| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hao Huang, Peipei Yan, Taoping Sun, Xiaoxing Mo, Jiawei Yin, Peiyun Li, Yalun Zhu, Shuang Rong, Wei Yang, Xiaoyi Chen, Liegang Li. Procyanidins Extracted from Lotus Seedpod Ameliorate Amyloid- Oxidative medicine and cellular longevity. vol 2018. 2019-01-07. PMID:30538801. |
procyanidins extracted from lotus seedpod ameliorate amyloid- alzheimer's disease (ad) is a progressive neurodegenerative disease, which is characterized by extracellular senile plaque deposits, intracellular neurofibrillary tangles, and neuronal apoptosis. |
2019-01-07 |
2023-08-13 |
Not clear |
| Huanhuan Luo, Liying Cao, Xuan Liang, Ana Du, Ting Peng, He L. Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones. Molecular neurobiology. vol 55. issue 10. 2018-12-18. PMID:29430620. |
in neurodegenerative diseases, pathogenic proteins tend to misfold and form aggregates that are difficult to remove and able to induce excessive endoplasmic reticulum (er) stress, leading to neuronal injury and apoptosis. |
2018-12-18 |
2023-08-13 |
Not clear |
| Dinesh Kumar Verma, Sonam Gupta, Joyshree Biswas, Neeraj Joshi, Abhishek Singh, Parul Gupta, Shubhangini Tiwari, K Sivarama Raju, Swati Chaturvedi, M Wahajuddin, Sarika Sing. New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: Participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 6 Pt A. 2018-12-11. PMID:29551729. |
new therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. |
2018-12-11 |
2023-08-13 |
rat |
| Bin Yu, Shan Li, Wenying Qiu, Minghui Wang, Junwei Du, Yusen Zhang, Xing Che. Prediction of subcellular location of apoptosis proteins by incorporating PsePSSM and DCCA coefficient based on LFDA dimensionality reduction. BMC genomics. vol 19. issue 1. 2018-12-11. PMID:29914358. |
apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. |
2018-12-11 |
2023-08-13 |
human |
| Sujuan Chen, Dandan Guo, Wei Zhang, Yunfei Xie, Haijie Yang, Binfeng Cheng, Lei Wang, Rui Yang, Jiajia Bi, Zhiwei Fen. Biglycan, a Nitric Oxide-Downregulated Proteoglycan, Prevents Nitric Oxide-Induced Neuronal Cell Apoptosis via Targeting Erk1/2 and p38 Signaling Pathways. Journal of molecular neuroscience : MN. vol 66. issue 1. 2018-11-09. PMID:30088173. |
nitric oxide (no), a gaseous signaling molecule, induces apoptosis and mediates neurodegenerative diseases and brain injury. |
2018-11-09 |
2023-08-13 |
human |
| Jing Fan, Ted M Dawson, Valina L Dawso. Cell Death Mechanisms of Neurodegeneration. Advances in neurobiology. vol 15. 2018-11-01. PMID:28674991. |
besides apoptosis, necroptosis, and autophagy, an important form of death termed parthanatos plays a prominent role in stroke and several neurodegenerative diseases, which is due to parp-1 overactivation, par accumulation, nuclear translocation of the mitochondria protein aif, and large-scale dna cleavage. |
2018-11-01 |
2023-08-13 |
Not clear |
| Hai-Jie Yang, Fei Ju, Xin-Xin Guo, Shuang-Ping Ma, Lei Wang, Bin-Feng Cheng, Rui-Juan Zhuang, Bin-Bin Zhang, Xiang Shi, Zhi-Wei Feng, Mian Wan. RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Scientific reports. vol 7. 2018-10-24. PMID:28134320. |
nitric oxide (no)-induced apoptosis in neurons is an important cause of neurodegenerative disease in humans. |
2018-10-24 |
2023-08-13 |
human |
| Adaze Bijou Enogieru, William Haylett, Donavon Charles Hiss, Soraya Bardien, Okobi Eko Ekp. Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders. Oxidative medicine and cellular longevity. vol 2018. 2018-10-22. PMID:30050657. |
a wide range of neurodegenerative diseases (nds), including alzheimer's disease, parkinson's disease, huntington's disease, and prion diseases, share common mechanisms such as neuronal loss, apoptosis, mitochondrial dysfunction, oxidative stress, and inflammation. |
2018-10-22 |
2023-08-13 |
Not clear |
| Y Chandrasekhar, G Phani Kumar, E M Ramya, K R Anilakuma. Gallic Acid Protects 6-OHDA Induced Neurotoxicity by Attenuating Oxidative Stress in Human Dopaminergic Cell Line. Neurochemical research. vol 43. issue 6. 2018-10-15. PMID:29671234. |
these findings indicate that gallic acid is able to protect the neuronal cells against 6-ohda induced injury and proved that gallic acid might potentially serve as an agent for prevention of several human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2018-10-15 |
2023-08-13 |
human |
| Fatma Helvacioglu, Ersin Kandemir, Busra Karabacak, Idil Karatas, Ahmet Pecen, Ipek Ercan, Tugce Sencelikel, Attila Dagdevire. Effect of Creatine on Rat Sciatic Nerve Injury: A Comparative Ultrastructural Study. Turkish neurosurgery. vol 28. issue 1. 2018-06-20. PMID:27858383. |
as it is expected to prevent apoptosis and diminish oxidative stress, it is also studied in a number of neurodegenerative diseases for its beneficial effect in recent years. |
2018-06-20 |
