| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ismene Karakasilioti, Irene Kamileri, Georgia Chatzinikolaou, Theodoros Kosteas, Eleni Vergadi, Andria Rasile Robinson, Iannis Tsamardinos, Tania A Rozgaja, Sandra Siakouli, Christos Tsatsanis, Laura J Niedernhofer, George A Garini. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell metabolism. vol 18. issue 3. 2014-03-21. PMID:24011075. |
we find that persistent dna damage in ap2-ercc1f/- fat depots and in adipocytes ex vivo triggers the induction of proinflammatory factors by promoting transcriptionally active histone marks and the dissociation of nuclear receptor corepressor complexes from promoters; the response is cell autonomous and requires ataxia telangiectasia mutated (atm). |
2014-03-21 |
2023-08-12 |
mouse |
| Alberto Zambrano, Verónica García-Carpizo, María Esther Gallardo, Raquel Villamuera, Maria Ana Gómez-Ferrería, Angel Pascual, Nicolas Buisine, Laurent M Sachs, Rafael Garesse, Ana Arand. The thyroid hormone receptor β induces DNA damage and premature senescence. The Journal of cell biology. vol 204. issue 1. 2014-03-20. PMID:24395638. |
t3 induces a rapid activation of atm (ataxia telangiectasia mutated)/prkaa (adenosine monophosphate-activated protein kinase) signal transduction and recruitment of the nrf1 (nuclear respiratory factor 1) and thrb to the promoters of genes with a key role on mitochondrial respiration. |
2014-03-20 |
2023-08-12 |
mouse |
| Rahul A Parikh, Leonard J Appleman, Julie E Bauman, Madhav Sankunny, Dale W Lewis, Anda Vlad, Susanne M Golli. Upregulation of the ATR-CHEK1 pathway in oral squamous cell carcinomas. Genes, chromosomes & cancer. vol 53. issue 1. 2014-03-19. PMID:24142626. |
the atr-chek1 pathway is upregulated and overactivated in ataxia telangiectasia (at) cells, which lack functional atm protein. |
2014-03-19 |
2023-08-12 |
Not clear |
| Bella Bielorai, Tamar Fisher, Dalia Waldman, Yaniv Lerenthal, Andreea Nissenkorn, Tali Tohami, Dina Marek, Ninette Amariglio, Amos Tore. Acute lymphoblastic leukemia in early childhood as the presenting sign of ataxia-telangiectasia variant. Pediatric hematology and oncology. vol 30. issue 6. 2014-03-17. PMID:23509889. |
a-t variant is characterized by a milder clinical phenotype and is caused by missense or leaky splice site mutations that produce residual ataxia telangiectasia mutated (atm) kinase activity. |
2014-03-17 |
2023-08-12 |
Not clear |
| J Selvarajah, K Nathawat, A Moumen, M Ashcroft, V A Carrol. Chemotherapy-mediated p53-dependent DNA damage response in clear cell renal cell carcinoma: role of the mTORC1/2 and hypoxia-inducible factor pathways. Cell death & disease. vol 4. 2014-03-12. PMID:24136229. |
further analysis revealed cpt regulated endothelin-1 (et-1) in a p53-dependent manner: cpt increased et-1 mrna abundance in vhl-defective ccrcc cell lines that was significantly augmented in their vhl-expressing counterparts that displayed increased phosphorylation and accumulation of p53; p53 sirna suppressed cpt-induced increase in et-1 mrna, as did an inhibitor of ataxia telangiectasia mutated (atm) signaling, suggesting a role for atm-dependent phosphorylation of p53 in the induction of et-1. |
2014-03-12 |
2023-08-12 |
Not clear |
| K Penicud, A Behren. DMAP1 is an essential regulator of ATM activity and function. Oncogene. vol 33. issue 4. 2014-03-11. PMID:23318425. |
the hereditary autosomal recessive disease ataxia telangiectasia (a-t) is caused by mutation in the dna damage kinase atm. |
2014-03-11 |
2023-08-12 |
Not clear |
