| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arun Gupta, Clayton R Hunt, Raj K Pandita, Juhee Pae, K Komal, Mayank Singh, Jerry W Shay, Rakesh Kumar, Kiyoshi Ariizumi, Nobuo Horikoshi, Walter N Hittelman, Chandan Guha, Thomas Ludwig, Tej K Pandit. T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Mutagenesis. vol 28. issue 3. 2013-10-22. PMID:23386701. |
similarly, ataxia telangiectasia mutated (atm)-deficient mice exhibit severe defects in t-cell maturation and eventually develop thymomas. |
2013-10-22 |
2023-08-12 |
mouse |
| S Biswas, Q Shi, A Wernick, A Aiello, S S Zinke. The loss of the BH3-only Bcl-2 family member Bid delays T-cell leukemogenesis in Atm-/- mice. Cell death and differentiation. vol 20. issue 7. 2013-10-22. PMID:23470523. |
loss of the atm (ataxia telangiectasia mutated)-mediated ddr in mice results in t-cell leukemia driven by accumulation of dna damage accrued during normal t-cell development. |
2013-10-22 |
2023-08-12 |
mouse |
| Masatoshi Takagi, Masaki Sato, Jinhua Piao, Satoshi Miyamoto, Takeshi Isoda, Masanobu Kitagawa, Hiroaki Honda, Shuki Mizutan. ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia. DNA repair. vol 12. issue 7. 2013-10-21. PMID:23694754. |
since ataxia telangiectasia mutated (atm) is a central player of the dna damage-response pathway, we studied whether loss of this pathway accelerates blast crisis. |
2013-10-21 |
2023-08-12 |
mouse |
| Matthew M Dobbin, Ram Madabhushi, Ling Pan, Yue Chen, Dohoon Kim, Jun Gao, Biafra Ahanonu, Ping-Chieh Pao, Yi Qiu, Yingming Zhao, Li-Huei Tsa. SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons. Nature neuroscience. vol 16. issue 8. 2013-10-17. PMID:23852118. |
we found that sirt1 was rapidly recruited to dsbs in postmitotic neurons, where it showed a synergistic relationship with ataxia telangiectasia mutated (atm). |
2013-10-17 |
2023-08-12 |
mouse |
| T Schepeler, P Lamy, V Hvidberg, J R Laurberg, N Fristrup, T Reinert, J Bartkova, L Tropia, J Bartek, T D Halazonetis, C-C Pan, M Borre, L Dyrskjøt, T F Orntof. A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response. Oncogene. vol 32. issue 31. 2013-10-01. PMID:22926521. |
the ddr signaling as evaluated by phospho-epitope-specific antibodies against ser139-phosphorylated h2a histone family member x (γh2ax), ataxia telangiectasia mutated (atm), and atm- and rad3-related (atr) was commonly activated in tumors with both moderate and high extent of accumulated genomic aberrations, the latter tumors showing a more frequent loss of atm expression. |
2013-10-01 |
2023-08-12 |
Not clear |
| Changxian Shen, Peter J Houghto. The mTOR pathway negatively controls ATM by up-regulating miRNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 29. 2013-09-25. PMID:23818585. |
the ataxia telangiectasia mutated (atm) checkpoint is the central surveillance system that maintains genome integrity. |
2013-09-25 |
2023-08-12 |
mouse |
| Hee Sung Kim, Min A Kim, Darren Hodgson, Christopher Harbron, Robert Wellings, Mark J O'Connor, Christopher Womack, Xiaolu Yin, Yung-Jue Bang, Seok-Ah Im, Byung Lan Lee, Woo Ho Ki. Concordance of ATM (ataxia telangiectasia mutated) immunohistochemistry between biopsy or metastatic tumor samples and primary tumors in gastric cancer patients. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 80. issue 3. 2013-09-20. PMID:23328638. |
concordance of atm (ataxia telangiectasia mutated) immunohistochemistry between biopsy or metastatic tumor samples and primary tumors in gastric cancer patients. |
2013-09-20 |
2023-08-12 |
human |
| Hee Sung Kim, Min A Kim, Darren Hodgson, Christopher Harbron, Robert Wellings, Mark J O'Connor, Christopher Womack, Xiaolu Yin, Yung-Jue Bang, Seok-Ah Im, Byung Lan Lee, Woo Ho Ki. Concordance of ATM (ataxia telangiectasia mutated) immunohistochemistry between biopsy or metastatic tumor samples and primary tumors in gastric cancer patients. Pathobiology : journal of immunopathology, molecular and cellular biology. vol 80. issue 3. 2013-09-20. PMID:23328638. |
atm (ataxia telangiectasia mutated) is one of several dna repair proteins that are suggested to sensitize tumor cells to the poly(adp-ribose) polymerase inhibitor olaparib when deficient. |
2013-09-20 |
2023-08-12 |
human |
| Terence M Williams, Shyam Nyati, Brian D Ross, Alnawaz Rehemtull. Molecular imaging of the ATM kinase activity. International journal of radiation oncology, biology, physics. vol 86. issue 5. 2013-09-16. PMID:23726004. |
ataxia telangiectasia mutated (atm) is a serine/threonine kinase critical to the cellular dna-damage response, including from dna double-strand breaks. |
2013-09-16 |
2023-08-12 |
human |
| Yingyi Zhang, Yu Zhao, Hang Li, Yinghui Li, Xiaoli Cai, Yu Shen, Hui Shi, Leilei Li, Qian Liu, Xiaodong Zhang, Lihong Y. The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells. The Journal of biological chemistry. vol 288. issue 26. 2013-09-09. PMID:23667255. |
strikingly, we found that the kinase ataxia telangiectasia mutated (atm) phosphorylated hbxip at ser(108). |
2013-09-09 |
