| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaia Chiara Mannino, Giorgio Sest. Individualized therapy for type 2 diabetes: clinical implications of pharmacogenetic data. Molecular diagnosis & therapy. vol 16. issue 5. 2013-03-28. PMID:23018631. |
in addition to these three major classes, we also review the available evidence on novel genes (cdk5 regulatory subunit associated protein 1-like 1 [cdkal1], insulin-like growth factor 2 mrna binding protein 2 [igf2bp2], potassium voltage-gated channel, kqt-like subfamily, member 1 [kcnq1], paired box 4 [pax4] and neuronal differentiation 1 [neurod1] transcription factors, ataxia telangiectasia mutated [atm], and serine racemase [srr]) that have recently been proposed as possible modulators of therapeutic response in subjects with t2dm. |
2013-03-28 |
2023-08-12 |
human |
| Masahiko Takahashi, Masaya Higuchi, Hideaki Matsuki, Manami Yoshita, Toshiaki Ohsawa, Masayasu Oie, Masahiro Fuji. Stress granules inhibit apoptosis by reducing reactive oxygen species production. Molecular and cellular biology. vol 33. issue 4. 2013-03-25. PMID:23230274. |
we also found that the antioxidant activity of usp10 requires the protein kinase activity of ataxia telangiectasia mutated (atm). |
2013-03-25 |
2023-08-12 |
Not clear |
| P Fortini, C Ferretti, B Pascucci, L Narciso, D Pajalunga, E M R Puggioni, R Castino, C Isidoro, M Crescenzi, E Dogliott. DNA damage response by single-strand breaks in terminally differentiated muscle cells and the control of muscle integrity. Cell death and differentiation. vol 19. issue 11. 2013-03-04. PMID:22705848. |
we demonstrate that, upon ssb induction, phosphorylation of h2ax occurs in myotubes and is largely ataxia telangiectasia mutated (atm)-dependent. |
2013-03-04 |
2023-08-12 |
mouse |
| Mohsen Foroughizadeh, Hossein Mozdarani, Keyvan Majidzadeh-A, Ahmad Kavian. Variation of ATM Gene Expression in Peripheral Blood Cells of Sporadic Breast Carcinomas in Iranian Patients. Avicenna journal of medical biotechnology. vol 4. issue 2. 2013-02-15. PMID:23408238. |
the ataxia telangiectasia mutated gene (atm), candidate for breast cancer susceptibility gene, encode a 350-kda protein belongs to the core components of dna-damage response machinery. |
2013-02-15 |
2023-08-12 |
Not clear |
| Gernot Neumayer, Angela Helfricht, Su Yeon Shim, Hoa Thi Le, Cecilia Lundin, Camille Belzil, Mathieu Chansard, Yaping Yu, Susan P Lees-Miller, Oliver J Gruss, Haico van Attikum, Thomas Helleday, Minh Dang Nguye. Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation. The Journal of biological chemistry. vol 287. issue 50. 2013-02-12. PMID:23045526. |
consistent with a role for tpx2 in the dna damage response, we found that the protein accumulates at dna double strand breaks and associates with the mediator of dna damage checkpoint 1 (mdc1) and the ataxia telangiectasia mutated (atm) kinase, both key regulators of γ-h2ax amplification. |
2013-02-12 |
2023-08-12 |
human |
| Radha M Golla, Min Li, Yulei Shen, Ming Ji, Ying Yan, Kai Fu, Timothy C Greiner, Timothy W McKeithan, Wing C Cha. Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. Hematological oncology. vol 30. issue 4. 2013-02-07. PMID:22170260. |
inhibition of poly(adp-ribose) polymerase (parp) and ataxia telangiectasia mutated (atm) on the chemosensitivity of mantle cell lymphoma to agents that induce dna strand breaks. |
2013-02-07 |
2023-08-12 |
Not clear |
