| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Wang, He Wang, Wei Zhang, Chen Shao, Peng Xu, Chang Hong Shi, Jian Guo Shi, Yu Mei Li, Qiang Fu, Wei Xue, Yong Hua Lei, Jing Yu Gao, Juan Ying Wang, Xiao Ping Gao, Jin Qing Li, Jian Lin Yuan, Yun Tao Zhan. Genistein sensitizes bladder cancer cells to HCPT treatment in vitro and in vivo via ATM/NF-κB/IKK pathway-induced apoptosis. PloS one. vol 8. issue 1. 2013-07-08. PMID:23365634. |
pretreatment with genistein sensitized bdec and bladder cancer cell lines to hcpt-induced dna damage by the synergistic activation of ataxia telangiectasia mutated (atm) kinase. |
2013-07-08 |
2023-08-12 |
Not clear |
| Gertjan J Driessen, Hanna Ijspeert, Corry M R Weemaes, Ásgeir Haraldsson, Margreet Trip, Adilia Warris, Michiel van der Flier, Nico Wulffraat, Mijke M M Verhagen, Malcolm A Taylor, Menno C van Zelm, Jacques J M van Dongen, Marcel van Deuren, Mirjam van der Bur. Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity. The Journal of allergy and clinical immunology. vol 131. issue 5. 2013-07-05. PMID:23566627. |
ataxia telangiectasia (at) is a multisystem dna-repair disorder caused by mutations in the ataxia telangiectasia mutated (atm) gene. |
2013-07-05 |
2023-08-12 |
Not clear |
| J Pietzner, P C Baer, R P Duecker, M B Merscher, C Satzger-Prodinger, I Bechmann, A Wietelmann, D Del Turco, C Doering, S Kuci, P Bader, S Schirmer, S Zielen, R Schuber. Bone marrow transplantation improves the outcome of Atm-deficient mice through the migration of ATM-competent cells. Human molecular genetics. vol 22. issue 3. 2013-07-01. PMID:23100326. |
we used an established clinically relevant non-myeloablative host-conditioning regimen and transplanted green fluorescent protein (gfp)-expressing ataxia telangiectasia mutated (atm)-competent bone marrow-derived cells (bmdcs) into atm-deficient mice. |
2013-07-01 |
2023-08-12 |
mouse |
| Hiroyuki Tamaichi, Masaki Sato, Andrew C G Porter, Toshiaki Shimizu, Shuki Mizutani, Masatoshi Takag. Ataxia telangiectasia mutated-dependent regulation of topoisomerase II alpha expression and sensitivity to topoisomerase II inhibitor. Cancer science. vol 104. issue 2. 2013-07-01. PMID:23163762. |
here we report the interaction of top2a with ataxia telangiectasia mutated (atm) and its phosphorylation in an atm-dependent manner after dna damage. |
2013-07-01 |
2023-08-12 |
Not clear |
| Hsin-Yi Chang, Meng-Her Shih, Hsuan-Cheng Huang, Shang-Ru Tsai, Hsueh-Fen Juan, Si-Chen Le. Middle infrared radiation induces G2/M cell cycle arrest in A549 lung cancer cells. PloS one. vol 8. issue 1. 2013-06-27. PMID:23335992. |
using quantitative pcr, we found that mir promoted the expression levels of atm (ataxia telangiectasia mutated), atr (ataxia-telangiectasia and rad3-related and rad3-related), tp53 (tumor protein p53), p21 (cdkn1a, cyclin-dependent kinase inhibitor 1a) and gadd45 (growth arrest and dna-damage inducible), but decreased the expression levels of cyclin b coding genes, ccnb1 and ccnb2, as well as cdk1 (cyclin-dependent kinase 1). |
2013-06-27 |
2023-08-12 |
Not clear |
| Steven Bowen, Darawalee Wangsa, Thomas Ried, Ferenc Livak, Richard J Hode. Concurrent V(D)J recombination and DNA end instability increase interchromosomal trans-rearrangements in ATM-deficient thymocytes. Nucleic acids research. vol 41. issue 8. 2013-06-27. PMID:23470994. |
during this stage, abnormal trans-rearrangements also take place between tcr loci, occurring at increased frequency in absence of the dna damage response mediator ataxia telangiectasia mutated (atm). |
2013-06-27 |
2023-08-12 |
Not clear |
