| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Jie Wang, Xiao-Guang Chen, Zhi-Yan Xiao, Geng-Tao Liu, Hua Su. Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells. Journal of Asian natural products research. vol 14. issue 7. 2012-10-23. PMID:22583615. |
ataxia telangiectasia mutated protein kinase (atm) was activated by gl331 through its autophosphorylation at ser1981, which led to the activation of dna damage signaling pathways including p53/p21 and chk2/cdc25a cascades. |
2012-10-23 |
2023-08-12 |
human |
| Jiabin Tang, Jean Y Wang, Laurie L Parke. Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. Chembiochem : a European journal of chemical biology. vol 13. issue 5. 2012-10-22. PMID:22334513. |
previous studies have established that ataxia telangiectasia mutated (atm) activates nuclear abl by phosphorylating serine 465 (s465) in the kinase domain in response to ionizing radiation (ir). |
2012-10-22 |
2023-08-12 |
Not clear |
| Yosef Shiloh, Yael Zi. The ATM protein: the importance of being active. The Journal of cell biology. vol 198. issue 3. 2012-10-18. PMID:22869592. |
the ataxia telangiectasia mutated (atm) protein kinase regulates the cellular response to deoxyribonucleic acid (dna) double-strand breaks by phosphorylating numerous players in the extensive dna damage response network. |
2012-10-18 |
2023-08-12 |
mouse |
| Jeremy A Daniel, Manuela Pellegrini, Baeck-Seung Lee, Zhi Guo, Darius Filsuf, Natalya V Belkina, Zhongsheng You, Tanya T Paull, Barry P Sleckman, Lionel Feigenbaum, André Nussenzwei. Loss of ATM kinase activity leads to embryonic lethality in mice. The Journal of cell biology. vol 198. issue 3. 2012-10-18. PMID:22869595. |
ataxia telangiectasia (a-t) mutated (atm) is a key deoxyribonucleic acid (dna) damage signaling kinase that regulates dna repair, cell cycle checkpoints, and apoptosis. |
2012-10-18 |
2023-08-12 |
mouse |
| Kenta Yamamoto, Yunyue Wang, Wenxia Jiang, Xiangyu Liu, Richard L Dubois, Chyuan-Sheng Lin, Thomas Ludwig, Christopher J Bakkenist, Shan Zh. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. The Journal of cell biology. vol 198. issue 3. 2012-10-18. PMID:22869596. |
ataxia telangiectasia (a-t) mutated (atm) kinase orchestrates deoxyribonucleic acid (dna) damage responses by phosphorylating numerous substrates implicated in dna repair and cell cycle checkpoint activation. |
2012-10-18 |
2023-08-12 |
mouse |
| Kazutetsu Aoshiba, Fang Zhou, Takao Tsuji, Atsushi Naga. DNA damage as a molecular link in the pathogenesis of COPD in smokers. The European respiratory journal. vol 39. issue 6. 2012-10-16. PMID:22267761. |
the numbers of dsb foci (phosphorylated histone 2ax (γh2ax), phosphorylated atm (ataxia telangiectasia mutated) substrate and phosphorylated p53-binding protein-1 foci) per cell in alveolar type i and ii cells and endothelial cells were higher in the copd patients than in the asymptomatic smokers and nonsmokers. |
2012-10-16 |
2023-08-12 |
Not clear |
| Petros Marangos, John Carrol. Oocytes progress beyond prophase in the presence of DNA damage. Current biology : CB. vol 22. issue 11. 2012-10-15. PMID:22578416. |
this lack of an efficient dna damage checkpoint is because oocytes fail to effectively activate the master regulator of the dna damage response pathway, atm (ataxia telangiectasia mutated) kinase. |
2012-10-15 |
2023-08-12 |
mouse |
| Bu Yin, Baeck-Seung Lee, Katherine S Yang-Iott, Barry P Sleckman, Craig H Bassin. Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes. Journal of immunology (Baltimore, Md. : 1950). vol 189. issue 3. 2012-10-15. PMID:22730535. |
the ataxia telangiectasia mutated (atm) kinase and h2ax histone tumor suppressor proteins are each critical for maintenance of cellular genomic stability and suppression of lymphomas harboring clonal translocations. |
2012-10-15 |
2023-08-12 |
mouse |
| Xiaofei E, Mary T Pickering, Michelle Debatis, Jonathan Castillo, Alexander Lagadinos, Shixia Wang, Shan Lu, Timothy F Kowali. An E2F1-mediated DNA damage response contributes to the replication of human cytomegalovirus. PLoS pathogens. vol 7. issue 5. 2012-10-09. PMID:21589897. |
human cytomegalovirus (hcmv) infection induces a ddr centered on the activation of ataxia telangiectasia mutated (atm) protein kinase. |
2012-10-09 |
2023-08-12 |
human |
| J Berg. Analysis of the p53 Status of Tumors : An Overview of Methods. Methods in molecular medicine. vol 28. 2012-10-02. PMID:21374038. |
the activation by these may involve interaction with the ataxia telangiectasia gene (atm). |
2012-10-02 |
2023-08-12 |
mouse |
| Kara A Boltz, Katherine Leehy, Xiangyu Song, Andrew D Nelson, Dorothy E Shippe. ATR cooperates with CTC1 and STN1 to maintain telomeres and genome integrity in Arabidopsis. Molecular biology of the cell. vol 23. issue 8. 2012-09-28. PMID:22357613. |
here we show that cst and atr (ataxia telangiectasia mutated [atm] and rad3-related) act synergistically to maintain telomere length and genome stability in arabidopsis. |
