| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Arindam P Ghosh, Barbara J Klocke, Mary E Ballestas, Kevin A Rot. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. PloS one. vol 7. issue 6. 2013-03-21. PMID:22761832. |
endoplasmic reticulum (er) stress-induced apoptosis has been implicated in various neurodegenerative diseases including parkinson disease, alzheimer disease and huntington disease. |
2013-03-21 |
2023-08-12 |
Not clear |
| Hamid Reza Momen. Role of calpain in apoptosis. Cell journal. vol 13. issue 2. 2013-03-20. PMID:23507938. |
the activation of calpain has been implicated in neuronal apoptosis following spinal cord injuries and neurodegenerative diseases. |
2013-03-20 |
2023-08-12 |
Not clear |
| Kelly N Holohan, Debomoy K Lahiri, Bryan P Schneider, Tatiana Foroud, Andrew J Sayki. Functional microRNAs in Alzheimer's disease and cancer: differential regulation of common mechanisms and pathways. Frontiers in genetics. vol 3. 2013-01-22. PMID:23335942. |
we propose a pathway-driven model in which some molecular processes show an inverse relationship between cancer and neurodegenerative disease (e.g., proliferation and apoptosis) whereas others are more parallel in their activity (e.g., immune activation and inflammation). |
2013-01-22 |
2023-08-12 |
Not clear |
| Won Ho Kong, Dong Kyung Sung, Ki Su Kim, Ho Sang Jung, Eun Ji Gho, Seok Hyun Yun, Sei Kwang Hah. Self-assembled complex of probe peptide--E. Coli RNA I conjugate and nano graphene oxide for apoptosis diagnosis. Biomaterials. vol 33. issue 30. 2012-12-18. PMID:22818651. |
caspase-3 plays an important role in the initiation and propagation of apoptosis which is involved in various kinds of diseases including neurodegenerative diseases and inflammatory diseases. |
2012-12-18 |
2023-08-12 |
Not clear |
| Jae-Kyo Jeong, Jae-Suk Seo, Myung-Hee Moon, You-Jin Lee, Jae-Won Seol, Sang-Youel Par. Hypoxia-inducible factor-1 α regulates prion protein expression to protect against neuron cell damage. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:22036844. |
based on our previous findings that hypoxia protects neuronal cells from prp (106-126)-induced apoptosis and increases cellular prion protein (prp(c)) expression, we hypothesized that hypoxia-related genes, including hypoxia-inducible factor-1 alpha (hif-1α), may regulate prp(c) expression and that these genes may be involved in prion-related neurodegenerative diseases. |
2012-11-23 |
2023-08-12 |
human |
| Simona Esposito, Andrea Pristerà, Giovanna Maresca, Sebastiano Cavallaro, Armando Felsani, Fulvio Florenzano, Luigi Manni, Maria T Ciotti, Loredano Pollegioni, Tiziana Borsello, Nadia Can. Contribution of serine racemase/d-serine pathway to neuronal apoptosis. Aging cell. vol 11. issue 4. 2012-11-13. PMID:22507034. |
these findings are relevant to our understanding of neuronal apoptosis and nmdar activity regulation, raising further questions as to the role of sr/d-serine in those neuro-pathophysiological processes, such as aging and neurodegenerative diseases characterized by a convergence of apoptotic mechanisms and nmdar dysfunction. |
2012-11-13 |
2023-08-12 |
Not clear |
| T F Oo, R E Burk. Animal models of induced apoptotic death in the substantia nigra. Methods in molecular medicine. vol 62. 2012-10-02. PMID:21318770. |
in recent years, there has been a tremendous growth of interest in apoptosis as a mechanism of disease in a wide range of human disorders including the neurodegenerative diseases, such as parkinson's disease (pd) (1). |
2012-10-02 |
2023-08-12 |
human |
| Jane Bayani, Eleftherios P Diamandi. The physiology and pathobiology of human kallikrein-related peptidase 6 (KLK6). Clinical chemistry and laboratory medicine. vol 50. issue 2. 2012-10-02. PMID:22047144. |
the observed dysregulated expression in cancers, neurodegenerative diseases and skin conditions has led to the discovery that klk6 participates in other cellular pathways including inflammation, receptor activation and regulation of apoptosis. |
2012-10-02 |
2023-08-12 |
human |
| Guangyu Li, Fei Cai, Wei Yan, Cairong Li, Jianghua Wan. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 127. issue 2. 2012-09-24. PMID:22430071. |
mclr-treated hippocampi showed alterations in proteins involved in cytoskeleton, neurodegenerative disease, oxidative stress, apoptosis, and energy metabolism. |
2012-09-24 |
2023-08-12 |
rat |
| John J Mieyal, P Boon Choc. Posttranslational modification of cysteine in redox signaling and oxidative stress: Focus on s-glutathionylation. Antioxidants & redox signaling. vol 16. issue 6. 2012-09-17. PMID:22136616. |
the forum review articles consider the role of s-glutationylation in regulation of the peroxiredoxin enzymes, the special redox environment of the mitochondria, redox regulation pertinent to the function of the cardiovascular system, mechanisms of redox-activated apoptosis in the pulmonary system, and the role of glutathionylation in the initiation, propagation, and treatment of neurodegenerative diseases. |
2012-09-17 |
2023-08-12 |
Not clear |
