| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Sang Hong, Seung-Woo Hong, Seung-Mi Kim, Dong-Hoon Jin, Jae-Sik Shin, Dok Hyun Yoon, Kyu-Pyo Kim, Jae-Lyun Lee, Dae Seog Heo, Jung Shin Lee, Tae Won Ki. Bortezomib induces G2-M arrest in human colon cancer cells through ROS-inducible phosphorylation of ATM-CHK1. International journal of oncology. vol 41. issue 1. 2012-08-31. PMID:22552540. |
investigation of g2-m phase-related cell cycle proteins involved in the response to bortezomib revealed that the ataxia telangiectasia mutated (atm)-cell cycle checkpoint kinase 1 (chk1) pathway, but not atm and rad3-related (atr), was activated, resulting in the inactivation of cdc2. |
2012-08-31 |
2023-08-12 |
human |
| Philipp J Hohensinner, Jörg J Goronzy, Cornelia M Weyan. Telomere dysfunction, autoimmunity and aging. Aging and disease. vol 2. issue 6. 2012-08-23. PMID:22396899. |
patients with ra have other defects in dna repair mechanisms, including the kinase ataxia telangiectasia mutated (atm), critically involved in the repair of dna double strand breaks. |
2012-08-23 |
2023-08-12 |
Not clear |
| Chen Hu, Shengping Zhang, Xuan Gao, Xiaojing Gao, Xiaohong Xu, Ya Lv, Yan Zhang, Zhenhong Zhu, Changqing Zhang, Qiao Li, Jiemin Wong, Yongping Cui, Wen Zhang, Lin Ma, Chuangui Wan. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. The Journal of biological chemistry. vol 287. issue 23. 2012-08-20. PMID:22496453. |
ataxia telangiectasia mutated (atm)-chk2 and atm- and rad3-related (atr)-chk1 are two primary kinase signaling cascades activated in response to dna damage. |
2012-08-20 |
2023-08-12 |
Not clear |
| Karen S Yee, Lukasz Grochola, Garth Hamilton, Anna Grawenda, Elisabeth E Bond, Helge Taubert, Peter Wurl, Gareth L Bond, Eric O'Neil. A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcoma. Cancer research. vol 72. issue 9. 2012-08-17. PMID:22389451. |
rassf1a (ras association domain containing family 1a), a tumor suppressor gene that is frequently inactivated in human cancers, is phosphorylated by ataxia telangiectasia mutated (atm) on ser131 upon dna damage, leading to activation of a p73-dependent apoptotic response. |
2012-08-17 |
2023-08-12 |
human |
| Jiali Li, Jianmin Chen, Christopher L Ricupero, Ronald P Hart, Melanie S Schwartz, Alexander Kusnecov, Karl Herru. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nature medicine. vol 18. issue 5. 2012-07-27. PMID:22466704. |
nuclear accumulation of hdac4 in atm deficiency promotes neurodegeneration in ataxia telangiectasia. |
2012-07-27 |
2023-08-12 |
mouse |
| Jiali Li, Jianmin Chen, Christopher L Ricupero, Ronald P Hart, Melanie S Schwartz, Alexander Kusnecov, Karl Herru. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nature medicine. vol 18. issue 5. 2012-07-27. PMID:22466704. |
ataxia telangiectasia is a neurodegenerative disease caused by mutation of the atm gene. |
2012-07-27 |
2023-08-12 |
mouse |
| Jiali Li, Jianmin Chen, Christopher L Ricupero, Ronald P Hart, Melanie S Schwartz, Alexander Kusnecov, Karl Herru. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nature medicine. vol 18. issue 5. 2012-07-27. PMID:22466704. |
here we report that ataxia telangiectasia mutated (atm) deficiency causes nuclear accumulation of histone deacetylase 4 (hdac4) in neurons and promotes neurodegeneration. |
2012-07-27 |
2023-08-12 |
mouse |
