| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Prashant Rai, Marcus Parrish, Ian Jun Jie Tay, Na Li, Shelley Ackerman, Fang He, Jimmy Kwang, Vincent T Chow, Bevin P Engelwar. Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 26. 2015-11-17. PMID:26080406. |
here, we show that s. pneumoniae induces toxic dna double-strand breaks (dsbs) in human alveolar epithelial cells, as indicated by ataxia telangiectasia mutated kinase (atm)-dependent phosphorylation of histone h2ax and colocalization with p53-binding protein (53bp1). |
2015-11-17 |
2023-08-13 |
human |
| Lili Cao, Hidehiko Kawai, Megumi Sasatani, Daisuke Iizuka, Yuji Masuda, Toshiya Inaba, Keiji Suzuki, Akira Ootsuyama, Toshiyuki Umata, Kenji Kamiya, Fumio Suzuk. A novel ATM/TP53/p21-mediated checkpoint only activated by chronic γ-irradiation. PloS one. vol 9. issue 8. 2015-11-09. PMID:25093836. |
we demonstrate a critical role for the ataxia telangiectasia mutated (atm)/tumor protein p53 (tp53)/p21 pathway in regulating dna-damage-associated cell fate. |
2015-11-09 |
2023-08-13 |
mouse |
| Zhongli Du, Wencheng Zhang, Yuling Zhou, Dianke Yu, Xiabin Chen, Jiang Chang, Yan Qiao, Meng Zhang, Ying Huang, Chen Wu, Zefen Xiao, Wen Tan, Dongxin Li. Associations of ATM Polymorphisms With Survival in Advanced Esophageal Squamous Cell Carcinoma Patients Receiving Radiation Therapy. International journal of radiation oncology, biology, physics. vol 93. issue 1. 2015-11-09. PMID:26094126. |
to investigate whether single nucleotide polymorphisms (snps) in the ataxia telangiectasia mutated (atm) gene are associated with survival in patients with esophageal squamous cell carcinoma (escc) receiving radiation therapy or chemoradiation therapy or surgery only. |
2015-11-09 |
2023-08-13 |
Not clear |
| Ji Yong Kim, Jai-Sung Lee, Yong-Seok Han, Jun Hee Lee, Inhyu Bae, Yeo Min Yoon, Sang Mo Kwon, Sang Hun Le. Pretreatment with Lycopene Attenuates Oxidative Stress-Induced Apoptosis in Human Mesenchymal Stem Cells. Biomolecules & therapeutics. vol 23. issue 6. 2015-11-04. PMID:26535076. |
h2o2-induced ros increased the levels of phosphorylated p38 mitogen activated protein kinase (mapk), jun-n-terminal kinase (jnk), ataxia telangiectasia mutated (atm), and p53, which were inhibited by lycopene pretreatment. |
2015-11-04 |
2023-08-13 |
human |
| Wen-Cheng Chou, Ling-Yueh Hu, Chia-Ni Hsiung, Chen-Yang She. Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway. Carcinogenesis. vol 36. issue 8. 2015-10-19. PMID:26025911. |
base lesions, which are structurally simple and predominantly fixed by base excision repair (ber), can trigger the ataxia telangiectasia mutated (atm)-checkpoint kinase 2 (chk2) pathway, a ddr component. |
2015-10-19 |
2023-08-13 |
Not clear |
| Peijing Zhang, Li Wang, Cristian Rodriguez-Aguayo, Yuan Yuan, Bisrat G Debeb, Dahu Chen, Yutong Sun, M James You, Yongqing Liu, Douglas C Dean, Wendy A Woodward, Han Liang, Xianbin Yang, Gabriel Lopez-Berestein, Anil K Sood, Ye Hu, K Kian Ang, Junjie Chen, Li M. miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nature communications. vol 5. 2015-10-15. PMID:25476932. |
mechanistically, radiation suppresses mir-205 expression through ataxia telangiectasia mutated (atm) and zinc finger e-box binding homeobox 1 (zeb1). |
2015-10-15 |
2023-08-13 |
Not clear |
| Laura L Daniel, Christopher R Daniels, Saghar Harirforoosh, Cerrone R Foster, Mahipal Singh, Krishna Sing. Deficiency of ataxia telangiectasia mutated kinase delays inflammatory response in the heart following myocardial infarction. Journal of the American Heart Association. vol 3. issue 6. 2015-10-08. PMID:25520329. |
