| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Kabacik, G Manning, C Raffy, S Bouffler, C Badi. Time, dose and ataxia telangiectasia mutated (ATM) status dependency of coding and noncoding RNA expression after ionizing radiation exposure. Radiation research. vol 183. issue 3. 2015-05-25. PMID:25738893. |
time, dose and ataxia telangiectasia mutated (atm) status dependency of coding and noncoding rna expression after ionizing radiation exposure. |
2015-05-25 |
2023-08-13 |
human |
| Silvia Svegliati, Giusi Marrone, Antonio Pezone, Tatiana Spadoni, Antonella Grieco, Gianluca Moroncini, Domenico Grieco, Maria Vinciguerra, Savina Agnese, Astrid Jüngel, Oliver Distler, Anna Maria Musti, Armando Gabrielli, Enrico V Avvediment. Oxidative DNA damage induces the ATM-mediated transcriptional suppression of the Wnt inhibitor WIF-1 in systemic sclerosis and fibrosis. Science signaling. vol 7. issue 341. 2015-05-22. PMID:25185156. |
the dna damage checkpoint kinase ataxia telangiectasia mutated (atm) mediated wif-1 silencing through the phosphorylation of the transcription factor c-jun, which in turn activated the expression of the gene encoding activating transcription factor 3 (atf3). |
2015-05-22 |
2023-08-13 |
Not clear |
| Mary Helen Barcellos-Hoff, Francis A Cucinott. New tricks for an old fox: impact of TGFβ on the DNA damage response and genomic stability. Science signaling. vol 7. issue 341. 2015-05-22. PMID:25185158. |
subsequent studies demonstrated that tgfβ depletion compromises cell survival in response to radiation and impairs activation of the ddr because of severely reduced activity of ataxia telangiectasia mutated (atm), a serine/threonine protein kinase that is rapidly activated by dna double-strand breaks. |
2015-05-22 |
2023-08-13 |
human |
| J Hennig, M P McShane, N Cordes, I Ek. APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM. Cell death & disease. vol 5. 2015-05-18. PMID:24763056. |
in addition, appl knockdown diminished radiogenic hyperphosphorylation of ataxia telangiectasia mutated (atm). |
2015-05-18 |
2023-08-13 |
Not clear |
| S Rondeau, S Vacher, L De Koning, A Briaux, A Schnitzler, W Chemlali, C Callens, R Lidereau, I Bièch. ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels. British journal of cancer. vol 112. issue 6. 2015-05-13. PMID:25742469. |
ataxia telangiectasia mutated (atm) is a kinase that has a central role in the maintenance of genomic integrity by activating cell cycle checkpoints and promoting repair of dna double-strand breaks (dsb). |
2015-05-13 |
2023-08-13 |
Not clear |
| Shinya Takahashi, Kei H Kojo, Natsumaro Kutsuna, Masaki Endo, Seiichi Toki, Hiroko Isoda, Seiichiro Hasezaw. Differential responses to high- and low-dose ultraviolet-B stress in tobacco Bright Yellow-2 cells. Frontiers in plant science. vol 6. 2015-05-08. PMID:25954287. |
caffeine, an inhibitor of ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3-related (atr) checkpoint kinases, reduced the rate of cell death in high-uv-b-irradiated cells. |
2015-05-08 |
2023-08-13 |
Not clear |
| Urbain Weyemi, Christophe E Redon, Towqir Aziz, Rohini Choudhuri, Daisuke Maeda, Palak R Parekh, Michael Y Bonner, Jack L Arbiser, William M Bonne. NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 7. 2015-05-04. PMID:25646414. |
ataxia telangiectasia (a-t), a rare autosomal recessive disorder characterized by progressive cerebellar degeneration and a greatly increased incidence of cancer among other symptoms, is caused by a defective or missing ataxia telangiectasia mutated (atm) gene. |
2015-05-04 |
2023-08-13 |
mouse |
| Anetta Härtlova, Saskia F Erttmann, Faizal Am Raffi, Anja M Schmalz, Ulrike Resch, Sharath Anugula, Stefan Lienenklaus, Lisa M Nilsson, Andrea Kröger, Jonas A Nilsson, Torben Ek, Siegfried Weiss, Nelson O Gekar. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Immunity. vol 42. issue 2. 2015-05-01. PMID:25692705. |
dysfunction in ataxia-telangiectasia mutated (atm), a central component of the dna repair machinery, results in ataxia telangiectasia (at), a cancer-prone disease with a variety of inflammatory manifestations. |
2015-05-01 |
2023-08-13 |
mouse |
| Jianhua Xiong, Dilyana Todorova, Ning-Yuan Su, Jinchul Kim, Pei-Jen Lee, Zhouxin Shen, Steven P Briggs, Yang X. Stemness factor Sall4 is required for DNA damage response in embryonic stem cells. The Journal of cell biology. vol 208. issue 5. 2015-04-28. PMID:25733712. |
in this paper, we show that the stemness factor sall4 is required for activating the critical ataxia telangiectasia mutated (atm)-dependent cellular responses to dna double-stranded breaks (dsbs) in mouse escs and confer their resistance to dsb-induced cytotoxicity. |
2015-04-28 |
2023-08-13 |
mouse |
| Kyoko Tsukiyama-Kohar. Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. International journal of molecular sciences. vol 13. issue 11. 2015-04-23. PMID:23203124. |
