| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Domagoj Vucic, Vishva M Dixit, Ingrid E Wert. Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death. Nature reviews. Molecular cell biology. vol 12. issue 7. 2011-09-28. PMID:21697901. |
furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia and graft rejection, and diminished apoptosis can lead to autoimmune diseases and cancer. |
2011-09-28 |
2023-08-12 |
Not clear |
| Andres Klein, Carola Maldonado, Lina M Vargas, Marcela Gonzalez, Fermín Robledo, Karen Perez de Arce, Francisco J Muñoz, Claudio Hetz, Alejandra R Alvarez, Silvana Zanlung. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiology of disease. vol 41. issue 1. 2011-09-27. PMID:20883783. |
niemann-pick type c (npc) is a neurodegenerative disease characterized by the intralysosomal accumulation of cholesterol leading to neuronal apoptosis. |
2011-09-27 |
2023-08-12 |
mouse |
| Majid Assadi, Reza Nemati, Iraj Nabipour, Hooman Salimipour, Abdullatif Amin. Radiolabeled annexin V imaging: a useful technique for determining apoptosis in multiple sclerosis. Medical hypotheses. vol 77. issue 1. 2011-09-26. PMID:21440374. |
however, they are unable to detect apoptosis in neurodegenerative diseases. |
2011-09-26 |
2023-08-12 |
Not clear |
| Sanjay L Dholakiya, Kenza E Benzeroua. Protective effect of diosmin on LPS-induced apoptosis in PC12 cells and inhibition of TNF-α expression. Toxicology in vitro : an international journal published in association with BIBRA. vol 25. issue 5. 2011-09-26. PMID:21477647. |
several studies have demonstrated a link between increased pro-inflammatory mediators and apoptosis in neurodegenerative diseases. |
2011-09-26 |
2023-08-12 |
Not clear |
| Donald Raymond Daudt, Thomas Yori. FKBP51 protects 661w cell culture from staurosporine-induced apoptosis. Molecular vision. vol 17. 2011-09-20. PMID:21617754. |
neurodegenerative diseases and neurotraumas typically result in apoptosis of specific neurons leading to the pathology observed during the disease state. |
2011-09-20 |
2023-08-12 |
Not clear |
| Niloufar Ansari, Fariba Khodagholi, Mohsen Amini, Fatemeh Shaerzade. Attenuation of LPS-induced apoptosis in NGF-differentiated PC12 cells via NF-κB pathway and regulation of cellular redox status by an oxazine derivative. Biochimie. vol 93. issue 5. 2011-09-15. PMID:21295107. |
neuronal cell death due to apoptosis is a common characteristic of neurodegenerative diseases. |
2011-09-15 |
2023-08-12 |
rat |
| Mohammad Shamsul Ola, Mohd Nawaz, Haseeb Ahsa. Role of Bcl-2 family proteins and caspases in the regulation of apoptosis. Molecular and cellular biochemistry. vol 351. issue 1-2. 2011-08-26. PMID:21210296. |
apoptosis is a highly regulated form of cell death, and dysregulation of apoptosis results in pathological conditions including cancer, autoimmune and neurodegenerative diseases. |
2011-08-26 |
2023-08-12 |
Not clear |
| Kyoji Iked. [Mitochondrial function in bone resorption and formation]. Nihon rinsho. Japanese journal of clinical medicine. vol 69. issue 7. 2011-08-16. PMID:21774358. |
mitochondria are involved in diverse biological processes through energy production, ros generation and apoptosis, and mitochondrial dysfunction causes metabolic disorders, neurodegenerative disease, cancer and aging. |
2011-08-16 |
2023-08-12 |
Not clear |
| Tomasz M Stępkowski, Marcin K Kruszewsk. Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis. Free radical biology & medicine. vol 50. issue 9. 2011-08-08. PMID:21295136. |
the roles of keap1 molecular binding partners in apoptosis regulation during carcinogenesis and in neurodegenerative diseases are also discussed. |
2011-08-08 |
2023-08-12 |
Not clear |
| Kumar Sapkota, Seung Kim, Se-Eun Park, Sung-Jun Ki. Detoxified extract of Rhus verniciflua stokes inhibits rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y. Cellular and molecular neurobiology. vol 31. issue 2. 2011-07-18. PMID:21061154. |
these results suggest that rvs may protect dopaminergic neurons against rotenone-induced apoptosis by multiple functions and contribute to neuroprotection in neurodegenerative diseases, such as pd. |
2011-07-18 |
2023-08-12 |
human |
| Hongwen He, Weiguo Dong, Fang Huan. Anti-amyloidogenic and anti-apoptotic role of melatonin in Alzheimer disease. Current neuropharmacology. vol 8. issue 3. 2011-07-14. PMID:21358971. |
it is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in ad. |
2011-07-14 |
2023-08-12 |
Not clear |
