| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shigeki Miyamot. Nuclear initiated NF-κB signaling: NEMO and ATM take center stage. Cell research. vol 21. issue 1. 2011-04-12. PMID:21187855. |
an example is a pathway that involves the dna damage-responsive kinase ataxia telangiectasia mutated (atm) and a series of post-translational modifications of nf-κb essential modulator (nemo) in the nucleus of a genotoxin-exposed cell. |
2011-04-12 |
2023-08-12 |
human |
| Akshar Y Patel, Todd M McDonald, Larry D Spears, James Kain Ching, Jonathan S Fishe. Ataxia telangiectasia mutated influences cytochrome c oxidase activity. Biochemical and biophysical research communications. vol 405. issue 4. 2011-04-11. PMID:21266166. |
cells lacking ataxia telangiectasia mutated (atm) have impaired mitochondrial function. |
2011-04-11 |
2023-08-12 |
mouse |
| Kaixin Zhou, Celine Bellenguez, Chris C A Spencer, Amanda J Bennett, Ruth L Coleman, Roger Tavendale, Simon A Hawley, Louise A Donnelly, Chris Schofield, Christopher J Groves, Lindsay Burch, Fiona Carr, Amy Strange, Colin Freeman, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Nicholas Craddock, Panos Deloukas, Serge Dronov, Audrey Duncanson, Sarah Edkins, Emma Gray, Sarah Hunt, Janusz Jankowski, Cordelia Langford, Hugh S Markus, Christopher G Mathew, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Nilesh J Samani, Richard Trembath, Ananth C Viswanathan, Nicholas W Wood, Lorna W Harries, Andrew T Hattersley, Alex S F Doney, Helen Colhoun, Andrew D Morris, Calum Sutherland, D Grahame Hardie, Leena Peltonen, Mark I McCarthy, Rury R Holman, Colin N A Palmer, Peter Donnelly, Ewan R Pearso. Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes. Nature genetics. vol 43. issue 2. 2011-03-31. PMID:21186350. |
in a combined meta-analysis, we identified a snp, rs11212617, associated with treatment success (n = 3,920, p = 2.9 × 10(-9), odds ratio = 1.35, 95% ci 1.22-1.49) at a locus containing atm, the ataxia telangiectasia mutated gene. |
2011-03-31 |
2023-08-12 |
rat |
| Eric J Gapud, Yair Dorsett, Bu Yin, Elsa Callen, Andrea Bredemeyer, Grace K Mahowald, Kazuo Q Omi, Laura M Walker, Jeffrey J Bednarski, Peter J McKinnon, Craig H Bassing, Andre Nussenzweig, Barry P Sleckma. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 5. 2011-03-23. PMID:21245316. |
ataxia telangiectasia mutated (atm) and dna-pkcs kinases have overlapping activities during chromosomal signal joint formation. |
2011-03-23 |
2023-08-12 |
Not clear |
| Eric J Gapud, Yair Dorsett, Bu Yin, Elsa Callen, Andrea Bredemeyer, Grace K Mahowald, Kazuo Q Omi, Laura M Walker, Jeffrey J Bednarski, Peter J McKinnon, Craig H Bassing, Andre Nussenzweig, Barry P Sleckma. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 5. 2011-03-23. PMID:21245316. |
rag dsbs are generated in g1-phase developing lymphocytes, where they activate the ataxia telangiectasia mutated (atm) and dna-pkcs kinases to orchestrate diverse cellular dna damage responses including dsb repair. |
2011-03-23 |
2023-08-12 |
Not clear |
| P Pawlikowska, I Leray, B de Laval, S Guihard, R Kumar, F Rosselli, F Porte. ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response. Cell death and differentiation. vol 17. issue 11. 2011-03-21. PMID:20467439. |
the iex-1 protein is rapidly induced by γ-irradiation, genotoxic agents or replication inhibitors, in a way dependent on ataxia telangiectasia mutated (atm) activity and is necessary for mcl-1 nuclear translocation. |
2011-03-21 |
2023-08-12 |
Not clear |
| Ludovic Deriano, Julie Chaumeil, Marc Coussens, Asha Multani, YiFan Chou, Alexander V Alekseyenko, Sandy Chang, Jane A Skok, David B Rot. The RAG2 C terminus suppresses genomic instability and lymphomagenesis. Nature. vol 471. issue 7336. 2011-03-21. PMID:21368836. |
defects in dna damage response factors such as ataxia telangiectasia mutated (atm) protein and combined deficiencies in classical non-homologous end joining and p53 predispose to rag-initiated genomic rearrangements and lymphomagenesis. |
2011-03-21 |
2023-08-12 |
mouse |
| Claudia Cosentino, Domenico Grieco, Vincenzo Costanz. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. The EMBO journal. vol 30. issue 3. 2011-03-17. PMID:21157431. |
ataxia telangiectasia (a-t) is a human disease caused by atm deficiency characterized among other symptoms by radiosensitivity, cancer, sterility, immunodeficiency and neurological defects. |
2011-03-17 |
2023-08-12 |
human |
| Sang-Ah Lee, Kyoung-Mu Lee, Seung-Joon Lee, Keun-Young Yoo, Sue Kyung Park, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kan. Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk. Nutrition and cancer. vol 62. issue 8. 2011-03-08. PMID:21058196. |
antioxidant vitamins intake, ataxia telangiectasia mutated (atm) genetic polymorphisms, and breast cancer risk. |
2011-03-08 |
2023-08-12 |
Not clear |
| Sang-Ah Lee, Kyoung-Mu Lee, Seung-Joon Lee, Keun-Young Yoo, Sue Kyung Park, Dong-Young Noh, Sei-Hyun Ahn, Daehee Kan. Antioxidant vitamins intake, ataxia telangiectasia mutated (ATM) genetic polymorphisms, and breast cancer risk. Nutrition and cancer. vol 62. issue 8. 2011-03-08. PMID:21058196. |
