| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zbigniew Darzynkiewicz, Frank Traganos, Hong Zhao, H Dorota Halicka, Joanna Skommer, Donald Wlodkowi. Analysis of individual molecular events of DNA damage response by flow- and image-assisted cytometry. Methods in cell biology. vol 103. 2011-11-07. PMID:21722802. |
examples of cytometric detection of activation of ataxia telangiectasia mutated (atm), and check 2 (chk2) protein kinases using phospho-specific abs targeting ser1981 and thr68 of these proteins, respectively are also presented. |
2011-11-07 |
2023-08-12 |
Not clear |
| Eric J Gapud, Barry P Sleckma. Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell cycle (Georgetown, Tex.). vol 10. issue 12. 2011-11-02. PMID:21673501. |
the ataxia telangiectasia mutated (atm) and the dna-dependent protein kinase catalytic subunit (dna-pkcs), two related kinases, both function in the repair of dna breaks generated during antigen receptor gene assembly. |
2011-11-02 |
2023-08-12 |
Not clear |
| Isabella M Toller, Kai J Neelsen, Martin Steger, Mara L Hartung, Michael O Hottiger, Manuel Stucki, Behnam Kalali, Markus Gerhard, Alessandro A Sartori, Massimo Lopes, Anne Mülle. Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 36. 2011-11-02. PMID:21896770. |
the dna discontinuities trigger a damage-signaling and repair response involving the sequential ataxia telangiectasia mutated (atm)-dependent recruitment of repair factors--p53-binding protein (53bp1) and mediator of dna damage checkpoint protein 1 (mdc1)--and histone h2a variant x (h2ax) phosphorylation. |
2011-11-02 |
2023-08-12 |
human |
| Zbigniew Darzynkiewicz, H Dorota Halicka, Hong Zhao, Monika Podhoreck. Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry. Methods in molecular biology (Clifton, N.J.). vol 761. 2011-11-01. PMID:21755443. |
the protocol presented in this chapter describes the methodology of assessment of phosphorylation of histone h2ax-ser139, atm/atr substrate on ser/thr at sq/tq cluster domains as well as ataxia telangiectasia mutated (atm) protein kinase in cells treated with inhibitors of dna replication. |
2011-11-01 |
2023-08-12 |
Not clear |
| Cerrone R Foster, Mahipal Singh, Venkateswaran Subramanian, Krishna Sing. Ataxia telangiectasia mutated kinase plays a protective role in β-adrenergic receptor-stimulated cardiac myocyte apoptosis and myocardial remodeling. Molecular and cellular biochemistry. vol 353. issue 1-2. 2011-10-18. PMID:21404020. |
here we investigated expression of various apoptosis-related genes affected by β-ar stimulation, and examined first time the role of ataxia telangiectasia mutated kinase (atm) in cardiac myocyte apoptosis and myocardial remodeling following β-ar stimulation. |
2011-10-18 |
2023-08-12 |
mouse |
| Eric J Gapud, Baeck-Seung Lee, Grace K Mahowald, Craig H Bassing, Barry P Sleckma. Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. Journal of immunology (Baltimore, Md. : 1950). vol 187. issue 4. 2011-09-29. PMID:21742970. |
ataxia telangiectasia mutated (atm) and dna-dependent protein kinase catalytic subunits (dna-pkcs) are members of the phosphatidylinositol 3-like family of serine/threonine kinases that phosphorylate serines or threonines when positioned adjacent to a glutamine residue (sq/tq). |
2011-09-29 |
2023-08-12 |
Not clear |
| A Reiman, V Srinivasan, G Barone, J I Last, L L Wootton, E G Davies, M M Verhagen, M A Willemsen, C M Weemaes, P J Byrd, L Izatt, D F Easton, D J Thompson, A M Taylo. Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours. British journal of cancer. vol 105. issue 4. 2011-09-26. PMID:21792198. |
lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual atm kinase activity against childhood tumours. |
2011-09-26 |
2023-08-12 |
Not clear |
| A Reiman, V Srinivasan, G Barone, J I Last, L L Wootton, E G Davies, M M Verhagen, M A Willemsen, C M Weemaes, P J Byrd, L Izatt, D F Easton, D J Thompson, A M Taylo. Lymphoid tumours and breast cancer in ataxia telangiectasia; substantial protective effect of residual ATM kinase activity against childhood tumours. British journal of cancer. vol 105. issue 4. 2011-09-26. PMID:21792198. |
immunodeficiency in ataxia telangiectasia (a-t) is less severe in patients expressing some mutant or normal atm kinase activity. |
2011-09-26 |
2023-08-12 |
Not clear |
| Lei Guo, Xiaojun Liu, Yingjun Jiang, Kiyohiro Nishikawa, William Plunket. DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor. Molecular pharmacology. vol 80. issue 2. 2011-09-16. PMID:21546556. |
dna-dependent protein kinase and ataxia telangiectasia mutated (atm) promote cell survival in response to nk314, a topoisomerase iiα inhibitor. |
2011-09-16 |
2023-08-12 |
Not clear |
| Lei Guo, Xiaojun Liu, Yingjun Jiang, Kiyohiro Nishikawa, William Plunket. DNA-dependent protein kinase and ataxia telangiectasia mutated (ATM) promote cell survival in response to NK314, a topoisomerase IIα inhibitor. Molecular pharmacology. vol 80. issue 2. 2011-09-16. PMID:21546556. |
