| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rong Chen, William Plunket. Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia. Best practice & research. Clinical haematology. vol 23. issue 1. 2011-01-13. PMID:20620979. |
as their actions are independent of p53 or ataxia telangiectasia mutated (atm) function, agents that act by such mechanisms are promising to overcome resistance to current cll therapy. |
2011-01-13 |
2023-08-12 |
Not clear |
| Victoria J Weston, Ceri E Oldreive, Anna Skowronska, David G Oscier, Guy Pratt, Martin J S Dyer, Graeme Smith, Judy E Powell, Zbigniew Rudzki, Pamela Kearns, Paul A H Moss, A Malcolm R Taylor, Tatjana Stankovi. The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Blood. vol 116. issue 22. 2011-01-13. PMID:20739657. |
the ataxia telangiectasia mutated (atm) gene is frequently inactivated in lymphoid malignancies such as chronic lymphocytic leukemia (cll), t-prolymphocytic leukemia (t-pll), and mantle cell lymphoma (mcl) and is associated with defective apoptosis in response to alkylating agents and purine analogues. |
2011-01-13 |
2023-08-12 |
Not clear |
| Yanrong Su, Jarah A Meador, Charles R Geard, Adayabalam S Balaje. Analysis of ionizing radiation-induced DNA damage and repair in three-dimensional human skin model system. Experimental dermatology. vol 19. issue 8. 2011-01-06. PMID:19650866. |
53bp1 and phosphorylated ataxia telangiectasia mutated(ser1981) (atm(ser1981)). |
2011-01-06 |
2023-08-12 |
human |
| Majid Momeny, Majid Zakidizaji, Reza Ghasemi, Ahmad R Dehpour, Maryam Rahimi-Balaei, Yassan Abdolazimi, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed H Ghaffar. Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Medical oncology (Northwood, London, England). vol 27. issue 3. 2010-12-30. PMID:19763917. |
in addition, an expressive enhancement in mrna levels of p73, cyclin-dependent kinase inhibitor 1a (p21), tumor protein 53-induced nuclear protein 1 (tp53inp1), wnk lysine deficient protein kinase 2 (wnk2) and lipocalin 2 coupled with a significant reduction in transcriptional levels of nf-kappab inhibitor beta (ikk2), nemo, bcl2-like 1 (bcl-x(l)), inhibitor of apoptosis protein 1 (ciap2), x-linked inhibitor of apoptosis protein (xiap), survivin, bcl-2, tip60, ataxia telangiectasia (atm), shp-2 and sirtuin (sirt1) were observed. |
2010-12-30 |
2023-08-12 |
human |
| Nnennaya Kanu, Kay Penicud, Mariya Hristova, Barnaby Wong, Elaine Irvine, Florian Plattner, Gennadij Raivich, Axel Behren. The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain. The Journal of biological chemistry. vol 285. issue 49. 2010-12-30. PMID:20889973. |
atm mutations cause the genetic disorder ataxia telangiectasia, which is primarily characterized by progressive neurodegeneration and cancer susceptibility. |
2010-12-30 |
2023-08-12 |
mouse |
| Hakan Cam, John B Easton, Anthony High, Peter J Houghto. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Molecular cell. vol 40. issue 4. 2010-12-30. PMID:21095582. |
here we show that hypoxia results in ataxia telangiectasia mutated (atm)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (hif-1α) on serine(696) and mediates downregulation of mtorc1 signaling. |
2010-12-30 |
2023-08-12 |
Not clear |
| Raina A Tamakawa, Helen B Fleisig, Judy M Y Won. Telomerase inhibition potentiates the effects of genotoxic agents in breast and colorectal cancer cells in a cell cycle-specific manner. Cancer research. vol 70. issue 21. 2010-12-21. PMID:20837664. |
