| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mahvash Zakikhani, Miguel Bazile, Sina Hashemi, Shiva Javeshghani, Daina Avizonis, Julie St Pierre, Michael N Polla. Alterations in cellular energy metabolism associated with the antiproliferative effects of the ATM inhibitor KU-55933 and with metformin. PloS one. vol 7. issue 11. 2013-05-22. PMID:23185347. |
ku-55933 is a specific inhibitor of the kinase activity of the protein encoded by ataxia telangiectasia mutated (atm), an important tumor suppressor gene with key roles in dna repair. |
2013-05-22 |
2023-08-12 |
Not clear |
| Qunwei Wang, Hester A Franks, Stephanie J Lax, Mohamed El Refaee, Anna Malecka, Sabaria Shah, Ian Spendlove, Michael J Gough, Claire Seedhouse, Srinivasan Madhusudan, Poulam M Patel, Andrew M Jackso. The ataxia telangiectasia mutated kinase pathway regulates IL-23 expression by human dendritic cells. Journal of immunology (Baltimore, Md. : 1950). vol 190. issue 7. 2013-05-21. PMID:23460736. |
in this study, we show for first time, to our knowledge, that the ataxia telangiectasia mutated (atm) pathway, involved in dna damage sensing, acts as an il-23 repressor. |
2013-05-21 |
2023-08-12 |
human |
| Konstantina Marinoglo. The role of the DNA damage response kinase ataxia telangiectasia mutated in neuroprotection. The Yale journal of biology and medicine. vol 85. issue 4. 2013-05-15. PMID:23239948. |
ataxia telangiectasia mutated (atm), one of the major kinases of the dna damage response (ddr), is a node that links ddr, neuronal development, and neurodegeneration [2,9-12]. |
2013-05-15 |
2023-08-12 |
human |
| Seog-Young Kim, Juong G Rhee, Xinxin Song, Edward V Prochownik, Douglas R Spitz, Yong J Le. Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM. PloS one. vol 7. issue 11. 2013-05-13. PMID:23185620. |
unlike non-stem cells, csc-like cells have little/no sublethal damage repair, a low intracellular level of ataxia telangiectasia mutated (atm) and delay of γ-h2ax foci removal (dna strand break repair). |
2013-05-13 |
2023-08-12 |
Not clear |
| Mohammad Reza Ahmadianpour, Parviz Abdolmaleki, Seyed Javad Mowla, Saman Hosseinkhan. Gamma radiation alters cell cycle and induces apoptosis in p53 mutant E6.1 Jurkat cells. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 71. issue 1. 2013-05-06. PMID:23079488. |
also, phosphorylated atm (ataxia telangiectasia mutated) and e2f1 (elongation factor) proteins were detected by western blot analysis. |
2013-05-06 |
2023-08-12 |
human |
| Emilie Rass, Gurushankar Chandramouly, Shan Zha, Frederick W Alt, Anyong Xi. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. The Journal of biological chemistry. vol 288. issue 10. 2013-04-30. PMID:23355489. |
ataxia telangiectasia mutated (atm) is dispensable for endonuclease i-scei-induced homologous recombination in mouse embryonic stem cells. |
2013-04-30 |
2023-08-12 |
mouse |
| Emilie Rass, Gurushankar Chandramouly, Shan Zha, Frederick W Alt, Anyong Xi. Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells. The Journal of biological chemistry. vol 288. issue 10. 2013-04-30. PMID:23355489. |
ataxia telangiectasia mutated (atm) is activated upon dna double strand breaks (dsbs) and phosphorylates numerous dsb response proteins, including histone h2ax on serine 139 (ser-139) to form γ-h2ax. |
2013-04-30 |
2023-08-12 |
mouse |
| Josefa Blanco-Rodrígue. Programmed phosphorylation of histone H2AX precedes a phase of DNA double-strand break-independent synapsis in mouse meiosis. Reproduction (Cambridge, England). vol 144. issue 6. 2013-04-26. PMID:23035256. |
a second wave of ataxia telangiectasia mutated (atm) and rad3-related (atr)-dependent γh2ax formation has been observed in atm-null mice during zygotene, suggesting that this wave of phosphorylation also occurs in normal mice. |
2013-04-26 |
2023-08-12 |
mouse |
| Alessandro Raso, Donatella Vecchio, Enrico Cappelli, Monica Ropolo, Alessandro Poggi, Paolo Nozza, Roberto Biassoni, Samantha Mascelli, Valeria Capra, Fotios Kalfas, Paolo Severi, Guido Frosin. Characterization of glioma stem cells through multiple stem cell markers and their specific sensitization to double-strand break-inducing agents by pharmacological inhibition of ataxia telangiectasia mutated protein. Brain pathology (Zurich, Switzerland). vol 22. issue 5. 2013-04-24. PMID:22257080. |
previous studies have shown that tumor-driving glioma stem cells (gsc) may promote radio-resistance by constitutive activation of the dna damage response started by the ataxia telangiectasia mutated (atm) protein. |
2013-04-24 |
2023-08-12 |
Not clear |
| Stian Knappskog, Ranjan Chrisanthar, Erik Løkkevik, Gun Anker, Bjørn Østenstad, Steinar Lundgren, Terje Risberg, Ingvil Mjaaland, Beryl Leirvaag, Hrvoje Miletic, Per E Lønnin. Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancer. Breast cancer research : BCR. vol 14. issue 2. 2013-04-24. PMID:22420423. |
