| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jill K Morris, Eric D Vidoni, Robyn A Honea, Jeffrey M Burn. Impaired glycemia increases disease progression in mild cognitive impairment. Neurobiology of aging. vol 35. issue 3. 2014-09-29. PMID:24411018. |
insulin resistance and type 2 diabetes are associated with cognitive decline and increased risk for alzheimer's disease (ad). |
2014-09-29 |
2023-08-12 |
human |
| Fernanda G De Felice, Sergio T Ferreir. Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease. Diabetes. vol 63. issue 7. 2014-09-03. PMID:24931033. |
inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to alzheimer disease. |
2014-09-03 |
2023-08-13 |
Not clear |
| Mark Yarchoan, Steven E Arnol. Repurposing diabetes drugs for brain insulin resistance in Alzheimer disease. Diabetes. vol 63. issue 7. 2014-09-03. PMID:24931035. |
repurposing diabetes drugs for brain insulin resistance in alzheimer disease. |
2014-09-03 |
2023-08-13 |
Not clear |
| André Kleinridders, Heather A Ferris, Weikang Cai, C Ronald Kah. Insulin action in brain regulates systemic metabolism and brain function. Diabetes. vol 63. issue 7. 2014-09-03. PMID:24931034. |
in addition, insulin signaling modulates phosphorylation of tau protein, an early component in the development of alzheimer disease. |
2014-09-03 |
2023-08-13 |
Not clear |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
the reduction of insulin levels in hippocampal areas is associated with alzheimer's disease. |
2014-08-18 |
2023-08-12 |
rat |
| Takayuki Nemoto, Fumiyo Toyoshima-Aoyama, Toshihiko Yanagita, Toyoaki Maruta, Hiroshi Fujita, Tomohiro Koshida, Tetsu Yonaha, Akihiko Wada, Akira Sawaguchi, Manabu Murakam. New insights concerning insulin synthesis and its secretion in rat hippocampus and cerebral cortex: amyloid-β1-42-induced reduction of proinsulin level via glycogen synthase kinase-3β. Cellular signalling. vol 26. issue 2. 2014-08-18. PMID:24269535. |
these results demonstrate that synthesized insulin is secreted from rat hippocampal and cortical neuron's dense-core vesicles, and that activation of gsk-3β in aβ(1-42)-induced alzheimer's model hippocampal neurons decreases the insulin synthesis. |
2014-08-18 |
2023-08-12 |
rat |
| Wei Qiao Qiu, Haihao Zh. Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease? Frontiers in aging neuroscience. vol 6. 2014-08-14. PMID:25120481. |
amylin, a gut-brain axis hormone, and amyloid-beta peptides (aβ), a major component of the alzheimer's disease (ad) brain, share several features, including similar β-sheet secondary structures, binding to the same receptor and being degraded by the same protease, insulin degrading enzyme (ide). |
2014-08-14 |
2023-08-13 |
human |
| Anna M Barron, Emily R Rosario, Reem Elteriefi, Christian J Pik. Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease. PloS one. vol 8. issue 10. 2014-08-07. PMID:24205258. |
multiple factors of metabolic syndrome have been implicated in the pathogenesis of alzheimer's disease (ad), including abdominal obesity, insulin resistance, endocrine dysfunction and dyslipidemia. |
2014-08-07 |
2023-08-12 |
mouse |
| Inês Sebastião, Emanuel Candeias, Maria S Santos, Catarina R de Oliveira, Paula I Moreira, Ana I Duart. Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease - How Anti-Diabetics Could be a Solution for Dementia. Frontiers in endocrinology. vol 5. 2014-07-29. PMID:25071725. |
insulin as a bridge between type 2 diabetes and alzheimer disease - how anti-diabetics could be a solution for dementia. |
2014-07-29 |
2023-08-13 |
Not clear |
| Laura Caberlotto, Mario Lauria, Thanh-Phuong Nguyen, Marco Scott. The central role of AMP-kinase and energy homeostasis impairment in Alzheimer's disease: a multifactor network analysis. PloS one. vol 8. issue 11. 2014-07-25. PMID:24265728. |
this approach allowed us to present evidence in favor of one of the competing theories about ad underlying processes, specifically evidence supporting a predominant role of metabolism-associated biological process terms, including autophagy, insulin and fatty acid metabolic processes in alzheimer, with a focus on amp-activated protein kinase. |
2014-07-25 |