| L P Vaites, Z Lian, E K Lee, B Yin, A DeMicco, C H Bassing, J A Dieh. ATM deficiency augments constitutively nuclear cyclin D1-driven genomic instability and lymphomagenesis. Oncogene. vol 33. issue 1. 2014-03-03. PMID:23318439. |
to interrogate potential synergy between constitutively nuclear cyclin d1 expression and impaired dsb-induced checkpoint integrity, ataxia telangiectasia mutated (atm)-deficient mice harboring the eμ-d1t286a transgene were generated and evaluated for tumor onset. |
2014-03-03 |
2023-08-12 |
mouse |
| Carmela Passaro, Antonella Abagnale, Silvana Libertini, Massimiliano Volpe, Ginevra Botta, Laura Cella, Roberto Pacelli, Gunnel Halldèn, David Gillespie, Giuseppe Portell. Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocrine-related cancer. vol 20. issue 5. 2014-03-03. PMID:23839822. |
we also show that dl922-947 triggers a dna damage response, characterized by mobilization of the mrn complex (composed by mre11-rad50-nbs1), accumulation of γh2ax, and activation of the checkpoint kinases ataxia telangiectasia mutated (atm) and chk1. |
2014-03-03 |
2023-08-12 |
Not clear |
| Michael A Batey, Yan Zhao, Suzanne Kyle, Caroline Richardson, Andrew Slade, Niall M B Martin, Alan Lau, David R Newell, Nicola J Curti. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer. Molecular cancer therapeutics. vol 12. issue 6. 2014-02-24. PMID:23512991. |
ataxia telangiectasia mutated (atm) kinase signals dna double-strand breaks (dsb) to cell-cycle arrest via p53 and dna repair. |
2014-02-24 |
2023-08-12 |
mouse |
| Veronika Navrkalova, Ludmila Sebejova, Jana Zemanova, Zuzana Jaskova, Martin Trbuse. The p53 pathway induction is not primarily dependent on Ataxia Telangiectasia Mutated (ATM) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells. Leukemia & lymphoma. vol 54. issue 8. 2014-02-24. PMID:23808769. |
the p53 pathway induction is not primarily dependent on ataxia telangiectasia mutated (atm) gene activity after fludarabine treatment in chronic lymphocytic leukemia cells. |
2014-02-24 |
2023-08-12 |
Not clear |
| Chen Chen, Liguo Zhang, Nai-Jia Huang, Bofu Huang, Sally Kornblut. Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 51. 2014-02-24. PMID:24297933. |
ataxia telangiectasia mutant (atm) is an s/t-q-directed kinase that is critical for the cellular response to double-stranded breaks (dsbs) in dna. |
2014-02-24 |
2023-08-12 |
human |
| Patrizia Morciano, Yi Zhang, Giovanni Cenci, Yikang S Ron. A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila. G3 (Bethesda, Md.). vol 3. issue 6. 2014-02-20. PMID:23604076. |
using drosophila as a model system, we identified a stringent requirement for the conserved function of ataxia telangiectasia mutated (atm) in telomere protection during early embryonic development. |
2014-02-20 |
2023-08-12 |
drosophila_melanogaster |
| Joseph Puccini, Sonia Shalini, Anne K Voss, Magtouf Gatei, Claire H Wilson, Devendra K Hiwase, Martin F Lavin, Loretta Dorstyn, Sharad Kuma. Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 49. 2014-02-07. PMID:24248351. |
to further investigate this, ataxia telangiectasia mutated ko (atm(-/-)) mice, which develop spontaneous thymic lymphomas, were used to generate atm(-/-)casp2(-/-) mice. |
2014-02-07 |
2023-08-12 |
mouse |
| Tetsuya Hisanaga, Ali Ferjani, Gorou Horiguchi, Naoko Ishikawa, Ushio Fujikura, Minoru Kubo, Taku Demura, Hiroo Fukuda, Takashi Ishida, Keiko Sugimoto, Hirokazu Tsukay. The ATM-dependent DNA damage response acts as an upstream trigger for compensation in the fas1 mutation during Arabidopsis leaf development. Plant physiology. vol 162. issue 2. 2014-01-28. PMID:23616603. |