atm (ataxia telangiectasia mutated protein) is the key activator of p53 and chk2 in response to genotoxic stress. |
2013-04-24 |
2023-08-12 |
Not clear |
| Ying Yan, Patrick M Greer, Phu T Cao, Ryan H Kolb, Kenneth H Cowa. RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation. Breast cancer research : BCR. vol 14. issue 2. 2013-04-24. PMID:22494620. |
g2/m checkpoint activation involves activation of ataxia telangiectasia mutated (atm)/atm- and rad3-related (atr) kinases and inhibition of cdc25 phosphatases, resulting in inhibition of cdc2 kinase and subsequent g2/m cell-cycle arrest. |
2013-04-24 |
2023-08-12 |
Not clear |
| Ling Wang, Adam J Mosel, Gregory G Oakley, Aimin Pen. Deficient DNA damage signaling leads to chemoresistance to cisplatin in oral cancer. Molecular cancer therapeutics. vol 11. issue 11. 2013-04-23. PMID:22973056. |
these deficiencies are consistent with reduced expression of components of the ataxia telangiectasia mutated (atm)-dependent signaling pathway and, in particular, strong upregulation of wip1, a negative regulator of the atm pathway. |
2013-04-23 |
2023-08-12 |
Not clear |
| Aditi Nadkarni, Meena Shrivastav, Ann C Mladek, Paul M Schwingler, Patrick T Grogan, Junjie Chen, Jann N Sarkari. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. Journal of neuro-oncology. vol 110. issue 3. 2013-04-23. PMID:23054561. |
ataxia telangiectasia mutated (atm) kinase is critical in sensing and repairing dna double-stranded breaks (dsbs) such as those induced by temozolomide (tmz). |
2013-04-23 |
2023-08-12 |
Not clear |
| Huihua Xiong, Zhongxing Liao, Zhensheng Liu, Ting Xu, Qiming Wang, Hongliang Liu, Ritsuko Komaki, Daniel Gomez, Li-E Wang, Qingyi We. ATM polymorphisms predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. International journal of radiation oncology, biology, physics. vol 85. issue 4. 2013-04-22. PMID:23154078. |
the ataxia telangiectasia mutated (atm) gene mediates detection and repair of dna damage. |
2013-04-22 |
2023-08-12 |
Not clear |
| Peter J McKinno. ATM and the molecular pathogenesis of ataxia telangiectasia. Annual review of pathology. vol 7. 2013-04-12. PMID:22035194. |
atm and the molecular pathogenesis of ataxia telangiectasia. |
2013-04-12 |
2023-08-12 |
Not clear |
| Peter J McKinno. ATM and the molecular pathogenesis of ataxia telangiectasia. Annual review of pathology. vol 7. 2013-04-12. PMID:22035194. |
ataxia telangiectasia (a-t) results from inactivation of the atm protein kinase. |
2013-04-12 |
2023-08-12 |
Not clear |
| Tsung-Ying Yang, Gee-Chen Chang, Kun-Chieh Chen, Hsiao-Wen Hung, Kuo-Hsuan Hsu, Chi-Hao Wu, Gwo-Tarng Sheu, Shih-Lan Hs. Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53-dependent and -independent signaling pathways. Molecular carcinogenesis. vol 52. issue 3. 2013-04-12. PMID:22086658. |
the molecular events of pemetrexed-mediated apoptosis was associated with the activation of ataxia telangiectasia mutated (atm)/p53-dependent and -independent signaling pathways, which promoted intrinsic and extrinsic apoptosis by upregulating bax, puma, fas, dr4, and dr5 and activating the caspase signaling cascade. |
2013-04-12 |
2023-08-12 |
Not clear |
| Natalie C Steinel, Baeck-Seung Lee, Anthony T Tubbs, Jeffrey J Bednarski, Emily Schulte, Katherine S Yang-Iott, David G Schatz, Barry P Sleckman, Craig H Bassin. The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements. The Journal of experimental medicine. vol 210. issue 2. 2013-04-12. PMID:23382544. |
dna double-strand breaks (dsbs) induced by the rag endonuclease during v(d)j recombination activate the ataxia telangiectasia mutated (atm) and dna-dependent protein kinase (dna-pk) kinases. |
2013-04-12 |
2023-08-12 |
Not clear |
| Minli Wang, Janapriya Saha, Megumi Hada, Jennifer A Anderson, Janice M Pluth, Peter O'Neill, Francis A Cucinott. Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways. Nucleic acids research. vol 41. issue 2. 2013-04-04. PMID:23221633. |
cellular damage from ionizing radiation (ir) is in part due to dna damage and reactive oxygen species, which activate dna damage response (ddr) and cytokine signaling pathways, including the ataxia telangiectasia mutated (atm) and transforming growth factor (tgf)β/smad pathways. |
2013-04-04 |
2023-08-12 |
human |
| A-P Sappino, R Buser, Q Seguin, M Fernet, L Lesne, F Gumy-Pause, W Reith, V Favaudon, S J Mandriot. The CEACAM1 tumor suppressor is an ATM and p53-regulated gene required for the induction of cellular senescence by DNA damage. Oncogenesis. vol 1. 2013-04-04. PMID:23552604. |
here we report that ceacam1 is strongly upregulated during the cellular response to dna double-strand breaks (dsbs) starting from the lowest doses of dsb inducers used, and that upregulation is mediated by the ataxia telangiectasia mutated (atm)/p53 pathway. |
2013-04-04 |
2023-08-12 |
mouse |