2023-08-13 |
rat |
| Tae-Ho Jang, In-Hye Lim, Chang Min Kim, Jae Young Choi, Eun-Ae Kim, Tae-Jin Lee, Hyun Ho Par. Rescuing neuronal cell death by RAIDD- and PIDD- derived peptides and its implications for therapeutic intervention in neurodegenerative diseases. Scientific reports. vol 6. 2018-05-02. PMID:27502430. |
our peptides are novel neuronal cell apoptosis inhibitors that might serve as a prototype for development of drugs for the treatment of neurodegenerative diseases. |
2018-05-02 |
2023-08-13 |
Not clear |
| Alejandro O Sodero, Monica Rodriguez-Silva, Chiara Salio, Marco Sassoè-Pognetto, Jeremy W Chamber. Sab is differentially expressed in the brain and affects neuronal activity. Brain research. vol 1670. 2018-04-26. PMID:28606781. |
sab (sh3 binding protein 5 or sh3bp5) is a mitochondrial scaffold protein involved in signaling associated with mitochondrial dysfunction and apoptosis; furthermore, sab is a crucial signaling platform for neurodegenerative disease. |
2018-04-26 |
2023-08-13 |
mouse |
| Kisang Kwon, Young-Sook Kwon, Seung-Whan Kim, Kweon Yu, Kyung-Ho Lee, O-Yu Kwo. Luteolin-induced apoptosis through activation of endoplasmic reticulum stress sensors in pheochromocytoma cells. Molecular medicine reports. vol 16. issue 1. 2018-03-26. PMID:28498401. |
the results suggested that the understanding of the molecular mechanisms underlying luteolin‑induced apoptosis may be useful in cancer therapeutics, chemoprevention and neurodegenerative diseases, such as parkinson's disease and alzheimer's disease. |
2018-03-26 |
2023-08-13 |
rat |
| Yinan Nan, Shaoqing Wang, William Ji. Caspase independent cleavages of TDP-43 generates 35kD fragment that cause apoptosis of breast cancer cells. Biochemical and biophysical research communications. vol 497. issue 1. 2018-03-23. PMID:29421661. |
due to its central role in neurodegenerative disease pathogenesis, most research recently has focused on its role associated with neurodegeneration disease, research on neuron and glial cell showed that pathological tdp-43 is associated with cell apoptosis which lead to loss of functional neurons and glial cells. |
2018-03-23 |
2023-08-13 |
Not clear |
| Niels H Skotte, Shaun S Sanders, Roshni R Singaraja, Dagmar E Ehrnhoefer, Kuljeet Vaid, Xiaofan Qiu, Srinivasaragavan Kannan, Chandra Verma, Michael R Hayde. Palmitoylation of caspase-6 by HIP14 regulates its activation. Cell death and differentiation. vol 24. issue 3. 2018-01-19. PMID:27911442. |
caspase-6 (casp6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases alzheimer and huntington disease. |
2018-01-19 |
2023-08-13 |
Not clear |
| Kristian K Starheim, Thomas V Kalvik, Geir Bjørkøy, Thomas Arnese. Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization. Bioscience reports. vol 37. issue 2. 2018-01-16. PMID:28356483. |
golgi stack scattering is observed in cellular processes such as apoptosis and mitosis, and has also been associated with disruption of cellular lipid metabolism and neurodegenerative diseases. |
2018-01-16 |
2023-08-13 |
human |
| Yingting Wang, Shulong Jiang, Hongli Wang, Haiyan Bi. A mucoadhesive, thermoreversible in situ nasal gel of geniposide for neurodegenerative diseases. PloS one. vol 12. issue 12. 2018-01-16. PMID:29240797. |
geniposide could inhibit oxidative stress, reduce apoptosis, protect neuron, and has been used for therapy of the neurodegenerative diseases. |
2018-01-16 |
2023-08-13 |
Not clear |
| Yi Cui, Nuo Xu, Wei Xu, Guoxing X. Mesenchymal stem cells attenuate hydrogen peroxide-induced oxidative stress and enhance neuroprotective effects in retinal ganglion cells. In vitro cellular & developmental biology. Animal. vol 53. issue 4. 2018-01-15. PMID:27864663. |
the apoptosis of retinal ganglion cells leads to visual impairment and blindness in ocular neurodegenerative diseases, especially in diabetic retinopathy (dr). |
2018-01-15 |
2023-08-13 |
Not clear |
| Ankit Shah, Anil Kuma. Methamphetamine-mediated endoplasmic reticulum (ER) stress induces type-1 programmed cell death in astrocytes via ATF6, IRE1α and PERK pathways. Oncotarget. vol 7. issue 29. 2018-01-08. PMID:27323860. |
conversely, the er stress-mediated apoptosis has been implicated in several neurodegenerative diseases. |
2018-01-08 |
2023-08-13 |
mouse |
| Pandian Nagakannan, Mohamed Ariff Iqbal, Albert Yeung, James A Thliveris, Mojgan Rastegar, Saeid Ghavami, Eftekhar Eftekharpou. Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27693380. |
our study provides evidence that excessive oxidative stress inhibits protein degradation systems and affects the final stages of autophagy by inhibiting autolysosome maturation: a novel mechanistic link between protein aggregation and conversion of autophagy to apoptosis that can be applicable to neurodegenerative diseases. |
2017-12-25 |
2023-08-13 |
Not clear |