2023-08-12 |
human |
| Danilo B Medinas, Claudio Het. Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes. Cell metabolism. vol 18. issue 6. 2014-07-15. PMID:24315366. |
altered insulin signaling and neuroinflammation are emerging features of alzheimer's disease. |
2014-07-15 |
2023-08-12 |
Not clear |
| Pjotr Bekkering, Ismael Jafri, Frans J van Overveld, Ger T Rijker. The intricate association between gut microbiota and development of type 1, type 2 and type 3 diabetes. Expert review of clinical immunology. vol 9. issue 11. 2014-07-14. PMID:24138599. |
in addition, insulin resistance in the brain has been recently associated with alzheimer's disease. |
2014-07-14 |
2023-08-12 |
Not clear |
| Olivier Thibault, Katie L Anderson, Chris DeMoll, Lawrence D Brewer, Philip W Landfield, Nada M Porte. Hippocampal calcium dysregulation at the nexus of diabetes and brain aging. European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872402. |
recently it has become clear that conditions of insulin resistance/metabolic syndrome, obesity and diabetes, are linked with moderate cognitive impairment in normal aging and elevated risk of alzheimer's disease. |
2014-07-02 |
2023-08-12 |
Not clear |
| Geert Jan Biessel. Sweet memories: 20 years of progress in research on cognitive functioning in diabetes. European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:23872409. |
i will discuss how we tried to establish animal models, how developments from clinical and experimental studies from around the world led us to reconsider our concepts, and how findings from research on diabetic neuropathy, insulin signaling in the brain, alzheimer's disease and dementia, and vascular disease and stroke converged and helped to create new ideas and refute others. |
2014-07-02 |
2023-08-12 |
Not clear |
| Brenna Cholerton, Laura D Baker, Suzanne Craf. Insulin, cognition, and dementia. European journal of pharmacology. vol 719. issue 1-3. 2014-07-02. PMID:24070815. |
with insulin resistance-associated conditions reaching epidemic proportions, the prevalence of alzheimer's disease and other cognitive disorders will continue to rise exponentially. |
2014-07-02 |
2023-08-12 |
Not clear |
| Harriet M Jackson, Ileana Soto, Leah C Graham, Gregory W Carter, Gareth R Howel. Clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of Alzheimer's disease. BMC genomics. vol 14. 2014-06-30. PMID:24274089. |
clustering of transcriptional profiles identifies changes to insulin signaling as an early event in a mouse model of alzheimer's disease. |
2014-06-30 |
2023-08-12 |
mouse |
| Wei Sun, Jin-Bao Ban, Ni Zhang, Yu-Kun Zu, Wen-Xiao Su. Perinatal exposure to Di-(2-ethylhexyl)-Phthalate leads to cognitive dysfunction and phospho-tau level increase in aged rats. Environmental toxicology. vol 29. issue 5. 2014-06-17. PMID:22610992. |
given the potential relationship between insulin resistance and pathogenesis of alzheimer's disease (ad) in elderly life, we investigated the relationship between perinatal dehp exposure and ad pathogenesis. |
2014-06-17 |
2023-08-12 |
rat |
| Kohei Yuyama, Susumu Mitsutake, Yasuyuki Igarash. Pathological roles of ceramide and its metabolites in metabolic syndrome and Alzheimer's disease. Biochimica et biophysica acta. vol 1841. issue 5. 2014-06-03. PMID:23948264. |
the public health burden of metabolic syndrome (mets), a multiplex risk factor that arises from insulin resistance accompanying abnormal adipose conditions, and alzheimer's disease (ad), the most common form of dementia, continues to expand. |
2014-06-03 |
2023-08-12 |
human |
| Bikash Medhi, Mrinmoy Chakrabart. Insulin resistance: an emerging link in Alzheimer's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 34. issue 10. 2014-06-02. PMID:23670236. |
insulin resistance: an emerging link in alzheimer's disease. |
2014-06-02 |
2023-08-12 |
Not clear |
| Toshiyasu Sasaoka, Tsutomu Wada, Hiroshi Tsunek. [Insulin resistance and cognitive function]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 4. 2014-05-27. PMID:24796090. |
stimulation of insulin signaling is a developing therapeutic approach in alzheimer disease. |
2014-05-27 |
2023-08-13 |
Not clear |