PMID:29215007. |
in addition, aberrant interaction of the microtubule-associated protein tau with filamentous actin is connected to synaptic impairment in alzheimer's disease. |
2018-09-18 |
2023-08-13 |
Not clear |
| Juan Carlos Polanco, Chuanzhou Li, Nela Durisic, Robert Sullivan, Jürgen Göt. Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons. Acta neuropathologica communications. vol 6. issue 1. 2018-09-18. PMID:29448966. |
in alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. |
2018-09-18 |
2023-08-13 |
mouse |
| Joaquín G Cordero, Ramón García-Escudero, Jesús Avila, Ricardo Gargini, Vega García-Escuder. Benefit of Oleuropein Aglycone for Alzheimer's Disease by Promoting Autophagy. Oxidative medicine and cellular longevity. vol 2018. 2018-09-17. PMID:29675133. |
alzheimer's disease is a proteinopathy characterized by accumulation of hyperphosphorylated tau and |
2018-09-17 |
2023-08-13 |
Not clear |
| Tamas Halmos, Ilona Sub. [Alzheimer's disease and diabetes - the common pathogenesis]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 18. issue 1. 2018-09-14. PMID:27038867. |
in alzheimer's disease, deposition of amyloid ß in the brain, hyperphosphorylation of tau proteins and dysruption of neurofibrilles are characteristic. |
2018-09-14 |
2023-08-13 |
human |
| Hai Yuan, Lingling Du, Pingping Ge, Xiaotong Wang, Qing Xi. Association of microtubule-associated protein tau gene polymorphisms with the risk of sporadic Alzheimer's disease: a meta-analysis. The International journal of neuroscience. vol 128. issue 6. 2018-09-07. PMID:29098924. |
association of microtubule-associated protein tau gene polymorphisms with the risk of sporadic alzheimer's disease: a meta-analysis. |
2018-09-07 |
2023-08-13 |
Not clear |
| Hai Yuan, Lingling Du, Pingping Ge, Xiaotong Wang, Qing Xi. Association of microtubule-associated protein tau gene polymorphisms with the risk of sporadic Alzheimer's disease: a meta-analysis. The International journal of neuroscience. vol 128. issue 6. 2018-09-07. PMID:29098924. |
numerous epidemiological studies were published to investigate the role of microtubule-associated protein tau (mapt) gene variations (rs7521g/a, rs242557g/a, rs1467967a/g, rs2471738c/t and rs3785883g/a) in sad, and these genetic polymorphisms may be a risk factor for sporadic alzheimer's disease (sad). |
2018-09-07 |
2023-08-13 |
Not clear |
| Miguel Medin. An Overview on the Clinical Development of Tau-Based Therapeutics. International journal of molecular sciences. vol 19. issue 4. 2018-09-07. PMID:29641484. |
tauopathies such as alzheimer's disease (ad), frontotemporal lobar degeneration, or progressive supranuclear palsy constitute a group of brain disorders defined by neurodegeneration and the presence of tau aggregates in the affected brains regions. |
2018-09-07 |
2023-08-13 |
Not clear |
| Denisa Floriana Vasilica Pîrşcoveanu, Ionica Pirici, Valerica Tudorică, Tudor Adrian Bălşeanu, Valeria Carmen Albu, Simona Bondari, Ana Maria Bumbea, Mircea Pîrşcovean. Tau protein in neurodegenerative diseases - a review. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. vol 58. issue 4. 2018-09-05. PMID:29556602. |
in alzheimer's disease (ad), there are intraneuronal neurofibrillary tangles composed of the microtubule-associated protein tau (mapt). |
2018-09-05 |
2023-08-13 |
human |
| Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine. vol 22. issue 1. 2018-09-04. PMID:29228900. |
effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to alzheimer's disease-like tau hyperphosphorylation. |
2018-09-04 |
2023-08-13 |
rat |
| Zhihui Gai, Donghong Su, Yawen Wang, Wenlong Li, Bo Cui, Kang Li, Xiaojun She, Rui Wan. Effects of chronic noise on the corticotropin-releasing factor system in the rat hippocampus: relevance to Alzheimer's disease-like tau hyperphosphorylation. Environmental health and preventive medicine. vol 22. issue 1. 2018-09-04. PMID:29228900. |
