| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| K-W Lee, Y-S Tsai, F-Y Chiang, J-L Huang, K-Y Ho, Y-H Yang, W-R Kuo, M-K Chen, C-S Li. Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology. vol 22. issue 5. 2011-08-10. PMID:21127011. |
lower ataxia telangiectasia mutated (atm) mrna expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. |
2011-08-10 |
2023-08-12 |
Not clear |
| K-W Lee, Y-S Tsai, F-Y Chiang, J-L Huang, K-Y Ho, Y-H Yang, W-R Kuo, M-K Chen, C-S Li. Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology. vol 22. issue 5. 2011-08-10. PMID:21127011. |
ataxia telangiectasia mutated (atm) kinase is a critical regulator in initiating dna damage response and activating dna repair. |
2011-08-10 |
2023-08-12 |
Not clear |
| Takashi Sugihara, Hayato Murano, Masako Nakamura, Kazuaki Ichinohe, Kimio Tanak. Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway. Molecular cancer research : MCR. vol 9. issue 4. 2011-08-09. PMID:21357441. |
the ataxia telangiectasia mutated (atm)-p53 pathway is a well-known main signal transduction pathway for cellular responses, which is activated by γ-ray irradiation. |
2011-08-09 |
2023-08-12 |
mouse |
| Laurence M Wood, Surendran Sankar, Ryan E Reed, Arthur L Haas, Leroy F Liu, Peter McKinnon, Shyamal D Desa. A novel role for ATM in regulating proteasome-mediated protein degradation through suppression of the ISG15 conjugation pathway. PloS one. vol 6. issue 1. 2011-08-02. PMID:21298066. |
ataxia telangiectasia (a-t) is an inherited immunodeficiency disorder wherein mutation of the atm kinase is responsible for the a-t pathogenesis. |
2011-08-02 |
2023-08-12 |
mouse |
| Jeesun Kim, Jeon Hwangbo, Paul K Y Won. p38 MAPK-Mediated Bmi-1 down-regulation and defective proliferation in ATM-deficient neural stem cells can be restored by Akt activation. PloS one. vol 6. issue 1. 2011-08-02. PMID:21305053. |
a-t (ataxia telangiectasia) is a genetic disease caused by a mutation in the atm (a-t mutated) gene that leads to neurodegeneration. |
2011-08-02 |
2023-08-12 |
mouse |
| Michael G Kemp, Laura A Lindsey-Boltz, Aziz Sanca. The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. The Journal of biological chemistry. vol 286. issue 22. 2011-08-01. PMID:21487018. |
the dna damage response kinases dna-dependent protein kinase (dna-pk) and ataxia telangiectasia mutated (atm) are stimulated by bulky adduct-containing dna. |
2011-08-01 |
2023-08-12 |
human |
| Michael G Kemp, Laura A Lindsey-Boltz, Aziz Sanca. The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. The Journal of biological chemistry. vol 286. issue 22. 2011-08-01. PMID:21487018. |
using this cell-free system together with a variety of pharmacological, genetic, and biochemical approaches, we identified the dna damage response kinases dna-dependent protein kinase (dna-pk) and ataxia telangiectasia mutated (atm) as bulky dna damage-stimulated kinases that phosphorylate physiologically important residues on the checkpoint proteins p53, chk1, and rpa. |
2011-08-01 |
2023-08-12 |
human |
| Antje Krüger, Markus Ralse. ATM is a redox sensor linking genome stability and carbon metabolism. Science signaling. vol 4. issue 167. 2011-07-26. PMID:21467295. |
the kinase ataxia telangiectasia mutated (atm) regulates this metabolic shift in mammalian cells. |
2011-07-26 |
2023-08-12 |
Not clear |
| Irena Szumiel, Nicolas Fora. Chromatin acetylation, β-amyloid precursor protein and its binding partner FE65 in DNA double strand break repair. Acta biochimica Polonica. vol 58. issue 1. 2011-07-15. PMID:21403922. |
tip60 dependent activation of atm (ataxia telangiectasia mutated kinase) is an early event in the response to dna breakage. |
2011-07-15 |
2023-08-12 |
Not clear |
| Nicholas Willis, Nicholas Rhin. Regulation of DNA replication by the S-phase DNA damage checkpoint. Cell division. vol 4. 2011-07-14. PMID:19575778. |
this slowing was the first dna damage checkpoint response discovered and its study led to the discovery of the central checkpoint kinase, ataxia telangiectasia mutated (atm). |
2011-07-14 |
2023-08-12 |
Not clear |
| Jeong Ho Seok, Kyeong Ah Park, Hee Sun Byun, Minho Won, Sanghee Shin, Byung-Lyul Choi, Hyunji Lee, Young-Rae Kim, Jang Hee Hong, Jongsun Park, Gang Min Hu. Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 12. issue 4. 2011-07-14. PMID:19967054. |
