| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John R Mercer, Emma Yu, Nichola Figg, Kian-Kai Cheng, Tracy A Prime, Julian L Griffin, Mojgan Masoodi, Antonio Vidal-Puig, Michael P Murphy, Martin R Bennet. The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/-/ApoE-/- mice. Free radical biology & medicine. vol 52. issue 5. 2012-06-04. PMID:22210379. |
we assessed the impact of decreasing mitochondrial oxidative damage and ros with the mitochondria-targeted antioxidant mitoq in models of atherosclerosis and the metabolic syndrome (fat-fed apoe(-/-) mice and atm(+/-)/apoe(-/-) mice, which are also haploinsufficient for the protein kinase, ataxia telangiectasia mutated (atm). |
2012-06-04 |
2023-08-12 |
mouse |
| Christelle Morris, Nozomi Tomimatsu, Derek J Richard, David Cluet, Sandeep Burma, Kum Kum Khanna, Pierre Jalino. INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer research. vol 72. issue 8. 2012-06-01. PMID:22508697. |
in addition, int6 silencing prevented sustained accumulation of ataxia telangiectasia mutated (atm) at dna damage sites in cells treated with γ-radiation or the radiomimetic drug neocarzinostatin. |
2012-06-01 |
2023-08-12 |
human |
| Bin-Chuan Ji, Chien-Chih Yu, Su-Tso Yang, Te-Chun Hsia, Jai-Sing Yang, Kuang-Chi Lai, Yang-Ching Ko, Jen-Jyh Lin, Tung-Yuan Lai, Jing-Gung Chun. Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells. Oncology reports. vol 27. issue 4. 2012-05-30. PMID:22227970. |
dna damage and repair gene expression (mrna) were evaluated by using real-time pcr assay and the results indicated that 50 and 250 nm deguelin for a 24-h exposure in nci-h460 cells, decreased the gene levels of breast cancer 1, early onset (brca1), dna-dependent serine/threonine protein kinase (dna-pk), o6-methylguanine-dna methyltransferase (mgmt), p53, ataxia telangiectasia mutated (atm) and ataxia-telangiectasia and rad3-related (atr) mrna expressions. |
2012-05-30 |
2023-08-12 |
human |
| Wei-Hsin Chiu, Sheng-Jei Luo, Chia-Ling Chen, Jai-Hong Cheng, Chia-Yuan Hsieh, Chi-Yun Wang, Wei-Ching Huang, Wu-Chou Su, Chiou-Feng Li. Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells. Biochemical pharmacology. vol 83. issue 9. 2012-05-21. PMID:22285910. |
unlike cisplatin, which causes dna damage in each phase of the cell cycle, vnr and nocodazole induced aberrant jnk-regulated dna damage in prometaphase; however, inhibiting atm (ataxia telangiectasia, mutated) and atr (atm and rad3-related) did not reverse mitotic arrest or apoptosis. |
2012-05-21 |
2023-08-12 |
Not clear |
| Agnel Sfeir, Titia de Lang. Removal of shelterin reveals the telomere end-protection problem. Science (New York, N.Y.). vol 336. issue 6081. 2012-05-17. PMID:22556254. |
the data establish that the end-protection problem is specified by six pathways [atm (ataxia telangiectasia mutated) and atr (ataxia telangiectasia and rad3 related) signaling, classical-nhej, alt-nhej, homologous recombination, and resection] and show how shelterin acts with general dna damage response factors to solve this problem. |
2012-05-17 |
2023-08-12 |
mouse |
| Guozhu Xie, Junfang Zhan, Yunhong Tian, Ying Liu, Zhixian Chen, Chen Ren, Quanquan Sun, Jianping Lian, Longhua Chen, Jian Ruan, Changsheng Ye, Aimin Sun, Yawei Yua. Mammosphere cells from high-passage MCF7 cell line show variable loss of tumorigenicity and radioresistance. Cancer letters. vol 316. issue 1. 2012-05-16. PMID:22108532. |
the radioresistant mss showed significant cell cycle arrest in g2/m phase after x-ray irradiation and expressed higher ataxia telangiectasia mutated (atm) mrna levels. |
2012-05-16 |
2023-08-12 |
Not clear |