| Gabriel Balmus, Min Zhu, Sucheta Mukherjee, Amy M Lyndaker, Kelly R Hume, Jaesung Lee, Mark L Riccio, Anthony P Reeves, Nathan B Sutter, Drew M Noden, Rachel M Peters, Robert S Weis. Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1. Human molecular genetics. vol 21. issue 15. 2013-06-25. PMID:22575700. |
the human genomic instability syndrome ataxia telangiectasia (a-t), caused by mutations in the gene encoding the dna damage checkpoint kinase atm, is characterized by multisystem defects including neurodegeneration, immunodeficiency and increased cancer predisposition. |
2013-06-25 |
2023-08-12 |
mouse |
| Laura Zannini, Giacomo Buscemi, Ja-Eun Kim, Enrico Fontanella, Domenico Deli. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. Journal of molecular cell biology. vol 4. issue 5. 2013-06-21. PMID:22735644. |
here, we report that, in human cell lines, dna damage triggered the phosphorylation of dbc1 on thr454 by atm (ataxia telangiectasia-mutated) and atr (ataxia telangiectasia and rad3-related) kinases. |
2013-06-21 |
2023-08-12 |
human |
| James V Gruber, Philip Ludwig, Robert Holt. Modulation of cellular senescence in fibroblasts and dermal papillae cells in vitro. Journal of cosmetic science. vol 64. issue 2. 2013-06-20. PMID:23578831. |
the mechanism of senescence control is believed to be related to the peptide's ability to reversibly downregulate ataxia telangiectasia mutated (atm) and p53 protein expression. |
2013-06-20 |
2023-08-12 |
Not clear |
| Luigi Carlessi, Elena Fusar Poli, Domenico Deli. Brain and induced pluripotent stem cell-derived neural stem cells as an in vitro model of neurodegeneration in ataxia-telangiectasia. Experimental biology and medicine (Maywood, N.J.). vol 238. issue 3. 2013-06-20. PMID:23598976. |
the ataxia telangiectasia mutated (atm) kinase is a key transducer of the cellular response to dna double strand breaks and its deficiency causes ataxia-telangiectasia (a-t), a pleiotropic genetic disorder primarily characterized by cerebellar neuropathy, immunodeficiency and cancer predisposition. |
2013-06-20 |
2023-08-12 |
mouse |
| Yvonne Kiefer, Christoph Schulte, Markus Tiemann, Joern Bullerdie. Chronic lymphocytic leukemia-associated chromosomal abnormalities and miRNA deregulation. The application of clinical genetics. vol 5. 2013-06-19. PMID:23776377. |
in some of these aberrations the molecular target has been identified as eg, ataxia telangiectasia mutated (atm) in case of deletions of chromosomal region 11q22~23 and the genes encoding micrornas mir-15a/16-1 as likely targets of deletions of chromosomal band 13q14.3. |
2013-06-19 |
2023-08-12 |
Not clear |
| Guida Landouré, Fanny Mochel, Katherine Meilleur, Madani Ly, Modibo Sangaré, Nouhoum Bocoum, Koumba Bagayoko, Thomas Coulibaly, Amadou M Sarr, Hamidou O Bâ, Souleymane Coulibaly, Cheick O Guinto, Mahamadou Touré, Moussa Traoré, Kenneth H Fischbec. Novel mutation in the ATM gene in a Malian family with ataxia telangiectasia. Journal of neurology. vol 260. issue 1. 2013-06-14. PMID:23142947. |
novel mutation in the atm gene in a malian family with ataxia telangiectasia. |
2013-06-14 |
2023-08-12 |
Not clear |
| Alessandra Montecucco, Giuseppe Biamont. Pre-mRNA processing factors meet the DNA damage response. Frontiers in genetics. vol 4. 2013-06-14. PMID:23761808. |
recent high-throughput screenings in human cells and budding yeast have identified several factors implicated in rna metabolism that are targets of dna damage checkpoint kinases: atm (ataxia telangiectasia mutated) and atr (atm-rad3 related) (tel1 and mec1 in budding yeast, respectively). |
