| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Libing Song, Chuyong Lin, Zhiqiang Wu, Hui Gong, Yong Zeng, Jueheng Wu, Mengfeng Li, Jun L. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PloS one. vol 6. issue 9. 2012-01-26. PMID:21980462. |
mir-18a impairs dna damage response through downregulation of ataxia telangiectasia mutated (atm) kinase. |
2012-01-26 |
2023-08-12 |
Not clear |
| Libing Song, Chuyong Lin, Zhiqiang Wu, Hui Gong, Yong Zeng, Jueheng Wu, Mengfeng Li, Jun L. miR-18a impairs DNA damage response through downregulation of ataxia telangiectasia mutated (ATM) kinase. PloS one. vol 6. issue 9. 2012-01-26. PMID:21980462. |
ataxia telangiectasia mutated (atm) kinase, which functions as the primary sensor and transducer of dna damage signal, has been demonstrated to play an important role in the ddr and cancer prevention. |
2012-01-26 |
2023-08-12 |
Not clear |
| Julian Lange, Jing Pan, Francesca Cole, Michael P Thelen, Maria Jasin, Scott Keene. ATM controls meiotic double-strand-break formation. Nature. vol 479. issue 7372. 2012-01-25. PMID:22002603. |
our findings explain previously puzzling phenotypes of atm-null mice and provide a molecular basis for the gonadal dysgenesis observed in ataxia telangiectasia, the human syndrome caused by atm deficiency. |
2012-01-25 |
2023-08-12 |
mouse |
| Alex Pines, Christian D Kelstrup, Mischa G Vrouwe, Jordi C Puigvert, Dimitris Typas, Branislav Misovic, Anton de Groot, Louise von Stechow, Bob van de Water, Erik H J Danen, Harry Vrieling, Leon H F Mullenders, Jesper V Olse. Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells. Molecular and cellular biology. vol 31. issue 24. 2012-01-23. PMID:22006019. |
although the atm (ataxia telangiectasia mutated) and atr (atm and rad3-related) consensus sequence (s/t-q motif) was significantly overrepresented among hyperphosphorylated peptides, about half of the >2-fold-upregulated phosphorylation sites based on the consensus sequence were not direct substrates of atm and atr. |
2012-01-23 |
2023-08-12 |
Not clear |
| Lenka Stefancikova, Mojmir Moulis, Pavel Fabian, Ingrid Vasova, Frantisek Zedek, Barbora Ravcukova, Jan Muzik, Petr Kuglik, Vladimira Vranova, Iva Falkova, Renata Hrabalkova, Jana Smardov. Prognostic impact of p53 aberrations for R-CHOP-treated patients with diffuse large B-cell lymphoma. International journal of oncology. vol 39. issue 6. 2012-01-20. PMID:21874232. |
we used fish to analyze loss of the p53 and atm (ataxia telangiectasia mutated) gene deletions. |
2012-01-20 |
2023-08-12 |
Not clear |
| X F Mu, X L Jin, M M J Farnham, Y Li, C O'Neil. DNA damage-sensing kinases mediate the mouse 2-cell embryo's response to genotoxic stress. Biology of reproduction. vol 85. issue 3. 2012-01-12. PMID:21593482. |
a family of phosphoinositide-3-kinase-related protein kinases, which includes ataxia telangiectasia mutated (atm) and ataxia telangiectasia and rad3 related (atr) kinases, play key roles in sensing dna damage. |
2012-01-12 |
2023-08-12 |
mouse |
| Moon Hee Lee, Angela M Mabb, Grace B Gill, Edward T H Yeh, Shigeki Miyamot. NF-κB induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Molecular cell. vol 43. issue 2. 2012-01-03. PMID:21777808. |
we further show that nf-κb induces senp2 (and senp1) transcription selectively in response to genotoxic stimuli, which involves ataxia telangiectasia mutated (atm)-dependent histone methylation of senp2 promoter κb regions and nf-κb recruitment. |
2012-01-03 |
2023-08-12 |
Not clear |
| Marlen Keimling, Meta Volcic, Andreea Csernok, Britta Wieland, Thilo Dörk, Lisa Wiesmülle. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21778326. |
functional characterization connects individual patient mutations in ataxia telangiectasia mutated (atm) with dysfunction of specific dna double-strand break-repair signaling pathways. |
2011-12-27 |
2023-08-12 |
Not clear |
| Marlen Keimling, Meta Volcic, Andreea Csernok, Britta Wieland, Thilo Dörk, Lisa Wiesmülle. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21778326. |
ataxia telangiectasia mutated (atm) has multiple functions in homologous recombination (hr) and nonhomologous end joining (nhej), which lead to conflicting data regarding its dna double-strand break-repair (dsbr) functions in previous studies. |
2011-12-27 |
2023-08-12 |
Not clear |
| Marlen Keimling, Meta Volcic, Andreea Csernok, Britta Wieland, Thilo Dörk, Lisa Wiesmülle. Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 11. 2011-12-27. PMID:21778326. |
to explore the effect of clinically relevant atm mutations, we characterized dsbr between mutated egfp genes and atm kinase signaling in 9 lymphoblastoid cell lines (lcls) derived from patients with ataxia telangiectasia (at) with defined vs. 3 control lcls without atm mutations. |
2011-12-27 |
2023-08-12 |
Not clear |
