| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toran Sanli, Gregory R Steinberg, Gurmit Singh, Theodoros Tsakiridi. AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer biology & therapy. vol 15. issue 2. 2014-11-12. PMID:24100703. |
ionizing radiation and chemotherapy activate ampk in cancer cells to mediate signal transduction downstream of ataxia telangiectasia mutated (atm) to activate p53- p21(cip1)/p27(kip1) and inhibit mtor. |
2014-11-12 |
2023-08-12 |
human |
| Yulu Gu, Xiaoli Liu, Yaqin Yu, Jieping Shi, Lizhe Ai, Hui Sun, Joseph Sam Kanu, Chong Wang, Yawen Li. Association of ATM Gene Polymorphism with PTC Metastasis in Female Patients. International journal of endocrinology. vol 2014. 2014-11-11. PMID:25386189. |
ataxia telangiectasia mutated (atm) gene is critical in the process of recognizing and repairing dna lesions and is related to invasion and metastasis of malignancy. |
2014-11-11 |
2023-08-13 |
Not clear |
| Alice C Holly, Luke C Pilling, Dena Hernandez, Benjamin P Lee, Andrew Singleton, Luigi Ferrucci, David Melzer, Lorna W Harrie. Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans. Mechanisms of ageing and development. vol 135. 2014-10-22. PMID:24463145. |
a proportion of splicing factors are regulated during ageing by mechanisms involving the ataxia telangiectasia mutated (atm) gene, but the factors that determine the remaining proportion have yet to be identified. |
2014-10-22 |
2023-08-12 |
Not clear |
| Józefa Węsierska-Gądek, Sarah Heinz. Interactions Between Ataxia Telangiectasia Mutated Kinase Inhibition, Poly(ADP-ribose) Polymerase-1 Inhibition and BRCA1 Status in Breast Cancer Cells. Journal of cancer prevention. vol 19. issue 2. 2014-10-22. PMID:25337581. |
in addition, interference with the dna damage signaling pathway via (for instance) ataxia telangiectasia mutated (atm) kinase inhibition may induce synthetic lethality in dna repair-deficient breast cancer cells and pharmacological interference with atm activity may sensitize breast cancer cells to parp-1 inactivation. |
2014-10-22 |
2023-08-13 |
Not clear |
| Cerrone R Foster, Laura L Daniel, Christopher R Daniels, Suman Dalal, Mahipal Singh, Krishna Sing. Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. PloS one. vol 8. issue 12. 2014-10-21. PMID:24358288. |
ataxia telangiectasia mutated kinase (atm) is a cell cycle checkpoint protein activated in response to dna damage. |
2014-10-21 |
2023-08-12 |
Not clear |
| Qian Cai, Lijuan Fu, Zi Wang, Nanqin Gan, Xiaoxia Dai, Yinsheng Wan. α-N-methylation of damaged DNA-binding protein 2 (DDB2) and its function in nucleotide excision repair. The Journal of biological chemistry. vol 289. issue 23. 2014-10-07. PMID:24753253. |
moreover, loss of this methylation conferred compromised atm (ataxia telangiectasia mutated) activation, decreased efficiency in cyclobutane pyrimidine dimer repair, and elevated sensitivity of cells toward uv light exposure. |
2014-10-07 |
2023-08-13 |
human |
| Jie Kang, Xian-Zhao Deng, You-Ben Fan, Bo W. Relationships of FOXE1 and ATM genetic polymorphisms with papillary thyroid carcinoma risk: a meta-analysis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 35. issue 7. 2014-10-06. PMID:24756757. |
we conducted the meta-analysis of all relevant case-control studies aiming to evaluate the relationships of common polymorphisms in forkhead box e1 (foxe1) and ataxia telangiectasia mutated (atm) genes to the risk of papillary thyroid carcinoma (ptc). |
2014-10-06 |
2023-08-13 |
Not clear |
| Yan Ma, Julia Chapman, Mark Levine, Kishore Polireddy, Jeanne Drisko, Qi Che. High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy. Science translational medicine. vol 6. issue 222. 2014-09-28. PMID:24500406. |
data show that millimolar ascorbate, acting as a pro-oxidant, induced dna damage and depleted cellular adenosine triphosphate (atp), activated the ataxia telangiectasia mutated (atm)/adenosine monophosphate-activated protein kinase (ampk) pathway, and resulted in mammalian target of rapamycin (mtor) inhibition and death in ovarian cancer cells. |
2014-09-28 |
2023-08-12 |
mouse |
| Maria Saveria Gilardini Montani, Andrea Prodosmo, Venturina Stagni, Dania Merli, Laura Monteonofrio, Veronica Gatti, Maria Pia Gentileschi, Daniela Barilà, Silvia Sodd. ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition. Journal of experimental & clinical cancer research : CR. vol 32. 2014-09-26. PMID:24252502. |
the ataxia telangiectasia mutated (atm) kinase is a key ddr protein whose heterozygous germline mutation is a moderate-risk factor for developing breast cancer. |
2014-09-26 |
2023-08-12 |
Not clear |
| Jienny Lee, Jae Youl Cho, Sang Yeol Lee, Kyung-Woo Lee, Jongsung Lee, Jae-Young Son. Vanillin protects human keratinocyte stem cells against ultraviolet B irradiation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 63. 2014-09-22. PMID:24184596. |
attempts to elucidate a possible mechanism underlying the vanillin-mediated effects revealed that vanillin significantly reduced uvb-induced phosphorylation of ataxia telangiectasia mutated (atm), serine threonine kinase checkpoint kinase 2 (chk2), tumor suppressor protein 53 (p53), p38/mitogen-activated protein kinase (p38), c-jun n-terminal kinase/stress-activated protein kinase (jnk), s6 ribosomal protein (s6rp), and histone 2a family member x (h2a.x). |