2013-06-14 |
2023-08-12 |
human |
| Fu-Shin Chueh, Yung-Liang Chen, Shu-Chun Hsu, Jai-Sing Yang, Shu-Ching Hsueh, Bin-Chuan Ji, Hsu-Feng Lu, Jing-Gung Chun. Triptolide induced DNA damage in A375.S2 human malignant melanoma cells is mediated via reduction of DNA repair genes. Oncology reports. vol 29. issue 2. 2013-06-13. PMID:23233170. |
the real-time pcr technique was used to examine dna damage and repair gene expression (mrna) and results indicated that triptolide led to a decrease in the ataxia telangiectasia mutated (atm), ataxia-telangiectasia and rad3-related (atr), breast cancer 1, early onset (brca-1), p53, dna-dependent serine/threonine protein kinase (dna-pk) and o6-methylguanine-dna methyltransferase (mgmt) mrna expression. |
2013-06-13 |
2023-08-12 |
human |
| Anja M Duursma, Robert Driscoll, Josh E Elias, Karlene A Cimpric. A role for the MRN complex in ATR activation via TOPBP1 recruitment. Molecular cell. vol 50. issue 1. 2013-06-10. PMID:23582259. |
it has key roles in sensing and processing dna double-strand breaks, as well as in activation of atm (ataxia telangiectasia mutated). |
2013-06-10 |
2023-08-12 |
xenopus_laevis |
| Tianyi Zhang, Kay Penicud, Christopher Bruhn, Joanna I Loizou, Nnennaya Kanu, Zhao-Qi Wang, Axel Behren. Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell reports. vol 2. issue 6. 2013-06-07. PMID:23219553. |
ataxia telangiectasia mutated (atm) protein kinase activation by dna double-strand breaks (dsbs) requires the mre11-rad50-nbs1 (mrn) complex, whereas atm interactor (atmin) protein is required for atm signaling induced by changes in chromatin structure. |
2013-06-07 |
2023-08-12 |
Not clear |
| Jamile Abud, Patricia Koehler-Santos, Patricia Ashton-Prolla, João Carlos Proll. CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families. Arquivos de gastroenterologia. vol 49. issue 4. 2013-06-05. PMID:23329222. |
chek2 encodes a cell cycle checkpoint kinase that plays an important role in the dna damage repair pathway, activated mainly by atm (ataxia telangiectasia mutated) in response to double-stranded dna breaks. |
2013-06-05 |
2023-08-12 |
Not clear |
| Ramya Kumareswaran, Olga Ludkovski, Alice Meng, Jenna Sykes, Melania Pintilie, Robert G Bristo. Chronic hypoxia compromises repair of DNA double-strand breaks to drive genetic instability. Journal of cell science. vol 125. issue Pt 1. 2013-06-03. PMID:22266907. |
the response of phosphorylated histone h2ax (γ-h2ax), phosphorylated ataxia telangiectasia mutated [atm(ser1981)], and the p53 binding protein 1 (53bp1) was quantified by intranuclear dna repair foci and western blotting. |
2013-06-03 |
2023-08-12 |
human |
| Chang-Shen Lin, Yu-Chu Wang, Jau-Ling Huang, Chi-Chun Hung, Jeff Yi-Fu Che. Autophagy and reactive oxygen species modulate cytotoxicity induced by suppression of ATM kinase activity in head and neck cancer cells. Oral oncology. vol 48. issue 11. 2013-05-29. PMID:22763242. |
because ataxia telangiectasia mutated (atm)-deficient cells are hypersensitive to ionizing irradiation and dna-damaging agents, atm kinase inhibition is thought to enhance radiochemotherapy efficacy. |
2013-05-29 |
2023-08-12 |
Not clear |
| Zhiwei Wang, Hiroyuki Inuzuka, Jiateng Zhong, Hidefumi Fukushima, Lixin Wan, Pengda Liu, Wenyi We. DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. vol 3. issue 9. 2013-05-28. PMID:22976441. |
consistent with previous studies, we found that inactivation of the ataxia telangiectasia mutated (atm) kinase, in turn, impaired dna damage-induced mdm2 destruction. |
2013-05-28 |
2023-08-12 |
Not clear |