| Young Joo Choi, Yang Jee Kim, Joong Won Lee, Younghyun Lee, Yong-Beom Lim, Hai Won Chun. Cyto-/genotoxic effect of CdSe/ZnS quantum dots in human lung adenocarcinoma cells for potential photodynamic UV therapy applications. Journal of nanoscience and nanotechnology. vol 12. issue 3. 2012-07-26. PMID:22755033. |
qd-induced cell death was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (mtt), apoptosis, and lactate dehydrogenase (ldh) assays, as well as by real-time pcr analysis of differential mrna levels of genes, such as ataxia telangiectasia mutated (atm), p53, and caspase-9, involved in apoptosis. |
2012-07-26 |
2023-08-12 |
human |
| Stefan Karger, Kerstin Krause, Cornelia Engelhardt, Carl Weidinger, Oliver Gimm, Henning Dralle, Sien-Yi Sheu-Grabellus, Kurt Werner Schmid, Dagmar Fuhre. Distinct pattern of oxidative DNA damage and DNA repair in follicular thyroid tumours. Journal of molecular endocrinology. vol 48. issue 3. 2012-07-24. PMID:22331172. |
moreover, activation of dna damage checkpoints (ataxia telangiectasia mutated (atm) and h2a histone family, member x (h2afx (h2afx))) and proliferation index (mib-1) were quantified in 28 non-oxyphilic and 24 oxyphilic ftcs. |
2012-07-24 |
2023-08-12 |
rat |
| Hee-Don Chae, So Youn Kim, Sang Eun Park, Jeongbin Kim, Deug Y Shi. p53 and DNA-dependent protein kinase catalytic subunit independently function in regulating actin damage-induced tetraploid G1 arrest. Experimental & molecular medicine. vol 44. issue 3. 2012-07-23. PMID:22198295. |
in this study, we investigated the role of p53, ataxia telangiectasia mutated protein (atm), and catalytic subunit of dna-dependent protein kinase (dna-pkcs) in tetraploid g1 arrest induced by actin damage. |
2012-07-23 |
2023-08-12 |
Not clear |
| Ying Li, Shinya Mitsuhashi, Makoto Ikejo, Nobuaki Miura, Takeshi Kawamura, Takao Hamakubo, Makoto Ubukat. Relationship between ATM and ribosomal protein S6 revealed by the chemical inhibition of Ser/Thr protein phosphatase type 1. Bioscience, biotechnology, and biochemistry. vol 76. issue 3. 2012-07-20. PMID:22451389. |
the ataxia telangiectasia mutated (atm) is a ser/thr kinase which is the core of the dna damage signaling apparatus. |
2012-07-20 |
2023-08-12 |
Not clear |
| Megan McKerlie, Sichun Lin, Xu-Dong Zh. ATM regulates proteasome-dependent subnuclear localization of TRF1, which is important for telomere maintenance. Nucleic acids research. vol 40. issue 9. 2012-07-17. PMID:22266654. |
ataxia telangiectasia mutated (atm), a pi-3 kinase essential for maintaining genomic stability, has been shown to regulate trf1, a negative mediator of telomerase-dependent telomere extension. |
2012-07-17 |
2023-08-12 |
Not clear |
| Kevin W McCool, Shigeki Miyamot. DNA damage-dependent NF-κB activation: NEMO turns nuclear signaling inside out. Immunological reviews. vol 246. issue 1. 2012-07-17. PMID:22435563. |
post-translational modification of nf-κb essential modulator (nemo) plays a central role in linking the cellular dna damage response to nf-κb via the ataxia telangiectasia mutated (atm) kinase. |
2012-07-17 |
2023-08-12 |
human |
| b' Julien Lang, Ondrej Smetana, Lenin Sanchez-Calderon, Fr\\xc3\\xa9d\\xc3\\xa9ric Lincker, Julie Genestier, Anne-Catherine Schmit, Guy Houln\\xc3\\xa9, Marie-Edith Chabout\\xc3\\xa. Plant \\xce\\xb3H2AX foci are required for proper DNA DSB repair responses and colocalize with E2F factors. The New phytologist. vol 194. issue 2. 2012-07-09. PMID:22339405.' |
