| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qi Wang, Sinisa D Grozdanic, Matthew M Harper, Nicolas Hamouche, Helga Kecova, Tatjana Lazic, Chenxu Y. Exploring Raman spectroscopy for the evaluation of glaucomatous retinal changes. Journal of biomedical optics. vol 16. issue 10. 2012-03-05. PMID:22029368. |
glaucoma is a chronic neurodegenerative disease characterized by apoptosis of retinal ganglion cells and subsequent loss of visual function. |
2012-03-05 |
2023-08-12 |
Not clear |
| Alexandre Chenal, Charlotte Vendrely, Heidi Vitrac, Johanna C Karst, Alexis Gonneaud, Clément E Blanchet, Sylvain Pichard, Elisabeth Garcia, Bénédicte Salin, Patrice Catty, Daniel Gillet, Nicolas Hussy, Christel Marquette, Christine Almunia, Vincent Forg. Amyloid fibrils formed by the programmed cell death regulator Bcl-xL. Journal of molecular biology. vol 415. issue 3. 2012-02-29. PMID:22119486. |
the potential causality between the accumulation of bcl-xl into amyloid deposits and abnormal apoptosis during neurodegenerative diseases is discussed. |
2012-02-29 |
2023-08-12 |
human |
| Ko Fujimori, Ayano Fukuhara, Takashi Inui, Maria Allhor. Prevention of paraquat-induced apoptosis in human neuronal SH-SY5Y cells by lipocalin-type prostaglandin D synthase. Journal of neurochemistry. vol 120. issue 2. 2012-02-09. PMID:22043816. |
thus, l-pgds might potentially serve as an agent for prevention of human neurodegenerative diseases caused by oxidative stress and apoptosis. |
2012-02-09 |
2023-08-12 |
human |
| Ting-Fang Kuo, Hideki Tatsukawa, Soichi Kojim. New insights into the functions and localization of nuclear transglutaminase 2. The FEBS journal. vol 278. issue 24. 2012-01-23. PMID:22051117. |
through this mechanism, tg2 controls cell growth or survival, differentiation and apoptosis, and is involved in the pathogenesis and/or treatment of neurodegenerative diseases, liver diseases and cancers. |
2012-01-23 |
2023-08-12 |
Not clear |
| Clivia Pazin Miwa, Maria Noêmia Martins de Lima, Felipe Scalco, Gustavo Vedana, Raquel Mattos, Liana Lisboa Fernandez, Arlete Hilbig, Nadja Schröder, Monica R M Viann. Neonatal iron treatment increases apoptotic markers in hippocampal and cortical areas of adult rats. Neurotoxicity research. vol 19. issue 4. 2012-01-20. PMID:20369315. |
oxidative stress, cellular damage, and neuronal apoptosis are believed to underlie the progressive cognitive decline that accompanies natural aging and to be exacerbated in neurodegenerative diseases. |
2012-01-20 |
2023-08-12 |
rat |
| Evgeny V Mymrikov, Alim S Seit-Nebi, Nikolai B Guse. Large potentials of small heat shock proteins. Physiological reviews. vol 91. issue 4. 2011-12-13. PMID:22013208. |
hspb8 also seems to be directly or indirectly involved in regulation of apoptosis and carcinogenesis, contributes to cardiac cell hypertrophy and survival and, when mutated, might be involved in development of neurodegenerative diseases. |
2011-12-13 |
2023-08-12 |
human |
| Jhih-Bin Chen, Eric Minwei Liu, Ting-Rong Chern, Chieh-Wen Yang, Chia-I Lin, Nai-Kuei Huang, Yun-Lian Lin, Yijuang Chern, Jung-Hsin Lin, Jim-Min Fan. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. vol 6. issue 8. 2011-11-28. PMID:21692183. |
in agreement with competitive ligand binding assay results, these compounds also prevent apoptosis in serum-deprived pc12 cells, rendering a crucial function in neuroprotection and potential utility in the treatment of neurodegenerative diseases. |
2011-11-28 |
2023-08-12 |
Not clear |
| Raquel Gómez-Sintes, Félix Hernández, José J Lucas, Jesús Avil. GSK-3 Mouse Models to Study Neuronal Apoptosis and Neurodegeneration. Frontiers in molecular neuroscience. vol 4. 2011-11-23. PMID:22110426. |
it is important to dissect this duality since, among the diseases in which gsk-3 is involved, excessive cell death is crucial in some illnesses like neurodegenerative diseases, while a deficient apoptosis is occurring in others such as cancer or autoimmune diseases. |
2011-11-23 |
2023-08-12 |
mouse |
| Cecília da Silva Ferreira, Carla Cristina Maganhin, Ricardo dos Santos Simões, Manoel João Batista Castello Girão, Edmund Chada Baracat, José Maria Soare. [Melatonin: cell death modulator]. Revista da Associacao Medica Brasileira (1992). vol 56. issue 6. 2011-11-14. PMID:21271142. |
when apoptosis is out of control, it contributes to the emergence of several neoplastic, autoimmune and neurodegenerative diseases. |
2011-11-14 |
2023-08-12 |
Not clear |
| Carlotta Giorgi, Mariusz R Wieckowski, Pier Paolo Pandolfi, Paolo Pinto. Mitochondria associated membranes (MAMs) as critical hubs for apoptosis. Communicative & integrative biology. vol 4. issue 3. 2011-11-10. PMID:21980573. |