| Radha M Golla, Min Li, Yulei Shen, Ming Ji, Ying Yan, Kai Fu, Timothy C Greiner, Timothy W McKeithan, Wing C Cha. Inhibition of poly(ADP-ribose) polymerase (PARP) and ataxia telangiectasia mutated (ATM) on the chemosensitivity of mantle cell lymphoma to agents that induce DNA strand breaks. Hematological oncology. vol 30. issue 4. 2013-02-07. PMID:22170260. |
there is a high incidence of genomic aberration of ataxia telangiectasia mutated (atm) and genes encoding proteins involved in the atm pathway in mantle cell lymphoma (mcl). |
2013-02-07 |
2023-08-12 |
Not clear |
| Michele Menotta, Sara Biagiotti, Marzia Bianchi, Luciana Chessa, Mauro Magnan. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23055520. |
dexamethasone partially rescues ataxia telangiectasia-mutated (atm) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. |
2013-02-07 |
2023-08-12 |
Not clear |
| Michele Menotta, Sara Biagiotti, Marzia Bianchi, Luciana Chessa, Mauro Magnan. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23055520. |
ataxia telangiectasia (at) is a rare genetic disease, still incurable, resulting from biallelic mutations in the ataxia telangiectasia-mutated (atm) gene. |
2013-02-07 |
2023-08-12 |
Not clear |
| Michele Menotta, Sara Biagiotti, Marzia Bianchi, Luciana Chessa, Mauro Magnan. Dexamethasone partially rescues ataxia telangiectasia-mutated (ATM) deficiency in ataxia telangiectasia by promoting a shortened protein variant retaining kinase activity. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23055520. |
in conclusion, dexamethasone treatment may partly restore atm activity in ataxia telangiectasia cells by a new molecular mechanism that overcomes most of the mutations so far described within this gene. |
2013-02-07 |
2023-08-12 |
Not clear |
| Cerrone R Foster, QinQin Zha, Laura L Daniel, Mahipal Singh, Krishna Sing. Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis. Experimental physiology. vol 97. issue 4. 2013-02-01. PMID:22179422. |
ataxia telangiectasia mutated kinase (atm) is involved in cell cycle checkpoints, dna repair and apoptosis. |
2013-02-01 |
2023-08-12 |
mouse |
| Michelle Badura, Steve Braunstein, Jiri Zavadil, Robert J Schneide. DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 46. 2013-02-01. PMID:23112151. |
increased expression of eif4g1, common in breast cancers, was found to selectively increase translation of mrnas involved in cell survival and the ddr, preventing autophagy and apoptosis [survivin, hypoxia inducible factor 1α (hif1α), x-linked inhibitor of apoptosis (xiap)], promoting cell cycle arrest [growth arrest and dna damage protein 45a (gadd45a), protein 53 (p53), atr-interacting protein (atrip), check point kinase 1 (chk1)] and dna repair [p53 binding protein 1 (53bp1), breast cancer associated proteins 1, 2 (brca1/2), poly-adp ribose polymerase (parp), replication factor c2-5 (rfc2-5), ataxia telangiectasia mutated gene 1 (atm), meiotic recombination protein 11 (mre-11), and others]. |
2013-02-01 |
2023-08-12 |
Not clear |
| Stefanie C Huelsenbeck, Anne Schorr, Wynand P Roos, Johannes Huelsenbeck, Christian Henninger, Bernd Kaina, Gerhard Frit. Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons. The Journal of biological chemistry. vol 287. issue 46. 2013-01-31. PMID:23012366. |
at low dose, doxorubicin activated ataxia telangiectasia mutated (atm) but not atm and rad3-related (atr). |
2013-01-31 |
2023-08-12 |
rat |
| Shengqin Liu, Stephen O Opiyo, Karoline Manthey, Jason G Glanzer, Amanda K Ashley, Courtney Amerin, Kyle Troksa, Meena Shrivastav, Jac A Nickoloff, Greg G Oakle. Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic acids research. vol 40. issue 21. 2013-01-30. PMID:22977173. |
