| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y Shilo. ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709050. |
the ataxia telangiectasia mutated (atm) protein is a prominent example of such a relay. |
2002-03-12 |
2023-08-12 |
Not clear |
| Tej K Pandit. ATM function and telomere stability. Oncogene. vol 21. issue 4. 2002-03-08. PMID:11850786. |
the gene responsible for ataxia telangiectasia (a-t) is atm (ataxia-telangiectasia mutant), a master controller of cellular pathways and networks, orchestrating the responses to a specific type of dna damage: the double strand break. |
2002-03-08 |
2023-08-12 |
human |
| Bo Xu, Seong-Tae Kim, Dae-Sik Lim, Michael B Kasta. Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation. Molecular and cellular biology. vol 22. issue 4. 2002-03-01. PMID:11809797. |
ionizing irradiation (ir) induces measurable arrests in the g(1), s, and g(2) phases of the mammalian cell cycle, and the atm (ataxia telangiectasia mutated) protein plays a role in initiating checkpoint pathways in all three of these cell cycle phases. |
2002-03-01 |
2023-08-12 |
Not clear |
| Mana Miyakoda, Keiji Suzuki, Seiji Kodama, Masami Watanab. Activation of ATM and phosphorylation of p53 by heat shock. Oncogene. vol 21. issue 7. 2002-02-28. PMID:11850826. |
we observed little or no phosphorylation of p53 at ser15 in two primary ataxia telangiectasia fibroblast cells, that are defective in atm. |
2002-02-28 |
2023-08-12 |
human |
| Paul S Bradshaw, Alison Condie, Estella Matutes, Daniel Catovsky, Martin R Yuill. Breakpoints in the ataxia telangiectasia gene arise at the RGYW somatic hypermutation motif. Oncogene. vol 21. issue 3. 2002-02-14. PMID:11821961. |
the mature sporadic t-cell malignancy, t-cell prolymphocytic leukemia (t-pll) is remarkable for frequently harbouring somatic mutations of the ataxia telangiectasia (a-t) gene, atm. |
2002-02-14 |
2023-08-12 |
Not clear |
| I Silins, N Finnberg, A Ståhl, J Högberg, U Steniu. Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat. Carcinogenesis. vol 22. issue 12. 2002-02-04. PMID:11751435. |
an inhibitor of dna-dependent protein kinase (dna-pk) and ataxia telangiectasia mutated (atm), wortmannin, blocked the den-induced p53 response in non-eaf hepatocytes. |
2002-02-04 |
2023-08-12 |
rat |
| Alicja M Gruszka-Westwood, Shayne Atkinson, Brenda M Summersgill, Janet Shipley, Manal O Elnenaei, Paresh Jain, Rifat A Hamoudi, Jaspal S Kaeda, Andrew C Wotherspoon, Estella Matutes, Daniel Catovsk. Unusual case of leukemic mantle cell lymphoma with amplified CCND1/IGH fusion gene. Genes, chromosomes & cancer. vol 33. issue 2. 2002-01-31. PMID:11793447. |
the band 11q23 harbors the ataxia telangiectasia mutated (atm) gene recently proposed to be involved in the pathogenesis of mcl with high incidence of deletions in this locus. |
2002-01-31 |
2023-08-12 |
human |
| Kazuhiko Yamane, Xianglin Wu, Junjie Che. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Molecular and cellular biology. vol 22. issue 2. 2002-01-29. PMID:11756551. |
in response to dna strand breaks, topbp1 phosphorylation depends on the ataxia telangiectasia mutated protein (atm) in vivo. |
2002-01-29 |
2023-08-12 |
human |
| Tatjana Stankovic, Grant S Stewart, Christopher Fegan, Paul Biggs, James Last, Philip J Byrd, Russell D Keenan, Paul A H Moss, Alexander M R Taylo. Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage. Blood. vol 99. issue 1. 2002-01-28. PMID:11756185. |
it was previously demonstrated that ataxia telangiectasia mutated (atm) gene mutations can occur in b-cll and cause a defect in the p53 pathway. |
2002-01-28 |
2023-08-12 |
Not clear |
| M Futaki, J M Li. Chromosomal breakage syndromes and the BRCA1 genome surveillance complex. Trends in molecular medicine. vol 7. issue 12. 2002-01-17. PMID:11733219. |
mutations in atm, nbs1, mre11, blm, wrn, and fancd2 are responsible for ataxia telangiectasia (at), nijmegen breakage syndrome, at-like disorder, bloom and werner syndrome, and fanconi anemia group d2, respectively. |
2002-01-17 |
2023-08-12 |
human |
| Carl W Miller, Takayuki Ikezoe, Utz Krug, Wolf-K Hofmann, Sigal Tavor, Vijaya Vegesna, Kunihiro Tsukasaki, Seisho Takeuchi, H Phillip Koeffle. Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. Genes, chromosomes & cancer. vol 33. issue 1. 2002-01-10. PMID:11746983. |
