| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elena Radi, Patrizia Formichi, Carla Battisti, Antonio Federic. Apoptosis and oxidative stress in neurodegenerative diseases. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:25056458. |
however, many dying neurons have been detected in brains of patients with neurodegenerative diseases, and these conditions are often associated with significant cell loss accompanied by typical morphological features of apoptosis such as chromatin condensation, dna fragmentation, and activation of cysteine-proteases, caspases. |
2015-06-29 |
2023-08-13 |
human |
| Elena Radi, Patrizia Formichi, Carla Battisti, Antonio Federic. Apoptosis and oxidative stress in neurodegenerative diseases. Journal of Alzheimer's disease : JAD. vol 42 Suppl 3. 2015-06-29. PMID:25056458. |
here we present an overview of the involvement of neuronal apoptosis and oxidative stress in the most important neurodegenerative diseases, mainly focusing the attention on several genetic disorders, discussing the interaction between primary genetic abnormalities and the apoptotic pathways. |
2015-06-29 |
2023-08-13 |
human |
| Mummedy Swamy, Dian Suhaili, K N S Sirajudeen, Zulkarnain Mustapha, Chandran Govindasam. Propolis ameliorates tumor nerosis factor-α, nitric oxide levels, caspase-3 and nitric oxide synthase activities in kainic acid mediated excitotoxicity in rat brain. African journal of traditional, complementary, and alternative medicines : AJTCAM. vol 11. issue 5. 2015-06-29. PMID:25395704. |
increased nitric oxide (no), neuronal inflammation and apoptosis have been proposed to be involved in excitotoxicity plays a part in many neurodegenerative diseases. |
2015-06-29 |
2023-08-13 |
rat |
| Agnieszka Kobylińska, Krystyna M Jana. [Health--promoting effect of quercetin in human diet]. Postepy higieny i medycyny doswiadczalnej (Online). vol 69. 2015-06-23. PMID:25589713. |
this compound at low concentrations can stimulate proliferation of human cells, so it can be a potential drug in the treatment of neurodegenerative diseases and in high concentrations, it induces apoptosis thereby eliminating the infected or abnormal cells and can serve as a potential anticancer drug with wide clinical application. |
2015-06-23 |
2023-08-13 |
human |
| Sandrine Jouan-Lanhouet, Franck Riquet, Linde Duprez, Tom Vanden Berghe, Nozomi Takahashi, Peter Vandenabeel. Necroptosis, in vivo detection in experimental disease models. Seminars in cell & developmental biology. vol 35. 2015-06-22. PMID:25160988. |
indeed, in addition to apoptosis, multiple forms of regulated necrosis have been associated with an increasing number of pathologies such as ischemia-reperfusion injury in brain, heart and kidney, inflammatory diseases, sepsis, retinal disorders, neurodegenerative diseases and infectious disorders. |
2015-06-22 |
2023-08-13 |
Not clear |
| Jung Soo Kim, Rok Won Heo, Hwajin Kim, Chin-Ok Yi, Hyun Joo Shin, Jong Woo Han, Gu Seob Ro. Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death. Journal of neural transmission (Vienna, Austria : 1996). vol 121. issue 10. 2015-06-16. PMID:24728926. |
parkin is an ubiquitin e3 ligase that mediates the ubiquitination of the bcl-2 family of proteins and its mutations are associated with neuronal apoptosis in neurodegenerative diseases. |
2015-06-16 |
2023-08-13 |
mouse |
| Grace Y Sun, Dennis Y Chuang, Yijia Zong, Jinghua Jiang, James C M Lee, Zezong Gu, Agnes Simony. Role of cytosolic phospholipase A2 in oxidative and inflammatory signaling pathways in different cell types in the central nervous system. Molecular neurobiology. vol 50. issue 1. 2015-06-10. PMID:24573693. |
in the central nervous system (cns), cpla(2) activation has been implicated in neuronal excitation, synaptic secretion, apoptosis, cell-cell interaction, cognitive and behavioral function, oxidative-nitrosative stress, and inflammatory responses that underline the pathogenesis of a number of neurodegenerative diseases. |
2015-06-10 |
2023-08-12 |
Not clear |
| Nicolas G Baza. Is there a molecular logic that sustains neuronal functional integrity and survival? Lipid signaling is necessary for neuroprotective neuronal transcriptional programs. Molecular neurobiology. vol 50. issue 1. 2015-06-10. PMID:25236258. |
in neurodegenerative diseases, apoptosis and other forms of cells death lead to selective neuronal loss. |
2015-06-10 |
2023-08-13 |
Not clear |
| Yiming Li, Yunshan Guo, Juan Tang, Jianli Jiang, Zhinan Che. New insights into the roles of CHOP-induced apoptosis in ER stress. Acta biochimica et biophysica Sinica. vol 46. issue 8. 2015-06-02. PMID:25016584. |
by now, chop-induced apoptosis in er stress has been implicated in numerous human diseases, such as neurodegenerative diseases, diabetes, ischemic diseases, tumor, and so on. |
2015-06-02 |
2023-08-13 |
human |
| Levent Tök, Mustafa Nazıroğlu, Abdülhadi Cihangir Uğuz, Ozlem Tö. Elevated hydrostatic pressures induce apoptosis and oxidative stress through mitochondrial membrane depolarization in PC12 neuronal cells: A cell culture model of glaucoma. Journal of receptor and signal transduction research. vol 34. issue 5. 2015-05-28. PMID:24809391. |
