| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jae Uk Shin, Chang Hoon Lee, Kyu Taek Lee, Jong Kyun Lee, Kwang Hyuck Lee, Kwang Min Kim, Kyoung-Mee Kim, Sang-Mo Park, Jong Chul Rhe. Prognostic significance of ATM and cyclin B1 in pancreatic neuroendocrine tumor. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 33. issue 5. 2012-12-26. PMID:22707287. |
ataxia telangiectasia mutated kinase (atm) and cyclin b1 are involved in cell cycle control. |
2012-12-26 |
2023-08-12 |
Not clear |
| Benjamin P C Chen, Mengxia Li, Aroumougame Asaithamb. New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress. Cancer letters. vol 327. issue 1-2. 2012-12-20. PMID:22155347. |
attention is now focused on identifying the molecular contributions of the key dna damage response kinases ataxia telangiectasia mutated (atm), dna-dependent protein kinase catalytic subunit (dna-pkcs), and atm- and rad3-related (atr) in the oxidative stress response. |
2012-12-20 |
2023-08-12 |
Not clear |
| En-Long Ma, Dong-Mei Zhao, Yan-Chun Li, Hong Cao, Qiu-Yu Zhao, Jian-Chun Li, Li-Xin Su. Activation of ATM-Chk2 by 16-dehydropregnenolone induces G1 phase arrest and apoptosis in HeLa cells. Journal of Asian natural products research. vol 14. issue 9. 2012-12-19. PMID:22694166. |
the growth inhibitory effect of 16-dhp was associated with g1 arrest mediated by ataxia telangiectasia mutated (atm)-checkpoint kinase 2 (chk2)-p53 signaling, as demonstrated by induction of the phosphorylations of atm, chk2, and p53 proteins. |
2012-12-19 |
2023-08-12 |
human |
| Cristian Moiola, Paola De Luca, Javier Cotignola, Kevin Gardner, Elba Vazquez, Adriana De Sierv. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 30. issue 3. 2012-12-13. PMID:22832221. |
recently we have reported that brca1 regulates the transcription of several genes in prostate cancer, including atm (ataxia telangiectasia mutated). |
2012-12-13 |
2023-08-12 |
human |
| Guangyun Tan, Jixiao Niu, Yuling Shi, Hongsheng Ouyang, Zhao-Hui W. NF-κB-dependent microRNA-125b up-regulation promotes cell survival by targeting p38α upon ultraviolet radiation. The Journal of biological chemistry. vol 287. issue 39. 2012-12-07. PMID:22854965. |
the dna damage-responsive kinase atm (ataxia telangiectasia mutated) is indispensable for uv-induced nf-κb activation, which may regulate p38α activation and ikkβ-dependent iκbα degradation in response to uv. |
2012-12-07 |
2023-08-12 |
Not clear |
| Valeria Marzano, Simonetta Santini, Claudia Rossi, Mirco Zucchelli, Annamaria D'Alessandro, Carlo Marchetti, Michele Mingardi, Venturina Stagni, Daniela Barilà, Andrea Urban. Proteomic profiling of ATM kinase proficient and deficient cell lines upon blockage of proteasome activity. Journal of proteomics. vol 75. issue 15. 2012-12-04. PMID:22641158. |
ataxia telangiectasia mutated (atm) protein kinase is a key effector in the modulation of the functionality of some important stress responses, including dna damage and oxidative stress response, and its deficiency is the hallmark of ataxia telangiectasia (a-t), a rare genetic disorder. |
2012-12-04 |
2023-08-12 |
Not clear |
| Jing He, Linda Z Shi, Lan N Truong, Chi-Sheng Lu, Niema Razavian, Yongjiang Li, Alejandro Negrete, Joseph Shiloach, Michael W Berns, Xiaohua W. Rad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses. The Journal of biological chemistry. vol 287. issue 38. 2012-12-04. PMID:22833675. |
we demonstrated that the human rad50 hook mutants are severely defective in various dna damage responses including atm (ataxia telangiectasia mutated) activation, homologous recombination, sensitivity to ir, and activation of the atr pathway. |
2012-12-04 |
2023-08-12 |
human |
| Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Mariame Ali Hassan, Yoshiaki Tabuchi, Takaharu Nomura, Takashi Kond. Ultrasound activates ataxia telangiectasia mutated- and rad3-related (ATR)-checkpoint kinase 1 (Chk1) pathway in human leukemia Jurkat cells. Ultrasonics sonochemistry. vol 19. issue 6. 2012-12-03. PMID:22571845. |
regarding dna damage response (ddr), chk1, known as a target of ataxia telangiectasia mutated (atm) and rad3-related (atr), was phosphorylated in cells after us exposure. |
2012-12-03 |
2023-08-12 |
human |
| b' Joaquim Duran-Vilaregut, Gemma Manich, Jaume Del Valle, Antoni Camins, Merc\\xc3\\xa8 Pall\\xc3\\xa0s, Jordi Vilaplana, Carme Pelegr\\xc3\\xa. Expression pattern of ataxia telangiectasia mutated (ATM), p53, Akt, and glycogen synthase kinase-3\\xce\\xb2 in the striatum of rats treated with 3-nitropropionic acid. Journal of neuroscience research. vol 90. issue 9. 2012-11-19. PMID:22505033.' |
expression pattern of ataxia telangiectasia mutated (atm), p53, akt, and glycogen synthase kinase-3β in the striatum of rats treated with 3-nitropropionic acid. |
2012-11-19 |
2023-08-12 |
rat |
| Rong Wan, Yiqun Mo, Lingfang Feng, Sufan Chien, David J Tollerud, Qunwei Zhan. DNA damage caused by metal nanoparticles: involvement of oxidative stress and activation of ATM. Chemical research in toxicology. vol 25. issue 7. 2012-11-19. PMID:22559321. |
to further investigate the pathways involved in the nano-co-induced dna damage, we measured the phosphorylation of ataxia telangiectasia mutant (atm). |
2012-11-19 |
2023-08-12 |
human |
| Kate Beishline, Crystal M Kelly, Beatrix A Olofsson, Sravanthi Koduri, Jacqueline Emrich, Roger A Greenberg, Jane Azizkhan-Cliffor. Sp1 facilitates DNA double-strand break repair through a nontranscriptional mechanism. Molecular and cellular biology. vol 32. issue 18. 2012-11-19. PMID:22826432. |
sp1 is a ubiquitously expressed transcription factor that is phosphorylated by ataxia telangiectasia mutated kinase (atm) in response to ionizing radiation and h(2)o(2). |
2012-11-19 |
2023-08-12 |
Not clear |
| Yasmine A Valentin-Vega, Michael B Kasta. A new role for ATM: regulating mitochondrial function and mitophagy. Autophagy. vol 8. issue 5. 2012-11-13. PMID:22617444. |
the various pathologies in ataxia telangiectasia (a-t) patients including t-cell lymphomagenesis have been attributed to defects in the dna damage response pathway because atm, the gene mutated in this disease, is a key mediator of this process. |
2012-11-13 |
2023-08-12 |
mouse |
| Jung-Il Chae, Dong-Wook Kim, Nayeon Lee, Young-Joo Jeon, Iksoo Jeon, Jihye Kwon, Jumi Kim, Yunjo Soh, Dong-Seok Lee, Kang Seok Seo, Nag-Jin Choi, Byoung Chul Park, Sung Hyun Kang, Joohyun Ryu, Seung-Hun Oh, Dong Ah Shin, Dong Ryul Lee, Jeong Tae Do, In-Hyun Park, George Q Daley, Jihwan Son. Quantitative proteomic analysis of induced pluripotent stem cells derived from a human Huntington's disease patient. The Biochemical journal. vol 446. issue 3. 2012-11-13. PMID:22694310. |
we also found that btf3 (basic transcription factor 3) is up-regulated in hd-ipscs, which leads to the induction of atm (ataxia telangiectasia mutated), followed by activation of the p53-mediated apoptotic pathway. |
2012-11-13 |
2023-08-12 |
human |
| Naoko Nishimaki, Mitsutoshi Tsukimoto, Akihiro Kitami, Shuji Kojim. Autocrine regulation of γ-irradiation-induced DNA damage response via extracellular nucleotides-mediated activation of P2Y6 and P2Y12 receptors. DNA repair. vol 11. issue 8. 2012-11-09. PMID:22682873. |
next, we examined the effect of p2 receptor inhibitors on activation of ataxia telangiectasia mutated (atm; a protein kinase) and accumulation of 53bp1 (a dna repair factor), both of which are important for dna repair, at dna damage sites. |
2012-11-09 |
2023-08-12 |
human |