ataxia‐telangiectasia results from mutations in ataxia telangiectasia mutated kinase (atm) gene. |
2015-10-08 |
2023-08-13 |
Not clear |
| Meng Su, Zhi-Hua Yin, Wei Wu, Xue-Lian Li, Bao-Sen Zho. Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy. Asian Pacific journal of cancer prevention : APJCP. vol 15. issue 24. 2015-10-06. PMID:25605158. |
the ataxia telangiectasia mutated (atm) protein and p53 play key roles in sensing and repairing radiation-induced dna double strand breaks (dsbs). |
2015-10-06 |
2023-08-13 |
Not clear |
| Xiang Ding, Yi Ding, Jirong Yue, Hengyi Xiao, Birong Don. [Advances of Research on Ataxia Telangiectasia Mutated Gene and Risk Factors of Cardiovascular Disease]. Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi. vol 32. issue 2. 2015-09-08. PMID:26211275. |
accumulated evidence has demonstrated that the loss or mutation of ataxia telangiectasia mutated (atm) gene can result in dna damage repair dysfunctions, telomere shortening, decreased antioxidant capacity, insulin resistance, increased lipid levels, etc., and thus can promote the occurrence of cardiovascular risk factors, such as aging, atherosclerosis and metabolic syndrome. |
2015-09-08 |
2023-08-13 |
human |
| Jun Sun, Su-Wen Wang, Chen L. ATP synthase: an identified target gene of bantam in paired female Schistosoma japonicum. Parasitology research. vol 114. issue 2. 2015-08-28. PMID:25407126. |
results showed that atp synthase (cax76793.1), one of the three selected predicted targets, was confirmed as the target of bantam; bantam mimic assay results also showed that the two other predicted targets, namely, ataxia telangiectasia mutated (atm)-related (xp_002571630.1), and ribosomal protein l30 (cax72575.1), were not confirmed as targets. |
2015-08-28 |
2023-08-13 |
Not clear |
| b' Jakub Chwastek, Danuta Jantas, W\\xc5\\x82adys\\xc5\\x82aw Laso\\xc5\\x8. [The role of ATM kinase in neurodegeneration]. Postepy biochemii. vol 60. issue 3. 2015-08-27. PMID:26263761.' |
ataxia telangiectasia (a-t) is rare disease, which is caused by a mutation of the atm protein. |
2015-08-27 |
2023-08-13 |
Not clear |
| Mengxia Li, Yu-Fen Lin, Guillermo A Palchik, Shinji Matsunaga, Dong Wang, Benjamin P C Che. The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair. Free radical biology & medicine. vol 76. 2015-08-25. PMID:25224041. |
dna-dependent protein kinase catalytic subunit (dna-pkcs) and ataxia telangiectasia mutated (atm) are the two major kinases involved in dna double-strand break (dsb) repair, and are required for cellular resistance to ionizing radiation. |
2015-08-25 |
2023-08-13 |
Not clear |
| Aaron A Goodarzi, Penny A Jegg. The heterochromatic barrier to DNA double strand break repair: how to get the entry visa. International journal of molecular sciences. vol 13. issue 9. 2015-08-21. PMID:23109886. |
the damage response protein kinase, ataxia telangiectasia mutated (atm), is required for hc-dsb repair but is dispensable for the relocalization of hc-dsbs. |
2015-08-21 |
2023-08-12 |
Not clear |
| Rebecca C Burgess, Bharat Burman, Michael J Kruhlak, Tom Mistel. Activation of DNA damage response signaling by condensed chromatin. Cell reports. vol 9. issue 5. 2015-08-17. PMID:25464843. |
using a protein-chromatin-tethering system to create defined chromatin domains, we show that interference with chromatin condensation results in failure to fully activate ddr. conversely, forced induction of local chromatin condensation promotes ataxia telangiectasia mutated (atm)- and atr-dependent activation of upstream ddr signaling in a break-independent manner. |
