| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gopal P Sapkota, Maria Deak, Agnieszka Kieloch, Nick Morrice, Aaron A Goodarzi, Carl Smythe, Yosef Shiloh, Susan P Lees-Miller, Dario R Aless. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical journal. vol 368. issue Pt 2. 2003-01-17. PMID:12234250. |
ionizing radiation induces ataxia telangiectasia mutated kinase (atm)-mediated phosphorylation of lkb1/stk11 at thr-366. |
2003-01-17 |
2023-08-12 |
xenopus_laevis |
| Gopal P Sapkota, Maria Deak, Agnieszka Kieloch, Nick Morrice, Aaron A Goodarzi, Carl Smythe, Yosef Shiloh, Susan P Lees-Miller, Dario R Aless. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. The Biochemical journal. vol 368. issue Pt 2. 2003-01-17. PMID:12234250. |
thr-366 lies in an optimal phosphorylation motif for the phosphoinositide 3-kinase-like kinases dna-dependent protein kinase (dna-pk), ataxia telangiectasia mutated kinase (atm) and ataxia telangiectasia-related kinase (atr), which function as sensors for dna damage in cells and mediate cellular responses to dna damage. |
2003-01-17 |
2023-08-12 |
xenopus_laevis |
| Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J Romanienko, Julio C Morales, Kazuhito Naka, Zhenfang Xia, R Daniel Camerini-Otero, Noboru Motoyama, Phillip B Carpenter, William M Bonner, Junjie Chen, André Nussenzwei. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature cell biology. vol 4. issue 12. 2003-01-09. PMID:12447390. |
activation of the ataxia telangiectasia mutated (atm) kinase triggers diverse cellular responses to ionizing radiation (ir), including the initiation of cell cycle checkpoints. |
2003-01-09 |
2023-08-12 |
mouse |
| Koji Nakanishi, Toshiyasu Taniguchi, Velvizhi Ranganathan, Helen V New, Lisa A Moreau, Maria Stotsky, Christopher G Mathew, Michael B Kastan, David T Weaver, Alan D D'Andre. Interaction of FANCD2 and NBS1 in the DNA damage response. Nature cell biology. vol 4. issue 12. 2003-01-09. PMID:12447395. |
ionizing radiation activates the ataxia telangiectasia kinase (atm)-dependent and nbs1-dependent phosphorylation of fancd2, resulting in an s-phase checkpoint. |
2003-01-09 |
2023-08-12 |
Not clear |
| Pia Roos-Mattjus, Benjamin T Vroman, Matthew A Burtelow, Matthew Rauen, Alex K Eapen, Larry M Karnit. Genotoxin-induced Rad9-Hus1-Rad1 (9-1-1) chromatin association is an early checkpoint signaling event. The Journal of biological chemistry. vol 277. issue 46. 2003-01-02. PMID:12228248. |
although we found that rad9 undergoes an additional phosphatidylinositol 3-kinase-related kinase (pikk)-dependent posttranslational modification, we also show that genotoxin-triggered 9-1-1 chromatin binding does not depend on the catalytic activity of the pikks ataxia telangiectasia-mutated (atm), ataxia telangiectasia and rad3-related (atr), or dna-pk. |
2003-01-02 |
2023-08-12 |
human |
| Larry H Thompson, David Schil. Recombinational DNA repair and human disease. Mutation research. vol 509. issue 1-2. 2002-12-20. PMID:12427531. |
ataxia telangiectasia (at), nijmegen breakage syndrome (nbs), and an ataxia-like disorder (atld), are chromosome instability disorders that are defective in the ataxia telangiectasia mutated (atm), nbs, and mre11 genes, respectively. |
2002-12-20 |
2023-08-12 |
human |
| Song Zhao, William Renthal, Eva Y-H P Le. Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses. Nucleic acids research. vol 30. issue 22. 2002-12-13. PMID:12433983. |
we show that the chromatin association of r/m/n is independent of ir and ataxia telangiectasia mutated (atm). |
2002-12-13 |
2023-08-12 |
Not clear |
| William K Kaufmann, Christine B Campbell, Dennis A Simpson, Paula B Deming, Leonid Filatov, Denise A Galloway, Xiu J Zhao, Andrew M Creighton, C Stephen Downe. Degradation of ATM-independent decatenation checkpoint function in human cells is secondary to inactivation of p53 and correlated with chromosomal destabilization. Cell cycle (Georgetown, Tex.). vol 1. issue 3. 2002-12-10. PMID:12429935. |
ataxia telangiectasia fibroblasts with defective g2 checkpoint response to ir displayed normal g2 delay after treatment with icrf-193, demonstrating that atm kinase was not required for signaling when chromatid decatenation was blocked. |
2002-12-10 |
2023-08-12 |
human |
| R A Clarke, Z H Fang, P J Marr, C S Lee, J H Kearsley, G Papadato. ATM induction insufficiency in a radiosensitive breast-cancer patient. Australasian radiology. vol 46. issue 3. 2002-10-16. PMID:12196249. |
the ataxia telangiectasia (a-t) gene (atm) is a dominant breast cancer gene with tumour suppressor activity. |
2002-10-16 |
2023-08-12 |
Not clear |
| Mingshan Yan, Xianghong Kuang, Wenan Qiang, Jianjun Shen, Kent Claypool, William S Lynn, Paul K Y Won. Prevention of thymic lymphoma development in Atm-/- mice by dexamethasone. Cancer research. vol 62. issue 18. 2002-10-08. PMID:12234978. |
