| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hadhemi Kaddour, Yosra Hamdi, Fatma Amri, Seyma Bahdoudi, Ibtissem Bouannee, Jérôme Leprince, Sami Zekri, Hubert Vaudry, Marie-Christine Tonon, David Vaudry, Mohamed Amri, Sana Mezghani, Olfa Masmoudi-Kouk. Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes. Journal of molecular neuroscience : MN. vol 69. issue 1. 2020-01-21. PMID:30343367. |
oxidative stress, associated with various neurodegenerative diseases, promotes ros generation, impairs cellular antioxidant defenses, and finally, triggers both neurons and astroglial cell death by apoptosis. |
2020-01-21 |
2023-08-13 |
rat |
| Randa Sghaier, Thomas Nury, Valerio Leoni, Claudio Caccia, Jean-Paul Pais De Barros, Ameur Cherif, Anne Vejux, Thibault Moreau, Khalifa Limem, Mohammad Samadi, John J Mackrill, Ahmed Slaheddine Masmoudi, Gérard Lizard, Amira Zarrou. Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol. The Journal of steroid biochemistry and molecular biology. vol 194. 2020-01-14. PMID:31344443. |
oxidative stress and mitochondrial dysfunction contribute to the pathogenesis of neurodegenerative diseases and favor lipid peroxidation, leading to increased levels of 7β-hydroxycholesterol (7β-ohc) which induces oxiapoptophagy (oxidative stress, apoptosis, autophagy). |
2020-01-14 |
2023-08-13 |
cat |
| Nami Kim, Dongmei Chen, Xiao Zhen Zhou, Tae Ho Le. Death-Associated Protein Kinase 1 Phosphorylation in Neuronal Cell Death and Neurodegenerative Disease. International journal of molecular sciences. vol 20. issue 13. 2019-12-06. PMID:31248062. |
however, the deregulation of neuronal apoptosis by various factors leads to neurodegenerative diseases such as ischemic stroke and alzheimer's disease (ad). |
2019-12-06 |
2023-08-13 |
Not clear |
| Dong Guo, Wenting Xie, Pan Xiong, Huifang Li, Siqi Wang, Guimiao Chen, Yuehong Gao, Jiechao Zhou, Ye Zhang, Guojun Bu, Maoqiang Xue, Jie Zhan. Cyclin-dependent kinase 5-mediated phosphorylation of chloride intracellular channel 4 promotes oxidative stress-induced neuronal death. Cell death & disease. vol 9. issue 10. 2019-11-25. PMID:30237421. |
oxidative stress can cause apoptosis in neurons and may result in neurodegenerative diseases. |
2019-11-25 |
2023-08-13 |
Not clear |
| Othman Ghribi, David A. DeWitt, Michael S. Forbes, Ayala Arad, Mary M. Herman, John Savor. Cyclosporin A inhibits Al-induced cytochrome c release from mitochondria in aged rabbits. Journal of Alzheimer's disease : JAD. vol 3. issue 4. 2019-11-20. PMID:12214041. |
neurodegenerative diseases including alzheimer's disease are characterized by a progressive and selective neuronal loss via an apoptosis mechanism, and there is a growing body of evidence which supports a central role of mitochondria in this apoptotic cell death. |
2019-11-20 |
2023-08-12 |
rabbit |
| D Cervia, C Perrotta, C Moscheni, C De Palma, E Clement. Nitric oxide and sphingolipids control apoptosis and autophagy with a significant impact on Alzheimer's disease. Journal of biological regulators and homeostatic agents. vol 27. issue 2 Suppl. 2019-11-20. PMID:24813312. |
aberrant regulation of signalling pathways promoting and regulating apoptosis and autophagy contributes to the development of most human neurodegenerative diseases characterised by progressive dysfunction and death of neuronal and glial cells. |
2019-11-20 |
2023-08-13 |
human |
| Zahida Parveen, Zohra Bibi, Nousheen Bibi, Juergen Neesen, Sajid Rashi. Disruption of murine Tcte3-3 induces tissue specific apoptosis via co-expression of Anxa5 and Pebp1. Computational biology and chemistry. vol 53PB. 2019-11-20. PMID:25462330. |