these e2f foci partially colocalize with γh2ax foci while their formation is ataxia telangiectasia mutated (atm)-dependent, requires the e2f transactivation domain with its retinoblastoma-binding site and is optimal in the presence of functional h2axs. |
2012-07-09 |
2023-08-12 |
Not clear |
| David White, Ilona U Rafalska-Metcalf, Alexey V Ivanov, Andrea Corsinotti, Hongzhuang Peng, Sheng-Chung Lee, Didier Trono, Susan M Janicki, Frank J Rausche. The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation. Molecular cancer research : MCR. vol 10. issue 3. 2012-07-05. PMID:22205726. |
kap1 is a heterochromatin protein and co-repressor that binds to hp1 during gene silencing but is also robustly phosphorylated by ataxia telangiectasia mutated (atm) at serine 824 in response to dna damage. |
2012-07-05 |
2023-08-12 |
Not clear |
| Fatema A Dhariwala, Himanshi Narang, Malini Krishn. Ionizing radiation induced signaling of DNA damage response molecules in RAW 264.7 and CD4⁺ T cells. Molecular and cellular biochemistry. vol 363. issue 1-2. 2012-07-02. PMID:22173400. |
ionizing radiation (ir) treatment results in activation of several dna damage response molecules, such as ataxia telangiectasia, mutated (atm), and dna-dependent protein kinase (dnapk) in mammals that are increasingly recognized for their potential roles in the sensing of dna damage and initiating the subsequent protein kinase cascade. |
2012-07-02 |
2023-08-12 |
mouse |
| Virginie Jacquemin, Guillaume Rieunier, Sandrine Jacob, Dorine Bellanger, Catherine Dubois d'Enghien, Anthony Laugé, Dominique Stoppa-Lyonnet, Marc-Henri Ster. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. European journal of human genetics : EJHG. vol 20. issue 3. 2012-06-13. PMID:22071889. |
underexpression and abnormal localization of atm products in ataxia telangiectasia patients bearing atm missense mutations. |
2012-06-13 |
2023-08-12 |
Not clear |
| S Ghosh, F Krux, V Binder, M Gombert, T Niehues, O Feyen, H-J Laws, A Borkhard. Array-based sequence capture and next-generation sequencing for the identification of primary immunodeficiencies. Scandinavian journal of immunology. vol 75. issue 3. 2012-06-12. PMID:22017423. |
in one patient with hepatosplenomegaly, recurrent infections and an elevated igm level, sequence analysis of the patient and his two unaffected parents identified atm (ataxia telangiectasia mutated) as the underlying defect. |
2012-06-12 |
2023-08-12 |
human |
| Paula Martínez, Juana M Flores, Maria A Blasc. 53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response. The Journal of cell biology. vol 197. issue 2. 2012-06-07. PMID:22508511. |
depletion of trf1 leads to telomere fusions as well as accumulation of γ-h2ax foci and activation of both the ataxia telangiectasia mutated (atm)- and the ataxia telangiectasia and rad3 related (atr)-mediated deoxyribonucleic acid (dna) damage response (ddr) pathways. |
2012-06-07 |
2023-08-12 |
mouse |
| Armin M Gamper, Serah Choi, Yoshihiro Matsumoto, Dibyendu Banerjee, Alan E Tomkinson, Christopher J Bakkenis. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22362778. |
ataxia telangiectasia (a-t) is a pleiotropic disease, with a characteristic hypersensitivity to ionizing radiation that is caused by biallelic mutations in a-t mutated (atm), a gene encoding a protein kinase critical for the induction of cellular responses to dna damage, particularly to dna double strand breaks. |
2012-06-06 |
2023-08-12 |
Not clear |