| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vishal Jinda. Glaucoma: an extension of various chronic neurodegenerative disorders. Molecular neurobiology. vol 48. issue 1. 2014-02-12. PMID:23397135. |
targets for therapeutic intervention in chronic neurodegenerative diseases and glaucoma include apoptosis, axonal transport, free radical damage, role of polyunsaturated fatty acids, chaperones, gene regulation, etc. |
2014-02-12 |
2023-08-12 |
Not clear |
| Kyoung Joo Cho, Hyun Woo Kim, So Yeong Cheon, Jong Eun Lee, Gyung Whan Ki. Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice. Biochemical and biophysical research communications. vol 441. issue 2. 2014-01-17. PMID:24021285. |
apoptosis signal-regulating kinase-1 (ask1), an early signaling element in the cell death pathway, has been suggested to participate in the pathology of neurodegenerative diseases, which may be associated with environmental factors that impact the diseases. |
2014-01-17 |
2023-08-12 |
mouse |
| M Jahanshahi, E G Nickmahzar, F Babakord. Effect of Gingko biloba extract on scopolamine-induced apoptosis in the hippocampus of rats. Anatomical science international. vol 88. issue 4. 2014-01-16. PMID:23828103. |
apoptosis is also involved in neurodegenerative diseases such as alzheimer's disease. |
2014-01-16 |
2023-08-12 |
rat |
| Meera Soundararajan, Annette K Roos, Pavel Savitsky, Panagis Filippakopoulos, Arminja N Kettenbach, Jesper V Olsen, Scott A Gerber, Jeyanthy Eswaran, Stefan Knapp, Jonathan M Elkin. Structures of Down syndrome kinases, DYRKs, reveal mechanisms of kinase activation and substrate recognition. Structure (London, England : 1993). vol 21. issue 6. 2014-01-02. PMID:23665168. |
dual-specificity tyrosine-(y)-phosphorylation-regulated kinases (dyrks) play key roles in brain development, regulation of splicing, and apoptosis, and are potential drug targets for neurodegenerative diseases and cancer. |
2014-01-02 |
2023-08-12 |
Not clear |
| Chun-Ming Wang, Ming-Yan Liu, Fang Wang, Min-Jie Wei, Shuang Wang, Chun-Fu Wu, Jing-Yu Yan. Anti-amnesic effect of pseudoginsenoside-F11 in two mouse models of Alzheimer's disease. Pharmacology, biochemistry, and behavior. vol 106. 2013-12-26. PMID:23541491. |
alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by amyloid β (aβ) deposits, elevated oxidative stress, and apoptosis of the neurons. |
2013-12-26 |
2023-08-12 |
mouse |
| Gye Sun Jeon, Jee-Eun Kim, Suk-Won Ahn, Kyung-Seok Park, Yoon-Ho Hong, In-Hae Ye, Ji-Seon Park, Seung Hyun Kim, Kwang-Woo Lee, Sung-Min Kim, Jung-Joon Sun. Effect of JGK-263 as a new glycogen synthase kinase-3β inhibitor on extrinsic apoptosis pathway in motor neuronal cells. Biochemical and biophysical research communications. vol 439. issue 2. 2013-11-26. PMID:23899525. |
gsk-3β inhibitor has been investigated as a modulator of apoptosis and has been shown to confer significant protective effects on cell death in neurodegenerative diseases. |
2013-11-26 |
2023-08-12 |
Not clear |
| Marco Fiocchetti, Elisabetta De Marinis, Paolo Ascenzi, Maria Marin. Neuroglobin and neuronal cell survival. Biochimica et biophysica acta. vol 1834. issue 9. 2013-09-26. PMID:23357651. |
the balance between neuronal apoptosis and survival sculpts the developing brain and has an important role in neurodegenerative diseases. |
2013-09-26 |
2023-08-12 |
Not clear |
| N N Besednova, L M Somova, S A Guliaev, T S Zaporozhet. [Neuroprotective effects of sulfated polysaccharides from seaweed]. Vestnik Rossiiskoi akademii meditsinskikh nauk. issue 5. 2013-09-26. PMID:24000668. |
consequently, sps can arrest a number of secondary pathological effects observed in neurodegenerative diseases (oxidative stress, inflammation, the phenomenon of increased neuronal apoptosis, toxic effects etc.). |
2013-09-26 |
2023-08-12 |
human |
| Mingming Ma, Xuejing Wang, Xuebing Ding, Jing Jing, Yaohua Ma, Junfang Ten. Protective effect of BAG5 on MPP+-induced apoptosis in PC12 cells. Neurological research. vol 34. issue 10. 2013-08-26. PMID:23146300. |
parkinson's disease (pd) is the most common neurodegenerative disease in humans, and an abundance of evidence has implicated apoptosis signaling pathways in the neurodegeneration of pd. |
2013-08-26 |
2023-08-12 |
Not clear |
| Janett Eckmann, Schamim H Eckert, Kristina Leuner, Walter E Muller, Gunter P Ecker. Mitochondria: mitochondrial membranes in brain ageing and neurodegeneration. The international journal of biochemistry & cell biology. vol 45. issue 1. 2013-08-20. PMID:22743330. |
in addition to atp synthesis mitochondria are key regulators of calcium homeostasis, free radical production, steroid synthesis and apoptosis, each of these factors could also be associated with essential mechanisms involved in neurodegenerative diseases. |
2013-08-20 |
2023-08-12 |
mouse |
| Ling Ye, Yunlong Huang, Lixia Zhao, Yuju Li, Lijun Sun, You Zhou, Guanxiang Qian, Jialin C Zhen. IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase. Journal of neurochemistry. vol 125. issue 6. 2013-08-06. PMID:23578284. |
