| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiqing Chai, Weina Kong, Lingyun Liu, Wenguo Yu, Zhenqing Zhang, Yimin Su. A viral vector expressing hypoxia-inducible factor 1 alpha inhibits hippocampal neuronal apoptosis. Neural regeneration research. vol 9. issue 11. 2014-09-10. PMID:25206774. |
our in vitro and in vivo findings demonstrate that hif-1 has potential for attenuating hippocampal neuronal apoptosis induced by amyloid-beta protein, and provides experimental support for treatment of neurodegenerative diseases using gene therapy. |
2014-09-10 |
2023-08-13 |
human |
| Agnieszka Wąsik, Małgorzata Kajta, Tomasz Lenda, Lucyna Antkiewicz-Michalu. Concentration-dependent opposite effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline on markers of apoptosis: in vitro and ex vivo studies. Neurotoxicity research. vol 25. issue 1. 2014-08-28. PMID:24190811. |
summarizing the studies, we suggest that 1bntiq is a rather weak endogenous neurotoxin; however, it should be taken into account that in higher μmoles concentrations, it can initiate apoptosis in the central nervous system and may be involved in the etiopathology of neurodegenerative diseases. |
2014-08-28 |
2023-08-12 |
rat |
| Tomohiro Omura, Masayuki Kaneko, Yasunobu Okuma, Kazuo Matsubara, Yasuyuki Nomur. Endoplasmic reticulum stress and Parkinson's disease: the role of HRD1 in averting apoptosis in neurodegenerative disease. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23710284. |
endoplasmic reticulum stress and parkinson's disease: the role of hrd1 in averting apoptosis in neurodegenerative disease. |
2014-08-13 |
2023-08-12 |
human |
| Costanza Savino, PierGiuseppe Pelicci, Marco Giorgi. The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration. Oxidative medicine and cellular longevity. vol 2013. 2014-08-13. PMID:23766859. |
mitochondrial-mediated oxidative stress and apoptosis play a crucial role in neurodegenerative disease and aging. |
2014-08-13 |
2023-08-12 |
mouse |
| Ana Joyce Munoz, Kwanjeera Wanichthanarak, Eugenio Meza, Dina Petranovi. Systems biology of yeast cell death. FEMS yeast research. vol 12. issue 2. 2014-07-02. PMID:22188402. |
programmed cell death (pcd) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. |
2014-07-02 |
2023-08-12 |
human |
| Mohammad Mijanur Rahman, Siew Hua Gan, Md Ibrahim Khali. Neurological effects of honey: current and future prospects. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-06-24. PMID:24876885. |
therefore, the ultimate biochemical impact of honey on specific neurodegenerative diseases, apoptosis, necrosis, neuroinflammation, synaptic plasticity, and behavior-modulating neural circuitry should be evaluated with appropriate mechanistic approaches using biochemical and molecular tools. |
2014-06-24 |
2023-08-13 |
Not clear |
| Angela Trovato Salinaro, Carolin Cornelius, Guido Koverech, Angela Koverech, Maria Scuto, Francesca Lodato, Vincenzo Fronte, Vera Muccilli, Michele Reibaldi, Antonio Longo, Maurizio G Uva, Vittorio Calabres. Cellular stress response, redox status, and vitagenes in glaucoma: a systemic oxidant disorder linked to Alzheimer's disease. Frontiers in pharmacology. vol 5. 2014-06-17. PMID:24936186. |
further, several heat shock proteins (hsps) members have been implicated both in neurodegenerative diseases and glaucomatous apoptosis. |
2014-06-17 |
2023-08-13 |
human |
| Juan A Marchal, Gabriel J Lopez, Macarena Peran, Ana Comino, Juan R Delgado, Javier A García-García, Veronica Conde, Fernando M Aranda, Carmen Rivas, Mariano Esteban, Maria A Garci. The impact of PKR activation: from neurodegeneration to cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 5. 2014-06-16. PMID:24522206. |
whereas pkr is recognized for its negative effects on neurodegenerative diseases, in part, inducing high level of apoptosis, the role of pkr activation in cancer remains controversial. |
2014-06-16 |
2023-08-12 |
Not clear |
| Francesc Puiggròs, Maria-Josepa Salvadó, Cinta Bladé, Lluís Arol. Differential modulation of apoptotic processes by proanthocyanidins as a dietary strategy for delaying chronic pathologies. Critical reviews in food science and nutrition. vol 54. issue 3. 2014-06-05. PMID:24188302. |
for example, inhibition of apoptotic signaling pathways is linked to the survival of pathological cells, which contributes to cancer, whereas excessive apoptosis is linked to neurodegenerative diseases, partially via oxidative stress. |
2014-06-05 |
2023-08-12 |
Not clear |
| Francesc Puiggròs, Maria-Josepa Salvadó, Cinta Bladé, Lluís Arol. Differential modulation of apoptotic processes by proanthocyanidins as a dietary strategy for delaying chronic pathologies. Critical reviews in food science and nutrition. vol 54. issue 3. 2014-06-05. PMID:24188302. |