our findings revealed that this sustained jnk activation was not mediated by the tnf (tumor necrosis factor) receptor signaling, but it required a functional atm (ataxia telangiectasia) activity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Zhiming Fang, Sergei Kozlov, Michael J McKay, Rick Woods, Geoff Birrell, Carl N Sprung, Dédée F Murrell, Kiran Wangoo, Linda Teng, John H Kearsley, Martin F Lavin, Peter H Graham, Raymond A Clark. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome integrity. vol 1. issue 1. 2011-07-14. PMID:20678261. |
in this respect, individuals with anomalies of the atm (ataxia telangiectasia) protein/gene are of particular interest as they may be at risk of both breast cancer and clinical radiosensitivity. |
2011-07-14 |
2023-08-12 |
Not clear |
| Jeff W Hill, Kristina Tansavatdi, Kristin L Lockett, Glenn O Allen, Cristiane Takita, Alan Pollack, Jennifer J H. Validation of the cell cycle G(2) delay assay in assessing ionizing radiation sensitivity and breast cancer risk. Cancer management and research. vol 1. 2011-07-14. PMID:21188122. |
our results suggest that cell cycle g(2) delay index may serve as the best parameter in assessing breast cancer risk, genetic regulation of ir-sensitivity, and mutations of ataxia telangiectasia mutated (atm) and tp53. |
2011-07-14 |
2023-08-12 |
Not clear |
| Shiyun Ling, Weei-Chin Li. EDD inhibits ATM-mediated phosphorylation of p53. The Journal of biological chemistry. vol 286. issue 17. 2011-07-14. PMID:21383020. |
we demonstrate that edd can physically interact with p53 and that this interaction blocks the phosphorylation of p53 by ataxia telangiectasia mutated (atm). |
2011-07-14 |
2023-08-12 |
Not clear |
| Dan-Xia Zhu, Wei Xu, Jian-Yong L. [Gene atm and chronic lymphocytic leukemia - review]. Zhongguo shi yan xue ye xue za zhi. vol 16. issue 5. 2011-07-12. PMID:18928637. |
the ataxia telangiectasia mutated gene (atm) is a tumor-suppressing gene, locates in the human chromosome 11q22-23. |
2011-07-12 |
2023-08-12 |
human |
| C T Cheung, R Singh, A R Yoon, M K Hasan, T Yaguchi, S C Kaul, C O Yun, R Wadhw. Molecular characterization of apoptosis induced by CARF silencing in human cancer cells. Cell death and differentiation. vol 18. issue 4. 2011-07-11. PMID:21052095. |
thus, we examined various cell death and survival pathways including the mitochondrial stress, ataxia telangiectasia mutated (atm)-atr, ras-map kinase and retinoblastoma cascades. |
2011-07-11 |
2023-08-12 |
mouse |
| Maria Giulia Bacalini, Debora Di Lonardo, Angela Catizone, Fabio Ciccarone, Tiziana Bruno, Michele Zampieri, Tiziana Guastafierro, Roberta Calabrese, Maurizio Fanciulli, Claudio Passananti, Paola Caiafa, Anna Real. Poly(ADP-ribosyl)ation affects stabilization of Che-1 protein in response to DNA damage. DNA repair. vol 10. issue 4. 2011-07-01. PMID:21317046. |
during the dna damage response, phosphorylation by ataxia telangiectasia mutated (atm) kinase and checkpoint kinase chk2 induces the stabilization of che-1 protein, which is critical for the maintenance of g2/m arrest. |
2011-07-01 |
2023-08-12 |
Not clear |
| Cameron J McDonald, Lesa Ostini, Daniel F Wallace, Abraham N John, Dianne J Watters, V Nathan Subramania. Iron loading and oxidative stress in the Atm-/- mouse liver. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 4. 2011-06-30. PMID:21292994. |
to investigate iron regulation in a-t, iron indexes, regulatory genes, and os markers were studied in livers of wild-type and ataxia telangiectasia mutated (atm) null mice on control or high-iron diets. |
2011-06-30 |
2023-08-12 |
mouse |
| Zhongfeng Wang, Baojie L. Mdm2 links genotoxic stress and metabolism to p53. Protein & cell. vol 1. issue 12. 2011-06-29. PMID:21213101. |
mdm2's oncogenic activity is mainly mediated by p53, which is activated by various stresses, especially genotoxic stress, via atm (ataxia telangiectasia mutated) and atr (atm and rad3-related). |
2011-06-29 |
2023-08-12 |
mouse |
| Claire M Connell, Atsushi Shibata, Laura A Tookman, Kyra M Archibald, Magdalena B Flak, Katrina J Pirlo, Michelle Lockley, Sally P Wheatley, Iain A McNeis. Genomic DNA damage and ATR-Chk1 signaling determine oncolytic adenoviral efficacy in human ovarian cancer cells. The Journal of clinical investigation. vol 121. issue 4. 2011-06-21. PMID:21383502. |
inhibition of ataxia telangiectasia and rad3-related checkpoint kinase 1 (atr-chk1), but not ataxia telangiectasia mutated (atm), promoted genomic dna damage and overreplication in resistant and partially sensitive cells. |
2011-06-21 |
2023-08-12 |
mouse |