chronic noise exposure has been associated with tau hyperphosphorylation and alzheimer's disease (ad)-like pathological changes, but the underlying mechanism is unknown. |
2018-09-04 |
2023-08-13 |
rat |
| Álvaro Sebastián-Serrano, Laura de Diego-García, Miguel Díaz-Hernánde. The Neurotoxic Role of Extracellular Tau Protein. International journal of molecular sciences. vol 19. issue 4. 2018-09-04. PMID:29584657. |
tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with alzheimer's disease (ad) being the most prevalent related disorder. |
2018-09-04 |
2023-08-13 |
Not clear |
| Sunhyo Kim, Ki Ju Choi, Sun-Jung Cho, Sang-Moon Yun, Jae-Pil Jeon, Young Ho Koh, Jihyun Song, Gail V W Johnson, Chulman J. Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. Scientific reports. vol 6. 2018-09-03. PMID:27112200. |
the neuronal accumulation of phosphorylated tau plays a critical role in the pathogenesis of alzheimer's disease (ad). |
2018-09-03 |
2023-08-13 |
Not clear |
| Gabor G Kovacs, Linda K Kwong, Murray Grossman, David J Irwin, Edward B Lee, John L Robinson, Eunran Suh, Vivianna M Van Deerlin, Virginia M Lee, John Q Trojanowsk. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain pathology (Zurich, Switzerland). vol 28. issue 2. 2018-08-30. PMID:28019685. |
these morphologies appeared in combination with alzheimer disease-related pathology and subcortical tau pathology compatible with psp. |
2018-08-30 |
2023-08-13 |
human |
| Huaqing Cui, Mengsheng Deng, Yonglan Zhang, Fei Yin, Jianhui Li. Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons. Neurochemical research. vol 43. issue 3. 2018-08-30. PMID:29427280. |
altered proteostasis induced by amyloid peptide aggregation and hyperphosphorylation of tau protein, is a prominent feature of alzheimer's disease, which highlights the occurrence of endoplasmic reticulum stress and triggers the activation of the unfolded protein response (upr), a signaling pathway that enforces adaptive programs to sustain proteostasis. |
2018-08-30 |
2023-08-13 |
Not clear |
| Yu-Ping Wei, Jin-Wang Ye, Xiong Wang, Li-Ping Zhu, Qing-Hua Hu, Qun Wang, Dan Ke, Qing Tian, Jian-Zhi Wan. Tau-Induced Ca Neuroscience bulletin. vol 34. issue 2. 2018-08-28. PMID:28646348. |
tau-induced ca hyperphosphorylated tau is the major protein component of neurofibrillary tangles in the brains of patients with alzheimer's disease (ad). |
2018-08-28 |
2023-08-13 |
human |
| Tong Li, Kerstin E Braunstein, Juhong Zhang, Ashley Lau, Leslie Sibener, Christopher Deeble, Philip C Won. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature communications. vol 7. 2018-08-27. PMID:27373369. |
the neuritic plaque facilitates pathological conversion of tau in an alzheimer's disease mouse model. |
2018-08-27 |
2023-08-13 |
mouse |
| Tong Li, Kerstin E Braunstein, Juhong Zhang, Ashley Lau, Leslie Sibener, Christopher Deeble, Philip C Won. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature communications. vol 7. 2018-08-27. PMID:27373369. |
a central question in alzheimer's disease (ad) is whether the neuritic plaque is necessary and sufficient for the development of tau pathology. |
2018-08-27 |
2023-08-13 |
mouse |
| A C Jiji, A Shine, Vinesh Vijaya. Direct Observation of Aggregation-Induced Backbone Conformational Changes in Tau Peptides. Angewandte Chemie (International ed. in English). vol 55. issue 38. 2018-08-27. PMID:27513615. |
these results on the specific interactions and conformational changes responsible for tau aggregation could prove useful for developing an efficient therapeutic intervention in alzheimer's disease. |
2018-08-27 |
2023-08-13 |
Not clear |