| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshiyasu Sasaoka, Tsutomu Wada, Hiroshi Tsunek. [Insulin resistance and cognitive function]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 4. 2014-05-27. PMID:24796090. |
further identification of the pathogenic mechanism connecting between alzheimer disease and insulin resistance contributes to development of novel therapeutics in alzheimer disease. |
2014-05-27 |
2023-08-13 |
Not clear |
| Miwa Ryo, Yoshiko Furiya, Satoshi Uen. [Metabolic syndrome]. Nihon rinsho. Japanese journal of clinical medicine. vol 72. issue 4. 2014-05-27. PMID:24796101. |
accumulating evidence has indicated that the increased insulin resistance in relation to visceral fat accumulation is potential risk of alzheimer's disease (ad) and vascular dementia. |
2014-05-27 |
2023-08-13 |
Not clear |
| M L Johnson, K S Nai. Assessment of old and new proteins: a novel methodology. Nutrition, metabolism, and cardiovascular diseases : NMCD. vol 23 Suppl 1. 2014-05-26. PMID:22784971. |
protein modifications and the accumulation of those proteins are implicated in a host of diseases from parkinson's and alzheimer's to both insulin independent and insulin dependent diabetes mellitus. |
2014-05-26 |
2023-08-12 |
Not clear |
| Suzanne M de la Mont. Intranasal insulin therapy for cognitive impairment and neurodegeneration: current state of the art. Expert opinion on drug delivery. vol 10. issue 12. 2014-05-21. PMID:24215447. |
growing evidence supports the concept that insulin resistance plays an important role in the pathogenesis of cognitive impairment and neurodegeneration, including in alzheimer's disease (ad). |
2014-05-21 |
2023-08-12 |
Not clear |
| Hiroyuki Umegak. Insulin resistance in the brain: A new therapeutic target for Alzheimer's disease. Journal of diabetes investigation. vol 4. issue 2. 2014-05-20. PMID:24843644. |
insulin resistance in the brain: a new therapeutic target for alzheimer's disease. |
2014-05-20 |
2023-08-13 |
Not clear |
| Suzanne M de la Monte, Ming Ton. Brain metabolic dysfunction at the core of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24380887. |
growing evidence supports the concept that alzheimer's disease (ad) is fundamentally a metabolic disease with molecular and biochemical features that correspond with diabetes mellitus and other peripheral insulin resistance disorders. |
2014-05-19 |
2023-08-12 |
Not clear |
| Chong Gao, Yueze Liu, Lin Li, Christian Hölsche. New animal models of Alzheimer's disease that display insulin desensitization in the brain. Reviews in the neurosciences. vol 24. issue 6. 2014-04-22. PMID:24259244. |
new animal models of alzheimer's disease that display insulin desensitization in the brain. |
2014-04-22 |
2023-08-12 |
mouse |
| Yoshiko Furiya, Miwa Ryo, Makoto Kawahara, Takao Kiriyama, Masami Morikawa, Satoshi Uen. Renin-angiotensin system blockers affect cognitive decline and serum adipocytokines in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 9. issue 5. 2014-03-25. PMID:23142434. |
accumulating evidence indicates an association of alzheimer's disease (ad) with the metabolic syndrome (mets), characterized by visceral fat accumulation with insulin resistance and altered secretion of adipocytokines such as adiponectin and leptin. |
2014-03-25 |
2023-08-12 |
Not clear |
| Narayan R Bhat, Lakshmi Thirumangalakud. Increased tau phosphorylation and impaired brain insulin/IGF signaling in mice fed a high fat/high cholesterol diet. Journal of Alzheimer's disease : JAD. vol 36. issue 4. 2014-03-24. PMID:23703152. |
the results, in concert with previous findings with the same model, suggest that high dietary fat/cholesterol elicits brain insulin resistance and altered iis leading to alzheimer's disease-like cognitive impairment in 'normal' mice. |
2014-03-24 |
2023-08-12 |
mouse |
| Colin D Chapman, William H Frey, Suzanne Craft, Lusine Danielyan, Manfred Hallschmid, Helgi B Schiöth, Christian Benedic. Intranasal treatment of central nervous system dysfunction in humans. Pharmaceutical research. vol 30. issue 10. 2014-03-21. PMID:23135822. |
thus, for a variety of growth factors, hormones, neuropeptides and therapeutics including insulin, oxytocin, orexin, and even stem cells, intranasal delivery is emerging as an efficient method of administration, and represents a promising therapeutic strategy for the treatment of diseases with cns involvement, such as obesity, alzheimer's disease, parkinson's disease, huntington's disease, depression, anxiety, autism spectrum disorders, seizures, drug addiction, eating disorders, and stroke. |
2014-03-21 |
2023-08-12 |
Not clear |
