| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Paula I Moreir. High-sugar diets, type 2 diabetes and Alzheimer's disease. Current opinion in clinical nutrition and metabolic care. vol 16. issue 4. 2014-01-27. PMID:23657152. |
this article discusses metabolic derangements induced by high-fructose/sucrose diets and presents evidence for the involvement of insulin resistance in sporadic alzheimer's disease pathogenesis. |
2014-01-27 |
2023-08-12 |
Not clear |
| Marta Dobarro, Lourdes Orejana, Norberto Aguirre, Maria J Ramíre. Propranolol reduces cognitive deficits, amyloid β levels, tau phosphorylation and insulin resistance in response to chronic corticosterone administration. The international journal of neuropsychopharmacology. vol 16. issue 6. 2014-01-15. PMID:23194475. |
chronic exposure to glucocorticoids might result not only in insulin resistance or cognitive deficits, but it is also considered as a risk factor for pathologies such as alzheimer's disease. |
2014-01-15 |
2023-08-12 |
mouse |
| Richard L Veec. Ketone esters increase brown fat in mice and overcome insulin resistance in other tissues in the rat. Annals of the New York Academy of Sciences. vol 1302. 2013-12-18. PMID:23909803. |
other effects of feeding ketone esters, in addition to their ability to induce brown fat, are discussed such as their ability to overcome certain aspects of insulin resistance and to ameliorate the accumulation of amyloid and phosphorylated tau protein in brain, and improve cognitive function, in a triple transgenic mouse model of alzheimer's disease. |
2013-12-18 |
2023-08-12 |
mouse |
| Amy Claxton, Laura D Baker, Charles W Wilkinson, Emily H Trittschuh, Darla Chapman, G Stennis Watson, Brenna Cholerton, Stephen R Plymate, Matthew Arbuckle, Suzanne Craf. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23507773. |
sex and apoe genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or alzheimer's disease. |
2013-12-10 |
2023-08-12 |
human |
| Amy Claxton, Laura D Baker, Charles W Wilkinson, Emily H Trittschuh, Darla Chapman, G Stennis Watson, Brenna Cholerton, Stephen R Plymate, Matthew Arbuckle, Suzanne Craf. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 4. 2013-12-10. PMID:23507773. |
a previous clinical trial demonstrated that four months of treatment with intranasal insulin improves cognition and function for patients with alzheimer's disease (ad) or mild cognitive impairment (mci), but prior studies suggest that response to insulin treatment may differ by sex and apoe ε4 carriage. |
2013-12-10 |
2023-08-12 |
human |
| Nathaniel Hodgson, Malav Trivedi, Christina Muratore, Shaomin Li, Richard Det. Soluble oligomers of amyloid-β cause changes in redox state, DNA methylation, and gene transcription by inhibiting EAAT3 mediated cysteine uptake. Journal of Alzheimer's disease : JAD. vol 36. issue 1. 2013-12-09. PMID:23579332. |
oxidative stress, hyperhomocysteinemia, altered dna methylation, and insulin resistance in the brain are associated with alzheimer's disease (ad), but the role of amyloid-β (aβ) in these events remains unclear. |
2013-12-09 |
2023-08-12 |
human |
| Leah R Hanson, Jared M Fine, Aleta L Svitak, Katherine A Faltese. Intranasal administration of CNS therapeutics to awake mice. Journal of visualized experiments : JoVE. issue 74. 2013-11-22. PMID:23608783. |
efficacy of therapeutics administered intranasally in this way to mice has been demonstrated in a number of studies including insulin in diabetic mouse models and deferoxamine in alzheimer's mouse models. |
2013-11-22 |
2023-08-12 |
mouse |
| Madhav Thambisetty, E Jeffrey Metter, An Yang, Hillary Dolan, Christopher Marano, Alan B Zonderman, Juan C Troncoso, Yun Zhou, Dean F Wong, Luigi Ferrucci, Josephine Egan, Susan M Resnick, Richard J O'Brie. Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging. JAMA neurology. vol 70. issue 9. 2013-11-13. PMID:23897112. |
glucose intolerance, insulin resistance, and pathological features of alzheimer disease in the baltimore longitudinal study of aging. |
2013-11-13 |
2023-08-12 |
Not clear |
| Rasoul Ghasemi, Leila Dargahi, Ali Haeri, Maryam Moosavi, Zahurin Mohamed, Abolhassan Ahmadian. Brain insulin dysregulation: implication for neurological and neuropsychiatric disorders. Molecular neurobiology. vol 47. issue 3. 2013-11-11. PMID:23335160. |
focusing on the molecular mechanisms, this review summarizes the recent findings on the involvement of insulin dysfunction in neurological disorders like alzheimer's disease, parkinson's disease and huntington's disease and also mental disorders like depression and psychosis sharing features of neuroinflammation and neurodegeneration. |
2013-11-11 |
2023-08-12 |
Not clear |
| David Blum, Luc Bué. Alzheimer's disease risk, obesity and tau: is insulin resistance guilty? Expert review of neurotherapeutics. vol 13. issue 5. 2013-11-07. PMID:23621301. |
alzheimer's disease risk, obesity and tau: is insulin resistance guilty? |
2013-11-07 |
2023-08-12 |