our genetic analysis further showed that activation of the dna damage response and the accompanying decrease of cell number in fas1 depend on ataxia telangiectasia mutated (atm) but not on atm and rad3 related. |
2014-01-28 |
2023-08-12 |
Not clear |
| Nuno Figueiredo, Angelo Chora, Helena Raquel, Nadja Pejanovic, Pedro Pereira, Björn Hartleben, Ana Neves-Costa, Catarina Moita, Dora Pedroso, Andreia Pinto, Sofia Marques, Hafeez Faridi, Paulo Costa, Raffaella Gozzelino, Jimmy L Zhao, Miguel P Soares, Margarida Gama-Carvalho, Jennifer Martinez, Qingshuo Zhang, Gerd Döring, Markus Grompe, J Pedro Simas, Tobias B Huber, David Baltimore, Vineet Gupta, Douglas R Green, João A Ferreira, Luis F Moit. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity. vol 39. issue 5. 2014-01-28. PMID:24184056. |
this salutary effect is strictly dependent on the activation of dna damage response and autophagy pathways in the lung, as demonstrated by deletion of the ataxia telangiectasia mutated (atm) or the autophagy-related protein 7 (atg7) specifically in this organ. |
2014-01-28 |
2023-08-12 |
mouse |
| Andrea Bisso, Michela Faleschini, Federico Zampa, Valeria Capaci, Jacopo De Santa, Libero Santarpia, Silvano Piazza, Vera Cappelletti, Mariagrazia Daidone, Reuven Agami, Giannino Del Sa. Oncogenic miR-181a/b affect the DNA damage response in aggressive breast cancer. Cell cycle (Georgetown, Tex.). vol 12. issue 11. 2014-01-17. PMID:23656790. |
in this study, we describe a new role for mir-181a/b as negative regulators of the dna damage response in breast cancer, impacting on the expression and activity of the stress-sensor kinase ataxia telangiectasia mutated (atm). |
2014-01-17 |
2023-08-12 |
human |
| Stanley Andrisse, Gaytri D Patel, Joseph E Chen, Andrea M Webber, Larry D Spears, Rikki M Koehler, Rona M Robinson-Hill, James K Ching, Imju Jeong, Jonathan S Fishe. ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle. PloS one. vol 8. issue 6. 2014-01-16. PMID:23776597. |
the glucose and dehydroascorbic acid (dha) transporter glut1 contains a phosphorylation site, s490, for ataxia telangiectasia mutated (atm). |
2014-01-16 |
2023-08-12 |
Not clear |
| Daniel G Petereit, L Jennifer Hahn, Shalini Kanekar, Amy Boylan, Søren M Bentzen, Mark Ritter, Amy R Mose. Prevalence of ATM Sequence Variants in Northern Plains American Indian Cancer Patients. Frontiers in oncology. vol 3. 2014-01-13. PMID:24416720. |
to identify sequence variants of the ataxia telangiectasia mutated (atm) gene and establish their prevalence rate among american indian (ai) as compared with non-ai cancer patients. |
2014-01-13 |
2023-08-12 |
Not clear |
| Jill E Hesse, Liwen Liu, Cynthia L Innes, Yuxia Cui, Stela S Palii, Richard S Paule. Genome-wide small RNA sequencing and gene expression analysis reveals a microRNA profile of cancer susceptibility in ATM-deficient human mammary epithelial cells. PloS one. vol 8. issue 5. 2014-01-10. PMID:23741392. |
deficiencies in the atm gene are the underlying cause for ataxia telangiectasia, a syndrome characterized by neurological, motor and immunological defects, and a predisposition to cancer. |
2014-01-10 |
2023-08-12 |
human |
| Xin Sun, Bin Liu, Jin Wang, Jun Li, Wen-Yue J. Inhibition of p21-activated kinase 4 expression suppresses the proliferation of Hep-2 laryngeal carcinoma cells via activation of the ATM/Chk1/2/p53 pathway. International journal of oncology. vol 42. issue 2. 2014-01-07. PMID:23229348. |
the levels of ataxia telangiectasia mutated (atm), the upstream protein of checkpoint kinase (chk)1 and chk2, also increased. |
2014-01-07 |
2023-08-12 |
mouse |