| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ziqiu Wang, Meifang Wang, Sid Kar, Brian I Car. Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. Journal of cellular physiology. vol 221. issue 1. 2009-08-28. PMID:19530246. |
we found that hkh40a activated ataxia telangiectasia mutated (atm) kinase, which then triggered activation of the chk1/2 signaling pathway, evidenced by chk1/2 mediated inhibitory phosphorylation of cdc25c protein phosphatase. |
2009-08-28 |
2023-08-12 |
Not clear |
| Marta Tajes Orduña, Carme Pelegrí Gabalda, Jordi Vilaplana Hortensi, Mercè Pallàs Lliberia, Antoni Camins Espun. An evaluation of the neuroprotective effects of melatonin in an in vitro experimental model of age-induced neuronal apoptosis. Journal of pineal research. vol 46. issue 3. 2009-08-17. PMID:19196437. |
in this model of aging, apoptosis was associated with an elevated dna damage, as demonstrated by an increase in the activation of ataxia telangiectasia muted (atm). |
2009-08-17 |
2023-08-12 |
Not clear |
| Nozomi Tomimatsu, Bipasha Mukherjee, Sandeep Burm. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO reports. vol 10. issue 6. 2009-08-13. PMID:19444312. |
the cellular response to dna double-strand breaks involves direct activation of ataxia telangiectasia mutated (atm) and indirect activation of ataxia telangiectasia and rad3 related (atr) in an atm/mre11/cell-cycle-dependent manner. |
2009-08-13 |
2023-08-12 |
Not clear |
| C Chargari, Y M Kirova, C Even, L Monnier, R Dendale, F Campana, A Fourque. [Adjuvant irradiation in breast cancer patients with ATM gene heterozygous mutations: special focus on clinical efficacy/toxicity]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. vol 13. issue 3. 2009-08-04. PMID:19162519. |
dysfunction of the ataxia telangiectasia mutated (atm) gene has been related to defective cell cycle control and genomic instability due to the impaired repair of dna double strand breaks. |
2009-08-04 |
2023-08-12 |
Not clear |
| Nazmul Huda, Hiromi Tanaka, Marc S Mendonca, David Gille. DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair. Molecular and cellular biology. vol 29. issue 13. 2009-07-30. PMID:19398584. |
previous results suggested a link between the transient induction of human trf2 phosphorylation at threonine 188 (t188) by the ataxia telangiectasia mutated protein kinase (atm) and the dna damage response. |
2009-07-30 |
2023-08-12 |
human |
| Kerry A George, Megumi Hada, Lori J Jackson, Todd Elliott, Tetsuya Kawata, Janice M Pluth, Francis A Cucinott. Dose response of gamma rays and iron nuclei for induction of chromosomal aberrations in normal and repair-deficient cell lines. Radiation research. vol 171. issue 6. 2009-07-30. PMID:19580482. |
the cell lines included fibroblasts deficient in atm (product of the gene that is mutated in ataxia telangiectasia patients) or nbs (product of the gene mutated in the nijmegen breakage syndrome) and gliomablastoma cells proficient in or lacking dna-dependent protein kinase (dna-pk) activity. |
2009-07-30 |
2023-08-12 |
Not clear |
| Lee J Martin, Zhiping Liu, Jacqueline Pipino, Barry Chestnut, Melissa A Lande. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cerebral cortex (New York, N.Y. : 1991). vol 19. issue 6. 2009-07-28. PMID:18820287. |
p53 phosphorylation is mediated by ataxia telangiectasia mutated (atm) kinase. |
2009-07-28 |
2023-08-12 |
mouse |
| Yulong Liang, Shiaw-Yih Lin, F Charles Brunicardi, John Goss, Kaiyi L. DNA damage response pathways in tumor suppression and cancer treatment. World journal of surgery. vol 33. issue 4. 2009-07-16. PMID:19034564. |
at the level of sensors, atm (ataxia telangiectasia mutated) and atr (atm-rad3-related) are proximal kinases that act as the core sensors of and are central to the entire ddr. |
2009-07-16 |
2023-08-12 |
human |
| Fabio Gentilini, Maria Elena Turba, Monica Forni, Stefano Cinott. Complete sequencing of full-length canine ataxia telangiectasia mutated mRNA and characterization of its putative promoter. Veterinary immunology and immunopathology. vol 128. issue 4. 2009-07-14. PMID:19131117. |
ataxia telangiectasia mutated (atm) protein is considered a "caretaker" of the genome integrity and a defective atm has been correlated with increased cancer risk in human beings. |
2009-07-14 |
2023-08-12 |
human |
| H Dorota Halicka, Vadim Mitlitski, Julie Heeter, Endre A Balazs, Zbigniew Darzynkiewic. Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan. International journal of molecular medicine. vol 23. issue 5. 2009-07-09. PMID:19360330. |
we recently reported that dna damage in pma-treated leukocytes is assessed by cytometric analysis of the induction of histone h2ax phosphorylation and ataxia telangiectasia mutated (atm) activation. |
2009-07-09 |
2023-08-12 |
human |
| Lan Shao, Hiroshi Fujii, Inés Colmegna, Hisashi Oishi, Jörg J Goronzy, Cornelia M Weyan. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. The Journal of experimental medicine. vol 206. issue 6. 2009-07-07. PMID:19451263. |
