| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eileen Daly, Christine Ecker, Brian Hallahan, Quinton Deeley, Michael Craig, Clodagh Murphy, Patrick Johnston, Debbie Spain, Nicola Gillan, Maria Gudbrandsen, Michael Brammer, Vincent Giampietro, Melissa Lamar, Lisa Page, Fiona Toal, Nicole Schmitz, Anthony Cleare, Dene Robertson, Katya Rubia, Declan G M Murph. Response inhibition and serotonin in autism: a functional MRI study using acute tryptophan depletion. Brain : a journal of neurology. vol 137. issue Pt 9. 2014-11-06. PMID:25070512. |
our findings demonstrate that individuals with autism have abnormal inhibitory networks, and that serotonin has a differential, opposite, effect on them in adults with and without autism. |
2014-11-06 |
2023-08-13 |
human |
| Kenneth D Gadow, Ryan M Smith, Julia K Pinsonneaul. Serotonin 2A receptor gene (HTR2A) regulatory variants: possible association with severity of depression symptoms in children with autism spectrum disorder. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 27. issue 2. 2014-10-21. PMID:24968012. |
serotonin 2a receptor gene (htr2a) regulatory variants: possible association with severity of depression symptoms in children with autism spectrum disorder. |
2014-10-21 |
2023-08-13 |
Not clear |
| Kenneth D Gadow, Ryan M Smith, Julia K Pinsonneaul. Serotonin 2A receptor gene (HTR2A) regulatory variants: possible association with severity of depression symptoms in children with autism spectrum disorder. Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology. vol 27. issue 2. 2014-10-21. PMID:24968012. |
our aim was to characterize the association of 2 functional single nucleotide polymorphisms (rs6311 and rs6314) in the serotonin 2a receptor gene (htr2a) with severity of depression symptoms in children with autism spectrum disorder. |
2014-10-21 |
2023-08-13 |
Not clear |
| Rhonda P Patrick, Bruce N Ame. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 6. 2014-10-06. PMID:24558199. |
serotonin and vitamin d have been proposed to play a role in autism; however, no causal mechanism has been established. |
2014-10-06 |
2023-08-12 |
Not clear |
| Rhonda P Patrick, Bruce N Ame. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 6. 2014-10-06. PMID:24558199. |
the proposed mechanism explains 4 major characteristics associated with autism: the low concentrations of serotonin in the brain and its elevated concentrations in tissues outside the blood-brain barrier; the low concentrations of the vitamin d hormone precursor 25-hydroxyvitamin d [25(oh)d3]; the high male prevalence of autism; and the presence of maternal antibodies against fetal brain tissue. |
2014-10-06 |
2023-08-12 |
Not clear |
| Raphaelle Mottolese, Jérôme Redouté, Nicolas Costes, Didier Le Bars, Angela Sirig. Switching brain serotonin with oxytocin. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 23. 2014-09-30. PMID:24912179. |
serotonin (5-ht) and oxytocin (oxt) are two neuromodulators involved in human affect and sociality and in disorders like depression and autism. |
2014-09-30 |
2023-08-13 |
human |
| Hamid Mostafavi Abdolmaleky, Shabnam Nohesara, Mohammad Ghadirivasfi, Arthur W Lambert, Hamidreza Ahmadkhaniha, Sait Ozturk, Chen Khuan Wong, Rahim Shafa, Ashraf Mostafavi, Sam Thiagalinga. DNA hypermethylation of serotonin transporter gene promoter in drug naïve patients with schizophrenia. Schizophrenia research. vol 152. issue 2-3. 2014-09-23. PMID:24411530. |
dysfunctional serotonin signaling has been linked to the pathogenesis of autism, obsessive compulsive disorder, mood disorders and schizophrenia. |
2014-09-23 |
2023-08-12 |
Not clear |
| Lucia Ciranna, Maria Vincenza Catani. 5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders. Frontiers in cellular neuroscience. vol 8. 2014-09-15. PMID:25221471. |
several abnormalities of serotonergic system have been described in patients with autism spectrum disorder (asd), including abnormal activity of 5-ht transporter, altered blood and brain 5-ht levels, reduced 5-ht synthesis and altered expression of 5-ht receptors in the brain. |
2014-09-15 |
2023-08-13 |
mouse |
| John Jacob, Vanessa Ribes, Steven Moore, Sean C Constable, Noriaki Sasai, Sebastian S Gerety, Darren J Martin, Chris P Sergeant, David G Wilkinson, James Brisco. Valproic acid silencing of ascl1b/Ascl1 results in the failure of serotonergic differentiation in a zebrafish model of fetal valproate syndrome. Disease models & mechanisms. vol 7. issue 1. 2014-09-08. PMID:24135485. |
altered serotonin homeostasis is also associated with autism. |
2014-09-08 |
2023-08-12 |
zebrafish |
| Shaik Mohammad Naushad, Jamal Md Nurul Jain, Chintakindi Krishna Prasad, Usha Naik, Radha Rama Devi Akell. Autistic children exhibit distinct plasma amino acid profile. Indian journal of biochemistry & biophysics. vol 50. issue 5. 2014-07-10. PMID:24772971. |
a low molar ratio of (tryptophan/large neutral amino acids) x 100 was observed in autism (5.4 vs 9.2), indicating lesser availability of tryptophan for neurotransmitter serotonin synthesis. |
