| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sergiy A Starosyla, Galyna P Volynets, Sergiy S Lukashov, Oksana B Gorbatiuk, Andriy G Golub, Volodymyr G Bdzhola, Sergiy M Yarmolu. Identification of apoptosis signal-regulating kinase 1 (ASK1) inhibitors among the derivatives of benzothiazol-2-yl-3-hydroxy-5-phenyl-1,5-dihydro-pyrrol-2-one. Bioorganic & medicinal chemistry. vol 23. issue 10. 2016-01-26. PMID:25882527. |
apoptosis signal-regulating kinase 1 (ask1) plays important roles in the pathogenesis of type 1 and type 2 diabetes, autoimmune disorders, cancer and neurodegenerative diseases suggesting that small compounds inhibiting ask1 could be used for the treatment of these pathologies. |
2016-01-26 |
2023-08-13 |
Not clear |
| Ramon Yarza, Silvia Vela, Maite Solas, Maria J Ramire. c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer's Disease. Frontiers in pharmacology. vol 6. 2016-01-21. PMID:26793112. |
in addition, activation of jnk has been identified as a key element responsible for the regulation of apoptosis signals and therefore, it is critical for pathological cell death associated with neurodegenerative diseases and, among them, with alzheimer's disease (ad). |
2016-01-21 |
2023-08-13 |
Not clear |
| Blanca Arango-Gonzalez, Dragana Trifunović, Ayse Sahaboglu, Katharina Kranz, Stylianos Michalakis, Pietro Farinelli, Susanne Koch, Fred Koch, Sandra Cottet, Ulrike Janssen-Bienhold, Karin Dedek, Martin Biel, Eberhart Zrenner, Thomas Euler, Per Ekström, Marius Ueffing, François Paquet-Duran. Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. PloS one. vol 9. issue 11. 2016-01-15. PMID:25392995. |
cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration. |
2016-01-15 |
2023-08-13 |
human |
| Dongfeng Wei, Tong Chen, Mingfei Yan, Wanghong Zhao, Fei Li, Weidong Cheng, Lixia Yua. Synthesis, characterization, antioxidant activity and neuroprotective effects of selenium polysaccharide from Radix hedysari. Carbohydrate polymers. vol 125. 2016-01-01. PMID:25857971. |
furthermore, both rhp and se-rhp3 had neuroprotective effects against aβ25-35-induced oxidative stress and apoptosis in sh-sy5y human neuroblastoma cells, which might be a potential therapeutic agent for preventing or treating neurodegenerative diseases. |
2016-01-01 |
2023-08-13 |
human |
| Wenbin Zeng, Xiaobo Wang, Pengfei Xu, Gang Liu, Henry S Eden, Xiaoyuan Che. Molecular imaging of apoptosis: from micro to macro. Theranostics. vol 5. issue 6. 2015-12-17. PMID:25825597. |
apoptosis, or programmed cell death, is involved in numerous human conditions including neurodegenerative diseases, ischemic damage, autoimmune disorders and many types of cancer, and is often confused with other types of cell death. |
2015-12-17 |
2023-08-13 |
human |
| Xiaoxi Han, Shengkun Sun, Ming Zhao, Xiang Cheng, Guozhu Chen, Song Lin, Yifu Guan, Xiaodan Y. Celastrol stimulates hypoxia-inducible factor-1 activity in tumor cells by initiating the ROS/Akt/p70S6K signaling pathway and enhancing hypoxia-inducible factor-1α protein synthesis. PloS one. vol 9. issue 11. 2015-12-14. PMID:25383959. |
celastrol, a tripterine derived from the traditional chinese medicine plant tripterygium wilfordii hook f. ("thunder of god vine"), has been reported to have multiple effects, such as anti-inflammation, suppression of tumor angiogenesis, inhibition of tumor growth, induction of apoptosis and protection of cells against human neurodegenerative diseases. |
2015-12-14 |
2023-08-13 |
human |
| En-Ping Jiang, He Li, Chun-Rong Yu, Chun-Yan Yu, Shu Jing, Hong-Xia Sun, Chun-Mei Wang, Xin-Tian Fan, Jian-Guang Chen, Sen Wan. Schisandrin B protects PC12 cells against oxidative stress of neurodegenerative diseases. Neuroreport. vol 26. issue 6. 2015-12-14. PMID:25756908. |
results indicate that sch b can protect pc12 cells from apoptosis by activating the phosphatidylinositol-3 kinase/akt signaling pathway and may emerge as a potential drug for neurodegenerative diseases. |
2015-12-14 |
2023-08-13 |
Not clear |
| Hai-Jie Yang, Mian Wang, Lei Wang, Bin-Feng Cheng, Xiao-Yu Lin, Zhi-Wei Fen. NF-κB regulates caspase-4 expression and sensitizes neuroblastoma cells to Fas-induced apoptosis. PloS one. vol 10. issue 2. 2015-11-16. PMID:25695505. |
found in neurons and neuroblastoma cells, fas-induced apoptosis and accompanied activation of nf-κb signaling were thought to be associated with neurodegenerative diseases. |
2015-11-16 |
2023-08-13 |
Not clear |
| Alex Stoyanov, Roger Pamphlet. Is the risk of motor neuron disease increased or decreased after cancer? An Australian case-control study. PloS one. vol 9. issue 7. 2015-11-13. PMID:25058637. |
this suggests that some pathogenetic mechanisms, such as apoptosis, are less relevant in smnd than in other neurodegenerative diseases where negative associations with cancer have been found. |
2015-11-13 |
2023-08-13 |
Not clear |
| Asokan Prema, Udaiyappan Janakiraman, Thamilarasan Manivasagam, Arokiasamy Justin Thenmozh. Neuroprotective effect of lycopene against MPTP induced experimental Parkinson's disease in mice. Neuroscience letters. vol 599. 2015-10-16. PMID:25980996. |
