| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasunori Fukumoto, Mariko Morii, Takahito Miura, Sho Kubota, Kenichi Ishibashi, Takuya Honda, Aya Okamoto, Noritaka Yamaguchi, Atsushi Iwama, Yuji Nakayama, Naoto Yamaguch. Src family kinases promote silencing of ATR-Chk1 signaling in termination of DNA damage checkpoint. The Journal of biological chemistry. vol 289. issue 18. 2014-08-02. PMID:24634213. |
src activity is required for the termination of checkpoint signaling, and inhibition of src activity induces persistent activation of ataxia telangiectasia mutated (atm)- and rad3-related (atr) and chk1 kinases. |
2014-08-02 |
2023-08-12 |
Not clear |
| Laurence Malbert-Colas, Anand Ponnuswamy, Vanesa Olivares-Illana, Anne-Sophie Tournillon, Nadia Naski, Robin Fåhraeu. HDMX folds the nascent p53 mRNA following activation by the ATM kinase. Molecular cell. vol 54. issue 3. 2014-07-23. PMID:24813712. |
here, we show that following phosphorylation by the ataxia telangiectasia mutated (atm) kinase at serine 403, the c-terminal ring domain of hdmx binds the nascent p53 mrna to promote a conformation that supports the p53 mrna-hdm2 interaction and the induction of p53 synthesis. |
2014-07-23 |
2023-08-13 |
Not clear |
| Bo Liu, Xin Chen, Zhao-Qi Wang, Wei-Min Ton. Nbn gene inactivation in the CNS of mouse inhibits the myelinating ability of the mature cortical oligodendrocytes. Glia. vol 62. issue 1. 2014-07-16. PMID:24272708. |
in this study presented here, we report that nbn-deficiency induces the enhanced apoptosis of the mature oligodendrocytes at postnatal day 7, which further affects the myelination of the nerve fibers of cerebrum and corpus callosum.the distinct regulatory roles of ataxia telangiectasia mutated (atm) signaling and protein kinase b(akt)/the mammalian target of rapamycin (akt/mtor) signaling are responsible for the enhanced apoptosis of the nbn-deficient oligodendrocytes. |
2014-07-16 |
2023-08-12 |
mouse |
| N G Alkema, T Tomar, A G J van der Zee, M Everts, G J Meersma, H Hollema, S de Jong, M A T M van Vugt, G B A Wisma. Checkpoint kinase 2 (Chk2) supports sensitivity to platinum-based treatment in high grade serous ovarian cancer. Gynecologic oncology. vol 133. issue 3. 2014-07-16. PMID:24657486. |
in the present study, we investigated the activation status of the ataxia telangiectasia mutated (atm) signaling axis within the ddr in a large, well-defined cohort of advanced stage hgsoc patients. |
2014-07-16 |
2023-08-12 |
Not clear |
| Marcus Eich, Wynand Paul Roos, Teodora Nikolova, Bernd Kain. Contribution of ATM and ATR to the resistance of glioblastoma and malignant melanoma cells to the methylating anticancer drug temozolomide. Molecular cancer therapeutics. vol 12. issue 11. 2014-07-07. PMID:23960094. |
key upstream players in the ddr are the phosphoinositide 3-kinases ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3 related (atr). |
2014-07-07 |
2023-08-12 |
Not clear |
| Mingzhen Zhang, Rong Xu, Xiaojun Xia, Yong Yang, Jianhua Gu, Guoting Qin, Xuewu Liu, Mauro Ferrari, Haifa She. Polycation-functionalized nanoporous silicon particles for gene silencing on breast cancer cells. Biomaterials. vol 35. issue 1. 2014-07-07. PMID:24103653. |
gene knockdown against the ataxia telangiectasia mutated (atm) cancer gene showed dramatic gene silencing efficacy. |
2014-07-07 |
2023-08-12 |
human |
| Lyne Khair, Jeroen E J Guikema, Erin K Linehan, Anna J Ucher, Niek G J Leus, Colin Ogilvie, Zhenkun Lou, Carol E Schrader, Janet Stavneze. ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination. Journal of immunology (Baltimore, Md. : 1950). vol 192. issue 10. 2014-06-24. PMID:24729610. |
the protein kinase ataxia telangiectasia mutated (atm) is an important proximal regulator of the dna damage response (ddr), and translocations involving s regions are increased in its absence. |
2014-06-24 |
2023-08-13 |
mouse |
| Donatella Vecchio, Antonio Daga, Elisa Carra, Daniela Marubbi, Gabriella Baio, Carlo E Neumaier, Stefano Vagge, Renzo Corvò, Maria Pia Brisigotti, Jean Louis Ravetti, Annalisa Zunino, Alessandro Poggi, Samantha Mascelli, Alessandro Raso, Guido Frosin. Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019. International journal of cancer. vol 135. issue 2. 2014-06-20. PMID:24443327. |
we have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (atm) protein sensitizes glioblastoma-initiating cells (gics) to ionizing radiation (ir). |
2014-06-20 |
2023-08-12 |
Not clear |
| Barbara Guerra, Kuniyoshi Iwabuchi, Olaf-Georg Issinge. Protein kinase CK2 is required for the recruitment of 53BP1 to sites of DNA double-strand break induced by radiomimetic drugs. Cancer letters. vol 345. issue 1. 2014-06-19. PMID:24333722. |
the ataxia telangiectasia mutated (atm) signaling pathway responds rapidly to dna double-strand breaks (dsbs) and it is characterized by recruitment of sensor, mediator, transducer and repair proteins to sites of dna damage. |
2014-06-19 |
2023-08-12 |
Not clear |
