| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Wen Liu, Shih-Yu Chen, Chia-Hsien Cheng, Hwai-Jong Cheng, Pei-Hsin Huan. Blm-s, a BH3-only protein enriched in postmitotic immature neurons, is transcriptionally upregulated by p53 during DNA damage. Cell reports. vol 9. issue 1. 2015-07-09. PMID:25263558. |
furthermore, blm-s is a direct target gene of p53 and ap1 via the ataxia telangiectasia mutated (atm)- and c-jun n-terminal kinase (jnk)-signaling pathways activated by dsbs. |
2015-07-09 |
2023-08-13 |
Not clear |
| Marta Wojewoda, Jarosław Walczak, Jerzy Duszyński, Joanna Szczepanowsk. Selenite activates the ATM kinase-dependent DNA repair pathway in human osteosarcoma cells with mitochondrial dysfunction. Biochemical pharmacology. vol 95. issue 3. 2015-07-09. PMID:25862479. |
however, we found the enhanced formation of dna double-strand breaks based on the level of histone γh2ax (phosphorylated at ser 139), which is known to be phosphorylated by atm (ataxia telangiectasia mutated) kinase in response to dna damage. |
2015-07-09 |
2023-08-13 |
human |
| E Y So, T Ouch. Translational initiation regulated by ATM in dendritic cells development. Cell death & disease. vol 5. 2015-07-07. PMID:25210801. |
ataxia telangiectasia mutated (atm) protein has been implicated in multiple pathways such as dna repair, cell cycle checkpoint, cell growth, development, and stem cell renewal. |
2015-07-07 |
2023-08-13 |
Not clear |
| Tarek M A Abdel-Fatah, Christina Perry, Arvind Arora, Nicola Thompson, Rachel Doherty, Paul M Moseley, Andrew R Green, Stephen Y T Chan, Ian O Ellis, Srinivasan Madhusuda. Is there a role for base excision repair in estrogen/estrogen receptor-driven breast cancers? Antioxidants & redox signaling. vol 21. issue 16. 2015-06-30. PMID:25111287. |
to test this hypothesis, we investigated 1406 er(+) early-stage breast cancers with 20 years' long-term clinical follow-up data for dna polymerase β (pol β), flap endonuclease 1 (fen1), ap endonuclease 1 (ape1), x-ray cross-complementation group 1 protein (xrcc1), single-strand monofunctional uracil glycosylase-1 (smug1), poly (adp-ribose) polymerase 1 (parp1), ataxia telangiectasia mutated and rad3 related (atr), ataxia telangiectasia mutated (atm), dna-dependent protein kinase catalytic subunit (dna-pkcs), chk1, chk2, p53, breast cancer susceptibility gene 1 (brca1), and topoisomerase 2 (topo2) expression. |
2015-06-30 |
2023-08-13 |
Not clear |
| Wenxia Jiang, Brian J Lee, Chen Li, Richard L Dubois, Monica Gostissa, Frederick W Alt, Shan Zh. Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency. Blood. vol 125. issue 17. 2015-06-29. PMID:25721125. |
ataxia telangiectasia mutated (atm) is a protein kinase and a master regulator of dna-damage responses. |
2015-06-29 |
2023-08-13 |
mouse |
| Jessica M Overstreet, Rohan Samarakoon, Diana Cardona-Grau, Roel Goldschmeding, Paul J Higgin. Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25480384. |
involvement of tumor suppressor ataxia telangiectasia mutated (atm) in the tgf-β1 pathway related to renal fibrosis is largely unknown. |
2015-06-22 |
2023-08-13 |
mouse |
| Junya Kobayashi, Yuichiro Saito, Michiyo Okui, Noriko Miwa, Kenshi Komats. Increased oxidative stress in AOA3 cells disturbs ATM-dependent DNA damage responses. Mutation research. Genetic toxicology and environmental mutagenesis. vol 782. 2015-06-22. PMID:25868131. |
ataxia telangiectasia (at) is caused by a mutation in the ataxia-telangiectasia-mutated (atm) gene; the condition is associated with hyper-radiosensitivity, abnormal cell-cycle checkpoints, and genomic instability. |