Not clear |
| Valory Pavlik, Paul Massman, Robert Barber, Rachelle Dood. Differences in the association of peripheral insulin and cognitive function in non-diabetic Alzheimer's disease cases and normal controls. Journal of Alzheimer's disease : JAD. vol 34. issue 2. 2013-10-29. PMID:23241558. |
differences in the association of peripheral insulin and cognitive function in non-diabetic alzheimer's disease cases and normal controls. |
2013-10-29 |
2023-08-12 |
Not clear |
| Valory Pavlik, Paul Massman, Robert Barber, Rachelle Dood. Differences in the association of peripheral insulin and cognitive function in non-diabetic Alzheimer's disease cases and normal controls. Journal of Alzheimer's disease : JAD. vol 34. issue 2. 2013-10-29. PMID:23241558. |
insulin resistance increases the risk of cognitive impairment and dementia, but higher insulin levels may be cognitively protective after a diagnosis of alzheimer's disease (ad). |
2013-10-29 |
2023-08-12 |
Not clear |
| Michael P Kurnellas, Chris M Adams, Raymond A Sobel, Lawrence Steinman, Jonathan B Rothbar. Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation. Science translational medicine. vol 5. issue 179. 2013-09-30. PMID:23552370. |
our previous work established that amyloidogenic peptides from the small heat shock protein αb crystallin (hspb5) and from amyloid β fibrils, characteristic of alzheimer's disease, were therapeutic in experimental autoimmune encephalomyelitis (eae), reflecting aspects of the pathology of ms. to understand the molecular basis for the therapeutic effect, we showed a set of amyloidogenic peptides composed of six amino acids, including those from tau, amyloid β a4, major prion protein (prp), hspb5, amylin, serum amyloid p, and insulin b chain, to be anti-inflammatory and capable of reducing serological levels of interleukin-6 and attenuating paralysis in eae. |
2013-09-30 |
2023-08-12 |
Not clear |
| Qing-Qing Yin, Jin-Jing Pei, Song Xu, Ding-Zhen Luo, Si-Qing Dong, Meng-Han Sun, Li You, Zhi-Jian Sun, Xue-Ping Li. Pioglitazone improves cognitive function via increasing insulin sensitivity and strengthening antioxidant defense system in fructose-drinking insulin resistance rats. PloS one. vol 8. issue 3. 2013-09-20. PMID:23527159. |
insulin resistance (ir) links alzheimer's disease (ad) with oxidative damage, cholinergic deficit, and cognitive impairment. |
2013-09-20 |
2023-08-12 |
rat |
| M Solas, G Gerenu, F J Gil-Bea, M J Ramíre. Mineralocorticoid receptor activation induces insulin resistance through c-Jun N-terminal kinases in response to chronic corticosterone: cognitive implications. Journal of neuroendocrinology. vol 25. issue 4. 2013-09-16. PMID:23181759. |
it is becoming evident that chronic exposure to glucocorticoids might not only result in insulin resistance or cognitive deficits, but also is considered as a risk factor for pathologies such as depression or alzheimer's disease. |
2013-09-16 |
2023-08-12 |
Not clear |
| Zhi-Gang Yao, Yu Liu, Ling Zhang, Lan Huang, Chun-Mei Ma, Yan-Feng Xu, Hua Zhu, Chuan Qi. Co-location of HDAC2 and insulin signaling components in the adult mouse hippocampus. Cellular and molecular neurobiology. vol 32. issue 8. 2013-09-13. PMID:22733364. |
we hope this could provide a valuable basis for understanding the roles of hdac2 and insulin on cognitive impairment of diabetes mellitus, involved alzheimer's disease, which is also called type 3 diabetes recently. |
2013-09-13 |
2023-08-12 |
mouse |
| Bing Zhang, Xi Can Tang, Hai Yan Zhan. Alternations of central insulin-like growth factor-1 sensitivity in APP/PS1 transgenic mice and neuronal models. Journal of neuroscience research. vol 91. issue 5. 2013-09-10. PMID:23401344. |
although many post-mortem studies have found evidence of central insulin resistance in alzheimer's disease (ad) patients, results on changes of central insulin-like growth factor-1 (igf-1) signaling in the pathological process of ad remain controversial. |
2013-09-10 |
2023-08-12 |
mouse |
| Yunyun Zhang, Bin Wang, Heming Wan, Qida Zhou, Tianjie L. Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease. Neuroscience letters. vol 541. 2013-09-03. PMID:23416320. |
meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to alzheimer's disease. |
2013-09-03 |
2023-08-12 |
Not clear |
| Yunyun Zhang, Bin Wang, Heming Wan, Qida Zhou, Tianjie L. Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease. Neuroscience letters. vol 541. 2013-09-03. PMID:23416320. |
the association between insulin degrading enzyme (ide) gene polymorphisms and alzheimer's disease (ad) risk has been widely reported, but results were somewhat controversial. |
2013-09-03 |
2023-08-12 |
Not clear |
| Collin Y Ewald, Chris L. The secreted Alzheimer-related amyloid precursor protein fragment has an essential role in C. elegans. Prion. vol 6. issue 5. 2013-08-30. PMID:23044509. |
alzheimer disease is also associated with insulin resistance (type 2 diabetes). |
2013-08-30 |
2023-08-12 |
human |