2015-08-17 |
2023-08-13 |
Not clear |
| Nuala McCabe, Conor Hanna, Steven M Walker, David Gonda, Jie Li, Katarina Wikstrom, Kienan I Savage, Karl T Butterworth, Clark Chen, D Paul Harkin, Kevin M Prise, Richard D Kenned. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer research. vol 75. issue 11. 2015-08-17. PMID:25870146. |
ataxia telangiectasia mutated (atm) is an important signaling molecule in the dna damage response (ddr). |
2015-08-17 |
2023-08-13 |
Not clear |
| Tomofumi Akasaka, Masahiko Tsujii, Jumpei Kondo, Yoshito Hayashi, Jin Ying, Yuquan Lu, Motohiko Kato, Takuya Yamada, Shunsuke Yamamoto, Takuya Inoue, Yoshiki Tsujii, Akira Maekawa, Tetsuji Fujinaga, Eri Shiraishi, Satoshi Hiyama, Takahiro Inoue, Shinichiro Shinzaki, Kenji Watabe, Tsutomu Nishida, Hideki Iijima, Tetsuo Takehar. 5‑FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53‑mutated colon cancer cells. International journal of oncology. vol 46. issue 1. 2015-08-11. PMID:25310623. |
5‑fu treatment induced dna damage and activation of ataxia telangiectasia mutated (atm) and chk1, leading to s‑phase arrest, and chk1 inhibition using sb218078 reduced s‑phase arrest and increased apoptosis in the presence of 5‑fu. |
2015-08-11 |
2023-08-13 |
Not clear |
| Elizabeth M Azzato, Charuhas Deshpande, Vania Aikawa, Charu Aggarwal, Evan Alley, Benjamin Jacobs, Jennifer Morrissette, Robert Dabe. Rare Complex Mutational Profile in an ALK Inhibitor-resistant Non-small Cell Lung Cancer. Anticancer research. vol 35. issue 5. 2015-08-06. PMID:25964588. |
herein we identified a kras q22k mutation and frameshift mutations in the genes encoding serine/threonine kinase 11 (stk11) and ataxia telangiectasia mutated serine/threonine kinase (atm) by next-generation sequencing in a patient with alk rearrangement-positive oligo-metastatic nsclc, whose disease progressed while on two alk-targeted therapies. |
2015-08-06 |
2023-08-13 |
rat |
| Hui Dong, Qiong Shi, Xiufang Song, Juanli Fu, Lihua Hu, Demei Xu, Chuanyang Su, Xiaomin Xia, Erqun Song, Yang Son. Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis. Toxicology and applied pharmacology. vol 286. issue 1. 2015-08-05. PMID:25818601. |
our data illustrated that pcb29-pq induces the phosphorylation of p53, which was mediated by ataxia telangiectasia mutated (atm) protein kinase. |
2015-08-05 |
2023-08-13 |
Not clear |
| Roberta Meschini, Elisa Morucci, Andrea Berni, Wilner Lopez-Martinez, Fabrizio Palitt. Role of chromatin structure modulation by the histone deacetylase inhibitor trichostatin A on the radio-sensitivity of ataxia telangiectasia. Mutation research. vol 777. 2015-08-03. PMID:25942615. |
besides, recently it has been reported that ataxia telangiectasia mutated (atm) mediated signalling modifies chromatin structure. |
2015-08-03 |
2023-08-13 |
Not clear |
| Ylli Doksani, Titia de Lang. The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harbor perspectives in biology. vol 6. issue 12. 2015-07-27. PMID:25228584. |
mammalian telomeres have to block nonhomologous end joining (nhej), thus preventing chromosome fusions; they need to control homologous recombination (hr), which could change telomere lengths; they have to avoid activating the atm (ataxia telangiectasia mutated) and atr (atm- and rad3-related) kinase pathways, which could induce cell cycle arrest; and they have to protect chromosome ends from hyperresection. |
2015-07-27 |
2023-08-13 |
Not clear |