| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yang Yu, Linjing Feng, Junnan Li, Xiaoxin Lan, Lixiang A, Xiaoyan Lv, Ming Zhang, Li Che. The alteration of autophagy and apoptosis in the hippocampus of rats with natural aging-dependent cognitive deficits. Behavioural brain research. vol 334. 2017-12-11. PMID:28688896. |
the present study was aim to explore aging-dependent changes in hippocampal autophagy and apoptosis in a natural aging rat model from adult to old stages and to discover a suitable age for treating neurodegenerative diseases. |
2017-12-11 |
2023-08-13 |
rat |
| Setsuko Tsuboi, Takashi Ji. Bioluminescence Resonance Energy Transfer (BRET)-coupled Annexin V-functionalized Quantum Dots for Near-Infrared Optical Detection of Apoptotic Cells. Chembiochem : a European journal of chemical biology. vol 18. issue 22. 2017-12-05. PMID:28901721. |
deregulation in apoptosis induces numerous diseases such as cancer, cardiovascular, and neurodegenerative diseases. |
2017-12-05 |
2023-08-13 |
Not clear |
| Hitoshi Shimano, Ryuichiro Sat. SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology. Nature reviews. Endocrinology. vol 13. issue 12. 2017-11-16. PMID:28849786. |
in addition, srebps are implicated in numerous pathogenic processes such as endoplasmic reticulum stress, inflammation, autophagy and apoptosis, and in this way, they contribute to obesity, dyslipidaemia, diabetes mellitus, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, chronic kidney disease, neurodegenerative diseases and cancers. |
2017-11-16 |
2023-08-13 |
Not clear |
| Sun-Oh Jeong, Yong Son, Ju Hwan Lee, Seung Won Choi, Sung Hun Kim, Yong-Kwan Cheong, Hun-Taeg Chung, Hyun-Ock Pa. Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-23. PMID:28917840. |
growing evidence indicates that endoplasmic reticulum (er) stress and/or er stress-mediated apoptosis may play a role in the pathogenesis of neurodegenerative diseases such as alzheimer's disease. |
2017-10-23 |
2023-08-13 |
Not clear |
| Sun-Oh Jeong, Yong Son, Ju Hwan Lee, Seung Won Choi, Sung Hun Kim, Yong-Kwan Cheong, Hun-Taeg Chung, Hyun-Ock Pa. Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells. Biochemical and biophysical research communications. vol 493. issue 1. 2017-10-23. PMID:28917840. |
these findings provide the first evidence showing that both no and nitrite can reduce er stress and subsequent apoptosis via no-sgc-cgmp pathway in neuronal cells and suggesting that no and/or nitrite may have therapeutic value in the treatment of er stress-associated neurodegenerative diseases. |
2017-10-23 |
2023-08-13 |
Not clear |
| Sercan Ergun, Serdar Oztuzc. Sequence-based analysis of 5'UTR and coding regions of CASP3 in terms of miRSNPs and SNPs in targetting miRNAs. Computational biology and chemistry. vol 62. 2017-10-16. PMID:27107179. |
deregulation of apoptosis occurs in many human conditions such as autoimmune disorders, ischemic damage, neurodegenerative diseases and different cancer types. |
2017-10-16 |
2023-08-13 |
human |
| Rajeev Gupt. Phosphorylation of rat brain purified mitochondrial Voltage-Dependent Anion Channel by c-Jun N-terminal kinase-3 modifies open-channel noise. Biochemical and biophysical research communications. vol 490. issue 4. 2017-09-21. PMID:28676395. |
it has been shown that c-jun n-terminal kinase-3 (jnk3) becomes activated by phosphorylation in various neurodegenerative diseases and phosphorylates outer mitochondrion associated proteins leading to neuronal apoptosis. |
2017-09-21 |
2023-08-13 |
rat |
| Liu-Hong Li, Qiu-Yun Tu, Xiao-Hua Deng, Jian Xia, De-Ren Hou, Ke Guo, Xiao-Hong Z. Mutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells. Brain research. vol 1662. 2017-09-05. PMID:28189560. |
the p53/mir-34a axis triggers apoptosis and suppresses viability in multiple types of cells, but little is known about its role in neurodegenerative diseases. |
2017-09-05 |
2023-08-13 |
mouse |
| Navya Lakkappa, Praveen T Krishnamurthy, Bruce D Hammock, D Velmurugan, M M Srinivas Bharat. Possible role of Epoxyeicosatrienoic acid in prevention of oxidative stress mediated neuroinflammation in Parkinson disorders. Medical hypotheses. vol 93. 2017-06-15. PMID:27372879. |
parkinson's disease (pd) is a multifactorial neurodegenerative disease involving oxidative stress, neuroinflammation and apoptosis. |
2017-06-15 |
2023-08-13 |
Not clear |
| Theetat Ruangjaroon, Daranee Chokchaichamnankit, Chantragan Srisomsap, Jisnuson Svasti, N Monique Paricharttanaku. Involvement of vimentin in neurite outgrowth damage induced by fipronil in SH-SY5Y cells. Biochemical and biophysical research communications. vol 486. issue 3. 2017-06-02. PMID:28322794. |