clonogenic assays demonstrated a significant sensitization in nk314-treated cells deficient in dna-dependent protein kinase (dna-pk) catalytic subunit, ku80, ataxia telangiectasia mutated (atm), brca2, or xrcc3 compared with wild-type cells, indicating that both nonhomologous end-joining and homologous recombination dna repair pathways contribute to cell survival. |
2011-09-16 |
2023-08-12 |
Not clear |
| Yu-Jen Chiu, Mann-Jen Hour, Chi-Cheng Lu, Jing-Gung Chung, Sheng-Chu Kuo, Wen-Wen Huang, Hui-Jye Chen, Yi-An Jin, Jai-Sing Yan. Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 29. issue 9. 2011-09-12. PMID:21425328. |
hmj-30 induced early phosphorylation of p53(ser18) was through the activation of ataxia telangiectasia mutated (atm) in u-2 os cells. |
2011-09-12 |
2023-08-12 |
human |
| Jacquelyn J Bower, Yingchun Zhou, Tong Zhou, Dennis A Simpson, Sonnet J Arlander, Richard S Paules, Marila Cordeiro-Stone, William K Kaufman. Revised genetic requirements for the decatenation G2 checkpoint: the role of ATM. Cell cycle (Georgetown, Tex.). vol 9. issue 8. 2011-09-09. PMID:20372057. |
a re-evaluation of ataxia telangiectasia (at) cell lines using the mitotic entry assay indicated that atm was required for the decatenation g2 checkpoint. |
2011-09-09 |
2023-08-12 |
human |
| Ellen D Jorgensen, Hong Zhao, Frank Traganos, Anthony P Albino, Zbigniew Darzynkiewic. DNA damage response induced by exposure of human lung adenocarcinoma cells to smoke from tobacco- and nicotine-free cigarettes. Cell cycle (Georgetown, Tex.). vol 9. issue 11. 2011-09-09. PMID:20404482. |
in the present study, we observed that exposure of a549 cells to cs from t/n-free cigarettes induced a smoke-dose dependent ddr as evidenced by phosphorylation (activation) of the ataxia telangiectasia mutated (atm) protein kinase and of the histone h2ax (γh2ax). |
2011-09-09 |
2023-08-12 |
human |
| Susanne A Gatz, Limei Ju, Ralph Gruber, Eva Hoffmann, Antony M Carr, Zhao-Qi Wang, Cong Liu, Penny A Jegg. Requirement for DNA ligase IV during embryonic neuronal development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 27. 2011-09-09. PMID:21734301. |
ablation of dna non-homologous end-joining (nhej) proteins, xrcc4 or dna ligase iv (ligiv), confers ataxia telangiectasia mutated (atm)-dependent apoptosis predominantly in the iz. |
2011-09-09 |
2023-08-12 |
mouse |
| Kayoko Kawakami, Hiroshi Nishida, Naoto Tatewaki, Yuki Nakajima, Tetsuya Konishi, Masao Hirayam. Persimmon leaf extract inhibits the ATM activity during DNA damage response induced by Doxorubicin in A549 lung adenocarcinoma cells. Bioscience, biotechnology, and biochemistry. vol 75. issue 4. 2011-09-06. PMID:21512242. |
moreover, ple decreased the phosphorylation of atm (ataxia telangiectasia mutated) in a dose-dependent manner. |
2011-09-06 |
2023-08-12 |
Not clear |
| Xin Duan, Larissa Ponomareva, Sudhakar Veeranki, Ravichandran Panchanathan, Eric Dickerson, Divaker Choube. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Molecular cancer research : MCR. vol 9. issue 5. 2011-08-30. PMID:21471287. |
accordingly, increased constitutive levels of ifi16 and aim2 proteins in ataxia telangiectasia mutated (atm) hdfs were associated with the activation of the ifn signaling and increased levels of il-1β. |
2011-08-30 |
2023-08-12 |
human |
| Xiao-Peng Zhang, Feng Liu, Wei Wan. Two-phase dynamics of p53 in the DNA damage response. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 22. 2011-08-23. PMID:21576488. |
in our model, p53 pulses are recurrently driven by ataxia telangiectasia mutated (atm) pulses triggered by dna damage. |
2011-08-23 |
2023-08-12 |
Not clear |
| Javier G Pizarro, Jaume Folch, Felix Junyent, Ester Verdaguer, Carme Auladell, Carlos Beas-Zarate, Mercè Pallàs, Antoni Camin. Antiapoptotic effects of roscovitine on camptothecin-induced DNA damage in neuroblastoma cells. Apoptosis : an international journal on programmed cell death. vol 16. issue 5. 2011-08-16. PMID:21424556. |
the results show that cpt induces apoptosis through the activation of ataxia telangiectasia mutated (atm)-induced cell-cycle alteration in neuroblastoma b65 cells. |
2011-08-16 |
2023-08-12 |
Not clear |
| Andrew Robert Exley, Samantha Buckenham, Elizabeth Hodges, Robert Hallam, Phil Byrd, James Last, Claire Trinder, Susan Harris, Nicholas Screaton, Anthony P Williams, A Malcolm R Taylor, John M Shneerso. Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia. Clinical immunology (Orlando, Fla.). vol 140. issue 1. 2011-08-11. PMID:21459046. |
atm kinase modulates pathways implicated in premature ageing and atm genotype predicts survival, yet immunodeficiency in ataxia telangiectasia is regarded as mild and unrelated to age. |
2011-08-11 |
2023-08-12 |
Not clear |
| Ying Gao, Richard B Hayes, Wen-Yi Huang, Neil E Caporaso, Laurie Burdette, Meredith Yeager, Stephen J Chanock, Sonja I Bernd. DNA repair gene polymorphisms and tobacco smoking in the risk for colorectal adenomas. Carcinogenesis. vol 32. issue 6. 2011-08-11. PMID:21504893. |
among the top findings, an snp (rs17503908) in ataxia telangiectasia mutated (atm) was inversely related to adenoma risk (or = 0.75, 95% ci = 0.63-0.91). |
2011-08-11 |
2023-08-12 |
Not clear |