checkpoint kinase 2 (chk2, cds1, rad53) is activated by ataxia telangiectasia mutated (atm) in response to gamma irradiation. |
2002-01-10 |
2023-08-12 |
Not clear |
| L Zentilin, A Marcello, M Giacc. Involvement of cellular double-stranded DNA break binding proteins in processing of the recombinant adeno-associated virus genome. Journal of virology. vol 75. issue 24. 2001-12-13. PMID:11711618. |
the ability of raav to transduce cells is greatly enhanced by a variety of agents that induce dna damage and is elevated in cells defective in the ataxia telangiectasia gene product (atm), showing increased genomic instability. |
2001-12-13 |
2023-08-12 |
Not clear |
| D Cortez, S Guntuku, J Qin, S J Elledg. ATR and ATRIP: partners in checkpoint signaling. Science (New York, N.Y.). vol 294. issue 5547. 2001-12-13. PMID:11721054. |
the checkpoint kinases atm (ataxia telangiectasia mutated) and atr (atm and rad3 related) transduce genomic stress signals to halt cell cycle progression and promote dna repair. |
2001-12-13 |
2023-08-12 |
human |
| M A van Vugt, V A Smits, R Klompmaker, R H Medem. Inhibition of Polo-like kinase-1 by DNA damage occurs in an ATM- or ATR-dependent fashion. The Journal of biological chemistry. vol 276. issue 45. 2001-12-05. PMID:11514540. |
here we have investigated the role of the checkpoint kinases atm (ataxia telangiectasia mutated) and atr (atm- and rad3-related) in dna damage-induced inhibition of plk1. |
2001-12-05 |
2023-08-12 |
Not clear |
| S Burma, B P Chen, M Murphy, A Kurimasa, D J Che. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. The Journal of biological chemistry. vol 276. issue 45. 2001-12-05. PMID:11571274. |
although the phosphatidylinositol 3-kinases, dna-pk (dna-dependent protein kinase), atm (ataxia telangiectasia mutated), and atr (atm and rad3-related), have all been implicated in h2ax phosphorylation, the specific kinase involved has not yet been identified. |
2001-12-05 |
2023-08-12 |
mouse |
| H Zhou, D E Hughes, M L Major, K Yoo, C Pesold, R H Cost. Atypical mouse cerebellar development is caused by ectopic expression of the forkhead box transcription factor HNF-3beta. Gene expression. vol 9. issue 4-5. 2001-12-04. PMID:11444531. |
undetectable levels of ataxia telangiectasia (atm), which is required for proper development of the purkinje dendritic arbor, were found in postnatal transgenic cerebella. |
2001-12-04 |
2023-08-12 |
mouse |
| N Dumaz, D M Milne, L J Jardine, D W Mee. Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover. The Biochemical journal. vol 359. issue Pt 2. 2001-12-04. PMID:11583595. |
these results define distinct roles for serines 15 and 20, two sites previously demonstrated to be dependent on phosphorylation through mechanisms mediated by dna damage and atm (ataxia telangiectasia mutated). |
2001-12-04 |
2023-08-12 |
mouse |
| J Pincheira, M Bravo, M H Navarrete, K Marcelain, J F López-Sáez, C de la Torr. Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. Mutagenesis. vol 16. issue 5. 2001-11-01. PMID:11507241. |
there is a checkpoint pathway in eukaryotic cells that depends on atm (ataxia telangiectasia mutated) kinase which activates the processes leading to the repair of dna damage and also lengthens the g(2) stage of the cell cycle. |
2001-11-01 |
2023-08-12 |
Not clear |
| J Pincheira, M Bravo, M H Navarrete, K Marcelain, J F López-Sáez, C de la Torr. Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. Mutagenesis. vol 16. issue 5. 2001-11-01. PMID:11507241. |
in cells from ataxia telangiectasia patients, due to their lack of active atm kinase, an increase in chromosomal aberrations and a failure to induce g(2) lengthening could be expected. |
2001-11-01 |
2023-08-12 |
Not clear |
| J Pincheira, M Bravo, M H Navarrete, K Marcelain, J F López-Sáez, C de la Torr. Ataxia telangiectasia: G2 checkpoint and chromosomal damage in proliferating lymphocytes. Mutagenesis. vol 16. issue 5. 2001-11-01. PMID:11507241. |
as caffeine is an inhibitor of atm kinase, these results suggest the existence of some redundant atm-independent checkpoint in g(2) of ataxia telangiectasia cells. |
2001-11-01 |
2023-08-12 |
Not clear |