apoptosis is a process of major biomedical interest, since its deregulation is involved in the pathogenesis of a broad variety of disorders (neoplasia, autoimmune disorders, viral and neurodegenerative diseases, to name a few). |
2011-11-10 |
2023-08-12 |
Not clear |
| Parco M Si. Muscle apoptotic response to denervation, disuse, and aging. Medicine and science in sports and exercise. vol 41. issue 10. 2011-11-08. PMID:19727026. |
the pathological consequences of aberrant regulation of apoptosis have been widely demonstrated in carcinogenesis, neurodegenerative diseases, autoimmune diseases, viral infections, and acquired immunodeficiency syndrome. |
2011-11-08 |
2023-08-12 |
Not clear |
| Dongmei Li, Hui Chen, Abigail Florentino, Deepu Alex, Patricia Sikorski, William A Fonzi, Richard Calderon. Enzymatic dysfunction of mitochondrial complex I of the Candida albicans goa1 mutant is associated with increased reactive oxidants and cell death. Eukaryotic cell. vol 10. issue 5. 2011-10-31. PMID:21398508. |
our observation of increased ros production associated with a defective ci and pcd is reminiscent of mitochondrial studies of patients with some types of neurodegenerative diseases where ci and/or ciii dysfunctions lead to increased ros and apoptosis. |
2011-10-31 |
2023-08-12 |
human |
| In Su Kim, Dong-Kug Choi, Hun Jong Jun. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules (Basel, Switzerland). vol 16. issue 7. 2011-10-24. PMID:21705974. |
these results indicate that vanillyl alcohol protected dopaminergic mn9d cells against mpp+-induced apoptosis by relieving oxidative stress and modulating the apoptotic process and is therefore a potential candidate for treatment of neurodegenerative diseases such as parkinson's disease. |
2011-10-24 |
2023-08-12 |
Not clear |
| Ling-Fei Wu, Yan-Qing Ye, Guan-You Huang, Hong-Biao Li, Guo-Ping Li, Ze-Jin Pu, Bi-Liu Wei, Jia-Lin Fen. Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis. Oncology reports. vol 26. issue 1. 2011-10-21. PMID:21479362. |
endoplasmic reticulum stress (ers)-mediated cell apoptosis has been implicated in the development of multiple diseases such as cancer, neurodegenerative diseases and ischemic reperfusion damage. |
2011-10-21 |
2023-08-12 |
human |
| Gonzalo Arboleda, Yolanda Cárdenas, Yeldy Rodríguez, Luis Carlos Morales, Luisa Matheus, Humberto Arboled. Differential regulation of AKT, MAPK and GSK3β during C2-ceramide-induced neuronal death. Neurotoxicology. vol 31. issue 6. 2011-09-29. PMID:20696185. |
evidence has implicated apoptosis as a mechanism underlying cell demise in diverse neurodegenerative diseases including parkinson's disease (pd). |
2011-09-29 |
2023-08-12 |
Not clear |
| Virve Cavallucci, Marcello D'Ameli. Matter of life and death: the pharmacological approaches targeting apoptosis in brain diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348825. |
neurodegenerative diseases that include amyotrophic lateral sclerosis, huntington's disease, alzheimer's disease, parkinson's disease, stroke, brain trauma and spinal cord injury, are associated with the inappropriate activation of a neuronal cell-suicide program called apoptosis. |
2011-09-29 |
2023-08-12 |
Not clear |
| Tommy Seaborn, Olfa Masmoudi-Kouli, Alain Fournier, Hubert Vaudry, David Vaudr. Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348830. |
apoptosis is a regulated process leading to cell death, which is implicated both in normal development and in various pathologies including heart failure, stroke and neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
the purpose of this review is to discuss potential pathways involved in the pathogenesis of neurodegenerative diseases, highlighting current pharmacological drug targets in neuronal apoptosis prevention. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
in the present study we discuss in depth the pathways involved in apoptosis and neuronal death in neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |
| Francesc X Sureda, Felix Junyent, Ester Verdaguer, Carme Auladell, Carme Pelegri, Jordi Vilaplana, Jaume Folch, Anna Maria Canudas, Carlos Beas Zarate, Merc Pallès, Antoni Camin. Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases. Current pharmaceutical design. vol 17. issue 3. 2011-09-29. PMID:21348832. |
this research contributes to the development of new methods in the field of apoptosis inhibitors that could provide the future tools for the treatment of alzheimer's and parkinson's disease, as well as other neurodegenerative diseases. |
2011-09-29 |
2023-08-12 |
Not clear |