| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masaki Nagane, Hironobu Yasui, Yuri Sakai, Tohru Yamamori, Koichi Niwa, Yuichi Hattori, Takashi Kondo, Osamu Inanam. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway. Biochemical and biophysical research communications. vol 456. issue 1. 2015-03-10. PMID:25498542. |
in this study, the involvement of ataxia telangiectasia mutated (atm) kinase and heat shock protein 90 (hsp90) in endothelial nitric oxide synthase (enos) activation was investigated in x-irradiated bovine aortic endothelial cells. |
2015-03-10 |
2023-08-13 |
cattle |
| Yasunori Fukumoto, Kazumasa Kuki, Mariko Morii, Takahito Miura, Takuya Honda, Kenichi Ishibashi, Hitomi Hasegawa, Sho Kubota, Yudai Ide, Noritaka Yamaguchi, Yuji Nakayama, Naoto Yamaguch. Lyn tyrosine kinase promotes silencing of ATM-dependent checkpoint signaling during recovery from DNA double-strand breaks. Biochemical and biophysical research communications. vol 452. issue 3. 2015-02-25. PMID:25173936. |
here, we show that src family kinases promote inactivation of ataxia telangiectasia mutated (atm)-dependent checkpoint signaling during recovery from dna double-strand breaks. |
2015-02-25 |
2023-08-13 |
Not clear |
| Yasunobu Matsuda, Ayumi Sanpei, Toshifumi Wakai, Masayuki Kubota, Mami Osawa, Yuki Hirose, Jun Sakata, Takashi Kobayashi, Shun Fujimaki, Masaaki Takamura, Satoshi Yamagiwa, Masahiko Yano, Shogo Ohkoshi, Yutaka Aoyag. Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase. International journal of clinical and experimental pathology. vol 7. issue 5. 2015-02-23. PMID:24966912. |
the involvement of ataxia telangiectasia mutated (atm) kinase in the enhanced redox system was investigated by examining the phosphorylation level of atm in hbx gene-transfected cells and in transgenic mice following redox system manipulation by treatment with hydrogen peroxide (h2o2) or antioxidant. |
2015-02-23 |
2023-08-13 |
mouse |
| Everett J Moding, Chang-Lung Lee, Katherine D Castle, Patrick Oh, Lan Mao, Shan Zha, Hooney D Min, Yan Ma, Shiva Das, David G Kirsc. Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. The Journal of clinical investigation. vol 124. issue 8. 2015-02-18. PMID:25036710. |
kinase inhibitors of atm, the gene mutated in ataxia telangiectasia, can sensitize tumor cells to radiation therapy, but concern that inhibiting atm in normal tissues will also increase normal tissue toxicity from radiation has limited their clinical application. |
2015-02-18 |
2023-08-13 |
mouse |
| Viki Swope, Christina Alexander, Renny Starner, Sandy Schwemberger, George Babcock, Zalfa A Abdel-Male. Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation. Pigment cell & melanoma research. vol 27. issue 4. 2015-02-12. PMID:24730569. |
α-msh up-regulated the levels of xpc, the enzyme that recognizes dna damage sites, enhanced the uv-induced phosphorylation of the dna damage sensors ataxia telangiectasia and rad3-related (atr) and ataxia telangiectasia mutated (atm) and their respect-ive substrates checkpoint kinases 1 and 2, and increased phosphorylated h2ax (γh2ax) formation. |
2015-02-12 |
2023-08-13 |
human |
| Xiuquan Luo, Masatoshi Suzuki, Shanaz A Ghandhi, Sally A Amundson, David A Boothma. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PloS one. vol 9. issue 6. 2015-02-12. PMID:24937130. |
recent studies suggest that the ataxia telangiectasia mutant (atm) kinase is not only a key protein mediating cellular responses to dna damage, but also regulates cellular senescence induced by telomere end exposure (in rs) or persistent dna damage (in sips). |
2015-02-12 |
2023-08-13 |
Not clear |
