| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kyoung Joo Cho, So Young Cheon, Gyung Whan Ki. Apoptosis signal-regulating kinase 1 mediates striatal degeneration via the regulation of C1q. Scientific reports. vol 6. 2016-12-13. PMID:26728245. |
apoptosis signal-regulating kinase-1 (ask1), an early signaling element in the cell death pathway, has been hypothesized to participate in the pathology of neurodegenerative diseases. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ankit Shah, Naveen K Vaidya, Hari K Bhat, Anil Kuma. HIV-1 gp120 induces type-1 programmed cell death through ER stress employing IRE1α, JNK and AP-1 pathway. Scientific reports. vol 6. 2016-12-13. PMID:26740125. |
the er stress-mediated apoptosis has been implicated in several neurodegenerative diseases; however, its role in hiv/neuroaids remains largely unexplored. |
2016-12-13 |
2023-08-13 |
mouse |
| Min Wang, Yu-Jiao Li, Yi Ding, Hui-Nan Zhang, Ting Sun, Kun Zhang, Le Yang, Yan-Yan Guo, Shui-Bing Liu, Ming-Gao Zhao, Yu-Mei W. Silibinin Prevents Autophagic Cell Death upon Oxidative Stress in Cortical Neurons and Cerebral Ischemia-Reperfusion Injury. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25561437. |
neuronal apoptosis and oxidative stress are involved in most of the neurodegenerative diseases, promoting neuron survival is critical for therapy. |
2016-11-14 |
2023-08-13 |
mouse |
| Garima Singh, Jingwen Zhang, Yilun Ma, Richard A Cerione, Marc A Antonya. The Different Conformational States of Tissue Transglutaminase Have Opposing Affects on Cell Viability. The Journal of biological chemistry. vol 291. issue 17. 2016-11-03. PMID:26893378. |
these findings provide important insights into how ttg participates in the pathogenesis of neurodegenerative diseases, particularly with regard to the actions of a c-terminal truncated form of ttg (tg-short) that has been linked to such disorders and induces apoptosis by assuming an open-like conformation. |
2016-11-03 |
2023-08-13 |
human |
| Liang Chen, Lejin Sun, Zhene Liu, Hongxia Wang, Cunli X. Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway. Journal of receptor and signal transduction research. vol 36. issue 1. 2016-10-25. PMID:26414235. |
cell damage and apoptosis induced by oxidative stress have been involved in various neurodegenerative diseases. |
2016-10-25 |
2023-08-13 |
Not clear |
| Shuang Hu, Di Wang, Junrong Zhang, Mengyan Du, Yingkun Cheng, Yan Liu, Ning Zhang, Di Wang, Yi W. Mitochondria Related Pathway Is Essential for Polysaccharides Purified from Sparassis crispa Mediated Neuro-Protection against Glutamate-Induced Toxicity in Differentiated PC12 Cells. International journal of molecular sciences. vol 17. issue 2. 2016-10-19. PMID:26821016. |
these results suggested that scwea protects against l-glu-induced neuronal apoptosis in dpc12 cells and may be a promising candidate for treatment against neurodegenerative disease. |
2016-10-19 |
2023-08-13 |
Not clear |
| J Hu, M Xu, J Yuan, B Li, S Entenman, H Yu, Q Y Zhen. Tauroursodeoxycholic acid prevents hearing loss and hair cell death in Cdh23(erl/erl) mice. Neuroscience. vol 316. 2016-10-18. PMID:26748055. |
tauroursodeoxycholic acid (tudca), a taurine-conjugated bile acid, has been used in experimental research and clinical applications related to liver disease, diabetes, neurodegenerative diseases, and other diseases associated with apoptosis. |
2016-10-18 |
2023-08-13 |
mouse |
| Ting Zhu, Deming Zhao, Zhiqi Song, Zhen Yuan, Chaosi Li, Yunsheng Wang, Xiangmei Zhou, Xiaomin Yin, Muhammad Farooque Hassan, Lifeng Yan. HDAC6 alleviates prion peptide-mediated neuronal death via modulating PI3K-Akt-mTOR pathway. Neurobiology of aging. vol 37. 2016-09-26. PMID:26507311. |
histone deacetylase 6 (hdac6) controls several major cellular responses to stress that play a role in neurodegenerative diseases, including aggresome formation, autophagy, and apoptosis. |
2016-09-26 |
2023-08-13 |
Not clear |
| Danya Ben-Hail, Varda Shoshan-Barmat. VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis. Biochimica et biophysica acta. vol 1863. issue 7 Pt A. 2016-09-08. PMID:27064145. |
finally, inhibitors of apoptosis could serve in pathological conditions where enhanced apoptosis is found, such as neurodegenerative diseases. |
2016-09-08 |
2023-08-13 |
Not clear |
| Baoman Wang, Fei Yuan, Xiangyin Kong, Lan-Dian Hu, Yu-Dong Ca. Identifying Novel Candidate Genes Related to Apoptosis from a Protein-Protein Interaction Network. Computational and mathematical methods in medicine. vol 2015. 2016-08-29. PMID:26543496. |
in addition, some diseases, such as obesity, cancer, and neurodegenerative diseases, can be cured through apoptosis, which produces few side effects. |
2016-08-29 |
2023-08-13 |
Not clear |
| Liang Zhou, Hongfeng Wang, Haigang Ren, Qingsong Hu, Zheng Ying, Guanghui Wan. Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease. Molecular neurobiology. vol 52. issue 3. 2016-08-08. PMID:25311206. |
b-cell lymphoma 2 (bcl-2) is a key regulator in autophagy, apoptosis, and mitochondria quality control in many cell types including neurons, and it plays important roles in the pathogenesis of neurodegenerative diseases mentioned above. |
2016-08-08 |