2014-07-10 |
2023-08-13 |
Not clear |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
abnormalities in 5-ht systems have been implicated in several psychiatric disorders, including autism, as evidenced by immunology, imaging, genetics, pharmacotherapy, and neuropathology. |
2014-07-03 |
2023-08-12 |
Not clear |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
although information is known regarding peripheral 5-ht in autism, there is emerging evidence that 5-ht systems in the central nervous system, including various 5-ht receptor subtypes and transporters, are affected in autism. |
2014-07-03 |
2023-08-12 |
Not clear |
| Adrian Oblak, Terrell T Gibbs, Gene J Blat. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23894004. |
this study provides potential substrates for decreased 5-ht modulation/innervation in the autism brain, and implicate two 5-ht receptor subtypes as potential neuromarkers for novel or existing pharmacotherapies. |
2014-07-03 |
2023-08-12 |
Not clear |
| T Levin-Decanini, N Maltman, S M Francis, S Guter, G M Anderson, E Cook, S Jaco. Parental broader autism subphenotypes in ASD affected families: relationship to gender, child's symptoms, SSRI treatment, and platelet serotonin. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23956104. |
parental broader autism subphenotypes in asd affected families: relationship to gender, child's symptoms, ssri treatment, and platelet serotonin. |
2014-07-03 |
2023-08-12 |
Not clear |
| T Levin-Decanini, N Maltman, S M Francis, S Guter, G M Anderson, E Cook, S Jaco. Parental broader autism subphenotypes in ASD affected families: relationship to gender, child's symptoms, SSRI treatment, and platelet serotonin. Autism research : official journal of the International Society for Autism Research. vol 6. issue 6. 2014-07-03. PMID:23956104. |
relationships between parental broader autism phenotype (bap) scores, gender, selective serotonin reuptake inhibitor (ssri) treatment, serotonin (5ht) levels, and the child's symptoms were investigated in a family study of autism spectrum disorder (asd). |
2014-07-03 |
2023-08-12 |
Not clear |
| Eric Hollande. Obsessive-compulsive disorder and spectrum across the life span. International journal of psychiatry in clinical practice. vol 9. issue 2. 2014-06-17. PMID:24930787. |
thus, in common with ocds, in bdd there is increased activity in the limbic regions; in pg there is evidence of deficiencies in 5-ht function and receptors; and in autism there are restricted interests and repetitive behaviours which may be influenced by serotonergic mechanisms. |
2014-06-17 |
2023-08-13 |
Not clear |
| Keiko Iwata, Hideo Matsuzaki, Taro Tachibana, Koji Ohno, Saori Yoshimura, Hironori Takamura, Kohei Yamada, Shinsuke Matsuzaki, Kazuhiko Nakamura, Kenji J Tsuchiya, Kaori Matsumoto, Masatsugu Tsujii, Toshirou Sugiyama, Taiichi Katayama, Norio Mor. N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. Molecular autism. vol 5. 2014-05-16. PMID:24834316. |
n-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. |
2014-05-16 |
2023-08-13 |
human |
| Keiko Iwata, Hideo Matsuzaki, Taro Tachibana, Koji Ohno, Saori Yoshimura, Hironori Takamura, Kohei Yamada, Shinsuke Matsuzaki, Kazuhiko Nakamura, Kenji J Tsuchiya, Kaori Matsumoto, Masatsugu Tsujii, Toshirou Sugiyama, Taiichi Katayama, Norio Mor. N-ethylmaleimide-sensitive factor interacts with the serotonin transporter and modulates its trafficking: implications for pathophysiology in autism. Molecular autism. vol 5. 2014-05-16. PMID:24834316. |
changes in serotonin transporter (sert) function have been implicated in autism. |
2014-05-16 |
2023-08-13 |
human |
| Undurti N Da. Autism as a disorder of deficiency of brain-derived neurotrophic factor and altered metabolism of polyunsaturated fatty acids. Nutrition (Burbank, Los Angeles County, Calif.). vol 29. issue 10. 2014-04-14. PMID:23911220. |
autism has a strong genetic and environmental basis in which inflammatory markers and factors concerned with synapse formation, nerve transmission, and information processing such as brain-derived neurotrophic factor (bdnf), polyunsaturated fatty acids (pufas): arachidonic (aa), eicosapentaenoic (epa), and docosahexaenoic acids (dha) and their products and neurotransmitters: dopamine, serotonin, acetylcholine, γ-aminobutyric acid, and catecholamines and cytokines are altered. |
2014-04-14 |
2023-08-12 |
Not clear |
| Rebecca A Harrington, Li-Ching Lee, Rosa M Crum, Andrew W Zimmerman, Irva Hertz-Picciott. Serotonin hypothesis of autism: implications for selective serotonin reuptake inhibitor use during pregnancy. Autism research : official journal of the International Society for Autism Research. vol 6. issue 3. 2014-02-19. PMID:23495208. |
serotonin hypothesis of autism: implications for selective serotonin reuptake inhibitor use during pregnancy. |
2014-02-19 |
2023-08-12 |
Not clear |