| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Izumi Horikawa, Kaori Fujita, Curtis C Harri. p53 governs telomere regulation feedback too, via TRF2. Aging. vol 3. issue 1. 2011-06-13. PMID:21266744. |
uncapped or dysfunctional telomeres are an endogenous dna damage that activates atm kinase (ataxia telangiectasia mutated) and then p53 to induce cellular senescence or apoptosis. |
2011-06-13 |
2023-08-12 |
Not clear |
| Shu-Chi Wang, Chu-Chiao Wu, Yuan-Yaw Wei, Ji-Hong Hong, Chi-Shiun Chian. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. International journal of radiation biology. vol 87. issue 4. 2011-06-01. PMID:21204616. |
to investigate the effects of ataxia telangiectasia mutated (atm)-regulated reactive oxygen species (ros) and cell death pathways on the response of u87mg glioma cells to ionising radiation (ir) and oxidative stress. |
2011-06-01 |
2023-08-12 |
human |
| Sharon Biton, Avi Ashkenaz. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell. vol 145. issue 1. 2011-05-27. PMID:21458669. |
upon dna damage, ataxia telangiectasia mutated (atm) kinase triggers multiple events to promote cell survival and facilitate repair. |
2011-05-27 |
2023-08-12 |
Not clear |
| Lie-Fen Shyur, Shu-Hua Lee, Shang-Tzen Chang, Chiu-Ping Lo, Yueh-Hsiung Kuo, Sheng-Yang Wan. Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 18. issue 1. 2011-05-24. PMID:20637573. |
our results show that taiwanin a time-dependently induced reactive oxygen species level and dna damage in mcf-7 cells, which were likely activated kinases ataxia telangiectasia mutated (atm) and checkpoint kinase (chk). |
2011-05-24 |
2023-08-12 |
Not clear |
| Kamyar Hadian, Daniel Krappman. Signals from the nucleus: activation of NF-kappaB by cytosolic ATM in the DNA damage response. Science signaling. vol 4. issue 156. 2011-05-20. PMID:21245467. |
the kinase ataxia telangiectasia mutated (atm) has a critical role in the activation of nf-κb in response to genotoxic stress. |
2011-05-20 |
2023-08-12 |
Not clear |
| Y Wang, Y Yu, A Tsuyada, X Ren, X Wu, K Stubblefield, E K Rankin-Gee, S E Wan. Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene. vol 30. issue 12. 2011-05-18. PMID:21102523. |
ataxia telangiectasia mutated (atm), a target gene of mir-181, exhibited reduced expression in mammospheres and upon tgf-β treatment. |
2011-05-18 |
2023-08-12 |
Not clear |
| Shu Kondo, Norbert Perrimo. A genome-wide RNAi screen identifies core components of the G₂-M DNA damage checkpoint. Science signaling. vol 4. issue 154. 2011-05-13. PMID:21205937. |
the checkpoint pathway transmits signals from the sites of dna damage to the cell cycle machinery through the evolutionarily conserved atm (ataxia telangiectasia mutated) and atr (atm- and rad3-related) kinase cascades. |
2011-05-13 |
2023-08-12 |
drosophila_melanogaster |
| Yi Zhong, Chutwadee Krisanapun, Seong-Ho Lee, Thararat Nualsanit, Carl Sams, Penchom Peungvicha, Seung Joon Bae. Molecular targets of apigenin in colorectal cancer cells: involvement of p21, NAG-1 and p53. European journal of cancer (Oxford, England : 1990). vol 46. issue 18. 2011-05-09. PMID:20709524. |
subsequently, we found that pro-apoptotic proteins (nag-1 and p53) and cell cycle inhibitor (p21) were induced in the presence of apigenin, and kinase pathways, including pkcδ and ataxia telangiectasia mutated (atm), play an important role in activating these proteins. |
2011-05-09 |
2023-08-12 |
mouse |
| Jelena Tomic, Brian Lichty, David E Spane. Aberrant interferon-signaling is associated with aggressive chronic lymphocytic leukemia. Blood. vol 117. issue 9. 2011-05-09. PMID:21205928. |
in chronic lymphocytic leukemia (cll) cells, the duration of ifn-mediated stat3 phosphorylation was found to exhibit significant interpatient variability and was prolonged in cells with high risk features, such as 11q- and 17p-deletions involving ataxia telangiectasia mutated (atm) and p53. |
2011-05-09 |
2023-08-12 |
Not clear |
| Rakesh Kumar, Clayton R Hunt, Arun Gupta, Suraj Nannepaga, Raj K Pandita, Jerry W Shay, Robert Bachoo, Thomas Ludwig, Dennis K Burns, Tej K Pandit. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 9. 2011-05-09. PMID:21321203. |
at patients have mutations in the ataxia telangiectasia mutated (atm) gene [savitsky et al. |
2011-05-09 |
2023-08-12 |
mouse |
| Pei-Hua Lu, Mu-Xin Wei, Shu-Ping Si, Xiao Liu, Wei Shen, Guo-Qing Tao, Min-Bin Che. Association between polymorphisms of the ataxia telangiectasia mutated gene and breast cancer risk: evidence from the current studies. Breast cancer research and treatment. vol 126. issue 1. 2011-05-05. PMID:20665102. |
epidemiological studies have evaluated the association between ataxia telangiectasia mutated (atm) gene polymorphisms and breast cancer risk. |