2012-09-28 |
2023-08-12 |
Not clear |
| Georgina E Drury, Adam A Dowle, David A Ashford, Wanda M Waterworth, Jerry Thomas, Christopher E Wes. Dynamics of plant histone modifications in response to DNA damage. The Biochemical journal. vol 445. issue 3. 2012-09-26. PMID:22574698. |
conversely, mutants in the key dna damage signalling factor atm (ataxia telangiectasia mutated) display increased histone acetylation upon irradiation, linking the dna damage response with dynamic changes in histone modification in plants. |
2012-09-26 |
2023-08-12 |
Not clear |
| Adar Makovski, Etai Yaffe, Sally Shpungin, Uri Ni. Down-regulation of Fer induces ROS levels accompanied by ATM and p53 activation in colon carcinoma cells. Cellular signalling. vol 24. issue 7. 2012-09-25. PMID:22434045. |
accordingly, down regulation of fer led to the activation of the ataxia telangiectasia mutated protein (atm) and its down-stream effector-p53. |
2012-09-25 |
2023-08-12 |
Not clear |
| N van Leeuwen, G Nijpels, M L Becker, H Deshmukh, K Zhou, B H C Stricker, A G Uitterlinden, A Hofman, E van 't Riet, C N A Palmer, B Guigas, P E Slagboom, P Durrington, R A Calle, A Neil, G Hitman, S J Livingstone, H Colhoun, R R Holman, M I McCarthy, J M Dekker, L M 't Hart, E R Pearso. A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts. Diabetologia. vol 55. issue 7. 2012-09-25. PMID:22453232. |
in this study we aimed to replicate the previously reported association between the glycaemic response to metformin and the snp rs11212617 at a locus that includes the ataxia telangiectasia mutated (atm) gene in multiple additional populations. |
2012-09-25 |
2023-08-12 |
Not clear |
| Erin K Daugherity, Gabriel Balmus, Ahmed Al Saei, Elizabeth S Moore, Delbert Abi Abdallah, Arlin B Rogers, Robert S Weiss, Kirk J Maure. The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease. Cell cycle (Georgetown, Tex.). vol 11. issue 10. 2012-09-24. PMID:22544329. |
consistent with reports that the dna damage checkpoint kinase ataxia telangiectasia mutated (atm) is activated by oxidative stress, atm phosphorylation was induced in the livers of wild type mice following high fat diet feeding. |
2012-09-24 |
2023-08-12 |
mouse |
| Kiran Mahajan, Domenico Coppola, Bhupendra Rawal, Y Ann Chen, Harshani R Lawrence, Robert W Engelman, Nicholas J Lawrence, Nupam P Mahaja. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. The Journal of biological chemistry. vol 287. issue 26. 2012-09-20. PMID:22566699. |
here, we demonstrate that ptyr(267)-ar is recruited to the atm (ataxia telangiectasia mutated) enhancer in an ack1-dependent manner to up-regulate atm expression. |
2012-09-20 |
2023-08-12 |
mouse |
| Yiping Huang, Rafael Guerrero-Preston, Edward A Ratovitsk. Phospho-ΔNp63α-dependent regulation of autophagic signaling through transcription and micro-RNA modulation. Cell cycle (Georgetown, Tex.). vol 11. issue 6. 2012-09-13. PMID:22356768. |
cisplatin was shown to induce the ataxia telangiectasia mutated (atm)-dependent phosphorylation of tumor protein p63 isoform, (Δnp63α), leading to a transcriptional regulation of specific genes implicated in the control of cell death of squamous cell carcinoma (scc) cells. |
2012-09-13 |
2023-08-12 |
Not clear |
| Maike Zimmermann, Aruni S Arachchige-Don, Michaela S Donaldson, Robert F Dallapiazza, Colleen E Cowan, Mary C Horn. Elevated cyclin G2 expression intersects with DNA damage checkpoint signaling and is required for a potent G2/M checkpoint arrest response to doxorubicin. The Journal of biological chemistry. vol 287. issue 27. 2012-09-11. PMID:22589537. |
we show that dna double strand break-inducing chemotherapeutics stimulate cycg2 expression and correlate its up-regulation with checkpoint-induced cell cycle arrest and phospho-modification of proteins in the ataxia telangiectasia mutated (atm) and atm and rad3-related (atr) signaling pathways. |
2012-09-11 |
2023-08-12 |
Not clear |
| Hanna Dellago, Abdulhameed Khan, Monika Nussbacher, Anna Gstraunthaler, Ingo Lämmermann, Markus Schosserer, Christoph Mück, Dorothea Anrather, Annika Scheffold, Gustav Ammerer, Pidder Jansen-Dürr, Karl Lenhard Rudolph, Regina Voglauer-Grillari, Johannes Grillar. ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis. Aging. vol 4. issue 4. 2012-09-06. PMID:22529335. |
here we find that snevhprp19/hpso4 is phosphorylated at s149 in an ataxia telangiectasia mutated protein (atm)-dependent manner in response to oxidative stress and dna double strand break inducing agents. |
2012-09-06 |
2023-08-12 |
Not clear |
| Christine Pampeno, Alicia Hurtado, Daniel Meruel. ATM kinase is activated by sindbis viral vector infection. Virus research. vol 166. issue 1-2. 2012-09-05. PMID:22475743. |
the ataxia telangiectasia mutated (atm) kinase, a sentinel against genomic and cellular stress, was activated by sindbis vector infection at 3h post infection. |
2012-09-05 |
2023-08-12 |
Not clear |