notably, inhibition of ataxia telangiectasia mutated (atm) kinase, together with telomerase inhibition, synergistically increases the cytotoxicity induced by the g(2)-specific topoisomerase ii inhibitor etoposide. |
2010-12-21 |
2023-08-12 |
Not clear |
| Hung-Yi Chen, Hsu-Feng Lu, Jai-Sing Yang, Sheng-Chu Kuo, Chyi Lo, Mei-Due Yang, Tsan-Hung Chiu, Fu-Shin Chueh, Heng-Chien Ho, Yang-Ching Ko, Jing-Gung Chun. The novel quinolone CHM-1 induces DNA damage and inhibits DNA repair gene expressions in a human osterogenic sarcoma cell line. Anticancer research. vol 30. issue 10. 2010-12-10. PMID:21036739. |
real-time pcr analysis showed that treatment with 3 μm of chm-1 for 24 h reduced the mrna expression levels of ataxia telangiectasia mutated (atm), ataxia-telangiectasia and rad3-related (atr), breast cancer 1, early onset (brca1), 14-3-3sigma (14-3-3σ), dna-dependent serine/threonine protein kinase (dna-pk) and o(6)-methylguanine-dna methyltransferase (mgmt) genes in a time-dependent manner. |
2010-12-10 |
2023-08-12 |
human |
| Antonio F Santidrián, Diana M González-Gironès, Daniel Iglesias-Serret, Llorenç Coll-Mulet, Ana M Cosialls, Mercè de Frias, Clara Campàs, Eva González-Barca, Esther Alonso, Verena Labi, Benoit Viollet, Adalberto Benito, Gabriel Pons, Andreas Villunger, Joan Gi. AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. Blood. vol 116. issue 16. 2010-11-29. PMID:20664053. |
importantly, aicar induced apoptosis irrespective of the tumor suppressor tp53 or ataxia telangiectasia mutated (atm) status via induction of the mitochondrial pathway. |
2010-11-29 |
2023-08-12 |
mouse |
| Yongmei Qi, Norberta W Schoene, Frederick M Lartey, Wen-Hsing Chen. Selenium compounds activate ATM-dependent DNA damage response via the mismatch repair protein hMLH1 in colorectal cancer cells. The Journal of biological chemistry. vol 285. issue 43. 2010-11-24. PMID:20709753. |
the atm (ataxia telangiectasia mutated) protein responds to clastogens and initiates dna damage response. |
2010-11-24 |
2023-08-12 |
Not clear |
| James Kain Ching, Pooja Rajguru, Nandhini Marupudi, Sankha Banerjee, Jonathan S Fishe. A role for AMPK in increased insulin action after serum starvation. American journal of physiology. Cell physiology. vol 299. issue 5. 2010-11-22. PMID:20810907. |
we hypothesized that factors known to potentiate insulin action [e.g., amp-activated protein kinase (ampk) and p38] or to be involved in insulin signaling leading to glucose transport [e.g., akt, pkcζ, as160, and ataxia telangiectasia mutated (atm)] would be phosphorylated during serum starvation and would be responsible for increased insulin action after serum starvation. |
2010-11-22 |
2023-08-12 |
Not clear |
| Antoni Camins, Javier G Pizarro, Daniel Alvira, Javier Gutierrez-Cuesta, Aurelio Vazquez de la Torre, Jaume Folch, Francesc X Sureda, Ester Verdaguer, Felix Junyent, Joaquín Jordán, Isidre Ferrer, Mercè Pallà. Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease. Cellular and molecular life sciences : CMLS. vol 67. issue 22. 2010-11-16. PMID:20502937. |
in the present study we demonstrated that neurotoxin mpp(+)-induced dna damage is followed by ataxia telangiectasia muted (atm) activation either in cerebellar granule cells (cgc) or in b65 cell line. |
2010-11-16 |
2023-08-12 |
human |
| b' Venturina Stagni, Michele Mingardi, Simonetta Santini, Danilo Giaccari, Daniela Baril\\xc3\\xa. ATM kinase activity modulates cFLIP protein levels: potential interplay between DNA damage signalling and TRAIL-induced apoptosis. Carcinogenesis. vol 31. issue 11. 2010-11-16. PMID:20876284.' |
