| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Febin Farook, Michael DeCuypere, Keith Hyland, Toru Takumi, Mark S LeDoux, Lawrence T Reite. Altered serotonin, dopamine and norepinepherine levels in 15q duplication and Angelman syndrome mouse models. PloS one. vol 7. issue 8. 2013-01-16. PMID:22916201. |
in the duplication 15q autism mouse model, paternal but not maternal duplication animals showed a decrease in 5ht levels when compared to their wild type littermates, in accordance with previously published data. |
2013-01-16 |
2023-08-12 |
mouse |
| George Bartzoki. Neuroglialpharmacology: myelination as a shared mechanism of action of psychotropic treatments. Neuropharmacology. vol 62. issue 7. 2012-12-20. PMID:22306524. |
similarly, psychotropic treatments ranging from lithium and antipsychotics to serotonin reuptake inhibitors (ssris) and acetylcholinesterase inhibitors have been shown to be efficacious in a wide spectrum of psychiatric disorders ranging from autism, schizophrenia (sz), depression, and bipolar disorder (bd) to alzheimer's disease (ad). |
2012-12-20 |
2023-08-12 |
human |
| Eileen M Daly, Quinton Deeley, Christine Ecker, Michael Craig, Brian Hallahan, Clodagh Murphy, Patrick Johnston, Debbie Spain, Nicola Gillan, Michael Brammer, Vincent Giampietro, Melissa Lamar, Lisa Page, Fiona Toal, Anthony Cleare, Simon Surguladze, Declan G M Murph. Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion. Archives of general psychiatry. vol 69. issue 10. 2012-12-13. PMID:22638012. |
serotonin and the neural processing of facial emotions in adults with autism: an fmri study using acute tryptophan depletion. |
2012-12-13 |
2023-08-12 |
human |
| Csaba Juhász, Diane C Chugani, Geoffrey R Barger, William J Kupsky, Pulak K Chakraborty, Otto Muzik, Sandeep Mitta. Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity. Clinical nuclear medicine. vol 37. issue 9. 2012-12-13. PMID:22889771. |
pet studies with α[c-11]methyl-l-tryptophan (amt) have shown decreased serotonin synthesis based on a decrease of the unidirectional uptake rate (k-complex) in neuropsychiatric conditions such as autism and depression. |
2012-12-13 |
2023-08-12 |
Not clear |
| Camille Latapy, Véronique Rioux, Matthieu J Guitton, Jean-Martin Beaulie. Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826345. |
serotonin (5-ht) neurotransmission is thought to underlie mental illnesses, such as bipolar disorder, depression, autism and schizophrenia. |
2012-12-06 |
2023-08-12 |
mouse |
| Agnieszka Piechal, Kamilla Blecharz-Klin, Edyta Wyszogrodzka, Paulina Kołomańska, Paulina Rok-Bujko, Paweł Krząścik, Wojciech Kostowski, Ewa Widy-Tyszkiewicz, Małgorzata Filip, Roman Stefańsk. Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats. Pharmacological reports : PR. vol 64. issue 2. 2012-11-23. PMID:22661175. |
extensive previous research has suggested a role for serotonin (5-ht) in learning and memory processes, both in healthy individuals and pathological disorders including depression, autism and schizophrenia, most of which have a developmental onset. |
2012-11-23 |
2023-08-12 |
rat |
| David Q Beversdorf, Richard E Nordgren, Ali A Bonab, Alan J Fischman, Steven B Weise, Darin D Dougherty, Gretchen J Felopulos, Feng C Zhou, Margaret L Bauma. 5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults. The Journal of neuropsychiatry and clinical neurosciences. vol 24. issue 2. 2012-11-13. PMID:22772667. |
the serotonergic (5-ht) system is also critically involved in brain development, and abnormal brain synthesis of serotonin is observed in autism. |
2012-11-13 |
2023-08-12 |
human |
| David Q Beversdorf, Richard E Nordgren, Ali A Bonab, Alan J Fischman, Steven B Weise, Darin D Dougherty, Gretchen J Felopulos, Feng C Zhou, Margaret L Bauma. 5-HT2 receptor distribution shown by [18F] setoperone PET in high-functioning autistic adults. The Journal of neuropsychiatry and clinical neurosciences. vol 24. issue 2. 2012-11-13. PMID:22772667. |
furthermore, whole blood and platelet serotonin have been reported to be elevated in autism. |
2012-11-13 |
2023-08-12 |
human |
| George M Anderson, Margaret E Hertzig, P A McBrid. Brief report: Platelet-poor plasma serotonin in autism. Journal of autism and developmental disorders. vol 42. issue 7. 2012-10-26. PMID:21979109. |
brief report: platelet-poor plasma serotonin in autism. |
2012-10-26 |
2023-08-12 |
Not clear |
| George M Anderson, Margaret E Hertzig, P A McBrid. Brief report: Platelet-poor plasma serotonin in autism. Journal of autism and developmental disorders. vol 42. issue 7. 2012-10-26. PMID:21979109. |
possible explanations for the well-replicated platelet hyperserotonemia of autism include an alteration in the platelet's handling of serotonin (5-hydroxyserotonin, 5-ht) or an increased exposure of the platelet to 5-ht. |
2012-10-26 |
2023-08-12 |
Not clear |
| George M Anderson, Margaret E Hertzig, P A McBrid. Brief report: Platelet-poor plasma serotonin in autism. Journal of autism and developmental disorders. vol 42. issue 7. 2012-10-26. PMID:21979109. |
mean (± sd) concentrations of ppp 5-ht observed in the autism (n = 18), hyperserotonemic subgroup (n = 5) and control (n = 24) groups were 0.86 ± 0.53, 0.87 ± 0.43 and 0.86 ± 0.36 nm, respectively. |
