| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Joanna D Friesner, Bo Liu, Kevin Culligan, Anne B Brit. Ionizing radiation-dependent gamma-H2AX focus formation requires ataxia telangiectasia mutated and ataxia telangiectasia mutated and Rad3-related. Molecular biology of the cell. vol 16. issue 5. 2005-09-19. PMID:15772150. |
the dependency of this phosphorylation on the various pi3k-related protein kinases (in mammals, ataxia telangiectasia mutated and rad3-related [atr], ataxia telangiectasia mutated [atm], and dna-pkcs) has been a subject of debate; it has been suggested that atm is required for the induction of foci at dsbs, whereas atr is involved in the recognition of stalled replication forks. |
2005-09-19 |
2023-08-12 |
human |
| Laura M McLaughlin, Bruce Dempl. Nitric oxide-induced apoptosis in lymphoblastoid and fibroblast cells dependent on the phosphorylation and activation of p53. Cancer research. vol 65. issue 14. 2005-09-14. PMID:16024610. |
pretreatment with the pi3k family inhibitors also led to a switch from no-induced apoptosis to necrosis, which implicates a pi3k-related kinase such as ataxia telangiectasia mutated (atm) or atr (atm and rad3 related) in p53-dependent no-induced apoptosis. |
2005-09-14 |
2023-08-12 |
mouse |
| Stephan Gasser, Sandra Orsulic, Eric J Brown, David H Raule. The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor. Nature. vol 436. issue 7054. 2005-09-08. PMID:15995699. |
here we show that mouse and human nkg2d ligands are upregulated in non-tumour cell lines by genotoxic stress and stalled dna replication, conditions known to activate a major dna damage checkpoint pathway initiated by atm (ataxia telangiectasia, mutated) or atr (atm- and rad3-related) protein kinases. |
2005-09-08 |
2023-08-12 |
mouse |
| Lily Q Dong, Feng Li. PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle. American journal of physiology. Endocrinology and metabolism. vol 289. issue 2. 2005-09-08. PMID:16014356. |
so far, at least 10 kinases have been suggested to function as an hm kinase or the so-called "pdk2," including mitogen-activated protein (map) kinase-activated protein kinase-2 (mk2), integrin-linked kinase (ilk), p38 map kinase, protein kinase calpha (pkcalpha), pkcbeta, the nima-related kinase-6 (nek6), the mammalian target of rapamycin (mtor), the double-stranded dna-dependent protein kinase (dnk-pk), and the ataxia telangiectasia mutated (atm) gene product. |
2005-09-08 |
2023-08-12 |
Not clear |
| J H Olsen, J M D Hahnemann, A-L Børresen-Dale, S Tretli, R Kleinerman, R Sankila, L Hammarström, T E Robsahm, H Kääriäinen, A Bregård, K Brøndum-Nielsen, J Yuen, M Tucke. Breast and other cancers in 1445 blood relatives of 75 Nordic patients with ataxia telangiectasia. British journal of cancer. vol 93. issue 2. 2005-08-18. PMID:15942625. |
a large proportion of the members of at families are carriers of at-causing gene mutations in atm (ataxia telangiectasia mutated), and it has been hypothesised that these otherwise healthy carriers are predisposed to breast cancer. |
2005-08-18 |
2023-08-12 |
Not clear |
| Hong-wei Tang, Jian-chao Bian, Feng Jiang, Qiang Shen, Qian-xi Zhu, Hong-wei Zhang, Yi W. [Single nucleotide polymorphisms and point mutations of ataxia telangiectasia mutated gene in Chinese of Han ethnicity]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 21. issue 6. 2005-08-17. PMID:15583986. |
to explore the single nucleotide polymorphisms (snps) and point mutations of ataxia telangiectasia mutated (atm) gene in chinese of han ethnicity. |