2014-09-22 |
2023-08-12 |
mouse |
| Yunfei Zhou, Guohui Wan, Riccardo Spizzo, Cristina Ivan, Rohit Mathur, Xiaoxiao Hu, Xiangcang Ye, Jia Lu, Fan Fan, Ling Xia, George A Calin, Lee M Ellis, Xiongbin L. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Molecular oncology. vol 8. issue 1. 2014-09-19. PMID:24145123. |
in silico analysis identified ataxia telangiectasia mutated (atm), a primary mediator of the dna damage response, as a potential target of mir-203. |
2014-09-19 |
2023-08-12 |
Not clear |
| Jianhua Wu, Yanhong Xiao, Juang Liu, Hong Yang, Xiaomin Dong, San Hu, Shanrui Jin, Dongfang W. Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice. International journal of molecular medicine. vol 33. issue 2. 2014-09-18. PMID:24276232. |
individuals carrying mutations at both ataxia telangiectasia mutated (atm) gene alleles reportedly have increased plasma cholesterol and triglyceride levels. |
2014-09-18 |
2023-08-12 |
mouse |
| Qi Xie, Qian Bai, Ling-Yun Zou, Qian-Yong Zhang, Yong Zhou, Hui Chang, Long Yi, Jun-Dong Zhu, Man-Tian M. Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells. Genes, chromosomes & cancer. vol 53. issue 5. 2014-09-12. PMID:24532317. |
furthermore, genistein decreased dna methylation in the promoter region of multiple tumor suppressor genes (tsgs) such as ataxia telangiectasia mutated (atm), adenomatous polyposis coli (apc), phosphatase and tensin homolog (pten), mammary serpin peptidase inhibitor (serpinb5), and increased the mrna expression of these genes. |
2014-09-12 |
2023-08-12 |
human |
| Thomas Turner, Thomas Caspar. When heat casts a spell on the DNA damage checkpoints. Open biology. vol 4. 2014-09-12. PMID:24621867. |
why hyperthermia blocks the repair of broken chromosomes by changing the way that the dna damage checkpoint kinases ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3-related (atr) are activated is an unanswered question. |
2014-09-12 |
2023-08-12 |
Not clear |
| Xinwen Min, Jie Tang, Yinfang Wang, Minghua Yu, Libing Zhao, Handong Yang, Peng Zhang, Yexin M. PI3K-like kinases restrain Pim gene expression in endothelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 32. issue 1. 2014-09-11. PMID:22282239. |
rna interference (rnai) targeting dna-dependent protein kinase catalytic subunit (dna-pkcs) and ataxia telangiectasia mutated (atm) increased mrna expression of pim-3 and pim-1, respectively. |
2014-09-11 |
2023-08-12 |
human |
| Stephan Schiekofer, Izabela Bobak, Marcus E Kleber, Winfried Maerz, Gottfried Rudofsky, Klaus A Dugi, Jochen G Schneide. Association between a gene variant near ataxia telangiectasia mutated and coronary artery disease in men. Diabetes & vascular disease research. vol 11. issue 1. 2014-09-03. PMID:24281401. |
recently, a variant [single-nucleotide polymorphism (snp); rs11212617] near the gene for ataxia telangiectasia mutated (atm) has been associated with glycaemic response to metformin. |
2014-09-03 |
2023-08-12 |
Not clear |
| François Bélanger, Vincent Rajotte, Elliot A Drobetsk. A majority of human melanoma cell lines exhibits an S phase-specific defect in excision of UV-induced DNA photoproducts. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416382. |
consistently, in the case of dna photoproduct excision-proficient melanoma cells, sirna-mediated depletion of atr (but not of its immediate downstream effector kinase chk1) engenders deficient ner specifically during s. on the other hand simultaneous sirna-mediated depletion of ataxia telangiectasia mutated kinase (atm) and dna-dependent protein kinase catalytic subunit (dna-pkcs) exerts no significant effect on either phosphorylation of h2ax at 1 h post-uv or the efficiency of dna photoproduct removal. |
2014-09-02 |
2023-08-12 |
human |
| C A Cremona, A Behren. ATM signalling and cancer. Oncogene. vol 33. issue 26. 2014-08-28. PMID:23851492. |
atm, the protein kinase mutated in the rare human disease ataxia telangiectasia (a-t), has been the focus of intense scrutiny over the past two decades. |
2014-08-28 |
2023-08-12 |
human |
| Kyle L Poulsen, Jesus Olivero-Verbel, Kevin M Beggs, Patricia E Ganey, Robert A Rot. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response. The Journal of pharmacology and experimental therapeutics. vol 350. issue 1. 2014-08-26. PMID:24817034. |
moreover, tvx induced activation of the dna damage sensor kinases, ataxia telangiectasia mutated (atm) and rad3-related (atr). |
2014-08-26 |
2023-08-13 |
Not clear |
| Shin Hee Lee, Huiwen Cheng, Ye Yuan, Shiyong W. Regulation of ionizing radiation-induced adhesion of breast cancer cells to fibronectin by alpha5beta1 integrin. Radiation research. vol 181. issue 6. 2014-08-18. PMID:24785587. |
the increased surface expression of α5β1 integrin, along with the adhesion between the cells and fibronectin, could be inhibited by both ataxia telangiectasia mutated (atm) and rad3-related (atr) kinase inhibitors. |
2014-08-18 |
2023-08-13 |
Not clear |