dna-dependent protein kinase catalytic subunit (dna-pkcs) [a kinase related to ataxia telangiectasia mutated (atm) and atr] has well characterized roles in dna double-strand break repair, but poorly understood roles in replication stress-induced rpa phosphorylation. |
2013-01-30 |
2023-08-12 |
Not clear |
| Tej K Pandit. 14th International Workshop on Ataxia-Telangiectasia ATW2012. DNA repair. vol 11. issue 10. 2013-01-18. PMID:22921572. |
the fourteenth international ataxia-telangiectasia workshop 2012 (atw2012) (www.atw2012.com) on ataxia-telangiectasia (at) and the role of the ataxia telangiectasia mutated (atm) gene in dna repair, neurological disease, cancer and related topics was held from february 07 to 11, 2012 in delhi, india. |
2013-01-18 |
2023-08-12 |
Not clear |
| Nicholas J Roberts, Yuchen Jiao, Jun Yu, Levy Kopelovich, Gloria M Petersen, Melissa L Bondy, Steven Gallinger, Ann G Schwartz, Sapna Syngal, Michele L Cote, Jennifer Axilbund, Richard Schulick, Syed Z Ali, James R Eshleman, Victor E Velculescu, Michael Goggins, Bert Vogelstein, Nickolas Papadopoulos, Ralph H Hruban, Kenneth W Kinzler, Alison P Klei. ATM mutations in patients with hereditary pancreatic cancer. Cancer discovery. vol 2. issue 1. 2013-01-15. PMID:22585167. |
we used next-generation sequencing, including whole-genome and whole-exome analyses, and identified heterozygous, constitutional, ataxia telangiectasia mutated (atm) gene mutations in 2 kindreds with familial pancreatic cancer. |
2013-01-15 |
2023-08-12 |
Not clear |
| M Baritaud, L Cabon, L Delavallée, P Galán-Malo, M-E Gilles, M-N Brunelle-Navas, S A Susi. AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation. Cell death & disease. vol 3. 2013-01-14. PMID:22972376. |
employing a pharmacological approach and gene knockout cells, we also demonstrate in this paper that the phosphatidylinositol-3-oh kinase-related kinases (pikks) atm (ataxia telangiectasia mutated) and dna-dependent protein kinase (dna-pk) mediate γh2ax generation and, consequently, mnng-induced necroptosis. |
2013-01-14 |
2023-08-12 |
Not clear |
| Kari Alital. A radical view of pathological vasculature. Cell metabolism. vol 16. issue 3. 2013-01-07. PMID:22958916. |
(2012) in the july issue of nature medicine show that the ataxia telangiectasia mutated (atm) kinase counteracts excessive oxygen radical production in immature angiogenic blood vessels. |
2013-01-07 |
2023-08-12 |
Not clear |
| Yong Deuk Kim, Tiangang Li, Seung-Won Ahn, Don-Kyu Kim, Ji-Min Lee, Seung-Lark Hwang, Yong-Hoon Kim, Chul-Ho Lee, In-Kyu Lee, John Y L Chiang, Hueng-Sik Cho. Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation. The Journal of biological chemistry. vol 287. issue 44. 2013-01-07. PMID:22977252. |
ataxia telangiectasia mutated (atm) is a member of the phosphatidylinositol 3-kinase superfamily and regulates cell cycle progression. |
2013-01-07 |
2023-08-12 |
mouse |
| Gerard Lozanski, Amy S Ruppert, Nyla A Heerema, Arletta Lozanski, David M Lucas, Amber Gordon, John G Gribben, Vicki A Morrison, Kanti M Rai, Guido Marcucci, Richard A Larson, John C Byr. Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study. Leukemia & lymphoma. vol 53. issue 9. 2013-01-04. PMID:22369572. |
the impact of mutation of the atm (ataxia telangiectasia mutated) gene in chronic lymphocytic leukemia (cll) treatment outcome has not been examined. |
2013-01-04 |
2023-08-12 |
Not clear |