| Gomathi Chan, Muhamad Noor Alfarizal Kamarudin, Daniel Zin Hua Wong, Nor Hadiani Ismail, Faizuri Abdul Latif, Aurengzeb Hasan, Khalijah Awang, Habsah Abdul Kadi. Mitigation of H(2)O(2)-Induced Mitochondrial-Mediated Apoptosis in NG108-15 Cells by Novel Mesuagenin C from Mesua kunstleri (King) Kosterm. Evidence-based complementary and alternative medicine : eCAM. vol 2012. 2012-09-10. PMID:22956972. |
these findings confirmed the involvement of intrinsic apoptotic pathway in h(2)o(2)-induced apoptosis and suggested that mesuagenin c 3 may have potential therapeutic properties for neurodegenerative diseases. |
2012-09-10 |
2023-08-12 |
Not clear |
| Hiroyuki Uchino, Morika Suzuki, Ayano Okita, Yohko Yuhnaiyama, Mariko Shibuya, Daiki Usui, Ryoichi Miyashita, Kiyoshi Hatakeyam. [Organ protective effects of volatile anesthetics and perioperative outcomes]. Masui. The Japanese journal of anesthesiology. vol 61. issue 5. 2012-08-29. PMID:22702090. |
massive release of ca2+ from er induces ca2+ overload leading to mitochondria permeability transition (mpt) and induces apoptosis in the brain or aggravates the neurodegenerative disease. |
2012-08-29 |
2023-08-12 |
human |
| Valeria Gabriela Antico Arciuch, María Eugenia Elguero, Juan José Poderoso, María Cecilia Carrera. Mitochondrial regulation of cell cycle and proliferation. Antioxidants & redox signaling. vol 16. issue 10. 2012-07-25. PMID:21967640. |
in this process, many functions were transferred to the host cells, but mitochondria gained a central role in the regulation of cell proliferation and apoptosis, and in the modulation of metabolism; accordingly, defective organelles contribute to cell transformation and cancer, diabetes, and neurodegenerative diseases. |
2012-07-25 |
2023-08-12 |
Not clear |
| Matthew J Hart, Marcie Glicksman, Min Liu, Mohit K Sharma, Greg Cuny, Veronica Galva. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Analytical biochemistry. vol 421. issue 2. 2012-06-19. PMID:22178911. |
caspases, effectors of apoptosis, are key mediators of neuronal death in several neurodegenerative diseases. |
2012-06-19 |
2023-08-12 |
mouse |
| Joseph D Jebelli, Claudie Hooper, Gwenn A Garden, Jennifer M Pococ. Emerging roles of p53 in glial cell function in health and disease. Glia. vol 60. issue 4. 2012-06-12. PMID:22105777. |
although neurodegenerative diseases each display a distinct and diverse molecular pathology, apoptosis is a widespread hallmark feature and the multimodal capacity of the p53 system to orchestrate apoptosis and glial cell behavior highlights p53 as a potential unifying target for therapeutic intervention in neurodegeneration. |
2012-06-12 |
2023-08-12 |
Not clear |
| Joanna Tucka, Martin Bennett, Trevor Littlewoo. Cell death and survival signalling in the cardiovascular system. Frontiers in bioscience (Landmark edition). vol 17. 2012-05-24. PMID:22201742. |
apoptosis of neurons that fail to make appropriate connections is essential for the selection of correct neural signalling in the developing embryo, but its appearance in adults is often associated with neurodegenerative disease. |
2012-05-24 |
2023-08-12 |
Not clear |
| B Caballero, A Coto-Monte. An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain. Histology and histopathology. vol 27. issue 3. 2012-05-08. PMID:22237704. |
apoptosis is one of processes implicated in aging and neurodegenerative pathologies, and for the last decade, has been one of the most studied processes due to its essential role, not only in aging, but also in many neurodegenerative diseases, including parkinson's, alzheimer's and huntington's. |
2012-05-08 |
2023-08-12 |
Not clear |
| Petra Steinacker, Alastair Aitken, Markus Ott. 14-3-3 proteins in neurodegeneration. Seminars in cell & developmental biology. vol 22. issue 7. 2012-04-25. PMID:21920445. |
the reported function of 14-3-3 proteins in this context are as diverse as the mechanism involved in neurodegeneration, reaching from basal cellular processes like apoptosis, over involvement in features common to many neurodegenerative diseases, like protein stabilization and aggregation, to very specific processes responsible for the selective vulnerability of cellular populations in single neurodegenerative diseases. |
2012-04-25 |
2023-08-12 |
Not clear |
| Namiko Suematsu, Miki Hosoda, Ko Fujimor. Protective effects of quercetin against hydrogen peroxide-induced apoptosis in human neuronal SH-SY5Y cells. Neuroscience letters. vol 504. issue 3. 2012-03-15. PMID:21964380. |
thus, quercetin might potentially serve as an agent for prevention of neurodegenerative diseases caused by oxidative stress and apoptosis. |
2012-03-15 |
2023-08-12 |
human |
| Shuping Li, Wenhao Yu, Guo-Fu H. Angiogenin inhibits nuclear translocation of apoptosis inducing factor in a Bcl-2-dependent manner. Journal of cellular physiology. vol 227. issue 4. 2012-03-05. PMID:21678416. |
here we report that ang inhibits nuclear translocation of apoptosis inducing factor (aif), an important cell death-executing molecule known to play a dominant role in neurodegenerative diseases. |
2012-03-05 |
2023-08-12 |
Not clear |