2023-08-12 |
Not clear |
| S S Zinkel, X M Yin, A Gros. Rejuvenating Bi(d)ology. Oncogene. vol 32. issue 27. 2013-09-06. PMID:23069655. |
bid is also emerging-in its full-length form-as a pivotal sentinel of dna damage in the bone marrow regulated by the ataxia telangiectasia mutated (atm)/ataxia telangiectasia and rad3-related (atr) kinases. |
2013-09-06 |
2023-08-12 |
Not clear |
| Fumihiko Uchida, Katsuhiro Uzawa, Atsushi Kasamatsu, Hiroaki Takatori, Yosuke Sakamoto, Katsunori Ogawara, Masashi Shiiba, Hiroki Bukawa, Hideki Tanzaw. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PloS one. vol 8. issue 2. 2013-08-27. PMID:23418564. |
cell division cycle associated 2 (cdca2) recruits protein phosphatase 1 to chromatin to antagonize activation of ataxia telangiectasia mutated (atm)-dependent signal transduction. |
2013-08-27 |
2023-08-12 |
human |
| Kui Wang, Tao Zhang, Qiang Dong, Edouard Collins Nice, Canhua Huang, Yuquan We. Redox homeostasis: the linchpin in stem cell self-renewal and differentiation. Cell death & disease. vol 4. 2013-08-23. PMID:23492768. |
in this regard, we will discuss the regulatory mechanisms involved in the subtly orchestrated balance of redox status in stem cells by scavenger antioxidant enzyme systems that are well monitored by the hypoxia niches and crucial redox regulators including forkhead homeobox type o family (foxos), apurinic/apyrimidinic (ap) endonuclease1/redox factor-1 (ape1/ref-1), nuclear factor erythroid-2-related factor 2 (nrf2) and ataxia telangiectasia mutated (atm). |
2013-08-23 |
2023-08-12 |
Not clear |
| Liang-Nian Song, Cai Bowen, Edward P Gelman. Structural and functional interactions of the prostate cancer suppressor protein NKX3.1 with topoisomerase I. The Biochemical journal. vol 453. issue 1. 2013-08-20. PMID:23557481. |
nkx3.1 mediates the cellular response to dna damage by interacting with atm (ataxia telangiectasia mutated) and by activation of topoisomerase i. |
2013-08-20 |
2023-08-12 |
Not clear |
| C Bassi, J Ho, T Srikumar, R J O Dowling, C Gorrini, S J Miller, T W Mak, B G Neel, B Raught, V Stamboli. Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science (New York, N.Y.). vol 341. issue 6144. 2013-08-14. PMID:23888040. |
in cells exposed to genotoxic stress, sumo-pten was rapidly excluded from the nucleus dependent on the protein kinase ataxia telangiectasia mutated (atm). |
2013-08-14 |
2023-08-12 |
human |
| John M Furgason, El Mustapha Bahass. Targeting DNA repair mechanisms in cancer. Pharmacology & therapeutics. vol 137. issue 3. 2013-08-06. PMID:23107892. |
to increase the efficacy of these treatments, inhibitors of the major components of the ddr such as atm (ataxia telangiectasia mutated), atr (atm and rad3-related), dna-pk (dna-dependent protein kinase, catalytic subunit), chk1 (checkpoint protein 1) and chk2 (checkpoint protein 2) have been used to confer radio- and/or chemosensitivity upon cancer cells. |
2013-08-06 |
2023-08-12 |
Not clear |
| Mark Ambrose, Richard A Gatt. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood. vol 121. issue 20. 2013-08-05. PMID:23440242. |
many independent laboratories have since demonstrated that in replicating cells, ataxia telangiectasia mutated (atm) is predominantly a nuclear protein that is involved in the early recognition and response to double-stranded dna breaks. |
2013-08-05 |
2023-08-12 |
Not clear |
| Peter Ouillette, Jinghui Li, Rita Shaknovich, Yifeng Li, Ari Melnick, Kerby Shedden, Sami N Male. Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia. Genes, chromosomes & cancer. vol 51. issue 12. 2013-07-29. PMID:22952040. |
a subset of chronic lymphocytic leukemia (cll) carries mutations in ataxia telangiectasia mutated (atm). |
2013-07-29 |
2023-08-12 |
Not clear |
| Houda Mokrani-Benhelli, Laetitia Gaillard, Patricia Biasutto, Tangui Le Guen, Fabien Touzot, Nadia Vasquez, Jun Komatsu, Emmanuel Conseiller, Capucine Pïcard, Eliane Gluckman, Christine Francannet, Alain Fischer, Anne Durandy, Jean Soulier, Jean-Pierre de Villartay, Marina Cavazzana-Calvo, Patrick Rev. Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations. Human mutation. vol 34. issue 2. 2013-07-26. PMID:23111928. |
ataxia telangiectasia-mutated (atm) and ataxia telangiectasia and rad3-related (atr) kinases are two key regulators of dna-damage responses (ddr) that are mainly activated in response to dna double-strand breaks and single-stranded dna damages, respectively. |
2013-07-26 |
2023-08-12 |
human |
| James Kain Ching, Stephen H Luebbert, Roy L Collins, Zhihong Zhang, Nandhini Marupudi, Sankha Banerjee, Robin D Hurd, Lyle Ralston, Jonathan S Fishe. Ataxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle. Experimental physiology. vol 98. issue 2. 2013-07-08. PMID:22941977. |
reports that ataxia telangiectasia mutated (atm) is required for full activation of akt raise the hypothesis that atm plays a role in insulin-like growth factor 1 (igf-1) signalling through the akt/mammalian target of rapamycin (mtor) pathway. |
2013-07-08 |
2023-08-12 |
mouse |