| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yanxing Chen, Yanqiu Deng, Baorong Zhang, Cheng-Xin Gon. Deregulation of brain insulin signaling in Alzheimer's disease. Neuroscience bulletin. vol 30. issue 2. 2014-12-03. PMID:24652456. |
deregulated brain insulin signaling and its role in molecular pathogenesis have recently been reported in alzheimer's disease (ad). |
2014-12-03 |
2023-08-12 |
Not clear |
| Konrad Talbo. Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs. Neurodegenerative disease management. vol 4. issue 1. 2014-11-25. PMID:24640977. |
brain insulin resistance in alzheimer's disease and its potential treatment with glp-1 analogs. |
2014-11-25 |
2023-08-12 |
Not clear |
| Konrad Talbo. Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs. Neurodegenerative disease management. vol 4. issue 1. 2014-11-25. PMID:24640977. |
a promising strategy for developing such therapies is the treatment of brain insulin resistance, a common and early feature of alzheimer's disease, closely tied to cognitive decline and capable of promoting many biological abnormalities in the disorder. |
2014-11-25 |
2023-08-12 |
Not clear |
| Konrad Talbo. Brain insulin resistance in Alzheimer's disease and its potential treatment with GLP-1 analogs. Neurodegenerative disease management. vol 4. issue 1. 2014-11-25. PMID:24640977. |
fortunately, the us fda-approved antidiabetics exenatide (byetta; amylin pharmaceuticals, inc., ca, usa) and liraglutide (victoza; novo nordisk a/s, bagsvaerd, denmark) are showing much promise in reducing alzheimer's disease pathology and in restoring normal brain insulin responsiveness and cognitive function. |
2014-11-25 |
2023-08-12 |
Not clear |
| Danit Mechlovich, Tamar Amit, Orit Bar-Am, Silvia Mandel, Moussa B H Youdim, Orly Weinre. The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice. Current Alzheimer research. vol 11. issue 2. 2014-11-24. PMID:24359498. |
the novel multi-target iron chelator, m30 modulates hif-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of app/ps1 alzheimer's disease mice. |
2014-11-24 |
2023-08-12 |
mouse |
| Danit Mechlovich, Tamar Amit, Orit Bar-Am, Silvia Mandel, Moussa B H Youdim, Orly Weinre. The novel multi-target iron chelator, M30 modulates HIF-1α-related glycolytic genes and insulin signaling pathway in the frontal cortex of APP/PS1 Alzheimer's disease mice. Current Alzheimer research. vol 11. issue 2. 2014-11-24. PMID:24359498. |
increasing evidence suggests that dysregulation of brain insulin/insulin receptor (insr) and insulin signaling cascade are associated with the pathogenesis of alzheimer's disease (ad). |
2014-11-24 |
2023-08-12 |
mouse |
| Yanxing Chen, Zhihou Liang, Zhu Tian, Julie Blanchard, Chun-Ling Dai, Sonia Chalbot, Khalid Iqbal, Fei Liu, Cheng-Xin Gon. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23996345. |
alzheimer's disease (ad) involves several possible molecular mechanisms, including impaired brain insulin signaling and glucose metabolism. |
2014-10-27 |
2023-08-12 |
mouse |
| Enrique Blázquez, Esther Velázquez, Verónica Hurtado-Carneiro, Juan Miguel Ruiz-Albusa. Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Frontiers in endocrinology. vol 5. 2014-10-27. PMID:25346723. |
insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and alzheimer's disease. |
2014-10-27 |
2023-08-13 |
Not clear |
| Enrique Blázquez, Esther Velázquez, Verónica Hurtado-Carneiro, Juan Miguel Ruiz-Albusa. Insulin in the brain: its pathophysiological implications for States related with central insulin resistance, type 2 diabetes and Alzheimer's disease. Frontiers in endocrinology. vol 5. 2014-10-27. PMID:25346723. |
alterations of these functional activities may contribute to the manifestation of several clinical entities, such as central insulin resistance, type 2 diabetes mellitus (t2dm), and alzheimer's disease (ad). |
2014-10-27 |
2023-08-13 |
Not clear |
| N Mu, S C Xu, Q Chang, D P Rao, J P Chen, C M. Study of lipids, insulin metabolism, and paraoxonase-2-311 polymorphism in patients with different subtypes of Alzheimer's disease (translated version). East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan. vol 23. issue 3. 2014-10-26. PMID:24088404. |