ataxia telangiectasia mutated (atm) cells exist under a constant state of oxidative stress with high levels of reactive oxygen species, which are removed by cellular antioxidant vitamins. |
2011-03-08 |
2023-08-12 |
Not clear |
| Serah Choi, Armin M Gamper, Jason S White, Christopher J Bakkenis. Inhibition of ATM kinase activity does not phenocopy ATM protein disruption: implications for the clinical utility of ATM kinase inhibitors. Cell cycle (Georgetown, Tex.). vol 9. issue 20. 2011-03-07. PMID:20953138. |
biallelic mutations in ataxia-telangiectasia mutated (atm), which encodes for a protein kinase, cause ataxia telangiectasia (a-t). |
2011-03-07 |
2023-08-12 |
Not clear |
| Aaron A Goodarzi, Penny Jeggo, Markus Lobric. The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA repair. vol 9. issue 12. 2011-03-02. PMID:21036673. |
dna non-homologous end-joining (nhej) and homologous recombination (hr) represent the major dna double strand break (dsb) pathways in mammalian cells, whilst ataxia telangiectasia mutated (atm) lies at the core of the dsb signalling response. |
2011-03-02 |
2023-08-12 |
Not clear |
| Angela Alexander, Cheryl L Walke. Differential localization of ATM is correlated with activation of distinct downstream signaling pathways. Cell cycle (Georgetown, Tex.). vol 9. issue 18. 2011-02-17. PMID:20890104. |
atm, the gene mutated in the genetic disease ataxia telangiectasia (at), is a well-known protein involved in the dna double-strand break response, where it plays an important role in sensing damage and signaling to dna repair machinery and cell cycle checkpoints. |
2011-02-17 |
2023-08-12 |
Not clear |
| M Pedersen, S Tiong, S D Campbel. Molecular genetic characterization of Drosophila ATM conserved functional domains. Genome. vol 53. issue 10. 2011-02-17. PMID:20962884. |
in humans, loss of atm function is associated with ataxia telangiectasia, a neurodegenerative disease characterized by extreme sensitivity to dna damage. |
2011-02-17 |
2023-08-12 |
drosophila_melanogaster |
| Tae-Sun Kim, Makoto Kawaguchi, Mitsuko Suzuki, Cha-Gyun Jung, Kiyofumi Asai, Yuta Shibamoto, Martin F Lavin, Kum Kum Khanna, Yutaka Miur. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Disease models & mechanisms. vol 3. issue 11-12. 2011-02-14. PMID:20876357. |
ataxia telangiectasia (a-t) is a neurodegenerative disease caused by mutations in the large serine-threonine kinase atm. |
2011-02-14 |
2023-08-12 |
Not clear |
| Beth A Helmink, Anthony T Tubbs, Yair Dorsett, Jeffrey J Bednarski, Laura M Walker, Zhihui Feng, Girdhar G Sharma, Peter J McKinnon, Junran Zhang, Craig H Bassing, Barry P Sleckma. H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature. vol 469. issue 7329. 2011-02-11. PMID:21160476. |
moreover, the ataxia telangiectasia mutated (atm) kinase activates antagonistic pathways that modulate this resection. |
2011-02-11 |
2023-08-12 |
Not clear |
| Hwei-Chung Wang, Wen-Shin Chang, Ru-Yin Tsai, Chia-Wen Tsai, Liang-Chih Liu, Chen-Hsien Su, Hui-Ni Cheng, Yung-An Tsou, Shung-Shung Sun, Cheng-Chieh Lin, Da-Tian Ba. Association between ataxia telangiectasia mutated gene polymorphisms and breast cancer in Taiwanese females. Anticancer research. vol 30. issue 12. 2011-02-04. PMID:21187516. |
several epidemiological studies have investigated the association between ataxia telangiectasia mutated (atm) gene polymorphisms and breast cancer risk. |
2011-02-04 |
2023-08-12 |
Not clear |
| Elias A Rahal, Leigh A Henricksen, Yuling Li, R Scott Williams, John A Tainer, Kathleen Dixo. ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining. Cell cycle (Georgetown, Tex.). vol 9. issue 14. 2011-02-03. PMID:20647759. |
the human disorder ataxia telangiectasia (at), which is characterized by genetic instability and neurodegeneration, results from mutation of the ataxia telangiectasia mutated (atm) kinase. |
2011-02-03 |
2023-08-12 |
human |
| Marielle Ousset, Fanny Bouquet, Frédérique Fallone, Denis Biard, Cedric Dray, Philippe Valet, Bernard Salles, Catherine Mulle. Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease. Cell cycle (Georgetown, Tex.). vol 9. issue 14. 2011-02-03. PMID:20676049. |
the gene mutated in this disease, atm (ataxia telangiectasia mutated), encodes a protein kinase involved in dna double strand breaks signalling and repair. |
2011-02-03 |
2023-08-12 |
human |
| Mitsuaki Ojima, Asahi Furutani, Nobuhiko Ban, Michiaki Ka. Persistence of DNA double-strand breaks in normal human cells induced by radiation-induced bystander effect. Radiation research. vol 175. issue 1. 2011-01-20. PMID:21175351. |
we examined the generation of dsbs in cells by enumeration of phosphorylated ataxia telangiectasia mutated (atm) foci, which are correlated with dsb repair, in normal human fibroblast cells (mrc-5) after x irradiation at doses ranging from 1 to 1000 mgy. |
2011-01-20 |
2023-08-12 |
human |