2005-08-17 |
2023-08-12 |
Not clear |
| Maki Hasegawa, Shuichi Yamaguchi, Shiro Aizawa, Hidetoshi Ikeda, Kouichi Tatsumi, Yuko Noda, Katsuiku Hirokawa, Masanobu Kitagaw. Resistance against Friend leukemia virus-induced leukemogenesis in DNA-dependent protein kinase (DNA-PK)-deficient scid mice associated with defective viral integration at the Spi-1 and Fli-1 site. Leukemia research. vol 29. issue 8. 2005-08-12. PMID:15978944. |
in contrast, the knockout of another member of the pi-3k-related protein kinase family, encoded by the ataxia telangiectasia mutated (atm) gene, resulted in mice as sensitive to flv-induced leukemogenesis as the wild type mice. |
2005-08-12 |
2023-08-12 |
mouse |
| Jean-Philip Truman, Nuri Gueven, Martin Lavin, Steven Leibel, Richard Kolesnick, Zvi Fuks, Adriana Haimovitz-Friedma. Down-regulation of ATM protein sensitizes human prostate cancer cells to radiation-induced apoptosis. The Journal of biological chemistry. vol 280. issue 24. 2005-07-19. PMID:15837784. |
here, we show that tpa functions to decrease the cellular level of the atm (ataxia telangiectasia mutated) protein, known to repress cs activation (liao, w.-c., haimovitz-friedman, a., persaud, r., mcloughlin, m., ehleiter, d., zhang, n., gatei, m., lavin, m., kolesnick, r., and fuks, z. |
2005-07-19 |
2023-08-12 |
human |
| Pierre-Olivier Frappart, Wei-Min Tong, Ilja Demuth, Ivan Radovanovic, Zdenko Herceg, Adriano Aguzzi, Martin Digweed, Zhao-Qi Wan. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nature medicine. vol 11. issue 5. 2005-07-12. PMID:15821748. |
furthermore, nbn-deficient neuroprogenitors show proliferation defects (but not increased apoptosis) and contain more chromosomal breaks, which are accompanied by ataxia telangiectasia mutated protein (atm)-mediated p53 activation. |
2005-07-12 |
2023-08-12 |
mouse |
| Kyoung-Mu Lee, Ji-Yeob Choi, Sue Kyung Park, Hye-Won Chung, Byungchan Ahn, Keun-Young Yoo, Wonshik Han, Dong-Young Noh, Sei-Hyun Ahn, Ho Kim, Qingyi Wei, Daehee Kan. Genetic polymorphisms of ataxia telangiectasia mutated and breast cancer risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. vol 14. issue 4. 2005-06-28. PMID:15824150. |
to evaluate the role of genetic polymorphisms of ataxia telangiectasia mutated (atm) in the etiology of breast cancer, a hospital-based case-control study was conducted in korea. |
2005-06-28 |
2023-08-12 |
Not clear |
| Deborah Thompson, Silvia Duedal, Jennifer Kirner, Lesley McGuffog, James Last, Anne Reiman, Philip Byrd, Malcolm Taylor, Douglas F Easto. Cancer risks and mortality in heterozygous ATM mutation carriers. Journal of the National Cancer Institute. vol 97. issue 11. 2005-06-28. PMID:15928302. |
homozygous or compound heterozygous mutations in the atm gene are the principal cause of ataxia telangiectasia (a-t). |
2005-06-28 |
2023-08-12 |
Not clear |
| Karen Flatten, Nga T Dai, Benjamin T Vroman, David Loegering, Charles Erlichman, Larry M Karnitz, Scott H Kaufman. The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons. The Journal of biological chemistry. vol 280. issue 14. 2005-06-21. PMID:15699047. |
previous studies have indicated that both the ataxia telangiectasia mutated (atm)/checkpoint kinase (chk) 2 and atm- and rad 3-related (atr)/chk1 checkpoint pathways are activated after treatment with these agents. |
2005-06-21 |
2023-08-12 |
human |
| Giuseppe Nunnari, Elias Argyris, Jianhua Fang, Ketti E Mehlman, Roger J Pomerantz, René Danie. Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines. Virology. vol 335. issue 2. 2005-06-07. PMID:15840517. |