2011-05-05 |
2023-08-12 |
Not clear |
| Lin Cheng, Qiulian Wu, Zhi Huang, Olga A Guryanova, Qian Huang, Weinian Shou, Jeremy N Rich, Shideng Ba. L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1. The EMBO journal. vol 30. issue 5. 2011-05-05. PMID:21297581. |
l1cam regulates expression of nbs1, a critical component of the mre11-rad50-nbs1 (mrn) complex that activates ataxia telangiectasia mutated (atm) kinase and early checkpoint response. |
2011-05-05 |
2023-08-12 |
Not clear |
| Rajaneesh Anupam, Antara Datta, Matthew Kesic, Kari Green-Church, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Michael D Lairmor. Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21216954. |
human t-lymphotropic virus type 1 p30 interacts with reggamma and modulates atm (ataxia telangiectasia mutated) to promote cell survival. |
2011-05-04 |
2023-08-12 |
human |
| Rajaneesh Anupam, Antara Datta, Matthew Kesic, Kari Green-Church, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Michael D Lairmor. Human T-lymphotropic virus type 1 p30 interacts with REGgamma and modulates ATM (ataxia telangiectasia mutated) to promote cell survival. The Journal of biological chemistry. vol 286. issue 9. 2011-05-04. PMID:21216954. |
our data indicate that p30 specifically binds to cellular atm (ataxia telangiectasia mutated) and regγ (a nuclear 20 s proteasome activator). |
2011-05-04 |
2023-08-12 |
human |
| Ariel Bensimon, Alexander Schmidt, Yael Ziv, Ran Elkon, Shih-Ya Wang, David J Chen, Ruedi Aebersold, Yosef Shilo. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Science signaling. vol 3. issue 151. 2011-05-03. PMID:21139141. |
the main transducer of the dsb response is the nuclear protein kinase ataxia telangiectasia mutated (atm). |
2011-05-03 |
2023-08-12 |
human |
| Benjamin Barré, Olivier Coqueret, Neil D Perkin. Regulation of activity and function of the p52 NF-κB subunit following DNA damage. Cell cycle (Georgetown, Tex.). vol 9. issue 24. 2011-05-02. PMID:21131783. |
we have previously shown that after dna-damage, the p52 nf-kb subunit can function cooperatively with the p53 tumor suppressor to both repress and induce skp2 expression. however, the wider role and activation of p52 after dna-damage has not been determined. activation of nf-kb in response to dna break inducers can be mediated by atm (ataxia telangiectasia mutated)-dependent phosphorylation of nemo (nf-kb essential modulator), resulting in ikkβ mediated induction of the classical nf-kb pathway, leading to the induction of rela(p65)/p50 dimers. |
2011-05-02 |
2023-08-12 |
Not clear |
| Stephany J Veuger, Barbara W Durkac. Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation. DNA repair. vol 10. issue 2. 2011-05-02. PMID:21144805. |
ataxia telangiectasia mutated (atm) is a key regulator of the cellular response to dna double strand breaks (dsbs), and recent reports have demonstrated that atm is required for the activation of nf-κb following dna damage. |
2011-05-02 |
2023-08-12 |
mouse |
| A I Svirnovski, T F Serhiyenka, A M Kustanovich, P V Khlebko, V V Fedosenko, I B Taras, A V Baku. DNA-PK, ATM and MDR proteins inhibitors in overcoming fludarabine resistance in CLL cells. Experimental oncology. vol 32. issue 4. 2011-04-28. PMID:21270755. |
to perform the comparative study of the effects of dna-dependent protein kinase (dna-pk) inhibitors vanillin and nu7026, ataxia telangiectasia mutated kinase (atm)/ atm and rad3 related (atr) kinase inhibitor caffeine and multidrug resistance (mdr) protein modulator cyclosporine a (csa) on fludarabine resistant and sensitive lymphocytes from chronic lymphocytic leukemia (cll) patients. |
2011-04-28 |
2023-08-12 |
Not clear |
| Raffaella Di Micco, Gabriele Sulli, Miryana Dobreva, Michalis Liontos, Oronza A Botrugno, Gaetano Gargiulo, Roberto dal Zuffo, Valentina Matti, Giovanni d'Ario, Erica Montani, Ciro Mercurio, William C Hahn, Vassilis Gorgoulis, Saverio Minucci, Fabrizio d'Adda di Fagagn. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21336312. |
inactivation of atm (ataxia telangiectasia mutated) or p53 allows the proliferation of oncogene-expressing cells that retain increased heterochromatin induction. |
2011-04-27 |
2023-08-12 |
human |
| Sriram Bandi, Brigid Joseph, Ekaterine Berishvili, Rohit Singhania, Yao-Ming Wu, Kang Cheng, Sanjeev Gupt. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. The American journal of pathology. vol 178. issue 1. 2011-04-18. PMID:21224054. |
the expression of multiple hepatic genes was rapidly altered, including those representing pathways in oxidative/metabolic stress, inflammation, dna damage-repair, and ataxia telangiectasia mutant (atm) signaling pathways. |
2011-04-18 |
2023-08-12 |
mouse |