2015-06-22 |
2023-08-13 |
Not clear |
| Martin Andrs, Jan Korabecny, Eugenie Nepovimova, Daniel Jun, Zdenek Hodny, Simona Moravcova, Hana Hanzlikova, Kamil Kuc. The development of ataxia telangiectasia mutated kinase inhibitors. Mini reviews in medicinal chemistry. vol 14. issue 10. 2015-06-15. PMID:25138084. |
among the plethora of signal and effector proteins involved in ddr, three related kinases atm (ataxia telangiectasia mutated), atr (atm and rad3-related) and dna-pk (dna-dependent protein kinase) play the main roles in initiation and regulation of signaling pathways in response to dna double and single strand breaks (dsb and ssb). |
2015-06-15 |
2023-08-13 |
Not clear |
| Enea Gino Di Domenico, Elena Romano, Paola Del Porto, Fiorentina Ascenzion. Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. BioMed research international. vol 2014. 2015-06-15. PMID:25247188. |
the mammalian protein kinase ataxia telangiectasia mutated (atm) is a key regulator of the dna double-strand-break response and belongs to the evolutionary conserved phosphatidylinositol-3-kinase-related protein kinases. |
2015-06-15 |
2023-08-13 |
Not clear |
| Enea Gino Di Domenico, Elena Romano, Paola Del Porto, Fiorentina Ascenzion. Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance. BioMed research international. vol 2014. 2015-06-15. PMID:25247188. |
atm deficiency causes ataxia telangiectasia (at), a genetic disorder that is characterized by premature aging, cerebellar neuropathy, immunodeficiency, and predisposition to cancer. |
2015-06-15 |
2023-08-13 |
Not clear |
| C-Y Wang, E Y-H Huang, S-C Huang, B-C Chun. DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress. Oncogene. vol 34. issue 10. 2015-06-10. PMID:24662822. |
here, we examined the involvement of ataxia telangiectasia, mutated (atm), ataxia telangiectasia, mutated and rad3-related (atr) and dna-dependent protein kinase (dna-pk) and found that hu-induced centrosome amplification was inhibited by the depletion of dna-pkcs, but not atm and atr. |
2015-06-10 |
2023-08-12 |
Not clear |
| Brandy Verhalen, Joshua L Justice, Michael J Imperiale, Mengxi Jian. Viral DNA replication-dependent DNA damage response activation during BK polyomavirus infection. Journal of virology. vol 89. issue 9. 2015-06-10. PMID:25694603. |
in this report, we set out to determine what viral components are responsible for activating the two major phosphatidylinositol 3-kinase-like kinases (pi3kks) involved in the ddr: ataxia telangiectasia mutated (atm) kinase and atm and rad3-related (atr) kinase. |
2015-06-10 |
2023-08-13 |
human |
| Lidza Kalifa, Jennifer S Gewandter, Rhonda J Staversky, Elaine A Sia, Paul S Brookes, Michael A O'Reill. DNA double-strand breaks activate ATM independent of mitochondrial dysfunction in A549 cells. Free radical biology & medicine. vol 75. 2015-06-09. PMID:25048973. |
although numerous cell signaling pathways are activated when cells are injured, the ataxia telangiectasia mutant (atm) protein has emerged as a major regulator of the response to both mitochondrial dysfunction and nuclear dna double-strand breaks (dsbs). |
2015-06-09 |
2023-08-13 |
human |
| Chih-Ho Lai, Chia-Shuo Chang, Hsin-Ho Liu, Yuh-Shyan Tsai, Feng-Ming Hsu, Yung-Luen Yu, Cheng-Kuo Lai, Leah Gandee, Rey-Chen Pong, Heng-Wei Hsu, Lan Yu, Debabrata Saha, Jer-Tsong Hsie. Sensitization of radio-resistant prostate cancer cells with a unique cytolethal distending toxin. Oncotarget. vol 5. issue 14. 2015-06-05. PMID:25015118. |