2012-10-26 |
2023-08-12 |
Not clear |
| George M Anderson, Margaret E Hertzig, P A McBrid. Brief report: Platelet-poor plasma serotonin in autism. Journal of autism and developmental disorders. vol 42. issue 7. 2012-10-26. PMID:21979109. |
the results suggest that the hyperserotonemia of autism is not due to increased exposure of the platelet to 5-ht and make it more likely that the factor(s) contributing to the hyperserotonemia of autism have to do with the platelet's handling of 5-ht. |
2012-10-26 |
2023-08-12 |
Not clear |
| Gordon Burnan. Inter-hemispheric competition relieved in both: hypotheses for autism and schizophrenia from problem theory. Medical hypotheses. vol 79. issue 1. 2012-09-25. PMID:22525821. |
hypotheses are: (a) autistic children fail labelling at the start, and hence they encounter uncontrolled competition between the hemispheres; (b) with some, serotonin abnormality impairs sensory information processing and hence the labelling; (c) with some, a delay in myelination from autoimmune effects disrupts labelling; (d) the likelihood of this 'delay autism' is reduced by long chain omega oils; (e) self-pressuring, which underlies taking on challenges and play like hide and seek, brings relief from the competition by raising the influence of one side; (f) the same left-right competition occurs in confused episodes and schizophrenia in vulnerable people who encounter pressures to use both hemispheres at the same time; (g) some symptoms raise the influence on one side ideationally. |
2012-09-25 |
2023-08-12 |
human |
| Z C Flood, D L J Engel, C C Simon, K R Negherbon, L J Murphy, W Tamavimok, G M Anderson, S Janušoni. Brain growth trajectories in mouse strains with central and peripheral serotonin differences: relevance to autism models. Neuroscience. vol 210. 2012-09-21. PMID:22450231. |
brain growth trajectories in mouse strains with central and peripheral serotonin differences: relevance to autism models. |
2012-09-21 |
2023-08-12 |
mouse |
| T Sandhya, J Sowjanya, B Veeres. Bacopa monniera (L.) Wettst ameliorates behavioral alterations and oxidative markers in sodium valproate induced autism in rats. Neurochemical research. vol 37. issue 5. 2012-08-20. PMID:22322665. |
induction of autism significantly affected normal behavior, increased oxidative stress and serotonin level, altered histoarchitecture of cerebellum (decreased number of purkinje cells, neuronal degeneration and chromatolysis) when compared with normal control group. |
2012-08-20 |
2023-08-12 |
rat |
| Maila de Castro Lourenço das Neves, Fabien Tremeau, Rodrigo Nicolato, Hélio Lauar, Marco Aurélio Romano-Silva, Humberto Corre. Facial emotion recognition deficits in relatives of children with autism are not associated with 5HTTLPR. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 33. issue 3. 2012-06-08. PMID:21971779. |
this study was aimed at assessing facial emotion recognition in parents of children with autism and its associations with a functional polymorphism of the serotonin transporter (5httlpr). |
2012-06-08 |
2023-08-12 |
Not clear |
| Mushtaq A Margoob, Dhuha Mushta. Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? Indian journal of psychiatry. vol 53. issue 4. 2012-05-21. PMID:22303036. |
in this article, we review the status of evidence for association between the serotonin gene polymorphism and some common mental disorders like affective disorders, post-traumatic stress disorder, obsessive-compulsive disorder, suicide, autism, and other anxiety and personality disorders. |
2012-05-21 |
2023-08-12 |
Not clear |
| Gabriella A Horvath, Kathryn Selby, Ken Poskitt, Keith Hyland, Paula J Waters, Marion Coulter-Mackie, Sylvia G Stockler-Ipsirogl. Hemiplegic migraine, seizures, progressive spastic paraparesis, mood disorder, and coma in siblings with low systemic serotonin. Cephalalgia : an international journal of headache. vol 31. issue 15. 2012-04-04. PMID:22013141. |
disturbances in serotonin metabolism have been associated with autism, depression, and myoclonus related conditions, but serotonin has far more functions in the body. |
2012-04-04 |
2023-08-12 |
Not clear |
| C M Ciarleglio, H E S Resuehr, D G McMaho. Interactions of the serotonin and circadian systems: nature and nurture in rhythms and blues. Neuroscience. vol 197. 2012-02-27. PMID:21963350. |
the reciprocal connections of the serotonin and circadian systems likely have importance for neurobehavioral disorders, as suggested by their convergent contribution to a similar range of mood disorders including seasonal affective disorder (sad), bipolar disorder, and major depression, and as suggested by their overlapping relationship with the developmental disorder, autism spectrum disorder. |
2012-02-27 |
2023-08-12 |
Not clear |
| Gehan Ahmed Mostafa, Laila Yousef Al-Ayadh. A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. Journal of neuroinflammation. vol 8. 2012-02-23. PMID:21696608. |
one of the most consistent biological findings in autism is the elevated blood serotonin levels. |
2012-02-23 |
2023-08-12 |
Not clear |