proanthocyanidins, a class of flavonoids naturally found in fruits, vegetables, and beverages, have attracted a great deal of attention not only because they are strong antioxidants but also because they appear to exert a different modulation of apoptosis, stimulating apoptosis in damaged cells, thus preventing cancer or reducing apoptosis in healthy cells, and as a result, preserving the integrity of normal cells and protecting against neurodegenerative diseases. |
2014-06-05 |
2023-08-12 |
Not clear |
| Wendan Cheng, Dongying Wu, Qiang Zuo, Zhen Wang, Weimin Fa. Ginsenoside Rb1 prevents interleukin-1 beta induced inflammation and apoptosis in human articular chondrocytes. International orthopaedics. vol 37. issue 10. 2014-06-02. PMID:23835558. |
ginsenosides, the most important pharmacological ingredients of ginseng, have been proven to provide effective therapy for neurodegenerative diseases and can inhibit cell apoptosis. |
2014-06-02 |
2023-08-12 |
human |
| Marla Rivera-Oliver, Manuel Díaz-Río. Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: a review. Life sciences. vol 101. issue 1-2. 2014-06-02. PMID:24530739. |
interestingly, other studies using adenosine receptor agonists have also shown to provide a neuroprotective effect on various models of neurodegenerative diseases through the reduction of excitatory neurotransmitter release, apoptosis and inflammatory responses, among others. |
2014-06-02 |
2023-08-12 |
human |
| Heba M Mahdy, Mohamed R Mohamed, Manal A Emam, Amr M Karim, Ashraf B Abdel-Naim, Ashraf Abdel-Naim, Amani E Khalif. The anti-apoptotic and anti-inflammatory properties of puerarin attenuate 3-nitropropionic-acid induced neurotoxicity in rats. Canadian journal of physiology and pharmacology. vol 92. issue 3. 2014-05-16. PMID:24593790. |
these results indicate that pur may be a useful preventive approach to various neurodegenerative diseases with underlying apoptosis and neuroinflammation. |
2014-05-16 |
2023-08-12 |
rat |
| Sheng-Quan Hu, Wei Cui, Da-Ping Xu, Shing-Hung Mak, Jing Tang, Chung-Lit Choi, Yuan-Ping Pang, Yi-Fan Ha. Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway. CNS neuroscience & therapeutics. vol 19. issue 10. 2014-05-08. PMID:23826635. |
neuronal loss via apoptosis in cns is the fundamental mechanism underlying various neurodegenerative diseases. |
2014-05-08 |
2023-08-12 |
Not clear |
| Eun-Bum Kang, In-Su Kwon, Jung-Hoon Koo, Eung-Joon Kim, Chul-Hyun Kim, Jin Lee, Choon-Ho Yang, Young-Il Lee, In-Ho Cho, Joon-Yong Ch. Treadmill exercise represses neuronal cell death and inflammation during Aβ-induced ER stress by regulating unfolded protein response in aged presenilin 2 mutant mice. Apoptosis : an international journal on programmed cell death. vol 18. issue 11. 2014-05-08. PMID:23907580. |
er stress is involved in neurodegenerative diseases including ad, but the molecular mechanisms of neuronal apoptosis and inflammation by aβ-induced er stress to exercise training are not fully understood. |
2014-05-08 |
2023-08-12 |
mouse |
| Aleksandra Rodack. [Properties and functional diversity of glyceraldehyde-3-phosphate dehydrogenase]. Postepy higieny i medycyny doswiadczalnej (Online). vol 67. 2014-04-29. PMID:24018444. |
furthermore, other studies also indicate a role of gapdh in apoptosis, and age-related neurodegenerative disease e.g. |
2014-04-29 |
2023-08-12 |
Not clear |
| Jianhua Jiang, Juean Jiang, Yuanyi Zuo, Zhenlun G. Rapamycin protects the mitochondria against oxidative stress and apoptosis in a rat model of Parkinson's disease. International journal of molecular medicine. vol 31. issue 4. 2014-04-24. PMID:23426728. |
parkinson's disease (pd) is a neurodegenerative disease, in which oxidative stress and mitochondrial dysfunction are responsible for neuronal apoptosis. |
2014-04-24 |
2023-08-12 |
rat |
| Hamzeh Pasban-Aliabadi, Saeed Esmaeili-Mahani, Vahid Sheibani, Mehdi Abbasnejad, Anahita Mehdizadeh, Mohammad Mehdi Yaghoob. Inhibition of 6-hydroxydopamine-induced PC12 cell apoptosis by olive (Olea europaea L.) leaf extract is performed by its main component oleuropein. Rejuvenation research. vol 16. issue 2. 2014-03-21. PMID:23394606. |
however, some natural herbal products have been shown to rescue neurons from death and apoptosis in some of neurodegenerative diseases. |
2014-03-21 |
2023-08-12 |
rat |
| A J Kole, R P Annis, M Deshmuk. Mature neurons: equipped for survival. Cell death & disease. vol 4. 2014-02-25. PMID:23807218. |
examining the adaptations for inhibiting apoptosis during neuronal maturation is key to comprehending not just how neurons survive long term, but may also provide insight for understanding how neuronal toxicity in various neurodegenerative diseases may ultimately lead to cell death. |
2014-02-25 |
2023-08-12 |
Not clear |
| Guang Ji, Hui Ji, Xiaoye Mo, Ting Li, Yaduo Yu, Zhiping H. The role of GRASPs in morphological alterations of Golgi apparatus: mechanisms and effects. Reviews in the neurosciences. vol 24. issue 5. 2014-02-20. PMID:24002661. |
ga shows various morphological alterations in many neurodegenerative diseases and cell apoptosis induced by biochemical reagents, mechanisms in which oxidative stress is strongly involved. |
2014-02-20 |
2023-08-12 |
Not clear |