| Xiuquan Luo, Masatoshi Suzuki, Shanaz A Ghandhi, Sally A Amundson, David A Boothma. ATM regulates insulin-like growth factor 1-secretory clusterin (IGF-1-sCLU) expression that protects cells against senescence. PloS one. vol 9. issue 6. 2015-02-12. PMID:24937130. |
loss of atm activity, either by genomic mutation (atm-deficient fibroblasts from an ataxia telangiectasia patient) or by administration of a chemical inhibitor (aai, an inhibitor of atm and atr), blocks igf-1-sclu expression in senescent cells. |
2015-02-12 |
2023-08-13 |
Not clear |
| Ishani Sahama, Kate Sinclair, Kerstin Pannek, Martin Lavin, Stephen Ros. Radiological imaging in ataxia telangiectasia: a review. Cerebellum (London, England). vol 13. issue 4. 2015-02-09. PMID:24683014. |
such imaging approaches have yet to be applied in the study of a-t and could provide important new information regarding the relationship between mutation of the ataxia telangiectasia mutated (atm) gene and the integrity of motor circuitry. |
2015-02-09 |
2023-08-12 |
human |
| Shanthi Ganesan, Jackson Nteeba, Aileen F Keatin. Enhanced susceptibility of ovaries from obese mice to 7,12-dimethylbenz[a]anthracene-induced DNA damage. Toxicology and applied pharmacology. vol 281. issue 2. 2015-02-06. PMID:25448685. |
total ovarian rna and protein were isolated and abundance of ataxia telangiectasia mutated (atm), x-ray repair complementing defective repair in chinese hamster cells 6 (xrcc6), breast cancer type 1 (brca1), rad 51 homolog (rad51), poly [adp-ribose] polymerase 1 (parp1) and protein kinase, dna-activated, catalytic polypeptide (prkdc) were quantified by rt-pcr or western blot. |
2015-02-06 |
2023-08-13 |
mouse |
| Mohammad Rahman, Francesca Lovat, Giulia Romano, Federica Calore, Mario Acunzo, Erica Hlavin Bell, Patrick Nana-Sinka. miR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung. The Journal of biological chemistry. vol 289. issue 38. 2015-02-02. PMID:25092292. |
we observed an up-regulation of components of the ataxia telangiectasia mutated (atm)/chek1/p53 pathway in mir-15b/16-2-overexpressing cells after ir. |
2015-02-02 |
2023-08-13 |
human |
| Eiji Kubota, Christopher T Williamson, Ruiqiong Ye, Anifat Elegbede, Lars Peterson, Susan P Lees-Miller, D Gwyn Beb. Low ATM protein expression and depletion of p53 correlates with olaparib sensitivity in gastric cancer cell lines. Cell cycle (Georgetown, Tex.). vol 13. issue 13. 2015-01-29. PMID:24841718. |
we previously reported that mantle cell lymphoma cells with deficiency in ataxia telangiectasia mutated (atm) are sensitive to parp-1 inhibitors in vitro and in vivo. |
2015-01-29 |
2023-08-13 |
Not clear |
| Qing-He Zhang, Xiao-Jun Tian, Feng Liu, Wei Wan. A switch-like dynamic mechanism for the initiation of replicative senescence. FEBS letters. vol 588. issue 23. 2015-01-28. PMID:25315415. |
whereas trf2 (telomeric-repeat binding factor 2), atm (ataxia telangiectasia mutated) and p53 have been identified involved in senescence induction, how it is triggered remains unclear. |
2015-01-28 |
2023-08-13 |
Not clear |
| Marta Joanna Podralska, Agnieszka Stembalska, Ryszard Ślęzak, Aleksandra Lewandowicz-Uszyńska, Barbara Pietrucha, Sylwia Kołtan, Jadwiga Wigowska-Sowińska, Jacek Pilch, Maria Mosor, Iwona Ziółkowska-Suchanek, Agnieszka Dzikiewicz-Krawczyk, Ryszard Słomsk. Ten new ATM alterations in Polish patients with ataxia-telangiectasia. Molecular genetics & genomic medicine. vol 2. issue 6. 2015-01-23. PMID:25614872. |
inherited biallelic mutations of the atm gene are responsible for the development of ataxia telangiectasia (at). |
2015-01-23 |
2023-08-13 |
Not clear |