| Mark L Dallas, John P Boyle, Carol J Milligan, Rachael Sayer, Talitha L Kerrigan, Connor McKinstry, Peiyuan Lu, Jamel Mankouri, Mark Harris, Jason L Scragg, Hugh A Pearson, Chris Peer. Carbon monoxide protects against oxidant-induced apoptosis via inhibition of Kv2.1. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 25. issue 5. 2011-06-28. PMID:21248240. |
oxidative stress induces neuronal apoptosis and is implicated in cerebral ischemia, head trauma, and age-related neurodegenerative diseases. |
2011-06-28 |
2023-08-12 |
Not clear |
| Mariella Adriana Terán, Elena Martínez, Ana L Reyes, Andrea Paolino, Marcelo Vital, Patricia Esperón, Jose P Pacheco, Eduardo Savi. Biological studies in animal models using [99mTc](CO)3 recombinant annexin V as diagnostic agent of apoptotic processes. Nuclear medicine and biology. vol 38. issue 2. 2011-05-25. PMID:21315284. |
there are many diseases associated with variations in the expression of apoptosis such as organ rejection after transplantation, myocardial ischemia or infarct and neurodegenerative diseases. |
2011-05-25 |
2023-08-12 |
Not clear |
| Masako Okamoto, Nae Saito, Hirotatsu Kojima, Takayoshi Okabe, Kohsuke Takeda, Hidenori Ichijo, Toshio Furuya, Tetsuo Nagan. Identification of novel ASK1 inhibitors using virtual screening. Bioorganic & medicinal chemistry. vol 19. issue 1. 2011-05-05. PMID:21134755. |
apoptosis signal-regulating kinase 1 (ask1, also called map3k5) is a mitogen-activated protein kinase kinase kinase (map3k) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases. |
2011-05-05 |
2023-08-12 |
Not clear |
| Ira Tabas, David Ro. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature cell biology. vol 13. issue 3. 2011-04-27. PMID:21364565. |
in settings of chronic er stress, the associated apoptosis may contribute to pathophysiological processes involved in a number of prevalent diseases, including neurodegenerative diseases, diabetes, atherosclerosis and renal disease. |
2011-04-27 |
2023-08-12 |
Not clear |
| A Abdi, H Sadraie, L Dargahi, L Khalaj, A Ahmadian. Apoptosis inhibition can be threatening in Aβ-induced neuroinflammation, through promoting cell proliferation. Neurochemical research. vol 36. issue 1. 2011-04-18. PMID:20848191. |
neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. |
2011-04-18 |
2023-08-12 |
rat |
| X-S Cheng, M-S Li, J Du, Q-Y Jiang, L Wang, S-Y Yan, D-M Yu, J-B Den. Neuronal apoptosis in the developing cerebellum. Anatomia, histologia, embryologia. vol 40. issue 1. 2011-04-14. PMID:21231956. |
the results of this study suggest that the key period of neuronal apoptosis in the cerebellar cortex is between p0 and p14, indicating that this developmental period could be susceptible to treatment for congenital neurodegenerative diseases. |
2011-04-14 |
2023-08-12 |
mouse |
| Mireia Niso-Santano, José M Bravo-San Pedro, Rubén Gómez-Sánchez, Vicente Climent, Germán Soler, José M Fuentes, Rosa A González-Pol. ASK1 overexpression accelerates paraquat-induced autophagy via endoplasmic reticulum stress. Toxicological sciences : an official journal of the Society of Toxicology. vol 119. issue 1. 2011-03-25. PMID:20929985. |
er stress-induced ask1 activation could play an important role both in neuronal apoptosis and an autophagic response in the pathogenesis of several neurodegenerative diseases, including parkinson's disease. |
2011-03-25 |
2023-08-12 |
Not clear |
| In Su Kim, Sushruta Koppula, Byung Wook Kim, Min Dong Song, Ju Yeon Jung, Gwang Lee, Hee Soon Lee, Dong-Kug Cho. A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP(+)-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling. European journal of pharmacology. vol 650. issue 1. 2011-03-24. PMID:20946892. |
the results indicate that phid protects against mpp(+)-induced apoptosis by blocking reactive oxygen species stimulation and jnk signaling pathways in sh-sy5y cells, implicating the novel compound in the prevention of progressive neurodegenerative diseases such as parkinson's disease. |
2011-03-24 |
2023-08-12 |
Not clear |
| E Esposito, S Cuzzocre. New therapeutic strategy for Parkinson's and Alzheimer's disease. Current medicinal chemistry. vol 17. issue 25. 2011-03-07. PMID:20586718. |
many potential pathways of neuronal cell death have been implicated in a mouse model of neurodegenerative disease, including excitotoxicity, toxicity from reactive oxygen species (superoxide anion, nitric oxide, hydroxyl radical), apoptosis (caspase-dependent and -independent pathways), necrosis and glial injury. |
2011-03-07 |
2023-08-12 |
mouse |