these observations suggest that ataxia telangiectasia mutated (atm) down-regulates the proliferation of thymocytes, allowing t-cell development and differentiation. |
2002-10-08 |
2023-08-12 |
mouse |
| Atsushi Hirao, Alison Cheung, Gordon Duncan, Pierre-Marie Girard, Andrew J Elia, Andrew Wakeham, Hitoshi Okada, Talin Sarkissian, Jorge A Wong, Takashi Sakai, Elisa De Stanchina, Robert G Bristow, Toshio Suda, Scott W Lowe, Penny A Jeggo, Stephen J Elledge, Tak W Ma. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and cellular biology. vol 22. issue 18. 2002-09-27. PMID:12192050. |
chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (atm)-dependent and an atm-independent manner. |
2002-09-27 |
2023-08-12 |
mouse |
| Atsushi Hirao, Alison Cheung, Gordon Duncan, Pierre-Marie Girard, Andrew J Elia, Andrew Wakeham, Hitoshi Okada, Talin Sarkissian, Jorge A Wong, Takashi Sakai, Elisa De Stanchina, Robert G Bristow, Toshio Suda, Scott W Lowe, Penny A Jeggo, Stephen J Elledge, Tak W Ma. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and cellular biology. vol 22. issue 18. 2002-09-27. PMID:12192050. |
since the ataxia telangiectasia mutated (atm) gene is required for ir-induced activation of chk2, it has been assumed that atm and chk2 act in a linear pathway leading to p53 activation. |
2002-09-27 |
2023-08-12 |
mouse |
| Atsushi Hirao, Alison Cheung, Gordon Duncan, Pierre-Marie Girard, Andrew J Elia, Andrew Wakeham, Hitoshi Okada, Talin Sarkissian, Jorge A Wong, Takashi Sakai, Elisa De Stanchina, Robert G Bristow, Toshio Suda, Scott W Lowe, Penny A Jeggo, Stephen J Elledge, Tak W Ma. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and cellular biology. vol 22. issue 18. 2002-09-27. PMID:12192050. |
ir-induced apoptosis was restored in chk2(-/-) thymocytes by reintroduction of the wild-type chk2 gene but not by a chk2 gene in which the sites phosphorylated by atm and ataxia telangiectasia and rad3(+) related (atr) were mutated to alanine. |
2002-09-27 |
2023-08-12 |
mouse |
| Melissa T Jack, Richard A Woo, Atsushi Hirao, Alison Cheung, Tak W Mak, Patrick W K Le. Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response. Proceedings of the National Academy of Sciences of the United States of America. vol 99. issue 15. 2002-09-04. PMID:12097646. |
the checkpoint kinase, chk2, has been implicated in both of these responses and is believed to function in an ataxia telangiectasia (atm)-dependent manner. |
2002-09-04 |
2023-08-12 |
mouse |
| Martin R Yuille, Alison Condie, Chantelle D Hudson, Paul S Bradshaw, Elaine M Stone, Estella Matutes, Daniel Catovsky, Richard S Houlsto. ATM mutations are rare in familial chronic lymphocytic leukemia. Blood. vol 100. issue 2. 2002-08-30. PMID:12091354. |
the genetic basis of familial cll is poorly understood, but recently germ line mutations in the ataxia telangiectasia (atm) gene have been proposed to confer susceptibility to cll. |
2002-08-30 |
2023-08-12 |
Not clear |
| LiQi Li, Anatoly Sharipo, Esteban Chaves-Olarte, Maria G Masucci, Victor Levitsky, Monica Thelestam, Teresa Frisa. The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells. Cellular microbiology. vol 4. issue 2. 2002-05-22. PMID:11896765. |
early phosphorylation of h2ax was dependent on a functional ataxia telangiectasia mutated (atm) kinase. |
2002-05-22 |
2023-08-12 |
cattle |
| Shin'ichi Saito, Aaron A Goodarzi, Yuichiro Higashimoto, Yuka Noda, Susan P Lees-Miller, Ettore Appella, Carl W Anderso. ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. The Journal of biological chemistry. vol 277. issue 15. 2002-05-16. PMID:11875057. |
in response to ionizing radiation (ir), atm, the gene product mutated in ataxia telangiectasia, stabilizes and activates p53 through phosphorylation of ser(15) and (indirectly) ser(20). |
2002-05-16 |
2023-08-12 |
human |
| Ning Guo, Douglas V Faller, Cyrus Vazir. Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 13. issue 2. 2002-05-13. PMID:11864911. |
however, low doses of bpde elicited chk1 phosphorylation and s-phase arrest in at cells (from ataxia telangiectasia patients), demonstrating that atm is dispensable for s-phase checkpoint responses to this genotoxin. |
2002-05-13 |
2023-08-12 |
Not clear |
| Denis Jullien, Paola Vagnarelli, William C Earnshaw, Yasuhisa Adach. Kinetochore localisation of the DNA damage response component 53BP1 during mitosis. Journal of cell science. vol 115. issue Pt 1. 2002-04-30. PMID:11801725. |
several observations suggest that 53bp1 is a direct substrate for the ataxia telangiectasia mutated (atm) kinase. |
2002-04-30 |
2023-08-12 |
Not clear |
| Y Shilo. ATM (ataxia telangiectasia mutated): expanding roles in the DNA damage response and cellular homeostasis. Biochemical Society transactions. vol 29. issue Pt 6. 2002-03-12. PMID:11709050. |
atm (ataxia telangiectasia mutated): expanding roles in the dna damage response and cellular homeostasis. |
2002-03-12 |
2023-08-12 |
Not clear |