| Qingsong Liu, Sivapriya Kirubakaran, Wooyoung Hur, Mario Niepel, Kenneth Westover, Carson C Thoreen, Jinhua Wang, Jing Ni, Matthew P Patricelli, Kurt Vogel, Steve Riddle, David L Waller, Ryan Traynor, Takaomi Sanda, Zheng Zhao, Seong A Kang, Jean Zhao, A Thomas Look, Peter K Sorger, David M Sabatini, Nathanael S Gra. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. The Journal of biological chemistry. vol 287. issue 13. 2012-05-16. PMID:22223645. |
in vitro biochemical profiling at 10 μm revealed binding of pp242 to numerous kinases, although wye354 and ku63794 bound only to p38 kinases and pi3k isoforms and torin1 to ataxia telangiectasia mutated, atm and rad3-related protein, and dna-pk. |
2012-05-16 |
2023-08-12 |
Not clear |
| Kuntian Luo, Jian Yuan, Zhenkun Lo. Oligomerization of MDC1 protein is important for proper DNA damage response. The Journal of biological chemistry. vol 286. issue 32. 2012-05-11. PMID:21705321. |
here we show that ataxia telangiectasia, mutated (atm) phosphorylates mdc1 at thr-98 following dna damage, which promotes its oligomerization. |
2012-05-11 |
2023-08-12 |
Not clear |
| Yukihiro Furusawa, Takashi Iizumi, Yoshisada Fujiwara, Qing-Li Zhao, Yoshiaki Tabuchi, Takaharu Nomura, Takashi Kond. Inhibition of checkpoint kinase 1 abrogates G2/M checkpoint activation and promotes apoptosis under heat stress. Apoptosis : an international journal on programmed cell death. vol 17. issue 1. 2012-05-07. PMID:22080164. |
in human leukemia jurkat cells, interestingly, the ataxia telangiectasia and rad-3 related (atr)-chk1 pathway was preferentially activated rather than the ataxia telangiectasia mutated (atm)-checkpoint kinase 2 (chk2) pathway under hs. |
2012-05-07 |
2023-08-12 |
human |
| Cassandra J Adams, Ashley C W Pike, Sandra Maniam, Timothy D Sharpe, Amanda S Coutts, Stefan Knapp, Nicholas B La Thangue, Alex N Bulloc. The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 10. 2012-05-04. PMID:22362889. |
strap (stress-responsive activator of p300) is activated upon dna damage by ataxia telangiectasia mutated (atm) and chk2 kinases and is a key regulator of the p53 response. |
2012-05-04 |
2023-08-12 |
Not clear |
| Aurelia Barascu, Catherine Le Chalony, Gaëlle Pennarun, Diane Genet, Naima Imam, Bernard Lopez, Pascale Bertran. Oxidative stress induces an ATM-independent senescence pathway through p38 MAPK-mediated lamin B1 accumulation. The EMBO journal. vol 31. issue 5. 2012-05-03. PMID:22246186. |
these data reveal lamin b1 as a general molecular mediator that controls os-induced senescence, independent of established ataxia telangiectasia mutated (atm) roles in ois. |
2012-05-03 |
2023-08-12 |
Not clear |
| Youngsoo Lee, Erin R P Shull, Pierre-Olivier Frappart, Sachin Katyal, Vanessa Enriquez-Rios, Jingfeng Zhao, Helen R Russell, Eric J Brown, Peter J McKinno. ATR maintains select progenitors during nervous system development. The EMBO journal. vol 31. issue 5. 2012-05-03. PMID:22266795. |
the atr (atm (ataxia telangiectasia mutated) and rad3-related) checkpoint kinase is considered critical for signalling dna replication stress and its dysfunction can lead to the neurodevelopmental disorder, atr-seckel syndrome. |
2012-05-03 |
2023-08-12 |
Not clear |
| Anna Skowronska, Belinda Austen, Judith E Powell, Victoria Weston, David G Oscier, Martin J S Dyer, Estella Matutes, Guy Pratt, Christopher Fegan, Paul Moss, Malcolm A Taylor, Tatjana Stankovi. ATM germline heterozygosity does not play a role in chronic lymphocytic leukemia initiation but influences rapid disease progression through loss of the remaining ATM allele. Haematologica. vol 97. issue 1. 2012-05-01. PMID:21933854. |