| Sumanth Manohar, Matthew Harlow, Hahn Nguyen, Jing Li, Gerald R Hankins, Maiyon Par. Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition. Cell cycle (Georgetown, Tex.). vol 10. issue 15. 2011-12-13. PMID:21705858. |
chromatin modifying protein 1a (chmp1a) of the endosomal sorting complex required for transport (escrt)-iii family activates ataxia telangiectasia mutated (atm) for panc-1 cell growth inhibition. |
2011-12-13 |
2023-08-12 |
Not clear |
| Sumanth Manohar, Matthew Harlow, Hahn Nguyen, Jing Li, Gerald R Hankins, Maiyon Par. Chromatin modifying protein 1A (Chmp1A) of the endosomal sorting complex required for transport (ESCRT)-III family activates ataxia telangiectasia mutated (ATM) for PanC-1 cell growth inhibition. Cell cycle (Georgetown, Tex.). vol 10. issue 15. 2011-12-13. PMID:21705858. |
p53 is a substrate for ataxia telangiectasia mutated (atm), which can be activated upon chromatin condensation. |
2011-12-13 |
2023-08-12 |
Not clear |
| Jie Huang, Jianqi Yang, Biswanath Maity, Daisuke Mayuzumi, Rory A Fishe. Regulator of G protein signaling 6 mediates doxorubicin-induced ATM and p53 activation by a reactive oxygen species-dependent mechanism. Cancer research. vol 71. issue 20. 2011-12-12. PMID:21859827. |
doxorubicin (dxr), among the most widely used cancer chemotherapy agents, promotes cancer cell death via activation of ataxia telangiectasia mutated (atm) and the resultant upregulation of tumor suppressor p53. |
2011-12-12 |
2023-08-12 |
Not clear |
| Wei Zhang, Guang Peng, Shiaw-Yih Lin, Pumin Zhan. DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. The Journal of biological chemistry. vol 286. issue 41. 2011-12-12. PMID:21878640. |
although early ddr markers such as the phosphorylations of ataxia telangiectasia mutated (atm) and histone h2a.x (h2ax) can be readily detected, the ionizing radiation-induced foci (irif) formation of late ddr markers such as breast cancer type 1 susceptibility protein (brca1) and p53-binding protein 1 (53bp1) are absent until the telophase/cytokinesis stage. |
2011-12-12 |
2023-08-12 |
Not clear |
| Aruna Battu, Alo Ray, Altaf A Wan. ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation. Nucleic acids research. vol 39. issue 18. 2011-12-09. PMID:21727091. |
h3k56ac restoration is regulated by ataxia telangiectasia mutated (atm) checkpoint kinase. |
2011-12-09 |
2023-08-12 |
human |
| Jana Soukupova, Petr Pohlreich, Eva Seemanov. Characterisation of ATM mutations in Slavic Ataxia telangiectasia patients. Neuromolecular medicine. vol 13. issue 3. 2011-12-06. PMID:21833744. |
characterisation of atm mutations in slavic ataxia telangiectasia patients. |
2011-12-06 |
2023-08-12 |
Not clear |
| Jana Soukupova, Petr Pohlreich, Eva Seemanov. Characterisation of ATM mutations in Slavic Ataxia telangiectasia patients. Neuromolecular medicine. vol 13. issue 3. 2011-12-06. PMID:21833744. |
this autosomal recessive disorder is caused by mutations in the ataxia telangiectasia mutated (atm) gene coding for serine/threonine protein kinase with a crucial role in response to dna double-strand breaks. |
2011-12-06 |
2023-08-12 |
Not clear |
| Chao Wang, Zhi-Ling L. [ATM/H2AX and repair of sperm-DNA damage during cryopreservation]. Zhonghua nan ke xue = National journal of andrology. vol 17. issue 7. 2011-11-28. PMID:21823349. |
as a sensor of dna damage responses, protein kinase atm (ataxia telangiectasia mutated) can be initiated through rapid intermolecular autophosphorylation induced by dna damage, phosphorylate various proteins, and amplify the responses to dna damage. |
2011-11-28 |
2023-08-12 |
Not clear |
| Masaoki Kawasumi, Bianca Lemos, James E Bradner, Renee Thibodeau, Yong-son Kim, Miranda Schmidt, Erin Higgins, Sang-wahn Koo, Aimee Angle-Zahn, Adam Chen, Douglas Levine, Lynh Nguyen, Timothy P Heffernan, Isabel Longo, Anna Mandinova, Yao-Ping Lu, Allan H Conney, Paul Nghie. Protection from UV-induced skin carcinogenesis by genetic inhibition of the ataxia telangiectasia and Rad3-related (ATR) kinase. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 33. 2011-11-23. PMID:21844338. |
conversely, inhibition of other dna damage response pathways, such as ataxia telangiectasia mutated (atm) and brca1, promotes cancer. |
2011-11-23 |
2023-08-12 |
mouse |
| Lisa Woodbine, H Brunton, A A Goodarzi, A Shibata, P A Jegg. Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repair. Nucleic acids research. vol 39. issue 16. 2011-11-22. PMID:21596788. |
ataxia telangiectasia (atm) mutated and artemis, the proteins defective in ataxia telangiectasia and a class of radiosensitive-severe combined immunodeficiency (rs-scid), respectively, function in the repair of dna double strand breaks (dsbs), which arise in heterochromatic dna (hc-dsbs) following exposure to ionizing radiation (ir). |
2011-11-22 |
2023-08-12 |
mouse |