fipronil induced apoptosis involving caspase-6, which is an apoptotic effector highly implicated in neurodegenerative diseases. |
2017-06-02 |
2023-08-13 |
human |
| Danya Ben-Hail, Racheli Begas-Shvartz, Moran Shalev, Anna Shteinfer-Kuzmine, Arie Gruzman, Simona Reina, Vito De Pinto, Varda Shoshan-Barmat. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. The Journal of biological chemistry. vol 291. issue 48. 2017-05-26. PMID:27738100. |
apoptosis is thought to play a critical role in several pathological processes, such as neurodegenerative diseases (i.e. |
2017-05-26 |
2023-08-13 |
Not clear |
| Zhengmao Li, Fenzan Wu, Xie Zhang, Yi Chai, Daqing Chen, Yuetao Yang, Kebin Xu, Jiayu Yin, Rui Li, Hongxue Shi, Zhouguang Wang, Xiaokun Li, Jian Xiao, Hongyu Zhan. Valproate Attenuates Endoplasmic Reticulum Stress-Induced Apoptosis in SH-SY5Y Cells via the AKT/GSK3β Signaling Pathway. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28208696. |
endoplasmic reticulum (er) stress-induced apoptosis plays an important role in a range of neurological disorders, such as neurodegenerative diseases, spinal cord injury, and diabetic neuropathy. |
2017-04-28 |
2023-08-13 |
rat |
| A Hosseini, H R Sadeghnia, A Rajabia. Protective effects of peel and seed extracts of Citrus aurantium on glutamate-induced cytotoxicity in PC12 cell line. Folia neuropathologica. vol 54. issue 3. 2017-04-13. PMID:27764519. |
oxidative stress and apoptosis contribute to neuronal degeneration in many neurodegenerative diseases such as alzheimer's disease. |
2017-04-13 |
2023-08-13 |
rat |
| Wen-Xuan Yu, Chen-Qiang Lin, Qing Zhao, Xin-Jian Lin, Xiao-Li Don. Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 88. 2017-03-27. PMID:28135600. |
neuronal apoptosis caused by toxic stimuli such as oxidative stress is believed to be one of the major reasons in the pathologenesis of neurodegenerative diseases. |
2017-03-27 |
2023-08-13 |
Not clear |
| Hongbo Li, Chunhui Zhu, Baoying Wang, Wenhua Zhu, Yan Feng, Fangying Du, Shaolan Wang, Chenghu Hu, Jie Ma, Xiaorui Y. 17β-Estradiol Protects the Retinal Nerve Cells Suppressing TLR2 Mediated Immune-Inflammation and Apoptosis from Oxidative Stress Insult Independent of PI3K. Journal of molecular neuroscience : MN. vol 60. issue 2. 2017-03-23. PMID:27596287. |
the excessive apoptosis of retinal nerve cells (rncs) could cause a variety of retinal neurodegenerative diseases which could result in the irreversible blindness. |
2017-03-23 |
2023-08-13 |
rat |
| Jagatheesan Nataraj, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozhi, Musthafa Mohammed Ess. Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress. Nutritional neuroscience. vol 19. issue 6. 2017-03-10. PMID:25730317. |
mitochondrial dysfunction and oxidative stress-mediated apoptosis plays an important role in various neurodegenerative diseases including huntington's disease, parkinson's disease (pd) and alzheimer's disease (ad). |
2017-03-10 |
2023-08-13 |
human |
| Meizhu Zheng, Chunming Liu, Yajun Fan, Dongfang Shi, Yuchi Zhan. Protective Effects of Paeoniflorin Against MPP(+)-induced Neurotoxicity in PC12 Cells. Neurochemical research. vol 41. issue 6. 2017-03-06. PMID:27053303. |
pf has neuroprotective effects on mpp(+)-induced apoptosis in pc12 cells via regulating mitochondrial membrane potential and bcl-2/bax/caspase-3 signaling pathways, and this new insight will help develop a pf-based therapeutic strategy for treatmenting neurodegenerative diseases and injury. |
2017-03-06 |
2023-08-13 |
rat |
| Yu Xiong, Hong-Pei Ji, Wei-Tao Song, Ye-Wei Yin, Chao-Hua Xia, Bei Xu, Yi Xu, Xiao-Bo Xi. N-methyl-N-nitrosourea induces retinal degeneration in the rat via the inhibition of NF-κB activation. Cell biochemistry and function. vol 34. issue 8. 2017-01-31. PMID:27862073. |
retinitis pigmentosa (rp) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. |
2017-01-31 |
2023-08-13 |
rat |
| Maria Derksen, Christian Vorwerk, Detlef Sieme. Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. Protoplasma. vol 253. issue 3. 2016-12-14. PMID:26108743. |
the permeability transition pore (ptp) of inner mitochondrial membranes is a large conductance pathway for ions up to 1500 da which opening is responsible for ion equilibration and loss of membrane potential in apoptosis and thus in several neurodegenerative diseases. |
2016-12-14 |
2023-08-13 |
rat |
| Ye Tao, Tao Chen, Wei Fang, Guanghua Peng, Liqiang Wang, Limin Qin, Bei Liu, Yi Fei Huan. The temporal topography of the N-Methyl- N-nitrosourea induced photoreceptor degeneration in mouse retina. Scientific reports. vol 5. 2016-12-13. PMID:26685797. |
retinitis pigmentosa (rp) is a group of inherited neurodegenerative diseases characterized by the progressive photoreceptors apoptosis. |
2016-12-13 |
2023-08-13 |
mouse |