ataxia telangiectasia patients, with constitutional bi-allelic atm mutations, have a marked risk of lymphoid tumors and atm mutation carriers have a smaller risk of cancer. |
2012-05-01 |
2023-08-12 |
Not clear |
| Shun Fujimaki, Yasunobu Matsuda, Toshifumi Wakai, Ayumi Sanpei, Masayuki Kubota, Masaaki Takamura, Satoshi Yamagiwa, Masahiko Yano, Shogo Ohkoshi, Yutaka Aoyag. Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling. Cancer letters. vol 319. issue 1. 2012-04-27. PMID:22265862. |
here, we show that blockade of ataxia telangiectasia mutated (atm) improves the antitumor effects of sorafenib. |
2012-04-27 |
2023-08-12 |
Not clear |
| Y Darlington, T-A Nguyen, S-H Moon, A Herron, P Rao, C Zhu, X Lu, L A Donehowe. Absence of Wip1 partially rescues Atm deficiency phenotypes in mice. Oncogene. vol 31. issue 9. 2012-04-24. PMID:21765465. |
wild-type p53-induced phosphatase 1 (wip1) is a serine/threonine phosphatase that dephosphorylates proteins in the ataxia telangiectasia mutated (atm)-initiated dna damage response pathway. |
2012-04-24 |
2023-08-12 |
mouse |
| Y Darlington, T-A Nguyen, S-H Moon, A Herron, P Rao, C Zhu, X Lu, L A Donehowe. Absence of Wip1 partially rescues Atm deficiency phenotypes in mice. Oncogene. vol 31. issue 9. 2012-04-24. PMID:21765465. |
atm null mice, like atm-deficient humans with the inherited syndrome ataxia telangiectasia, exhibit radiation sensitivity, fertility defects, and are t-cell lymphoma prone. |
2012-04-24 |
2023-08-12 |
mouse |
| M A de la Cruz-Morcillo, M L L Valero, J L Callejas-Valera, L Arias-González, P Melgar-Rojas, E M Galán-Moya, E García-Gil, J García-Cano, R Sánchez-Priet. P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistance. Oncogene. vol 31. issue 9. 2012-04-24. PMID:21841826. |
in addition, ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3 related (atr) showed a redundancy of function for the final activation of p38mapk. |
2012-04-24 |
2023-08-12 |
Not clear |
| Jung-Hoon Yoon, Sang-Gun Ahn, Byung-Hoon Lee, Sung-Hoo Jung, Seon-Hee O. Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1. Biochemical pharmacology. vol 83. issue 6. 2012-04-13. PMID:22226932. |
capsaicin treatment also activated δ-h2ax, ataxia telangiectasia mutated (atm), dna-dependent protein kinase catalytic subunit (dna-pkcs), and poly(adp-ribose) polymerase (parp)-1. |
2012-04-13 |
2023-08-12 |
human |
| Yadong Wang, Juan Cheng, Daochuan Li, Huawei Duan, Haijun Yang, Ping Bin, Yufei Dai, Chuanfeng Huang, Xuemiao Liang, Shuguang Leng, Wen Chen, Yuxin Zhen. Modulation of DNA repair capacity by ataxia telangiectasia mutated gene polymorphisms among polycyclic aromatic hydrocarbons-exposed workers. Toxicological sciences : an official journal of the Society of Toxicology. vol 124. issue 1. 2012-04-12. PMID:21873372. |
the purpose of this study was to address the association between the ataxia telangiectasia mutated (atm) gene polymorphisms and susceptibility to dna repair capacity (drc) among polycyclic aromatic hydrocarbons (pahs)-exposed workers. |
2012-04-12 |
2023-08-12 |
human |
| Naokazu Chiba, Valentine Comaills, Bunsyo Shiotani, Fumiyuki Takahashi, Toshiyuki Shimada, Ken Tajima, Daniel Winokur, Tetsu Hayashida, Henning Willers, Elena Brachtel, Maria D M Vivanco, Daniel A Haber, Lee Zou, Shyamala Maheswara. Homeobox B9 induces epithelial-to-mesenchymal transition-associated radioresistance by accelerating DNA damage responses. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 8. 2012-04-12. PMID:21930940. |
in nonirradiated cells, hoxb9 induces spontaneous dna damage, phosphorylated histone 2ax and p53 binding protein 1 foci, and increases baseline ataxia telangiectasia mutated (atm) phosphorylation. |
2012-04-12 |
2023-08-12 |
Not clear |