study of lipids, insulin metabolism, and paraoxonase-2-311 polymorphism in patients with different subtypes of alzheimer's disease (translated version). |
2014-10-26 |
2023-08-12 |
Not clear |
| N Mu, S C Xu, Q Chang, D P Rao, J P Chen, C M. Study of lipids, insulin metabolism, and paraoxonase-2-311 polymorphism in patients with different subtypes of Alzheimer's disease (translated version). East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan. vol 23. issue 3. 2014-10-26. PMID:24088404. |
to investigate the characteristics of blood lipids, insulin metabolism, and paraoxonase-2-311 (pon2-311) polymorphism among patients with alzheimer's disease with different types of dementia. |
2014-10-26 |
2023-08-12 |
Not clear |
| Dax Fu, Lydia Finne. Metalloproteomics: challenges and prospective for clinical research applications. Expert review of proteomics. vol 11. issue 1. 2014-10-15. PMID:24433146. |
for example, zinc is important in insulin biosynthesis and may play a role in alzheimer's disease, but much of how the zinc-mediated process remains unknown. |
2014-10-15 |
2023-08-12 |
Not clear |
| Ann Tiiman, Andra Noormägi, Merlin Friedemann, Jekaterina Krishtal, Peep Palumaa, Vello Tõug. Effect of agitation on the peptide fibrillization: Alzheimer's amyloid-β peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions. Journal of peptide science : an official publication of the European Peptide Society. vol 19. issue 6. 2014-10-10. PMID:23609985. |
effect of agitation on the peptide fibrillization: alzheimer's amyloid-β peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions. |
2014-10-10 |
2023-08-12 |
Not clear |
| Ann Tiiman, Andra Noormägi, Merlin Friedemann, Jekaterina Krishtal, Peep Palumaa, Vello Tõug. Effect of agitation on the peptide fibrillization: Alzheimer's amyloid-β peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions. Journal of peptide science : an official publication of the European Peptide Society. vol 19. issue 6. 2014-10-10. PMID:23609985. |
we studied the fibrillization of four peptides--alzheimer's amyloid-β (aβ) 1-40 and 1-42, amylin and insulin. |
2014-10-10 |
2023-08-12 |
Not clear |
| Fernanda G De Felice, Mychael V Lourenco, Sergio T Ferreir. How does brain insulin resistance develop in Alzheimer's disease? Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529521. |
how does brain insulin resistance develop in alzheimer's disease? |
2014-10-06 |
2023-08-12 |
Not clear |
| Sophie M Steculorum, Maite Solas, Jens C Brünin. The paradox of neuronal insulin action and resistance in the development of aging-associated diseases. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529522. |
converging evidence from animal and human studies has indicated that insulin resistance in the central nervous system (cns) is observed in both t2dm and neurodegenerative disorders such as alzheimer's disease (ad), leading to the hypothesis that impaired neuronal insulin action might be a unifying pathomechanism in the development of both diseases. |
2014-10-06 |
2023-08-12 |
human |
| Konrad Talbot, Hoau-Yan Wan. The nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529520. |
the nature, significance, and glucagon-like peptide-1 analog treatment of brain insulin resistance in alzheimer's disease. |
2014-10-06 |
2023-08-12 |
human |
| Christian Hölsche. First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529523. |
first clinical data of the neuroprotective effects of nasal insulin application in patients with alzheimer's disease. |
2014-10-06 |
2023-08-12 |
human |
| Christian Hölsche. First clinical data of the neuroprotective effects of nasal insulin application in patients with Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529523. |
previous reviews have outlined the important role of insulin in the brain, and the observation that insulin signaling is desensitized in patients with alzheimer's disease (ad). |
2014-10-06 |
2023-08-12 |
human |
| Sergio T Ferreira, Julia R Clarke, Theresa R Bomfim, Fernanda G De Felic. Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 10. issue 1 Suppl. 2014-10-06. PMID:24529528. |
inflammation, defective insulin signaling, and neuronal dysfunction in alzheimer's disease. |
2014-10-06 |
2023-08-12 |
Not clear |