| Koralia E Paschalaki, Richard D Starke, Yanhua Hu, Nicolas Mercado, Andriana Margariti, Vassilis G Gorgoulis, Anna M Randi, Peter J Barne. Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. Stem cells (Dayton, Ohio). vol 31. issue 12. 2015-01-15. PMID:23897750. |
inhibition of dna damage response by silencing of ataxia telangiectasia mutated (atm) kinase resulted in upregulation of sirt1 expression and decreased senescence. |
2015-01-15 |
2023-08-12 |
mouse |
| Yulu Gu, Yaqin Yu, Lizhe Ai, Jieping Shi, Xiaoli Liu, Hui Sun, Yawen Li. Association of the ATM gene polymorphisms with papillary thyroid cancer. Endocrine. vol 45. issue 3. 2014-12-23. PMID:23925578. |
our study aimed to evaluate the association between single nucleotide polymorphisms (snps) of the ataxia telangiectasia mutated (atm) gene and ptc risk. |
2014-12-23 |
2023-08-12 |
Not clear |
| Bárbara Alcaraz Silva, Jessica R Stambaugh, Kyoko Yokomori, Jagesh V Shah, Michael W Bern. DNA damage to a single chromosome end delays anaphase onset. The Journal of biological chemistry. vol 289. issue 33. 2014-12-16. PMID:24982423. |
although phosphorylation of h2ax and the recruitment of several repair factors, such as ku70-ku80, occur in a comparable manner at both tip and non-tip damage sites, ddr factors such as ataxia telangiectasia mutated (atm), mdc1, wrn, and fancd2 are specifically recruited to tips but not to non-tips. |
2014-12-16 |
2023-08-13 |
Not clear |
| Alejandro Álvarez-Quilón, Almudena Serrano-Benítez, Jenna Ariel Lieberman, Cristina Quintero, Daniel Sánchez-Gutiérrez, Luis M Escudero, Felipe Cortés-Ledesm. ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nature communications. vol 5. 2014-12-03. PMID:24572510. |
ataxia telangiectasia is caused by mutations in atm and represents a paradigm for cancer predisposition and neurodegenerative syndromes linked to deficiencies in the dna-damage response. |
2014-12-03 |
2023-08-12 |
Not clear |
| Alejandro Álvarez-Quilón, Almudena Serrano-Benítez, Jenna Ariel Lieberman, Cristina Quintero, Daniel Sánchez-Gutiérrez, Luis M Escudero, Felipe Cortés-Ledesm. ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nature communications. vol 5. 2014-12-03. PMID:24572510. |
we therefore identify the nature of atm involvement in dsb repair, presenting blocked dna ends as a possible pathogenic trigger of ataxia telangiectasia and related disorders. |
2014-12-03 |
2023-08-12 |
Not clear |
| Young June Kim, Kwang Sung Ahn, Minjeong Kim, Min Ju Kim, Sang-Min Park, Junghyun Ryu, Jin Seop Ahn, Soon Young Heo, Jee Hyun Kang, You Jung Choi, Seong-Jun Choi, Hosup Shi. Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer. Biochemical and biophysical research communications. vol 452. issue 4. 2014-12-01. PMID:25193705. |
even though a-t is known to be caused by the mutations in the ataxia telangiectasia mutated (atm) gene, the correlation between abnormal cellular physiology caused by atm mutations and the multiple symptoms of a-t disease has not been clearly determined. |
2014-12-01 |
2023-08-13 |
mouse |
| Dalong Yi, Claire Lessa Alvim Kamei, Toon Cools, Sandy Vanderauwera, Naoki Takahashi, Yoko Okushima, Thomas Eekhout, Kaoru Okamoto Yoshiyama, John Larkin, Hilde Van den Daele, Phillip Conklin, Anne Britt, Masaaki Umeda, Lieven De Veylde. The Arabidopsis SIAMESE-RELATED cyclin-dependent kinase inhibitors SMR5 and SMR7 regulate the DNA damage checkpoint in response to reactive oxygen species. The Plant cell. vol 26. issue 1. 2014-11-24. PMID:24399300. |
surprisingly, hu-induced smr5/smr7 expression depends on ataxia telangiectasia mutated (atm) and suppressor of gamma response1, rather than on the anticipated replication stress-activated atm and rad3-related kinase. |
2014-11-24 |
2023-08-12 |
Not clear |