2023-08-13 |
Not clear |
| Sajjad Sisakhtnezhad, Leila Khosrav. Emerging physiological and pathological implications of tunneling nanotubes formation between cells. European journal of cell biology. vol 94. issue 10. 2016-07-04. PMID:26164368. |
moreover, the latest findings into their functional roles in physiological and pathological processes, such as signal transduction, micro and nano-particles delivery, immune responses, embryogenesis, cellular reprogramming, apoptosis, cancer, and neurodegenerative diseases initiation and progression and pathogens transfer, will be discussed. |
2016-07-04 |
2023-08-13 |
Not clear |
| Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhan. HMGB1 Promotes Mitochondrial Dysfunction-Triggered Striatal Neurodegeneration via Autophagy and Apoptosis Activation. PloS one. vol 10. issue 11. 2016-06-29. PMID:26565401. |
in this study, we focused on the high-mobility group box 1 (hmgb1) protein, which is important in oxidative stress signaling as well as in autophagy and apoptosis, to explore whether the mechanisms of autophagy and apoptosis in neurodegenerative diseases are associated with metabolic impairment. |
2016-06-29 |
2023-08-13 |
rat |
| Jie Wu, Ming Cheng, Qiufang Liu, Jinghua Yang, Shengwen Wu, Xiaobo Lu, Cuihong Jin, Honglin Ma, Yuan Ca. Protective Role of tert-Butylhydroquinone Against Sodium Fluoride-Induced Oxidative Stress and Apoptosis in PC12 Cells. Cellular and molecular neurobiology. vol 35. issue 7. 2016-06-24. PMID:25911493. |
in contrast, induction of detoxifying and antioxidant genes through activation of nf-e2-related factor 2 (nrf2) has been implicated in preventing oxidative stress and apoptosis in neurodegenerative diseases. |
2016-06-24 |
2023-08-13 |
rat |
| Yosra Hamdi, Hadhemi Kaddour, David Vaudry, Jérôme Leprince, Amira Zarrouk, Mohamed Hammami, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouk. Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes. Peptides. vol 71. 2016-06-17. PMID:26143507. |
oxidative stress, associated with a variety of disorders including neurodegenerative diseases, is a major cause of cellular dysfunction and biomolecule damages which play a crucial role in neuronal apoptosis. |
2016-06-17 |
2023-08-13 |
rat |
| Jie Wei, Hua Jiang, Hongrui Gao, Guangjie Wan. Raf-1 Kinase Inhibitory Protein (RKIP) Promotes Retinal Ganglion Cell Survival and Axonal Regeneration Following Optic Nerve Crush. Journal of molecular neuroscience : MN. vol 57. issue 2. 2016-06-17. PMID:26160696. |
raf-1 kinase inhibitory protein (rkip), a member of the phosphatidylethanolamine-binding protein (pebp) family, plays an important role in neuronal apoptosis and cognitive deficits associated with neurodegenerative diseases. |
2016-06-17 |
2023-08-13 |
mouse |
| Xiao-long Sun, Li Duan, Xi-ying Jiao, Liang-wei Che. [The "Yin/Yang" Functional Features of Neurotrophic Factors]. Sheng li ke xue jin zhan [Progress in physiology]. vol 46. issue 3. 2016-06-10. PMID:26521480. |
growing evidences have revealed that pro-forms of various neurotrophic factors, which are generated in process of protein synthesis and might exert opposite roles involving in inducement of neuronal apoptosis and implication in pathogenesis of neurodegenerative diseases. |
2016-06-10 |
2023-08-13 |
Not clear |
| Gabriela D Colpo, Bruna M Ascoli, Bianca Wollenhaupt-Aguiar, Bianca Pfaffenseller, Emily G Silva, Elizabeth O Cirne-Lima, João Quevedo, Flávio Kapczinski, Adriane R Ros. Mesenchymal stem cells for the treatment of neurodegenerative and psychiatric disorders. Anais da Academia Brasileira de Ciencias. vol 87. issue 2 Suppl. 2016-05-23. PMID:26247151. |
therapies with mscs have shown promising results neurodegenerative diseases, in addition to regulating inflammation, they can promote other beneficial effects, such as neuronal growth, decrease free radicals, and reduce apoptosis. |
2016-05-23 |
2023-08-13 |
Not clear |
| Wioletta Rozpędek, Łukasz Markiewicz, J Alan Diehl, Dariusz Pytel, Ireneusz Majstere. [The role of the adaptive stress response in the pathogenesis of neurodegenerative diseases, cancer and diabetes mellitus type 2]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 39. issue 234. 2016-04-15. PMID:26802695. |
recent research allows for a conclusion that the deregulation of upr is the main causative factor for functional cell loss and moreover, cell death by apoptosis, which is strictly linked to the pathology of human diseases to include: cancer, diabetes mellitus type 2 and neurodegenerative diseases such as alzheimer's, parkinson's and prion diseases. |
2016-04-15 |
2023-08-13 |
human |
| Neda Masoudian, Gholam Hossein Riazi, Ali Afrasiabi, Seyed Mohamad Sadegh Modaresi, Ali Dadras, Shahrbanoo Rafiei, Meysam Yazdankhah, Atiye Lyaghi, Mostafa Jarah, Shahin Ahmadian, Hossein Seidkhan. Variations of glutamate concentration within synaptic cleft in the presence of electromagnetic fields: an artificial neural networks study. Neurochemical research. vol 40. issue 4. 2016-04-05. PMID:25577979. |
excessive elevated concentrations of glu in synaptic cleft results in neural cell apoptosis which is called excitotoxicity causing neurodegenerative diseases. |
2016-04-05 |
2023-08-13 |
Not clear |