any discrepancy in apoptosis may trigger testicular and neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer. |
2019-11-20 |
2023-08-13 |
mouse |
| Joelle Makoukji, Fadi Saadeh, Karl Albert Mansour, Sally El-Sitt, Jamal Al Ali, Nihar Kinarivala, Paul C Trippier, Rose-Mary Boustan. Flupirtine derivatives as potential treatment for the neuronal ceroid lipofuscinoses. Annals of clinical and translational neurology. vol 5. issue 9. 2019-11-20. PMID:30250865. |
neuronal ceroid lipofuscinoses (ncl) are fatal inherited neurodegenerative diseases with established neuronal cell death and increased ceramide levels in brain, hence, a need for disease-modifying drug candidates, with potential to enhance growth, reduce apoptosis and lower ceramide in neuronal precursor pc12 cells and human ncl cell lines using enhanced flupirtine aromatic carbamate derivatives in vitro. |
2019-11-20 |
2023-08-13 |
human |
| Yong-Yue Gao, Zi-Huan Zhang, Zong Zhuang, Yue Lu, Ling-Yun Wu, Zhen-Nan Ye, Xiang-Sheng Zhang, Chun-Lei Chen, Wei Li, Chun-Hua Han. Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin β3/FAK/PI3K/AKT signaling pathway in rats after traumatic brain injury. Cell death & disease. vol 9. issue 9. 2019-11-15. PMID:30154436. |
previous studies have established that milk fat globule-egf factor-8 (mfg-e8) provides neuroprotection through modulation of inflammation, oxidative stress, and especially apoptosis in cerebral ischemia and neurodegenerative disease. |
2019-11-15 |
2023-08-13 |
human |
| N V Ivanisenko, I N Lavri. [Mechanisms of Procaspase-8 Activation in the Extrinsic Programmed Cell Death Pathway]. Molekuliarnaia biologiia. vol 53. issue 5. 2019-11-01. PMID:31661481. |
dysregulation of the apoptosis mechanisms is associated with the pathogenesis and progression of a number of oncological and neurodegenerative diseases. |
2019-11-01 |
2023-08-13 |
Not clear |
| Qi Xiong, Qin Ru, Xiang Tian, Mei Zhou, Lin Chen, Yi Li, Chaoying L. Krill oil protects PC12 cells against methamphetamine-induced neurotoxicity by inhibiting apoptotic response and oxidative stress. Nutrition research (New York, N.Y.). vol 58. 2019-10-17. PMID:30340818. |
oxidative stress and apoptosis are linked in the pathophysiology of many neurodegenerative diseases. |
2019-10-17 |
2023-08-13 |
human |
| Eduardo Duarte-Silva, Shyrlene Meiry da Rocha Araújo, Wilma Helena Oliveira, Deniele Bezerra de Lós, Maria Eduarda Rocha de França, Amanda Pires Bonfanti, Gabriela Peron, Livia de Lima Thomaz, Liana Verinaud, Ana Karolina de Santana Nunes, Christina Alves Peixot. Sildenafil ameliorates EAE by decreasing apoptosis in the spinal cord of C57BL/6 mice. Journal of neuroimmunology. vol 321. 2019-10-03. PMID:29957383. |
in most neuroinflammatory and/or neurodegenerative diseases, apoptosis is associated with disease development and pathology and inhibition of this process leads to considerable amelioration. |
2019-10-03 |
2023-08-13 |
mouse |
| Zhihui Zhu, Georg Reise. The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases. Neurochemistry international. vol 115. 2019-09-17. PMID:29425965. |
for neuroprotective mechanisms, shsps attenuate mitochondrial dysfunctions, reduce accumulation of misfolded proteins, block oxidative/nitrosative stress, and minimize neuronal apoptosis and neuroinflammation, which are molecular mechanisms commonly accepted to mirror the progression and development of neurodegenerative diseases. |
2019-09-17 |
2023-08-13 |
mouse |