as to conclude, lycopene reverses neurochemical deficts, oxidative stress, apoptosis and physiological abnormalities in pd mice and offer promise strategy in the treatment of this neurodegenerative disease. |
2015-10-16 |
2023-08-13 |
mouse |
| Peter G E Kenned. Viruses, apoptosis, and neuroinflammation--a double-edged sword. Journal of neurovirology. vol 21. issue 1. 2015-09-30. PMID:25604493. |
apoptosis has been reported in several neurodegenerative diseases and also psychiatric disorders but the true clinical significance of such observations is not certain, and, though interesting, it is very difficult to ascribe causation in these conditions. |
2015-09-30 |
2023-08-13 |
human |
| Lingxin Zhu, Jingwen Yang, Jie Zhang, Bin Pen. The presence of autophagy in human periapical lesions. Journal of endodontics. vol 39. issue 11. 2015-09-29. PMID:24139258. |
autophagy, a lysosome- or endosome-mediated self-degradation process, participates in diverse neurodegenerative diseases, cancer, and inflammatory diseases associated with apoptosis. |
2015-09-29 |
2023-08-12 |
human |
| Teng Yu, Joshua Zuber, Jinchao L. Targeting autophagy in skin diseases. Journal of molecular medicine (Berlin, Germany). vol 93. issue 1. 2015-09-08. PMID:25404245. |
in addition to its vital homeostatic role, this degradation pathway has been implicated in many different cellular processes such as cell apoptosis, inflammation, pathogen clearance, and antigen presentation and thereby has been linked to a variety of human disorders, including metabolic conditions, neurodegenerative diseases, cancers, and infectious diseases. |
2015-09-08 |
2023-08-13 |
human |
| Norsharina Ismail, Maznah Ismail, Siti Farhana Fathy, Siti Nor Asma Musa, Mustapha Umar Imam, Jhi Biau Foo, Shahid Iqba. Neuroprotective effects of germinated brown rice against hydrogen peroxide induced cell death in human SH-SY5Y cells. International journal of molecular sciences. vol 13. issue 8. 2015-08-31. PMID:22949825. |
therefore, gbr could be developed as a value added functional food to prevent neurodegenerative diseases caused by oxidative stress and apoptosis. |
2015-08-31 |
2023-08-12 |
human |
| Raynoo Thanan, Shinji Oikawa, Yusuke Hiraku, Shiho Ohnishi, Ning Ma, Somchai Pinlaor, Puangrat Yongvanit, Shosuke Kawanishi, Mariko Murat. Oxidative stress and its significant roles in neurodegenerative diseases and cancer. International journal of molecular sciences. vol 16. issue 1. 2015-08-28. PMID:25547488. |
in neurodegenerative diseases, dna damage may not only play a role in the induction of apoptosis, but also may inhibit cellular division via telomere shortening. |
2015-08-28 |
2023-08-13 |
Not clear |
| Eleonora Passeri, Italo Mocchetti, Charbel Mouss. Is human immunodeficiency virus-mediated dementia an autophagic defect that leads to neurodegeneration? CNS & neurological disorders drug targets. vol 13. issue 9. 2015-08-19. PMID:25106633. |
autophagy may protect against neuronal apoptosis, which is induced in a number of neurodegenerative diseases. |
2015-08-19 |
2023-08-13 |
human |
| Giovanni Sorrentino, Anna Comel, Fiamma Mantovani, Giannino Del Sa. Regulation of mitochondrial apoptosis by Pin1 in cancer and neurodegeneration. Mitochondrion. vol 19 Pt A. 2015-08-03. PMID:25132079. |
in this review we will discuss the impact of pin1 in regulating various aspects of apoptosis in different biological contexts with particular emphasis on cancer and neurodegenerative diseases. |
2015-08-03 |
2023-08-13 |
Not clear |
| Ayşe Karababa, Boris Görg, Freimut Schliess, Dieter Häussinge. O-GlcNAcylation as a novel ammonia-induced posttranslational protein modification in cultured rat astrocytes. Metabolic brain disease. vol 29. issue 4. 2015-07-20. PMID:24292976. |
in view of the complex involvement of o-glcnacylation in cell regulation, such as energy metabolism, apoptosis and circadian rhythmicity and in pathologies, such as neurodegenerative diseases, o-glcnacylation might contribute to the pathophysiology of hepatic encephalopathy. |
2015-07-20 |
2023-08-12 |
rat |
| Valérie Jolivel, Sébastien Arthaud, Béatrice Botia, Christophe Portal, Bruno Delest, Guillaume Clavé, Jérôme Leprince, Anthony Romieu, Pierre-Yves Renard, Omar Touzani, Heidi Ligeret, Pauline Noack, Marc Massonneau, Alain Fournier, Hubert Vaudry, David Vaudr. Biochemical characterization of a Caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis. Journal of molecular neuroscience : MN. vol 54. issue 3. 2015-07-14. PMID:24865411. |
apoptosis is a regulated process, leading to cell death, which is involved in several pathologies including neurodegenerative diseases and stroke. |
2015-07-14 |
2023-08-13 |
Not clear |
| Elena Radi, Patrizia Formichi, Carla Battisti, Antonio Federic. Apoptosis and oxidative stress in neurodegenerative diseases. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:25056458. |
apoptosis and oxidative stress in neurodegenerative diseases. |
2015-06-29 |
2023-08-13 |
human |