| Sabine Jurado, Kimberly Gleeson, Kristy O'Donnell, David J Izon, Carl R Walkley, Andreas Strasser, David M Tarlinton, Jörg Heierhors. The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. The Journal of experimental medicine. vol 209. issue 9. 2012-11-09. PMID:22891272. |
in this study, we show that absence of the essential atm (ataxia telangiectasia mutated) substrate chk2-interacting zn(2+)-finger protein (asciz; also known as atmin/znf822), a protein with dual functions in the dna damage response and as a transcription factor, leads to progressive cell loss from the pre-b stage onwards and severely diminished splenic b cell numbers in mice. |
2012-11-09 |
2023-08-12 |
mouse |
| Frank Roossink, Hylke W Wieringa, Maartje G Noordhuis, Klaske A ten Hoor, Mirjam Kok, Lorian Slagter-Menkema, Harry Hollema, Geertruida H de Bock, Elisabeth Pras, Elisabeth G E de Vries, Steven de Jong, Ate G J van der Zee, Ed Schuuring, G Bea A Wisman, Marcel A T M van Vug. The role of ATM and 53BP1 as predictive markers in cervical cancer. International journal of cancer. vol 131. issue 9. 2012-11-08. PMID:22323184. |
in a panel of cervical cancer cell lines, inactivation of ataxia telangiectasia mutated (atm) or its substrate p53-binding protein-1 (53bp1) clearly gave rise to cell cycle defects in response to irradiation. |
2012-11-08 |
2023-08-12 |
Not clear |
| Kenric A Gillespie, Kavi P Mehta, Laimonis A Laimins, Cary A Mood. Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers. Journal of virology. vol 86. issue 17. 2012-11-05. PMID:22740399. |
human papillomaviruses (hpv) activate the ataxia telangiectasia mutated (atm)-dependent dna damage response to induce viral genome amplification upon epithelial differentiation. |
2012-11-05 |
2023-08-12 |
human |
| Jifeng Wang, Baobing Zhao, Yuting Yi, Wei Zhang, Xuan Wu, Lianru Zhang, Yuemao She. Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-κB pathways. Biochemical pharmacology. vol 84. issue 7. 2012-11-01. PMID:22796259. |
the present results show that med induces dna damage through the production of reactive oxygen species (ros), which resulted in the phosphorylation of h2ax and the activation of the ataxia telangiectasia mutated kinase (atm) and p53 signaling pathways. |
2012-11-01 |
2023-08-12 |
Not clear |
| Tobias Sperka, Jianwei Wang, K Lenhard Rudolp. DNA damage checkpoints in stem cells, ageing and cancer. Nature reviews. Molecular cell biology. vol 13. issue 9. 2012-10-30. PMID:22914294. |
dna damage induces cell-intrinsic checkpoints, including p53 and retinoblastoma (rb), as well as upstream regulators (exonuclease 1 (exo1), ataxia telangiectasia mutated (atm), atr, p16(ink4a) and p19(arf)) and downstream targets (p21, puma (p53 upregulated modulator of apoptosis) and sestrins). |
2012-10-30 |
2023-08-12 |
Not clear |
| E Matute. Novel and emerging drugs for rarer chronic lymphoid leukaemias. Current cancer drug targets. vol 12. issue 5. 2012-10-29. PMID:22483155. |
emphasis is made on: 1- the novel agents targeting a variety of b and t-cell antigens expressed on the surface of the leukaemic cells; these are either unconjugated monoclonal antibodies (mcab) such as rituximab (anti-cd20), the second and third generation of anti-cd20 mcabs, alemtuzumab (anti-cd52), siplizumab (anti-cd2), daclizumab (anti-cd25) and kw-0761, an anti-chemokine receptor 4 (ccr4) or mcabs conjugated to toxins such as cd22 linked to the pseudomonas exotoxin or radiolabelled mcab; 2- the use of new purine nucleosides such as nelarabine and 3- agents targeting deregulated genes in the leukaemic cells from these diseases such as the poly (adp-ribose) polymerase (parp) olarapib in t-pll with deregulation of the ataxia telangiectasia mutated (atm) gene. |
2012-10-29 |
2023-08-12 |
Not clear |