moreover, the transcription factor sp1 was found to bind to this region in response to oxidative stress under the regulation of ataxia telangiectasia mutated (atm) kinase. |
2015-04-23 |
2023-08-12 |
Not clear |
| S-J Kwon, J-H Park, E-J Park, S-A Lee, H-S Lee, S W Kang, J Kwo. ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair. Oncogene. vol 34. issue 3. 2015-04-22. PMID:24413084. |
here, we show that ataxia telangiectasia mutated (atm) mediates the phosphorylation of brg1, the catalytic atpase of the swi/snf complex that contributes to dsb repair by binding γ-h2ax-containing nucleosomes via interaction with acetylated histone h3 and stimulating γ-h2ax formation, at ser-721 in response to dna damage. |
2015-04-22 |
2023-08-12 |
Not clear |
| Stanley Andrisse, Rikki M Koehler, Joseph E Chen, Gaytri D Patel, Vivek R Vallurupalli, Benjamin A Ratliff, Daniel E Warren, Jonathan S Fishe. Role of GLUT1 in regulation of reactive oxygen species. Redox biology. vol 2. 2015-04-22. PMID:25101238. |
ataxia telangiectasia mutated (atm) inhibitors and activators, previously shown to inhibit and augment glut1-mediated transport, increased and decreased ros levels, respectively. |
2015-04-22 |
2023-08-13 |
Not clear |
| W L Lai, W Y Hung, Y P Chin. The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase. Oncogene. vol 33. issue 45. 2015-04-21. PMID:24240686. |
one of the key regulators of this process is ataxia telangiectasia mutated (atm) kinase, which modulates the p53 level by direct and indirect phosphorylation. |
2015-04-21 |
2023-08-12 |
human |
| Yuri L Bunimovich, Evan Nair-Gill, Mireille Riedinger, Melissa N McCracken, Donghui Cheng, Jami McLaughlin, Caius G Radu, Owen N Witt. Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistance. PloS one. vol 9. issue 8. 2015-04-21. PMID:25101980. |
we show that ataxia telangiectasia mutated (atm) integrates the dna damage response with dna metabolism by regulating the salvage of deoxyribonucleosides. |
2015-04-21 |
2023-08-13 |
Not clear |
| Ling Fang, Sanjeev Choudhary, Bing Tian, Istvan Boldogh, Chunying Yang, Teodora Ivanciuc, Yinghong Ma, Roberto P Garofalo, Allan R Brasie. Ataxia telangiectasia mutated kinase mediates NF-κB serine 276 phosphorylation and interferon expression via the IRF7-RIG-I amplification loop in paramyxovirus infection. Journal of virology. vol 89. issue 5. 2015-04-20. PMID:25520509. |
recently, we discovered a nuclear oxidative stress-sensitive pathway mediated by the dna damage response protein, ataxia telangiectasia mutated (atm), in cytokine-induced nf-κb/rela ser 276 phosphorylation. |
2015-04-20 |
2023-08-13 |
Not clear |
| Jae Won Chang, Keun Hyung Park, Hye Sook Hwang, Yoo Seob Shin, Young-Taek Oh, Chul-Ho Ki. Protective effects of Korean red ginseng against radiation-induced apoptosis in human HaCaT keratinocytes. Journal of radiation research. vol 55. issue 2. 2015-04-13. PMID:24078877. |
western blots revealed krg-mediated reduced expression of ataxia telangiectasia mutated protein (atm), p53, c-jun n-terminal kinase (jnk), p38 and cleaved caspase-3, compared with their significant increase after radiation treatment. |
2015-04-13 |
2023-08-12 |
human |
| Paul A Jowsey, Peter G Blai. Fe65 Ser228 is phosphorylated by ATM/ATR and inhibits Fe65-APP-mediated gene transcription. The Biochemical journal. vol 465. issue 3. 2015-04-10. PMID:25397632. |
in the present study, we identified fe65 ser(228) as a novel target of the atm (ataxia telangiectasia mutated) and atr (ataxia-telangiectasia- and rad3-related protein) protein kinases, in a reaction that occurred independently of app. |
2015-04-10 |
2023-08-13 |
mouse |
| Takanori Katsube, Masahiko Mori, Hideo Tsuji, Tadahiro Shiomi, Bing Wang, Qiang Liu, Mitsuru Nenoi, Makoto Onod. Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks. Journal of biochemistry. vol 156. issue 2. 2015-03-30. PMID:24682951. |
oxidative stress-induced γh2ax was eliminated in dsb repair-deficient mutant cells as efficiently as in wild-type cells and was not necessarily accompanied by phosphorylated ataxia telangiectasia mutated (atm) or 53bp1 foci. |
2015-03-30 |
2023-08-12 |
Not clear |
| Sriram Bandi, Preeti Viswanathan, Sanjeev Gupt. Evaluation of cytotoxicity and DNA damage response with analysis of intracellular ATM signaling pathways. Assay and drug development technologies. vol 12. issue 5. 2015-03-30. PMID:24927134. |
deficiency or aberrancy in the dna damage response, for example, through ataxia telangiectasia mutated (atm) signaling, lead to pathophysiological perturbations in organs throughout the body. |
2015-03-30 |
2023-08-13 |
mouse |
| Chang Myeon Song, Tack-Kyun Kwon, Byung Lae Park, Yong Bae Ji, Kyung Ta. Single nucleotide polymorphisms of ataxia telangiectasia mutated and the risk of papillary thyroid carcinoma. Environmental and molecular mutagenesis. vol 56. issue 1. 2015-03-19. PMID:25196645. |
we evaluated the association between single nucleotide polymorphisms (snps) of ataxia telangiectasia mutated (atm) and the risk of ptc. |
2015-03-19 |
2023-08-13 |
Not clear |