| Gábor Molnár, Nóra Faragó, Ágnes K Kocsis, Márton Rózsa, Sándor Lovas, Eszter Boldog, Rita Báldi, Éva Csajbók, János Gardi, László G Puskás, Gábor Tamá. GABAergic neurogliaform cells represent local sources of insulin in the cerebral cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 4. 2014-03-11. PMID:24453306. |
insulin in the brain regulates the metabolism, molecular composition, and cognitive performance of microcircuits and reduces food intake; cerebral insulin levels are altered in diabetes, aging, obesity, and alzheimer's disease. |
2014-03-11 |
2023-08-12 |
rat |
| Harsh Sancheti, Garnik Akopian, Fei Yin, Roberta D Brinton, John P Walsh, Enrique Cadena. Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. PloS one. vol 8. issue 7. 2014-03-06. PMID:23875003. |
age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of alzheimer's disease. |
2014-03-06 |
2023-08-12 |
mouse |
| Maite Solas, Bárbara Aisa, Rosa M Tordera, María C Mugueta, María J Ramíre. Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1832. issue 12. 2014-02-20. PMID:24090692. |
stress contributes to the development of central insulin resistance during aging: implications for alzheimer's disease. |
2014-02-20 |
2023-08-12 |
mouse |
| Maite Solas, Bárbara Aisa, Rosa M Tordera, María C Mugueta, María J Ramíre. Stress contributes to the development of central insulin resistance during aging: implications for Alzheimer's disease. Biochimica et biophysica acta. vol 1832. issue 12. 2014-02-20. PMID:24090692. |
it is becoming evident that chronic exposure to stress not only might result in insulin resistance or cognitive deficits, but may also be considered a risk factor for pathologies such as depression or alzheimer's disease (ad). |
2014-02-20 |
2023-08-12 |
mouse |
| Roberta Semprini, Mauro Ragonese, Maurizio Poggi, Antonella Franze, Alessandro Martoran. Ageing as a Trait de Union between diabetes and dementia for frailty. CNS & neurological disorders drug targets. vol 12. issue 4. 2014-02-18. PMID:23574169. |
in this work the authors suggest a possible link between insulin, diabetes and alzheimer's disease, whose co-existence could be responsible for physical and cognitive decline but not for frailty. |
2014-02-18 |
2023-08-12 |
Not clear |
| Ning Jia, Kun Han, Jing-Jing Kong, Xiu-Mei Zhang, Sha Sha, Gui-Ru Ren, Yun-Peng Ca. (-)-Epigallocatechin-3-gallate alleviates spatial memory impairment in APP/PS1 mice by restoring IRS-1 signaling defects in the hippocampus. Molecular and cellular biochemistry. vol 380. issue 1-2. 2014-02-07. PMID:23660953. |
alzheimer's disease (ad) fundamentally represents a metabolic disease associated with brain insulin resistance. |
2014-02-07 |
2023-08-12 |
mouse |
| Clémentine Beuzelin, Irini Evnouchidou, Pascal Rigolet, Anne Cauvet-Burgevin, Pierre-Marie Girard, Delphine Dardalhon, Slobodan Culina, Abdelaziz Gdoura, Peter van Endert, Stefania Francescon. Deletion of the fission yeast homologue of human insulinase reveals a TORC1-dependent pathway mediating resistance to proteotoxic stress. PloS one. vol 8. issue 6. 2014-02-04. PMID:23826334. |
insulin degrading enzyme (ide) is a protease conserved through evolution with a role in diabetes and alzheimer's disease. |
2014-02-04 |
2023-08-12 |
human |
| Regina Kuliawat, Laura Klein, Zhenwei Gong, Marianna Nicoletta-Gentile, Anjana Nemkal, Lingguang Cui, Claire Bastie, Kai Su, Derek Huffman, Manju Surana, Nir Barzilai, Norman Fleischer, Radhika Muzumda. Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 27. issue 12. 2014-02-04. PMID:23995290. |
humanin (hn) is a 24-aa polypeptide that offers protection from alzheimer's disease and myocardial infarction, increases insulin sensitivity, improves survival of β cells, and delays onset of diabetes. |
2014-02-04 |
2023-08-12 |
mouse |
| Jessica Freiherr, Manfred Hallschmid, William H Frey, Yvonne F Brünner, Colin D Chapman, Christian Hölscher, Suzanne Craft, Fernanda G De Felice, Christian Benedic. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23719722. |
intranasal insulin as a treatment for alzheimer's disease: a review of basic research and clinical evidence. |
2014-02-03 |
2023-08-12 |
Not clear |
| Jessica Freiherr, Manfred Hallschmid, William H Frey, Yvonne F Brünner, Colin D Chapman, Christian Hölscher, Suzanne Craft, Fernanda G De Felice, Christian Benedic. Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence. CNS drugs. vol 27. issue 7. 2014-02-03. PMID:23719722. |
research in animals and humans has associated alzheimer's disease (ad) with decreased cerebrospinal fluid levels of insulin in combination with decreased insulin sensitivity (insulin resistance) in the brain. |
2014-02-03 |
2023-08-12 |
Not clear |