a combination of cdt and radiotherapy significantly elicited cell death in dab2ip-deficient pca cells by inhibiting the repair of ionizing radiation (ir)-induced dna double-strand break (dsb) during g2/m arrest, which is triggered by ataxia telangiectasia mutated (atm)-dependent dna damage checkpoint responses. |
2015-06-05 |
2023-08-13 |
mouse |
| G-H Ha, J-L Kim, A Petersson, S Oh, M F Denning, T Patel, E-K Breue. TACC3 deregulates the DNA damage response and confers sensitivity to radiation and PARP inhibition. Oncogene. vol 34. issue 13. 2015-06-04. PMID:24769898. |
in this study, we show that high levels of tacc3 lead to the accumulation of dna double-strand breaks (dsbs) and disrupt the normal cellular response to dna damage, at least in part, by negatively regulating the expression of ataxia telangiectasia mutated (atm) and the subsequent dna damage response (ddr) signaling cascade. |
2015-06-04 |
2023-08-13 |
human |
| L Carlessi, E Fusar Poli, G Bechi, M Mantegazza, B Pascucci, L Narciso, E Dogliotti, C Sala, C Verpelli, D Lecis, D Deli. Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency. Cell death & disease. vol 5. 2015-06-04. PMID:25032865. |
loss of ataxia telangiectasia mutated (atm) kinase, a key factor of the dna damage response (ddr) pathway, causes the cancer predisposing and neurodegenerative syndrome ataxia-telangiectasia (a-t). |
2015-06-04 |
2023-08-13 |
Not clear |
| Ley-Hian Low, Yuh-Lit Chow, Yijia Li, Choo-Peng Goh, Ulrich Putz, John Silke, Toru Ouchi, Jason Howitt, Seong-Seng Ta. Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response. The Journal of biological chemistry. vol 290. issue 11. 2015-05-29. PMID:25631046. |
a major response to dna damage is provided by the protein kinase atm (ataxia telangiectasia mutated) that is capable of commanding a plethora of signaling networks for dna repair, cell cycle arrest, and even apoptosis. |
2015-05-29 |
2023-08-13 |
Not clear |
| Cecil Han, Yunhua Liu, Guohui Wan, Hyun Jin Choi, Luqing Zhao, Cristina Ivan, Xiaoming He, Anil K Sood, Xinna Zhang, Xiongbin L. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell reports. vol 8. issue 5. 2015-05-28. PMID:25176654. |
this induction is facilitated by the ataxia telangiectasia mutated (atm)-mediated phosphorylation of ddx1. |
2015-05-28 |
2023-08-13 |
mouse |
| Shiyuan Hong, Anindya Dutta, Laimonis A Laimin. The acetyltransferase Tip60 is a critical regulator of the differentiation-dependent amplification of human papillomaviruses. Journal of virology. vol 89. issue 8. 2015-05-28. PMID:25673709. |
the life cycle of human papillomaviruses (hpvs) is dependent upon differentiation of the infected host epithelial cell as well as activation of the ataxia telangiectasia mutated (atm) dna repair pathway that in normal cells acts to repair double-strand dna breaks. |
2015-05-28 |
2023-08-13 |
human |
| Simran Khurana, Michael J Kruhlak, Jeongkyu Kim, Andy D Tran, Jinping Liu, Katherine Nyswaner, Lei Shi, Parthav Jailwala, Myong-Hee Sung, Ofir Hakim, Philipp Oberdoerffe. A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance. Cell reports. vol 8. issue 4. 2015-05-26. PMID:25131201. |
the macroh2a1/prdm2 module mediates an unexpected shift from accessible to condensed chromatin that requires the ataxia telangiectasia mutated (atm)-dependent accumulation of both proteins at dsbs in order to promote dsb-flanking h3k9 dimethylation. |
2015-05-26 |
2023-08-13 |
Not clear |