ra t cells failed to produce sufficient transcripts and protein of the dna repair kinase ataxia telangiectasia (at) mutated (atm). |
2009-07-07 |
2023-08-12 |
Not clear |
| Vladimir N Ivanov, Hongning Zhou, Michael A Partridge, Tom K He. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer research. vol 69. issue 8. 2009-06-19. PMID:19351839. |
the aim of the present study was to elucidate the effects of ataxia telangiectasia mutated (atm) kinase on the regulation of the extrinsic tumor necrosis factor-related apoptosis-inducing ligand (trail) receptor 2/dr5-mediated death pathway in human melanoma cells. |
2009-06-19 |
2023-08-12 |
human |
| Orban Komonyi, Tamas Schauer, Gabor Papai, Peter Deak, Imre M Boro. A product of the bicistronic Drosophila melanogaster gene CG31241, which also encodes a trimethylguanosine synthase, plays a role in telomere protection. Journal of cell science. vol 122. issue Pt 6. 2009-06-15. PMID:19240120. |
in contrast to atr kinase, mutations of atm (ataxia telangiectasia mutated) kinase, which acts in a partially overlapping pathway of telomere protection, do not suppress formation of telomere associations in the absence of dtl. |
2009-06-15 |
2023-08-12 |
drosophila_melanogaster |
| Yan Pan, Dexiao Yuan, Junxiang Zhang, Ping Xu, Honghong Chen, Chunlin Sha. Cadmium-induced adaptive response in cells of Chinese hamster ovary cell lines with varying DNA repair capacity. Radiation research. vol 171. issue 4. 2009-05-29. PMID:19397445. |
this response of cells to a further challenge with cadmium or radiation may be mediated through the ataxia telangiectasia mutated (atm) pathway. |
2009-05-29 |
2023-08-12 |
Not clear |
| Gena J Nichols, Jerome Schaack, David A Ornelle. Widespread phosphorylation of histone H2AX by species C adenovirus infection requires viral DNA replication. Journal of virology. vol 83. issue 12. 2009-05-28. PMID:19321613. |
experiments with inhibitors of the serine-threonine kinases ataxia telangiectasia mutated (atm), at- and rad3-related (atr), and dna protein kinase (dna-pk), the kinases responsible for h2ax phosphorylation, indicate that h2ax may be phosphorylated by atr during a wild-type adenovirus infection, with some contribution from atm and dna-pk. |
2009-05-28 |
2023-08-12 |
Not clear |
| Rachel A Schwartz, Christian T Carson, Christine Schuberth, Matthew D Weitzma. Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase. Journal of virology. vol 83. issue 12. 2009-05-28. PMID:19339345. |
we detected autophosphorylation of the kinases ataxia telangiectasia mutated (atm) and dna-dependent protein kinase catalytic subunit (dna-pkcs) and signaling to downstream targets smc1, chk1, chk2, h2ax, and xrcc4 and multiple sites on rpa32. |
2009-05-28 |
2023-08-12 |
Not clear |
| Alessandra Soriani, Alessandra Zingoni, Cristina Cerboni, Maria Luisa Iannitto, Maria Rosaria Ricciardi, Valentina Di Gialleonardo, Marco Cippitelli, Cinzia Fionda, Maria Teresa Petrucci, Anna Guarini, Robin Foà, Angela Santon. ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype. Blood. vol 113. issue 15. 2009-05-07. PMID:19098271. |
drug-induced dnam-1 and nkg2d ligand expression was abolished after treatment with the atm (ataxia telangiectasia mutated) and atr (atm- and rad3-related) pharmacologic inhibitors caffeine and ku-55933, and was preferentially associated with senescent cells arrested in the g2 phase of the cell cycle. |
2009-05-07 |
2023-08-12 |
Not clear |
| Sandeep Misri, Shruti Pandita, Tej K Pandit. Detecting ATM-dependent chromatin modification in DNA damage and heat shock response. Methods in molecular biology (Clifton, N.J.). vol 523. 2009-05-06. PMID:19381924. |
the ataxia telangiectasia-mutated gene product (atm), whose loss of function is responsible for ataxia telangiectasia (a-t), is a protein kinase that interacts with several substrates and is implicated in mitogenic signal transduction, chromosome condensation, meiotic recombination, cell-cycle control and telomere maintenance (pandita, expert reviews in molecular medicine 5:1-21, 2003; pandita, oncogene 21:611-618, 2002; matsuoka et al., science 316:1160-1166, 2007). |
2009-05-06 |
2023-08-12 |
Not clear |
| Paul A Jowsey, Faith M Williams, Peter G Blai. DNA damage, signalling and repair after exposure of cells to the sulphur mustard analogue 2-chloroethyl ethyl sulphide. Toxicology. vol 257. issue 3. 2009-04-20. PMID:19111594. |
finally, cees was found to induce the phosphorylation of p53 and chk2 and these events were mediated by both the atm ataxia telangiectasia mutated and atr (atm and rad-3 related) protein kinases. |
2009-04-20 |
2023-08-12 |
human |
| Che-Jen Hsiao, Yunn-Fang Ho, John T-A Hsu, Wei-Ling Chang, Yi-Cheng Chen, Ya-Ching Shen, Ping-Chiang Lyu, Jih-Hwa Gu. Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. Naunyn-Schmiedeberg's archives of pharmacology. vol 378. issue 6. 2009-04-17. PMID:18663430. |
mana-hox stimulated an increase of ataxia telangiectasia mutated (atm) phosphorylation on ser-1981, indicating the induction of dna double-strand breaks. |
2009-04-17 |
2023-08-12 |
human |