these include dna-pk (dna-dependent protein kinase), atr (ataxia telangiectasia and rad3-related), and, at least in some circumstances, atm (ataxia telangiectasia mutated). |
2005-06-07 |
2023-08-12 |
human |
| Utpal K Mukhopadhyay, Adrian M Senderowicz, Gerardo Ferbeyr. RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells. Cancer research. vol 65. issue 7. 2005-05-26. PMID:15805289. |
to test this idea, we knocked down ataxia telangiectasia mutated (atm) gene by rna interference in prostate cancer cell lines and in normal human diploid fibroblasts imr90. |
2005-05-26 |
2023-08-12 |
human |
| Marie Fernet, Moez Gribaa, Mustafa A M Salih, Mohamed Zein Seidahmed, Janet Hall, Michel Koeni. Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Human molecular genetics. vol 14. issue 2. 2005-05-17. PMID:15574463. |
after exposure to ionizing radiation, a dose-dependent defect in ataxia telangiectasia mutated (atm)-serine 1981, p53-serine 15 and chk2 phosphorylation, and p53 stabilization were noted, together with a failure to form mre11 foci and enhanced radiation sensitivity. |
2005-05-17 |
2023-08-12 |
Not clear |
| Tom Stiff, Caroline Reis, Gemma K Alderton, Lisa Woodbine, Mark O'Driscoll, Penny A Jegg. Nbs1 is required for ATR-dependent phosphorylation events. The EMBO journal. vol 24. issue 1. 2005-04-18. PMID:15616588. |
nbs1, the protein defective in nbs, functions in ataxia telangiectasia mutated protein (atm)-dependent signalling likely facilitating atm phosphorylation events. |
2005-04-18 |
2023-08-12 |
Not clear |
| Ismail Hassan Ismail, Susanne Nyström, Jonas Nygren, Ola Hammarste. Activation of ataxia telangiectasia mutated by DNA strand break-inducing agents correlates closely with the number of DNA double strand breaks. The Journal of biological chemistry. vol 280. issue 6. 2005-04-05. PMID:15546858. |
the protein kinase ataxia telangiectasia mutated (atm) is activated when cells are exposed to ionizing radiation (ir). |
2005-04-05 |
2023-08-12 |
Not clear |
| Juan Guinea Viniegra, Natalia Martínez, Pegah Modirassari, Javier Hernández Losa, Carlos Parada Cobo, Víctor Javier Sánchez-Arévalo Lobo, Clara Isabel Aceves Luquero, Luis Alvarez-Vallina, Santiago Ramón y Cajal, José María Rojas, Ricardo Sánchez-Priet. Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. The Journal of biological chemistry. vol 280. issue 6. 2005-04-05. PMID:15546863. |
the gene mutated in ataxia telangiectasia, atm, has been implicated in several cell functions such as cell cycle control and response to dna damage and insulin. |
2005-04-05 |
2023-08-12 |
mouse |
| Sally J York, Blaine N Armbruster, Patricia Greenwell, Thomas D Petes, John D Yor. Inositol diphosphate signaling regulates telomere length. The Journal of biological chemistry. vol 280. issue 6. 2005-04-05. PMID:15561716. |
this effect requires the presence of tel1, the yeast homologue of atm, the protein mutated in the human disease ataxia telangiectasia. |
2005-04-05 |
2023-08-12 |
human |
| Jonathan M Dermott, John M Gooya, Benyam Asefa, Sarah R Weiler, Mark Smith, Jonathan R Kelle. Inhibition of growth by p205: a nuclear protein and putative tumor suppressor expressed during myeloid cell differentiation. Stem cells (Dayton, Ohio). vol 22. issue 5. 2005-03-25. PMID:15342947. |
in addition, we have demonstrated that a putative ataxia telangiectasia, mutated (atm) kinase phosphorylation site specifically regulates the activity of p205. |
2005-03-25 |
2023-08-12 |
Not clear |