| C Manzl, L L Fava, G Krumschnabel, L Peintner, M C Tanzer, C Soratroi, F J Bock, F Schuler, B Luef, S Geley, A Villunge. Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome. Cell death & disease. vol 4. 2014-06-12. PMID:24309929. |
this effect reportedly relies on ataxia telangiectasia mutated (atm)-dependent and piddosome-mediated activation of caspase-2. |
2014-06-12 |
2023-08-12 |
mouse |
| Liwen Zhang, Dennis A Simpson, Cynthia L Innes, Jeff Chou, Pierre R Bushel, Richard S Paules, William K Kaufmann, Tong Zho. Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals. Physiological genomics. vol 45. issue 19. 2014-06-11. PMID:23943852. |
ataxia telangiectasia (at) is a rare autosomal recessive disease caused by mutations in the ataxia telangiectasia-mutated gene (atm). |
2014-06-11 |
2023-08-12 |
human |
| Cai Bowen, Jeong-Ho Ju, Ji-Hoon Lee, Tanya T Paull, Edward P Gelman. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell reports. vol 4. issue 3. 2014-06-05. PMID:23890999. |
within minutes of dna damage, nkx3.1 undergoes phosphorylation at tyrosine 222, which is required for a functional interaction with ataxia telangiectasia mutated (atm) kinase. |
2014-06-05 |
2023-08-12 |
Not clear |
| Yohko Yamaguchi, Hisanori Takenobu, Miki Ohira, Atsuko Nakazawa, Sayaka Yoshida, Nobuhiro Akita, Osamu Shimozato, Atsushi Iwama, Akira Nakagawara, Takehiko Kamij. Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway. European journal of cancer (Oxford, England : 1990). vol 50. issue 8. 2014-06-05. PMID:24559687. |
intriguingly, dmap1 induced ataxia telangiectasia mutated (atm) phosphorylation and focus formation in the presence of a dna damage reagent, doxorubicin. |
2014-06-05 |
2023-08-12 |
Not clear |
| Alice C Holly, David Melzer, Luke C Pilling, Alexander C Fellows, Toshiko Tanaka, Luigi Ferrucci, Lorna W Harrie. Changes in splicing factor expression are associated with advancing age in man. Mechanisms of ageing and development. vol 134. issue 9. 2014-06-04. PMID:23747814. |
ataxia telangiectasia mutated (atm) transcript expression correlated with splicing factor expression in human microarray data. |
2014-06-04 |
2023-08-12 |
human |
| Bryndon J Oleson, Katarzyna A Broniowska, Katherine H Schreiber, Vera L Tarakanova, John A Corbet. Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. The Journal of biological chemistry. vol 289. issue 16. 2014-06-04. PMID:24610783. |
nitric oxide induces ataxia telangiectasia mutated (atm) protein-dependent γh2ax protein formation in pancreatic β cells. |
2014-06-04 |
2023-08-12 |
rat |
| Bryndon J Oleson, Katarzyna A Broniowska, Katherine H Schreiber, Vera L Tarakanova, John A Corbet. Nitric oxide induces ataxia telangiectasia mutated (ATM) protein-dependent γH2AX protein formation in pancreatic β cells. The Journal of biological chemistry. vol 289. issue 16. 2014-06-04. PMID:24610783. |
in this study, the effects of cytokines on the activation of the dna double strand break repair factors histone h2ax (h2ax) and ataxia telangiectasia mutated (atm) were examined in pancreatic β cells. |
2014-06-04 |
2023-08-12 |
rat |
| Yulin Chen, Runan Yang, Peng Guo, Zhenyu J. Gadd45a deletion aggravates hematopoietic stem cell dysfunction in ATM-deficient mice. Protein & cell. vol 5. issue 1. 2014-05-30. PMID:24474198. |
ataxia telangiectasia mutated (atm) kinase plays an essential role in the maintenance of genomic stability. |
2014-05-30 |
2023-08-12 |
mouse |
| Ivana Rybanska-Spaeder, Taylor L Reynolds, Jeremy Chou, Mansi Prakash, Tameca Jefferson, David L Huso, Stephen Desiderio, Sonia Franc. 53BP1 is limiting for NHEJ repair in ATM-deficient model systems that are subjected to oncogenic stress or radiation. Molecular cancer research : MCR. vol 11. issue 10. 2014-05-28. PMID:23858098. |
the dna damage response (ddr) factors ataxia telangiectasia mutated (atm) and p53 binding protein 1 (53bp1) function as tumor suppressors in humans and mice, but the significance of their mutual interaction to the suppression of oncogenic translocations in vivo has not been investigated. |
2014-05-28 |
2023-08-12 |
mouse |
| Margarida Simões, Carlos Martins, Fernando Ferreir. Host DNA damage response facilitates African swine fever virus infection. Veterinary microbiology. vol 165. issue 1-2. 2014-05-27. PMID:23398667. |
we evaluated protein levels during asfv time-course infection, of several signalling cascade factors belonging to ddr pathways involved in double strand break repair - ataxia telangiectasia mutated (atm), atm-rad 3 related (atr) and dna dependent protein kinase catalytic subunit (dna-pkcs). |
2014-05-27 |
2023-08-12 |
Not clear |
| Shing Fai Chan, Sam Sances, Laurence M Brill, Shu-Ichi Okamoto, Rameez Zaidi, Scott R McKercher, Mohd W Akhtar, Nobuki Nakanishi, Stuart A Lipto. ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 13. 2014-05-19. PMID:24672010. |
mutations in the ataxia telangiectasia mutated (atm) gene, which encodes a kinase critical for the normal dna damage response, cause the neurodegenerative disorder ataxia-telangiectasia (at). |
2014-05-19 |
2023-08-12 |
mouse |