despite the importance of oxidative stress and apoptosis through mitochondrial depolarization in neurodegenerative diseases, their roles in etiology of glaucoma are poorly understood. |
2015-05-28 |
2023-08-13 |
rat |
| Wenna Chen, Ximing Li, Lian-Qun Jia, Jun Wang, Lin Zhang, Diandong Hou, Junyan Wang, Lu Re. Neuroprotective activities of catalpol against CaMKII-dependent apoptosis induced by LPS in PC12 cells. British journal of pharmacology. vol 169. issue 5. 2015-03-30. PMID:23550774. |
neurodegenerative diseases present progressive neurological disorder induced by cell death or apoptosis. |
2015-03-30 |
2023-08-12 |
Not clear |
| Ting Yu, Lei Li, Yanwen Bi, Zhen Liu, Huaxiang Liu, Zhenzhong L. Erythropoietin attenuates oxidative stress and apoptosis in Schwann cells isolated from streptozotocin-induced diabetic rats. The Journal of pharmacy and pharmacology. vol 66. issue 8. 2015-03-30. PMID:24673486. |
although erythropoietin (epo) was demonstrated to have neuroprotective effects in neurodegenerative diseases, the effects of epo on glucose-evoked oxidative stress and apoptosis of scs remain unknown. |
2015-03-30 |
2023-08-12 |
rat |
| Ran Lin, Alessia Angelin, Federico Da Settimo, Claudia Martini, Sabrina Taliani, Shigong Zhu, Douglas C Wallac. Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration. Aging cell. vol 13. issue 3. 2015-03-30. PMID:24977274. |
therefore, dtspo is an essential mediator of apoptosis in drosophila and plays a central role in controlling longevity and neurodegenerative disease, making it a promising drug target. |
2015-03-30 |
2023-08-13 |
drosophila_melanogaster |
| Md Shamim Hossain, Masataka Ifuku, Sachiko Take, Jun Kawamura, Kiyotaka Miake, Toshihiko Katafuch. Plasmalogens rescue neuronal cell death through an activation of AKT and ERK survival signaling. PloS one. vol 8. issue 12. 2015-03-02. PMID:24376709. |
neuronal cells are susceptible to many stresses, which will cause the apoptosis and neurodegenerative diseases. |
2015-03-02 |
2023-08-12 |
mouse |
| Jana Hroudová, Namrata Singh, Zdeněk Fiša. Mitochondrial dysfunctions in neurodegenerative diseases: relevance to Alzheimer's disease. BioMed research international. vol 2014. 2015-01-21. PMID:24900954. |
in the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ros production, impaired mitochondrial dynamics, and apoptosis. |
2015-01-21 |
2023-08-13 |
Not clear |
| Zhi Chen, Qingge Fu, Baoliang Shen, Xuan Huang, Kun Wang, Ping He, Fengning Li, Fan Zhang, Hongxing She. Enhanced p62 expression triggers concomitant autophagy and apoptosis in a rat chronic spinal cord compression model. Molecular medicine reports. vol 9. issue 6. 2015-01-05. PMID:24715058. |
p62 is a multidomain adapter protein, which is involved in apoptosis and cell survival as well as autophagy, and is a common component of protein aggregations in neurodegenerative diseases. |
2015-01-05 |
2023-08-13 |
rat |
| A-Rang Im, Sung-Wook Chae, Gui Jun Zhang, Mi-Young Le. Neuroprotective effects of Psoralea corylifolia Linn seed extracts on mitochondrial dysfunction induced by 3-nitropropionic acid. BMC complementary and alternative medicine. vol 14. 2014-12-22. PMID:25277760. |
mitochondrial dysfunction has been implicated in neuronal apoptosis associated with neurodegenerative diseases such as huntington's disease (hd). |
2014-12-22 |
2023-08-13 |
Not clear |
| Jun Ma, Rong Wu, Qiang Zhang, Jun-bing Wu, Jizhong Lou, Zheng Zheng, Jian-qing Ding, Zengqiang Yua. DJ-1 interacts with RACK1 and protects neurons from oxidative-stress-induced apoptosis. The Biochemical journal. vol 462. issue 3. 2014-10-28. PMID:24947010. |
taken together, the dj-1-rack1 complex protects neurons from oxidative stress-induced apoptosis, with the implication that dj-1 and rack1 might be novel targets in the treatment of neurodegenerative diseases. |
2014-10-28 |
2023-08-13 |
Not clear |
| Xiao-Long Sun, Bei-Yu Chen, Li Duan, Yi Xia, Zhuo-Jing Luo, Jing-Jie Wang, Zhi-Ren Rao, Liang-Wei Che. The proform of glia cell line-derived neurotrophic factor: a potentially biologically active protein. Molecular neurobiology. vol 49. issue 1. 2014-10-27. PMID:23934644. |
growing evidences have revealed that the proforms of several neurotrophins including nerve growth factor (ngf), brain-derived neurotrophic factor (bdnf), and neurotrophin-3 (nt3), by binding to p75 neurotrophin receptor and sortilin, could induce neuronal apoptosis and are implicated in the pathogenesis of various neurodegenerative diseases. |
2014-10-27 |
2023-08-12 |
Not clear |
| J C Koch, L Tönges, E Barski, U Michel, M Bähr, P Lingo. ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS. Cell death & disease. vol 5. 2014-10-21. PMID:24832597. |
taken together, our data characterize rock2 as a specific therapeutic target in neurodegenerative diseases and demonstrate new downstream effects of rock2 including axonal degeneration, apoptosis and autophagy. |
2014-10-21 |
2023-08-13 |
rat |