using primary rat and human neuronal cultures, we confirmed that interleukin-1β (il-1β) and tumor necrosis factor-α (tnf-α), two pro-inflammatory cytokines that are typically elevated in neurodegenerative disease states, induced neuronal death and apoptosis in vitro. |
2013-08-06 |
2023-08-12 |
human |
| M E Breuer, W J Koopman, S Koene, M Nooteboom, R J Rodenburg, P H Willems, J A M Smeitin. The role of mitochondrial OXPHOS dysfunction in the development of neurologic diseases. Neurobiology of disease. vol 51. 2013-07-24. PMID:22426394. |
malfunctions in mitochondrial respiration and atp production may prove disastrous for our cells and neurons, ultimately resulting in apoptosis, neurodegeneration and consequently, neurodegenerative diseases. |
2013-07-24 |
2023-08-12 |
Not clear |
| Josie J Gray, Amelia E Zommer, Ron J Bouchard, Nathan Duval, Craig Blackstone, Daniel A Linsema. N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress. Brain research. vol 1494. 2013-07-03. PMID:23220553. |
neuronal cell death via apoptosis or necrosis underlies several devastating neurodegenerative diseases associated with aging. |
2013-07-03 |
2023-08-12 |
mouse |
| Hadhemi Kaddour, Yosra Hamdi, David Vaudry, Magalie Basille, Laurence Desrues, Jérôme Leprince, Hélène Castel, Hubert Vaudry, Marie-Christine Tonon, Mohamed Amri, Olfa Masmoudi-Kouk. The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. Journal of neurochemistry. vol 125. issue 4. 2013-07-01. PMID:23286644. |
oxidative stress, induced by various neurodegenerative diseases, initiates a cascade of events leading to apoptosis, and thus plays a critical role in neuronal injury. |
2013-07-01 |
2023-08-12 |
Not clear |
| Ada Fiorini, Rukhsana Sultana, Eugenio Barone, Giovanna Cenini, Marzia Perluigi, Cesare Mancuso, Jian Cai, Jon B Klein, Daret St Clair, D Allan Butterfiel. Lack of p53 affects the expression of several brain mitochondrial proteins: insights from proteomics into important pathways regulated by p53. PloS one. vol 7. issue 11. 2013-06-11. PMID:23209608. |
although p53 promotes longevity by decreasing the risk of cancer through activation of apoptosis or cellular senescence, several findings suggest that an increase of its activity may have deleterious effects leading to selected aspects of the aging phenotype and neurodegenerative diseases. |
2013-06-11 |
2023-08-12 |
mouse |
| Eric Thouvenot, Serge Urbach, Oana Vigy, Martial Séveno, Nathalie Galéotti, Geneviève Nguyen, Joël Bockaert, Philippe Mari. Quantitative proteomic analysis reveals protein expression changes in the murine neuronal secretome during apoptosis. Journal of proteomics. vol 77. 2013-05-23. PMID:23009950. |
an alternative approach consists in comparing proteins secreted by healthy neurons and neurons degenerating by apoptosis, one of the mechanisms underlying neuronal death in neurodegenerative diseases. |
2013-05-23 |
2023-08-12 |
mouse |
| Daniel M Johnstone, Ross M Graham, Debbie Trinder, Carlos Riveros, John K Olynyk, Rodney J Scott, Pablo Moscato, Elizabeth A Milwar. Changes in brain transcripts related to Alzheimer's disease in a model of HFE hemochromatosis are not consistent with increased Alzheimer's disease risk. Journal of Alzheimer's disease : JAD. vol 30. issue 4. 2013-05-15. PMID:22466002. |
the effects appeared relatively specific for ad in that few genes pertaining to other important neurodegenerative diseases, notably parkinson's disease and huntington's disease, or to inflammation, oxidative stress, or apoptosis, showed altered transcript levels. |
2013-05-15 |
2023-08-12 |
mouse |
| Shang-Der Chen, Jiu-Haw Yin, Chi-Shin Hwang, Ching-Min Tang, Ding-I Yan. Anti-apoptotic and anti-oxidative mechanisms of minocycline against sphingomyelinase/ceramide neurotoxicity: implication in Alzheimer's disease and cerebral ischemia. Free radical research. vol 46. issue 8. 2013-05-09. PMID:22583533. |
emerging evidence reveals that sphingomyelinase/ceramide pathway plays a pivotal role in neurodegenerative diseases that involve mitochondrial dysfunction, oxidative stress and apoptosis. |
2013-05-09 |
2023-08-12 |
Not clear |
| Dusan Zencak, Karine Schouwey, Danian Chen, Per Ekström, Ellen Tanger, Rod Bremner, Maarten van Lohuizen, Yvan Arsenijevi. Retinal degeneration depends on Bmi1 function and reactivation of cell cycle proteins. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 7. 2013-04-08. PMID:23359713. |
reexpression of cell cycle proteins such as cyclin-dependent kinases (cdks) is a hallmark of neuronal apoptosis in neurodegenerative diseases. |
2013-04-08 |
2023-08-12 |
mouse |
| Wenzhi Ta. VDAC blockage by phosphorothioate oligonucleotides and its implication in apoptosis. Biochimica et biophysica acta. vol 1818. issue 6. 2013-04-03. PMID:22236836. |
impaired apoptosis contributes to cancer development, while enhanced apoptosis is detrimental in neurodegenerative diseases. |
2013-04-03 |
2023-08-12 |
Not clear |