we have recently identified ataxia telangiectasia mutated (atm) as a modulator of cflip(l) and cflip(s) protein levels in the dna damage response. |
2010-11-16 |
2023-08-12 |
Not clear |
| Chris T Williamson, Huong Muzik, Ali G Turhan, Alberto Zamò, Mark J O'Connor, D Gwyn Bebb, Susan P Lees-Mille. ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Molecular cancer therapeutics. vol 9. issue 2. 2010-11-10. PMID:20124459. |
the ataxia telangiectasia mutated (atm) gene is altered in several human cancers including mantle cell lymphoma (mcl). |
2010-11-10 |
2023-08-12 |
mouse |
| Gitanjali Jayachandran, Kentaro Ueda, Bingbing Wang, Jack A Roth, Lin J. NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. PloS one. vol 5. issue 8. 2010-11-04. PMID:20700484. |
nprl2 can phosphorylate ataxia telangiectasia mutated (atm) kinase activated by cisplatin and promote downstream gamma-h2ax formation in vitro and in vivo, which occurs during apoptosis concurrently with the initial appearance of high-molecular-weight dna fragments. |
2010-11-04 |
2023-08-12 |
mouse |
| Michael Hinz, Michael Stilmann, Seda Çöl Arslan, Kum Kum Khanna, Gunnar Dittmar, Claus Scheiderei. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activation. Molecular cell. vol 40. issue 1. 2010-11-01. PMID:20932475. |
the dna strand break sensor poly(adp-ribose)-polymerase-1 (parp-1) and the kinase ataxia telangiectasia mutated (atm) act as proximal signal mediators. |
2010-11-01 |
2023-08-12 |
Not clear |
| Mounia Alaoui-El-Azher, Jeffrey J Mans, Henry V Baker, Casey Chen, Ann Progulske-Fox, Richard J Lamont, Martin Handfiel. Role of the ATM-checkpoint kinase 2 pathway in CDT-mediated apoptosis of gingival epithelial cells. PloS one. vol 5. issue 7. 2010-10-28. PMID:20668524. |
western analysis, pharmacological inhibition and sirna silencing were performed in human immortalized gingival keratinocytes (higk) to dissect the functional role of the ataxia telangiectasia mutated (atm) pathway in the signal transduction steps triggered by the cdt. |
2010-10-28 |
2023-08-12 |
human |
| Monika Podhorecka, Dorota Halicka, Piotr Klimek, Malgorzata Kowal, Sylwia Chocholska, Anna Dmoszynsk. Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Annals of hematology. vol 89. issue 11. 2010-10-25. PMID:20499237. |
we analyzed expression of active caspase-3 and the bcl-2/bax ratio as markers of apoptosis and the expression of phosphorylated histone h2ax (named γh2ax) and activated atm kinase (ataxia telangiectasia mutated kinase), reporters of dna damage. |
2010-10-25 |
2023-08-12 |
Not clear |
| Jaime Lopez-Mosqueda, Nancy L Maas, Zophonias O Jonsson, Lisa G Defazio-Eli, James Wohlschlegel, David P Toczysk. Damage-induced phosphorylation of Sld3 is important to block late origin firing. Nature. vol 467. issue 7314. 2010-10-22. PMID:20865002. |
human cells derived from patients with ataxia telangiectasia are deficient in this process due to the lack of a functional ataxia telangiectasia mutated (atm) kinase and elicit radioresistant dna synthesis after γ-irradiation(2). |
2010-10-22 |
2023-08-12 |
human |
| Babak Razani, Chu Feng, Clay F Semenkovic. p53 is required for chloroquine-induced atheroprotection but not insulin sensitization. Journal of lipid research. vol 51. issue 7. 2010-10-18. PMID:20208057. |
atm, mutated in ataxia telangiectasia, is critical for the genotoxic stress response, and its deficiency is associated with accelerated atherosclerosis and insulin resistance in humans and mice. |
2010-10-18 |
2023-08-12 |
mouse |