| Leandro Bueno Berganti. Hypertension, Diabetes and Neurodegenerative Diseases: Is there a Clinical Link through the Ca2+/cAMP Signalling Interaction? Current hypertension reviews. vol 15. issue 1. 2019-08-13. PMID:30117399. |
the virtual mechanism of action could be attributed to a restoration and maintenance of ca2+ homeostasis, which is dysregulated in the neurodegenerative diseases, including also a reduction of neuronal apoptosis as part of these ccbs pleiotropic effects. |
2019-08-13 |
2023-08-13 |
Not clear |
| Olena Y Glushakova, Andriy O Glushakov, Cesar V Borlongan, Alex B Valadka, Ronald L Hayes, Alexander V Glushako. Role of Caspase-3-Mediated Apoptosis in Chronic Caspase-3-Cleaved Tau Accumulation and Blood-Brain Barrier Damage in the Corpus Callosum after Traumatic Brain Injury in Rats. Journal of neurotrauma. vol 35. issue 1. 2019-07-08. PMID:28637381. |
chronic tbi is associated with several pathological features that are also characteristic of neurodegenerative diseases, including tau pathologies, caspase-3-mediated apoptosis, neuroinflammation, and microvascular alterations. |
2019-07-08 |
2023-08-13 |
rat |
| H Lou, D Kang, Q Yang, C Lian, C Zhang, Z Li, H Tian, L Lu, G-T Xu, G Xu, J Zhan. Erythropoietin Protects Retina Against Ceramide 2-Induced Damage in Rat. Current molecular medicine. vol 17. issue 10. 2019-06-11. PMID:29577857. |
ceramide plays critical roles in cell proliferation, senescence and apoptosis, and is implicated in neurodegenerative diseases, etc. |
2019-06-11 |
2023-08-13 |
rat |
| Todd McLaughlin, Marek Falkowski, Joshua J Wang, Sarah X Zhan. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases. Advances in experimental medicine and biology. vol 1074. 2019-05-06. PMID:29721972. |
we summarize the diverse activities of erp29 in protein trafficking, cell survival and apoptosis, and er homeostasis and highlight a potential role of erp29 in neuroprotection in retinal and neurodegenerative diseases. |
2019-05-06 |
2023-08-13 |
Not clear |
| Hyun Ji Ha, Sunghark Kwon, Eui Man Jeong, Chang Min Kim, Ki Baek Lee, In-Gyu Kim, Hyun Ho Par. Structure of natural variant transglutaminase 2 reveals molecular basis of gaining stability and higher activity. PloS one. vol 13. issue 10. 2019-03-14. PMID:30321187. |
multi-functional transglutaminase 2 (tg2), which possesses protein cross-linking and gtp hydrolysis activities, is involved in various cellular processes, including apoptosis, angiogenesis, wound healing, and neuronal regeneration, and is associated with many human diseases, including inflammatory disease, celiac disease, neurodegenerative disease, diabetes, tissue fibrosis, and cancers. |
2019-03-14 |
2023-08-13 |
human |
| Youngchul Kim, Young Seo Kim, Hyun Young Kim, Min-Young Noh, Ji Young Kim, Young-Jun Lee, Jeongmin Kim, Jiseon Park, Seung Hyun Ki. Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke. Molecular neurobiology. vol 55. issue 9. 2019-02-04. PMID:29383691. |
in patients with stroke and neurodegenerative diseases, overactivation of poly(adp-ribose) polymerase-1 (parp-1) causes harmful effects by inducing apoptosis, necrosis, neuroinflammation, and immune dysregulation. |
2019-02-04 |
2023-08-13 |
Not clear |
| Siqi Li, Yongdui Chen, Desen Sun, Rongpai Bai, Xiangwei Gao, Yi Yang, Jinghao Sheng, Zhengping X. Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs. Molecular neurobiology. vol 55. issue 2. 2019-01-10. PMID:28127696. |
taken together, we hypothesize that pgrn a9d leads to the retention of ang in the cytoplasm to protect cells from pgrn a9d-induced apoptosis, implying that pgrn and ang act in concert to regulate the progress of neurodegenerative disease. |
2019-01-10 |
2023-08-13 |
human |